Science Quiz / Block8c ARTS

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Can you name the Block8c ARTS?

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Screening for T-cell lymphopenic disorders
immuno dz we learned that appears b/t 6-18mos
Chromosome that specifically affects proliferation/senescence
'streaky'/'sunburst' pattern of linear densities emanating from hilum
Dev Period: Encephalocele
Haemophilius influenzae (HiB) vaccine type?
impact of aging on arterial impedance
grey baby syndrome due to dec in?
Aging kidney depends on ? to maintain filtration
Dx: Survival requires PDA (mixing of the two circulations)
Dx: no connection b/t pulm veins and left atrium
changes directly dependent on the passage of time
Rx SE in babies: kernicterus
Lamin A permanently modified by lipid farnesyl group
Which trimester does IgG start crossing the placenta?
Rotavirus: type of vaccine
Gene: X-linked lissencephaly in males
Surfactant deficiency in newborn causes
Immuno dz where B cells stop working
Aging changes due to trauma and disease
Phase II metabolism of APAP in infants
Most difficult air leak to treat
Common physical change in adrenals of elderly
recurrent neisseria and meningitis suggest defects in?
elevated glucose AND elevated insulin
Heat loss mechanism for incubator
range of environmental temps w/ normal body termperature and minimal basal metabolic rate
Elderly - dec liver mass/hepatic blood flow also dec ? metabolism
MMR: type of vaccine used in US
Dx: 'egg on a string', inc pulm vasculature
Three main determinants of diastolic function are passive stiffness, uniformity of LV and ?
elderly - how to change dose for water soluble Rx?
Effect of aging on beta-adrenergic vasodilation
Conjugated vaccine vs serotypes A, C, Y, and W-135
Rx SE: grey baby syndrome 2/2 cardiac failure
Change dose of benzos in elderly
surrogate for true height w/ changes in age or spinal dz
glucose: 100+ age = maximum?
Presents w/ tetany in first few days of life
Change dose of warfarin in elderly
admin of preformed ab to a person exposed to or high likelihood of exposure
MC surgery in cerebral palsy
Dx: downward displacement of the tricuspid leaflets into the RV
Effect on renal clearance: CF
Gene: lissencephaly with anterior worse than posterior
Gene: recessive mutation causes lissencephaly
first place mononuclear and dendritic cells produced in fetus
Shunts blood flow from umbilical vein directly to IVC
GH noctural peaks dec in elderly resulting in dec in?
Systolic BP (men) inc 5 mmHg/decade until age ? then 10 mmHg/decade
'Off' signal for Ab production that may limit response in elderly
Effect on hepatic clearance: CF
neurotransmitter in nucleus basalis of Meynert
Effect of congenital heart disease on gastric emptying
Dx: recurrent bacterial infections, esp catalase pos organisms
fetal & neonatal heat production are based on?
non-enzymatic reaction b/t glucose and amine groups of proteins
Loss of high freqencies, difficulty in localization of sound and phoneme discrimination are all part of?
Dx: results from focal arrest in fetal lung dev around or before 7th week
Signal for anterior/posterior position of axis
Egg allergy is c/i to which vaccine?
rhizomelic chondrodysplasia, optic nerve hypoplasia
Pertussis: type of vaccine used in US
Dec renal clearance - change dosing by increasing?
When the foramen ovale closes, pressure in the RA is ? c/w the LA
Inc in ? = primary mech for insulin resistance in aging
Type of neuron migration - olfactory bulbs
formation and closure of neural tube 22-28d
Infant: vasoconstriction of peripheral blood vessels in hands and feet
Change in LV ejection fraction w/ aging
Cells escape from senescence because of?
MC fetal malformation
Varicella: type of vaccine used in US
Effect on hepatic clearance: CHD, sepsis
Lissenceaphy + dysmorphic facial appearance
Abnl heart sound considered nl over age 75
Test for scoliosis
Gene: DiGeorge + ptosis and deafness
Infant Dx: Cardiomegaly, pulm congestion, widened mediastinum
Dose adjustment of phenobarbital in infant?
absolute dec in amt of bone per unit volume
Dose adjustment of penicillin in infant?
Primary normal cells that do not senesce
'Ball and Valve' lung obstruction in neonate
Only vaccine given as early as birth
Polymicrogyria, posterior fossa cyst, chorioretinal lacunae
Gene: heterozygous deletion/mutation causes lissencephaly
downregulates Sonic Hedgehod ~42d gestation
Spinal abnormality in infant assoc w/ poorly controlled DM
Dev Period: Lissencephaly
Dx: Loss of mass in hippocampus by serial CT or MRI
Dx: delayed umbilical cord separation, recurrent soft tissue infections but no pus
Vd effect: septic shock
lissencephaly, posterior same as anterior
effect of aging on daily requirement for thyroxine replacement
Dx: inspired O2 100% x10min, then PaO2 less than 150mmHg
Single frontal incisor + epilepsy
Dx: 'boot shaped' heart, upturned apex
Infant: covering of sebaceous secretions and desquamated epithelial cells
MC complement component deficiency
elderly - how to change dose for lipid soluble Rx?
Hormone produced in largest quantity by the adrenal gland
CD4 or CD8: higher in infants
Impaired relaxation in elderly affects ? function
Besides anaphylaxis, what reaction to DTaP is a contraindication for booster?
MCC respiratory distress in newborns
Phase I Rxn imp: theophylline, diazepam, meperidine
If mom is HBsAg+, newborn should receive vaccine AND ?
Dev Period: Schizencephaly
Effect of aging on circulating norepi levels
Immature/altered permeability of intestinal mucosa affects drug absorption how?
First sign/muscle affected in DMD
Dx: single arterial vessel in the heart
Dev Period: Holoprosencephaly
In utero, thermoregulation of the fetus performed by:
Phase I Rxn imp: diazepam, phenobarbital, phenytoin
Technique to reduce evaporative heat loss and permit radiative heat transfer
Cause of diplegic cerebral palsy
B-cell tyrosine kinase deficiency
Effect of age on alpha-1-acid glycoprotein
Diminishing ability to maintain homeostasis w/ challenge is hallmark of?
Discrete opacities in crystalline lens
B or T cell: dependent on IL-7 expression
progeroid syndrome due to mutations in DNA helicase
normal cells have limited proliferative potential in vitro
bilateral schizencephaly due to lack of ?
E to A ratio determines over 60% of ?
Hepatitis A: type of vaccine
Elderly - how to change dose of vancomycin or digoxin
Primary type of heat loss in babies
Dev Period: Caudal Regression Syndrome
Epidermis stratum: anucleated outermost layer, physical interface with environment
first place PMNs produced in fetus
Protein used in the pneumococcal conjugated vaccine?
Dont take calcium and magnesium with which rx?
Dx: eczema, thrombocytopenia (microplatelets), diarrhea, recurrent infections
most free radicals generated by?
Signal for dorsal/ventral position of axis
Loss of neurons in elderly occur in basal nuclei, substantia nigra and ?
Epidermis stratum: keratinocyte proliferation and epidermal renewal
Loss of lean body mass seen w/ aging
Dx: Visible air bronchograms, 'ground-glass' lung, low lung volume
absent CD18 of 3 cell surface glycoproteins
Dx: narrowing or blockage of the nasal passages
Water or fat soluble - valium
Neurotransmitter in median raphe nucleus
immuno dz we learned that appears b/t 3-6mos
Heart anomaly assoc w/ maternal lithium use
Absence of thymic shadow on XR
Heat source mechanism for incubator
elderly suppress thyroid function while 'ill or malnourished'
effect of aging on glucagon levels
Neonate - lung abscess and meningitis
Which type of muscle fibers dec w/ age?
Epidermis stratum: tightly packed keratinocytes linked via desmosomal connections
Dev Period: Micro/megalencephaly
Immediate Tx: congenital diaphragmatic hernia
Change dose of adrenergic agents in elderly
admin of all or part of a microorganism to evoke an immunologic response that mimics natural infections
MC primary immunodeficiency
Gene: lissencephaly and ambiguous genitalia
Epidermis stratum: barrier lipid synthesis and corneocyte production via programmed cell death
Vd effect: cystic fibrosis
Neonate: Large lung volumes w/ diffuse, patchy infiltrates
genes that are beneficial before/during reproductive age but detrimental afterwards
Effect on hepatic clearance: CHD, sepsis
p450 effect: macrolide abx, itraconazole, ketoconazole
Old Brains recover poorly due to inadequate ? production
Development of ? depends on RAG-1 and RAG-2
MC acquired immunodeficiency
Counting mechanism for senescence
Morphine, furosemide in infants affected by dec?
brain - irregular masses of paired helical fibers
disorder of tone, posture, or mvt due to a non-progressive lesion in the developing brain
Missing 3rd and 4th pharyngeal pouches
Dx: Wider pulse pressure in young person
Dx w/ nitroblue tetrzolium test or chemiluminescence assay
Influenza - major genetic variations aka?
Predominant method of neonatal heat production
Lung Dz assoc w/ PFO and PDA
Fetus: Majority of CO from RV goes to?
Major site of drug biotransformation
mutation in Hutchinson-Gilford Syndrome
Change dose in pedi - hydrophilic drugs
When elderly exercise, ? pressure inc
Change dose in pedi - lipophilic drugs
bilateral schizencephaly + absence of septum pellucidum
Loss of accommodation in the older individual
Gastric pH at birth > ?
Lung Dz assoc w/ Low PaO2, Low sats w/ discordant pre/post ductal sats
Inc osmolality Rx increases risk of ? in infants
Phase of metabolism: cytochrome P450
Dx: ill, elderly person w/ high serum glucose
MC SE of VZV vaccine
p450 effect: rifmpin, phenytoin, carbamazepine
Dx: 'snowman shape' heart and pulmonary edema
Propranolol and atropine given to make heart go what rate?

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