Inhibits the degradation of warfarin by metabolizing P450 enzymes
Inhibits degradation of theophylline and caffeine potentially leading to seizures
these two agents for UTI are antagonistic
Combine w/ aminoglycoside for enterococci
Hydrolyzed by renal dipeptidase. Combined w/ Cilistatin (renal dipeptidase inihibitor)
Almost always combined w/ β¬-lactams (synergistic)
Antagonistic with Macrolides
Antagonistic w/ Chloramphenicol, Clindamycins Clarithro & Erythromycin but NOT Azithromycin potentiate effects of corticosteroids, cyclosporine, digoxin, warfarin (due to their met
Increases conc. of cyclosporine, Ca2+ channel blockers
Is a reversible MAOI: avoid tyramine rich food. Do not give concurrently w/ MAOI’s, bupropion, tricylic antidepressants, SSRI’s or St. John’s Wort
Induces P450 enzymes, can increase metabolism of many other drugs
Induces P450 enzymes, increases elimination of other drugs. Can cancel the contraceptive effects of oral contraceptives
Inhibits a P450 enzyme: inhibits metabolism of many other drugs (warfarin, cyclosporine, digoxin)-- ↑ blood levels and toxic effects
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