Science Quiz / Hem/Onc Pharm

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Can you name the Hem/Onc Pharm?

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QuestionAnswerNotes
No myelosuppression (but lung SE)
Activates antithrombin III
Tx: HIT
Cytokine to treat melanoma, renal cell carcinoma
SE of Taxanes
Bortezxomid is used to treat?
Which class? cyclophosphamide, ifosfamide
SE of vinblastine
Class: Bortezxomib
5-Fluorouracil inhibits
Adverse effect of tamoxifen
Great drug for solid tumors
Antibody in Trastuzumab: anti-?
Antibody in Rituximab: anti-?
Tx: colon, non-small cell lung, breast cancer
Class that crosses the BBB?
Mech of cisplatin
Antibody against GP IIb/IIIa receptor
Prevent Hematuria with R-CHOP
OK in pregnancy: heparin or warfarin
GnRH agonist, dec LH and FSH
Inhibits DNA polymerase
Tx OD of 5-FU
Taxanes prevent microtubule?
Antidote: tPA
Antidote: warfarin (besides vit K)
SE of methotrexate
QuestionAnswerNotes
Vinca alkaloids prevent microtuble?
SE of Trastuzumab/Herceptin
Key use of 5-FU
Iron chelator
SE: cyclophosphamide
Activates 6-MP (purine analog)
SE of vincristine
Interleukin used to help thrombocytopenia
Tamoxifen is an antagonist only in?
SE: abciximab
Anti-metabolites phase of action?
Tx OD of methotrexate
GnRH antagonist, no flare phenomenon
Cilostazol/dipyridamole inhibit:
Use of busulfan?
SE: Nephrotoxicity, ototoxicity, nausea
Aromatase stored in?
SE of busulfan?
Test to monitor heparin
SE of doxorubicin
SE: Osteoporosis and thromboembolism
Rx increases plasmin
Filgrastim, sargramostim used to help?
Inhibits adrenal and testicular androgen synthesis
Raloxifene is an agonist only in?
Cytarabine is analog of
OD: anion gap metabolic acidosis with respiratory alkalosis
QuestionAnswerNotes
Rx w/ inc toxicity with allopurinol
Class: carmustine, lomustine, Streptozocin
Warfarin blocks which enzyme
Class: anastrozole, exemestane
Purine analog metabolized by xanthine oxidase
Irinotecan/topotecan inhibit?
Test to monitor warfarin
Rituximab used to treat?
Lab to differentiate folate/B12 deficiency
Etoposide
Rx that inhibits ribonucleotide reductase
SE of bleomycin
Hemorrhagic cystitis w/ alk. agents due to buildup of?
SE avoided with lepirudin and bivalirudin
Methotrexate inhibits
Warfarin-induced skin necrosis - deficiency of?
Rx to prevent hemorrhagic cystitis
Phase of microtubule inhibitors
clopidogrel/ticlopidine block ? receptors
Tx: tumor lysis syndrome (besides hydration)
Class: Bevacizumab
Testosterone receptor antagonist
Cytokine used to treat melanoma, kaposi's sarcoma
Allopurinol given to leukemia pt to prevent?
Unique SE of flutamide
Antidote: heparin
Mechanism: irreversible acetylation

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