Science Quiz / Block8c ARTS

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Can you name the Block8c ARTS?

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Immuno dz where B cells stop working
Change in LV ejection fraction w/ aging
Dev Period: Schizencephaly
Vd effect: cystic fibrosis
Immediate Tx: congenital diaphragmatic hernia
p450 effect: macrolide abx, itraconazole, ketoconazole
Neonate - lung abscess and meningitis
Counting mechanism for senescence
Signal for dorsal/ventral position of axis
Fetus: Majority of CO from RV goes to?
Only vaccine given as early as birth
p450 effect: rifmpin, phenytoin, carbamazepine
Water or fat soluble - valium
Lung Dz assoc w/ Low PaO2, Low sats w/ discordant pre/post ductal sats
first place PMNs produced in fetus
downregulates Sonic Hedgehod ~42d gestation
Epidermis stratum: keratinocyte proliferation and epidermal renewal
Vd effect: septic shock
In utero, thermoregulation of the fetus performed by:
mutation in Hutchinson-Gilford Syndrome
Dx: 'boot shaped' heart, upturned apex
Cause of diplegic cerebral palsy
Pertussis: type of vaccine used in US
Change dose in pedi - hydrophilic drugs
MCC respiratory distress in newborns
Propranolol and atropine given to make heart go what rate?
Test for scoliosis
Hormone produced in largest quantity by the adrenal gland
Dx: 'egg on a string', inc pulm vasculature
Dx: inspired O2 100% x10min, then PaO2 less than 150mmHg
GH noctural peaks dec in elderly resulting in dec in?
Dec renal clearance - change dosing by increasing?
Dx: Wider pulse pressure in young person
formation and closure of neural tube 22-28d
impact of aging on arterial impedance
Chromosome that specifically affects proliferation/senescence
Elderly - dec liver mass/hepatic blood flow also dec ? metabolism
Effect of congenital heart disease on gastric emptying
immuno dz we learned that appears b/t 3-6mos
Which trimester does IgG start crossing the placenta?
Epidermis stratum: barrier lipid synthesis and corneocyte production via programmed cell death
Gene: X-linked lissencephaly in males
Predominant method of neonatal heat production
Aging kidney depends on ? to maintain filtration
MC complement component deficiency
Cells escape from senescence because of?
disorder of tone, posture, or mvt due to a non-progressive lesion in the developing brain
admin of all or part of a microorganism to evoke an immunologic response that mimics natural infections
MC acquired immunodeficiency
Major site of drug biotransformation
Polymicrogyria, posterior fossa cyst, chorioretinal lacunae
Neonate: Large lung volumes w/ diffuse, patchy infiltrates
Dx: downward displacement of the tricuspid leaflets into the RV
Inc osmolality Rx increases risk of ? in infants
Shunts blood flow from umbilical vein directly to IVC
Dx: no connection b/t pulm veins and left atrium
B-cell tyrosine kinase deficiency
Type of neuron migration - olfactory bulbs
Effect of age on alpha-1-acid glycoprotein
Phase I Rxn imp: diazepam, phenobarbital, phenytoin
Gene: heterozygous deletion/mutation causes lissencephaly
Effect on hepatic clearance: CHD, sepsis
MC fetal malformation
progeroid syndrome due to mutations in DNA helicase
Loss of lean body mass seen w/ aging
Systolic BP (men) inc 5 mmHg/decade until age ? then 10 mmHg/decade
recurrent neisseria and meningitis suggest defects in?
Impaired relaxation in elderly affects ? function
Primary type of heat loss in babies
Dev Period: Holoprosencephaly
range of environmental temps w/ normal body termperature and minimal basal metabolic rate
CD4 or CD8: higher in infants
genes that are beneficial before/during reproductive age but detrimental afterwards
immuno dz we learned that appears b/t 6-18mos
Discrete opacities in crystalline lens
Egg allergy is c/i to which vaccine?
Dx w/ nitroblue tetrzolium test or chemiluminescence assay
Immature/altered permeability of intestinal mucosa affects drug absorption how?
Heat source mechanism for incubator
Most difficult air leak to treat
effect of aging on glucagon levels
Phase II metabolism of APAP in infants
normal cells have limited proliferative potential in vitro
Effect of aging on circulating norepi levels
Epidermis stratum: anucleated outermost layer, physical interface with environment
Lamin A permanently modified by lipid farnesyl group
Epidermis stratum: tightly packed keratinocytes linked via desmosomal connections
Spinal abnormality in infant assoc w/ poorly controlled DM
Aging changes due to trauma and disease
Surfactant deficiency in newborn causes
Diminishing ability to maintain homeostasis w/ challenge is hallmark of?
Dx: recurrent bacterial infections, esp catalase pos organisms
lissencephaly, posterior same as anterior
If mom is HBsAg+, newborn should receive vaccine AND ?
Dx: eczema, thrombocytopenia (microplatelets), diarrhea, recurrent infections
Gene: lissencephaly with anterior worse than posterior
Morphine, furosemide in infants affected by dec?
Technique to reduce evaporative heat loss and permit radiative heat transfer
Hepatitis A: type of vaccine
Gastric pH at birth > ?
Change dose of warfarin in elderly
Inc in ? = primary mech for insulin resistance in aging
MMR: type of vaccine used in US
Rx SE in babies: kernicterus
Three main determinants of diastolic function are passive stiffness, uniformity of LV and ?
Loss of neurons in elderly occur in basal nuclei, substantia nigra and ?
Dose adjustment of phenobarbital in infant?
Signal for anterior/posterior position of axis
Phase I Rxn imp: theophylline, diazepam, meperidine
When the foramen ovale closes, pressure in the RA is ? c/w the LA
Dose adjustment of penicillin in infant?
Dev Period: Encephalocele
When elderly exercise, ? pressure inc
Gene: DiGeorge + ptosis and deafness
MC primary immunodeficiency
Infant: vasoconstriction of peripheral blood vessels in hands and feet
Dx: results from focal arrest in fetal lung dev around or before 7th week
B or T cell: dependent on IL-7 expression
Besides anaphylaxis, what reaction to DTaP is a contraindication for booster?
Development of ? depends on RAG-1 and RAG-2
Conjugated vaccine vs serotypes A, C, Y, and W-135
Dx: ill, elderly person w/ high serum glucose
Which type of muscle fibers dec w/ age?
changes directly dependent on the passage of time
Loss of high freqencies, difficulty in localization of sound and phoneme discrimination are all part of?
MC surgery in cerebral palsy
Rotavirus: type of vaccine
bilateral schizencephaly + absence of septum pellucidum
most free radicals generated by?
rhizomelic chondrodysplasia, optic nerve hypoplasia
Haemophilius influenzae (HiB) vaccine type?
Gene: lissencephaly and ambiguous genitalia
Change dose of adrenergic agents in elderly
absolute dec in amt of bone per unit volume
Infant Dx: Cardiomegaly, pulm congestion, widened mediastinum
Dx: Loss of mass in hippocampus by serial CT or MRI
Screening for T-cell lymphopenic disorders
elderly - how to change dose for lipid soluble Rx?
Presents w/ tetany in first few days of life
admin of preformed ab to a person exposed to or high likelihood of exposure
Infant: covering of sebaceous secretions and desquamated epithelial cells
Dev Period: Micro/megalencephaly
Missing 3rd and 4th pharyngeal pouches
Change dose of benzos in elderly
Dx: narrowing or blockage of the nasal passages
Primary normal cells that do not senesce
fetal & neonatal heat production are based on?
Effect on hepatic clearance: CF
Rx SE: grey baby syndrome 2/2 cardiac failure
Dev Period: Caudal Regression Syndrome
elderly - how to change dose for water soluble Rx?
Varicella: type of vaccine used in US
Lissenceaphy + dysmorphic facial appearance
surrogate for true height w/ changes in age or spinal dz
effect of aging on daily requirement for thyroxine replacement
non-enzymatic reaction b/t glucose and amine groups of proteins
First sign/muscle affected in DMD
E to A ratio determines over 60% of ?
bilateral schizencephaly due to lack of ?
Common physical change in adrenals of elderly
Absence of thymic shadow on XR
Heart anomaly assoc w/ maternal lithium use
Effect of aging on beta-adrenergic vasodilation
brain - irregular masses of paired helical fibers
neurotransmitter in nucleus basalis of Meynert
Dx: 'snowman shape' heart and pulmonary edema
MC SE of VZV vaccine
Dx: Visible air bronchograms, 'ground-glass' lung, low lung volume
Single frontal incisor + epilepsy
Influenza - major genetic variations aka?
Neurotransmitter in median raphe nucleus
Phase of metabolism: cytochrome P450
'Ball and Valve' lung obstruction in neonate
Dx: delayed umbilical cord separation, recurrent soft tissue infections but no pus
Protein used in the pneumococcal conjugated vaccine?
Old Brains recover poorly due to inadequate ? production
elderly suppress thyroid function while 'ill or malnourished'
Dev Period: Lissencephaly
Effect on renal clearance: CF
Dx: single arterial vessel in the heart
Heat loss mechanism for incubator
Loss of accommodation in the older individual
absent CD18 of 3 cell surface glycoproteins
Elderly - how to change dose of vancomycin or digoxin
first place mononuclear and dendritic cells produced in fetus
Abnl heart sound considered nl over age 75
elevated glucose AND elevated insulin
glucose: 100+ age = maximum?
Change dose in pedi - lipophilic drugs
Gene: recessive mutation causes lissencephaly
'Off' signal for Ab production that may limit response in elderly
Effect on hepatic clearance: CHD, sepsis
'streaky'/'sunburst' pattern of linear densities emanating from hilum
grey baby syndrome due to dec in?
Lung Dz assoc w/ PFO and PDA
Dont take calcium and magnesium with which rx?
Dx: Survival requires PDA (mixing of the two circulations)

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