Science Quiz / Hem/Onc Pharm

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Can you name the Hem/Onc Pharm?

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Rx increases plasmin
SE of busulfan?
Tx OD of methotrexate
Mechanism: irreversible acetylation
Inhibits DNA polymerase
Antibody in Rituximab: anti-?
GnRH agonist, dec LH and FSH
SE of bleomycin
SE: Nephrotoxicity, ototoxicity, nausea
Cytokine to treat melanoma, renal cell carcinoma
Lab to differentiate folate/B12 deficiency
Irinotecan/topotecan inhibit?
Antibody against GP IIb/IIIa receptor
Tx: colon, non-small cell lung, breast cancer
SE: abciximab
Vinca alkaloids prevent microtuble?
Class: anastrozole, exemestane
Antibody in Trastuzumab: anti-?
Mech of cisplatin
Warfarin blocks which enzyme
SE of vincristine
Iron chelator
Filgrastim, sargramostim used to help?
Test to monitor warfarin
Anti-metabolites phase of action?
Cytarabine is analog of
SE avoided with lepirudin and bivalirudin
Class that crosses the BBB?
Key use of 5-FU
Class: carmustine, lomustine, Streptozocin
Adverse effect of tamoxifen
SE of Trastuzumab/Herceptin
Methotrexate inhibits
Class: Bevacizumab
Tx: tumor lysis syndrome (besides hydration)
OD: anion gap metabolic acidosis with respiratory alkalosis
Purine analog metabolized by xanthine oxidase
Warfarin-induced skin necrosis - deficiency of?
Test to monitor heparin
Bortezxomid is used to treat?
Hemorrhagic cystitis w/ alk. agents due to buildup of?
Interleukin used to help thrombocytopenia
Allopurinol given to leukemia pt to prevent?
Use of busulfan?
SE of vinblastine
Class: Bortezxomib
OK in pregnancy: heparin or warfarin
Rx that inhibits ribonucleotide reductase
Antidote: heparin
SE of methotrexate
SE: cyclophosphamide
Activates 6-MP (purine analog)
Rituximab used to treat?
Antidote: tPA
Prevent Hematuria with R-CHOP
Raloxifene is an agonist only in?
Great drug for solid tumors
5-Fluorouracil inhibits
GnRH antagonist, no flare phenomenon
Cytokine used to treat melanoma, kaposi's sarcoma
Aromatase stored in?
Antidote: warfarin (besides vit K)
Tamoxifen is an antagonist only in?
Testosterone receptor antagonist
clopidogrel/ticlopidine block ? receptors
Unique SE of flutamide
Inhibits adrenal and testicular androgen synthesis
SE: Osteoporosis and thromboembolism
No myelosuppression (but lung SE)
Taxanes prevent microtubule?
Cilostazol/dipyridamole inhibit:
SE of doxorubicin
Activates antithrombin III
Rx to prevent hemorrhagic cystitis
Rx w/ inc toxicity with allopurinol
Phase of microtubule inhibitors
SE of Taxanes
Tx OD of 5-FU
Which class? cyclophosphamide, ifosfamide

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