Science Quiz / Hem/Onc Pharm

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Can you name the Hem/Onc Pharm?

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SE of bleomycin
Class: Bortezxomib
Mechanism: irreversible acetylation
Inhibits adrenal and testicular androgen synthesis
SE: Nephrotoxicity, ototoxicity, nausea
Lab to differentiate folate/B12 deficiency
Antibody in Trastuzumab: anti-?
Irinotecan/topotecan inhibit?
Activates 6-MP (purine analog)
Anti-metabolites phase of action?
SE: Osteoporosis and thromboembolism
Tx: tumor lysis syndrome (besides hydration)
Taxanes prevent microtubule?
Use of busulfan?
5-Fluorouracil inhibits
SE of methotrexate
SE of busulfan?
Antibody against GP IIb/IIIa receptor
Prevent Hematuria with R-CHOP
SE of doxorubicin
SE: cyclophosphamide
Warfarin-induced skin necrosis - deficiency of?
Class: carmustine, lomustine, Streptozocin
Rx that inhibits ribonucleotide reductase
GnRH antagonist, no flare phenomenon
Antidote: warfarin (besides vit K)
Cytokine to treat melanoma, renal cell carcinoma
Vinca alkaloids prevent microtuble?
Phase of microtubule inhibitors
Iron chelator
GnRH agonist, dec LH and FSH
Tx OD of methotrexate
Antidote: tPA
Aromatase stored in?
SE: abciximab
Interleukin used to help thrombocytopenia
SE of vinblastine
No myelosuppression (but lung SE)
Rx increases plasmin
Rx to prevent hemorrhagic cystitis
Class: Bevacizumab
Great drug for solid tumors
SE of vincristine
Purine analog metabolized by xanthine oxidase
Activates antithrombin III
Methotrexate inhibits
Tx OD of 5-FU
Testosterone receptor antagonist
Adverse effect of tamoxifen
Rituximab used to treat?
Bortezxomid is used to treat?
clopidogrel/ticlopidine block ? receptors
Cytokine used to treat melanoma, kaposi's sarcoma
Inhibits DNA polymerase
Class: anastrozole, exemestane
Tx: colon, non-small cell lung, breast cancer
Cilostazol/dipyridamole inhibit:
OD: anion gap metabolic acidosis with respiratory alkalosis
OK in pregnancy: heparin or warfarin
Test to monitor heparin
Allopurinol given to leukemia pt to prevent?
Cytarabine is analog of
Hemorrhagic cystitis w/ alk. agents due to buildup of?
Class that crosses the BBB?
Unique SE of flutamide
Antibody in Rituximab: anti-?
SE of Trastuzumab/Herceptin
SE of Taxanes
Key use of 5-FU
Tamoxifen is an antagonist only in?
Antidote: heparin
SE avoided with lepirudin and bivalirudin
Warfarin blocks which enzyme
Filgrastim, sargramostim used to help?
Rx w/ inc toxicity with allopurinol
Which class? cyclophosphamide, ifosfamide
Raloxifene is an agonist only in?
Test to monitor warfarin
Mech of cisplatin

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