Science Quiz / Hem/Onc Pharm

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Can you name the Hem/Onc Pharm?

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QuestionAnswerNotes
Anti-metabolites phase of action?
SE of Taxanes
Rituximab used to treat?
Purine analog metabolized by xanthine oxidase
Cytokine to treat melanoma, renal cell carcinoma
Rx to prevent hemorrhagic cystitis
Cytokine used to treat melanoma, kaposi's sarcoma
Tx OD of 5-FU
Mechanism: irreversible acetylation
Raloxifene is an agonist only in?
Antibody in Trastuzumab: anti-?
OK in pregnancy: heparin or warfarin
Filgrastim, sargramostim used to help?
GnRH antagonist, no flare phenomenon
Allopurinol given to leukemia pt to prevent?
Rx that inhibits ribonucleotide reductase
Methotrexate inhibits
Tx: colon, non-small cell lung, breast cancer
Which class? cyclophosphamide, ifosfamide
Cilostazol/dipyridamole inhibit:
SE: cyclophosphamide
SE of busulfan?
SE avoided with lepirudin and bivalirudin
Tamoxifen is an antagonist only in?
Inhibits adrenal and testicular androgen synthesis
Taxanes prevent microtubule?
Vinca alkaloids prevent microtuble?
QuestionAnswerNotes
Test to monitor heparin
5-Fluorouracil inhibits
Activates antithrombin III
Antidote: tPA
Antidote: warfarin (besides vit K)
Test to monitor warfarin
SE: abciximab
Antibody against GP IIb/IIIa receptor
SE: Osteoporosis and thromboembolism
Rx increases plasmin
Mech of cisplatin
Lab to differentiate folate/B12 deficiency
Tx OD of methotrexate
SE of vinblastine
Class: Bortezxomib
Bortezxomid is used to treat?
Key use of 5-FU
Tx: tumor lysis syndrome (besides hydration)
SE of methotrexate
Phase of microtubule inhibitors
clopidogrel/ticlopidine block ? receptors
Class: Bevacizumab
Great drug for solid tumors
Inhibits DNA polymerase
SE of bleomycin
SE: Nephrotoxicity, ototoxicity, nausea
OD: anion gap metabolic acidosis with respiratory alkalosis
QuestionAnswerNotes
Adverse effect of tamoxifen
Testosterone receptor antagonist
Activates 6-MP (purine analog)
Warfarin-induced skin necrosis - deficiency of?
Prevent Hematuria with R-CHOP
Irinotecan/topotecan inhibit?
Antibody in Rituximab: anti-?
Interleukin used to help thrombocytopenia
Hemorrhagic cystitis w/ alk. agents due to buildup of?
Tx: HIT
Aromatase stored in?
Class that crosses the BBB?
SE of Trastuzumab/Herceptin
SE of doxorubicin
SE of vincristine
Iron chelator
Warfarin blocks which enzyme
Class: anastrozole, exemestane
Use of busulfan?
Cytarabine is analog of
Class: carmustine, lomustine, Streptozocin
Unique SE of flutamide
GnRH agonist, dec LH and FSH
Rx w/ inc toxicity with allopurinol
Etoposide
Antidote: heparin
No myelosuppression (but lung SE)

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