Science Quiz / BCM Block 7 Renal

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Can you name the BCM Block 7 Renal?

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hintanswerextra fun facts
potassium sparing diuretics act distally (cortical collecting duct) and block aldosterone's habit of dumping K+ for Na+. amiloride and bactrim inhibit ENaC. Who antagonizes aldoste
syndrome caused by gain of function mutation leading to HTN, hypokalemia, metabolic alkalosis, low renin, low aldosterone
presents with Pressure (HTN), pain (HA), perspiration, palpitation, pallor, paroxysm
lumpy bumpy IgG & C3, subepithelial humps, nephritic syndrome
first line drug class for DM nephropathy
pH 7.56, Na 141, K+ 4.1, Cl 105, HCO3 26, PaCO2 60, PaO2 70. acute or chronic respiratory acidosis?
otherwise healthy person collapses/presents with neurologic dysfunction after running a marathon. give H20 (D5W), 0.9%m NaCl, or 3% NaCl??
name a cause of non-anion gap metabolic acidosis
older gentleman with weak stream progressing to oliguria/anuria. FeNA high or low?
nephrotic syndrome, older men, type II hypersensitivity to phospholipase A2 on podocytes; granular IgG/C3, subepithelial deposits
nephrotic syndrome, circulating factor directly damages podocytes, HIV/heroin association, IgM & c3 trapped in glomerulus
nephrotic syndrome, T-cell derived circulating factor causes damage to podocytes; no IF findings; tends to recur
pH 7.30, Na 139, K+ 3.9, Cl 104, HCO3 10. what do you expect PaCO2 to be?
hintanswerextra fun facts
name the syndrome: global or nodular mesangial sclerosis, thicking of glomerular & tubular GBM (leading to effacement of foot proceses & tubular atrophy), hyalinosis of renal ateri
nephritic syndrome of older men with no IF pathology or EM pathology (aside from GBM gap), caused by a type III hypersensitivity
person comes in with rash, eosinophilia, fever 2 wks after introduction to a new drug (This is AIN, a type of TIN). name one of the causative drugz
nephrotic syndrome in young women, circulating immune complex, tram tracking IgG/C3, subendothelial deposits, mesangial interposition, HCV
nephritic syndrome caused by type II hypersensitivity to collagen type IV, linear IgG and C3 deposits
AKI: FENa less than 1%, BUN/creatinine greater than 20. pre-renal, renal, or post-renal?
like math? pH 7.29, Na 140, K 4.1, Cl 104, HCO3 12. AG = ??
MCC ESRD; progresses from hyper-filtration to GBM thickening to microalbuminurea to NS to ESRD
most sensitive test for pheochromocytoma
so, amphoteracin B causes RTA type I (distal hypokalemic), bactrim causes type IV (distal hyperkalemic). which of our diuretics causes type II (proximal hypokalemic)?
this hormone causes the insertion of ENaC's into apical membrane in cortical collecting duct principal cells.
nephritic syndrome with mesangial deposits/proliferation, slow progression, poor prognosis
pt is vomiting. expected resultant acid/base disturbance?

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