Science Quiz / Block8c ARTS

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Can you name the Block8c ARTS?

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MC surgery in cerebral palsy
If mom is HBsAg+, newborn should receive vaccine AND ?
Loss of lean body mass seen w/ aging
rhizomelic chondrodysplasia, optic nerve hypoplasia
Immediate Tx: congenital diaphragmatic hernia
B-cell tyrosine kinase deficiency
Abnl heart sound considered nl over age 75
Dx: eczema, thrombocytopenia (microplatelets), diarrhea, recurrent infections
Vd effect: septic shock
Epidermis stratum: anucleated outermost layer, physical interface with environment
Which trimester does IgG start crossing the placenta?
Infant Dx: Cardiomegaly, pulm congestion, widened mediastinum
Vd effect: cystic fibrosis
Single frontal incisor + epilepsy
Effect of aging on beta-adrenergic vasodilation
Dx: delayed umbilical cord separation, recurrent soft tissue infections but no pus
CD4 or CD8: higher in infants
Predominant method of neonatal heat production
effect of aging on glucagon levels
Cells escape from senescence because of?
MMR: type of vaccine used in US
Protein used in the pneumococcal conjugated vaccine?
Morphine, furosemide in infants affected by dec?
elderly - how to change dose for lipid soluble Rx?
bilateral schizencephaly due to lack of ?
Infant: covering of sebaceous secretions and desquamated epithelial cells
Dx: 'boot shaped' heart, upturned apex
absolute dec in amt of bone per unit volume
Technique to reduce evaporative heat loss and permit radiative heat transfer
p450 effect: macrolide abx, itraconazole, ketoconazole
MC complement component deficiency
range of environmental temps w/ normal body termperature and minimal basal metabolic rate
Dx: inspired O2 100% x10min, then PaO2 less than 150mmHg
Loss of accommodation in the older individual
Phase I Rxn imp: diazepam, phenobarbital, phenytoin
p450 effect: rifmpin, phenytoin, carbamazepine
Presents w/ tetany in first few days of life
Spinal abnormality in infant assoc w/ poorly controlled DM
Heat loss mechanism for incubator
Gene: DiGeorge + ptosis and deafness
Infant: vasoconstriction of peripheral blood vessels in hands and feet
Major site of drug biotransformation
changes directly dependent on the passage of time
Change dose of warfarin in elderly
downregulates Sonic Hedgehod ~42d gestation
formation and closure of neural tube 22-28d
Dx: single arterial vessel in the heart
Gene: heterozygous deletion/mutation causes lissencephaly
Development of ? depends on RAG-1 and RAG-2
Dev Period: Micro/megalencephaly
In utero, thermoregulation of the fetus performed by:
Old Brains recover poorly due to inadequate ? production
Change dose of benzos in elderly
recurrent neisseria and meningitis suggest defects in?
Dont take calcium and magnesium with which rx?
Effect of age on alpha-1-acid glycoprotein
When the foramen ovale closes, pressure in the RA is ? c/w the LA
'Off' signal for Ab production that may limit response in elderly
first place mononuclear and dendritic cells produced in fetus
Rotavirus: type of vaccine
Epidermis stratum: keratinocyte proliferation and epidermal renewal
Cause of diplegic cerebral palsy
Aging changes due to trauma and disease
surrogate for true height w/ changes in age or spinal dz
Dx: Visible air bronchograms, 'ground-glass' lung, low lung volume
admin of preformed ab to a person exposed to or high likelihood of exposure
Fetus: Majority of CO from RV goes to?
MCC respiratory distress in newborns
Aging kidney depends on ? to maintain filtration
Signal for anterior/posterior position of axis
Dx: recurrent bacterial infections, esp catalase pos organisms
MC primary immunodeficiency
Discrete opacities in crystalline lens
Loss of neurons in elderly occur in basal nuclei, substantia nigra and ?
Surfactant deficiency in newborn causes
Water or fat soluble - valium
Dev Period: Lissencephaly
Hormone produced in largest quantity by the adrenal gland
Lung Dz assoc w/ Low PaO2, Low sats w/ discordant pre/post ductal sats
Heart anomaly assoc w/ maternal lithium use
Gene: lissencephaly and ambiguous genitalia
Dev Period: Encephalocele
Only vaccine given as early as birth
Neonate - lung abscess and meningitis
brain - irregular masses of paired helical fibers
MC fetal malformation
Dx: no connection b/t pulm veins and left atrium
GH noctural peaks dec in elderly resulting in dec in?
Effect of aging on circulating norepi levels
Neurotransmitter in median raphe nucleus
neurotransmitter in nucleus basalis of Meynert
Gastric pH at birth > ?
Immature/altered permeability of intestinal mucosa affects drug absorption how?
Dose adjustment of penicillin in infant?
impact of aging on arterial impedance
Loss of high freqencies, difficulty in localization of sound and phoneme discrimination are all part of?
Dx: Loss of mass in hippocampus by serial CT or MRI
Phase I Rxn imp: theophylline, diazepam, meperidine
Dx: Wider pulse pressure in young person
Effect on hepatic clearance: CHD, sepsis
bilateral schizencephaly + absence of septum pellucidum
Diminishing ability to maintain homeostasis w/ challenge is hallmark of?
Neonate: Large lung volumes w/ diffuse, patchy infiltrates
Influenza - major genetic variations aka?
Dx: downward displacement of the tricuspid leaflets into the RV
Absence of thymic shadow on XR
Epidermis stratum: barrier lipid synthesis and corneocyte production via programmed cell death
Elderly - dec liver mass/hepatic blood flow also dec ? metabolism
Effect of congenital heart disease on gastric emptying
Impaired relaxation in elderly affects ? function
Phase of metabolism: cytochrome P450
Counting mechanism for senescence
Missing 3rd and 4th pharyngeal pouches
Dx: narrowing or blockage of the nasal passages
Dx: Survival requires PDA (mixing of the two circulations)
immuno dz we learned that appears b/t 3-6mos
immuno dz we learned that appears b/t 6-18mos
E to A ratio determines over 60% of ?
elderly suppress thyroid function while 'ill or malnourished'
Dx: 'egg on a string', inc pulm vasculature
Dx w/ nitroblue tetrzolium test or chemiluminescence assay
absent CD18 of 3 cell surface glycoproteins
Rx SE: grey baby syndrome 2/2 cardiac failure
Phase II metabolism of APAP in infants
Dx: ill, elderly person w/ high serum glucose
admin of all or part of a microorganism to evoke an immunologic response that mimics natural infections
Besides anaphylaxis, what reaction to DTaP is a contraindication for booster?
MC acquired immunodeficiency
Rx SE in babies: kernicterus
Common physical change in adrenals of elderly
Type of neuron migration - olfactory bulbs
mutation in Hutchinson-Gilford Syndrome
Primary normal cells that do not senesce
Dec renal clearance - change dosing by increasing?
'Ball and Valve' lung obstruction in neonate
Gene: X-linked lissencephaly in males
Dev Period: Holoprosencephaly
Elderly - how to change dose of vancomycin or digoxin
Lamin A permanently modified by lipid farnesyl group
Dose adjustment of phenobarbital in infant?
Haemophilius influenzae (HiB) vaccine type?
Effect on hepatic clearance: CHD, sepsis
B or T cell: dependent on IL-7 expression
normal cells have limited proliferative potential in vitro
Lissenceaphy + dysmorphic facial appearance
Dx: 'snowman shape' heart and pulmonary edema
disorder of tone, posture, or mvt due to a non-progressive lesion in the developing brain
glucose: 100+ age = maximum?
grey baby syndrome due to dec in?
Change dose in pedi - hydrophilic drugs
Dev Period: Schizencephaly
Varicella: type of vaccine used in US
Change in LV ejection fraction w/ aging
MC SE of VZV vaccine
Immuno dz where B cells stop working
Effect on renal clearance: CF
Signal for dorsal/ventral position of axis
Dx: results from focal arrest in fetal lung dev around or before 7th week
Propranolol and atropine given to make heart go what rate?
lissencephaly, posterior same as anterior
Shunts blood flow from umbilical vein directly to IVC
fetal & neonatal heat production are based on?
Which type of muscle fibers dec w/ age?
'streaky'/'sunburst' pattern of linear densities emanating from hilum
elderly - how to change dose for water soluble Rx?
Chromosome that specifically affects proliferation/senescence
most free radicals generated by?
progeroid syndrome due to mutations in DNA helicase
Change dose of adrenergic agents in elderly
Primary type of heat loss in babies
Epidermis stratum: tightly packed keratinocytes linked via desmosomal connections
When elderly exercise, ? pressure inc
Polymicrogyria, posterior fossa cyst, chorioretinal lacunae
First sign/muscle affected in DMD
first place PMNs produced in fetus
Effect on hepatic clearance: CF
Inc in ? = primary mech for insulin resistance in aging
Gene: recessive mutation causes lissencephaly
Inc osmolality Rx increases risk of ? in infants
genes that are beneficial before/during reproductive age but detrimental afterwards
Screening for T-cell lymphopenic disorders
Conjugated vaccine vs serotypes A, C, Y, and W-135
effect of aging on daily requirement for thyroxine replacement
Change dose in pedi - lipophilic drugs
Egg allergy is c/i to which vaccine?
Systolic BP (men) inc 5 mmHg/decade until age ? then 10 mmHg/decade
Pertussis: type of vaccine used in US
Three main determinants of diastolic function are passive stiffness, uniformity of LV and ?
Dev Period: Caudal Regression Syndrome
Lung Dz assoc w/ PFO and PDA
non-enzymatic reaction b/t glucose and amine groups of proteins
Gene: lissencephaly with anterior worse than posterior
elevated glucose AND elevated insulin
Test for scoliosis
Most difficult air leak to treat
Hepatitis A: type of vaccine
Heat source mechanism for incubator

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