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analog of PABA, inhibits folic acid synthesis
analog of dihydrofolate, inhibits DHFR
inhibits DNA gyrase to inhibit DNA replication
older quinolone
reduced by bacterial enzymes to form reactive sp that destroys DNA
inhibitor of cell wall synthesis by preventing cross-linking
binds to B-lactamase, inhibits
B- lactam that comes in three generations
cell wall synthesis inhibitor that isn't a B lactam
binds to sites on membrane, can be displaced by divalent cations, req. O-dependent transport, used c B-lacatms
blocks AA-tRNA binding to A site on 30s subunit of 70s ribosome
inhibitor of protein synthesis, not commonly used d/t sig toxicities
binds 50s subunit preventing translocation in tRNA from A to P site
binds 50s subunit, blocks peptidyl transferase
binds 50s subunit, constricts exit channel
completely synthetic binder of 50s subunit, prevents formation of 70s initiation complex
only taken up by anaerobic bacteria and parasites, disrupts DNA
inhibits mycolic acid synthesis to prevent CW synth in mycobacteria
inhibits DNA dependent RNA pol for mycobacteria
poorly understood TB drug that might interfere c mycolic acid synth
Polyene macrolide that binds to cell membranes. Amphipathic, binds ergosterol, forms transmembrane pore.
converted to 5-FU, then 5-deoxyUMP, complexes c thymidylate synthase to block DNA synth
block ergosterol synth by inhibiting C-14a demethylase
