Science Quiz / 8b GUG

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Bladder cancer sx in 85% of cases
MC gynecological CA worldwide
MC breast carcinoma in situ
MC location of transitional cell cancer
Assoc w/ uterine hyperplasia/CA in postmenopausal women
Varicocele finding on U/S
MCC male infertility in the world
malignant germ cell tumor: AFP
postmenopausal, complex hyperplasia w/ atypia - tx?
Thin, long unilocular mass, associated with period
Colposcopy: cells w/ inc collagen turn white w/ ?
low value w/ anovulation: failure to centrally stimulate follicular growth
breast path - clown face
Mech: Change in transport speed of the ovum
Main mode of spread of ovarian cancer
Appendix testes remnant of ?
Papillary projections surrounded by Schiller-Duval bodies
MC tumor of myometrium
Condition during lactation, mimics inflammatory breast cancer
Permanent cessation of menses x1yr w/ high FSH, low E2
MC site to endometriosis
HTN dx in first 20 weeks of pregnancy
first line hormonal therapy of metastatic breast Ca in postmeno
normal strict morphology required to bind to?
division of ovum after 13 days
antepartum hemorrhage after 20 wks
'powder burn' lesions
% of simple atypical hyperplasia that progressed to cancer
MCC abnml uterine bleeding in adolescence
tx: stress urinary incontinence that inc sphincter tone
MCC abnml uterine bleeding in postmenopausal
CA most strongly associated w/ obesity
HTN after 20 wk gestation assoc w/ proteinuria
Uterine size discrepant from dates
hormonal therapy of metastatic breast Ca causing chemical castration
Abnormally deep implantation onto the myometrium
Targeted therapy for HER2+ breast CA
Appendix epididymis remnant of ?
Classic path change - failure of conversion of maternal vessels from low volume-high resistance to a high volume-low resistance system
Most important RF for uterine CA
pain with sex
Mutation assoc w/ high grade endometrioid tumors
MCC of amenorrhea (after pregnancy)
% of complex hyperplasia that progressed to cancer
MC site of involvement in endometriosis
Tumor marker of seminoma
Sperm with DNA damage is assoc w/ ?
hormone causing ovulation
C/I for anticholinergic therapy
testicular torsion perinatal only
MC histiological subtype of endometrial CA
reflex test to triage ASCUS pap smear in women > 21
Tumor marker for dysgerminoma
MC trisomy in spontaneous abortion
highest risk of prostate CA starting at what age?
Why is stage I breast Ca 10-year survival only 75%?
Induce fetal lung maturity - give mom ?
best imaging modality for tubal infertility
Contraceptive w/ SE: irregular bleeding, weight gain, bone loss
Zone sampled in pap smear and biopsy
Most common estrogenic ovarian tumor
Lady on tamoxifen w/ post-menopausal bleeding - next step?
Tumor from dense fibroconnective tissue of the breast
intraurethral Rx for ED
oligohydramnios and 'key hole' sign
MC histology of cervival CA
Converts androgens to estrogen
L1 proteins from HPV strains self-assemble into non-infectious units called?
Prevent sz in preeclampsia
lobular (breast) carcinoma in situ is assoc w/ invasive cancer where ?
Signet ring cells in ovary = ?
CA w/ high rate of extra-uterine dz, NO myometrial invasion of tumor
Tx: tubal factor infertility
'blue dot' sign and pain related to inflammation
Amniotic Fluid Index >90th %ile
MCC UTO in male children
Type of incontinence: neurogenic dysfunction
#1 killer of neonates
2nd most common primary site of mets to ovary
% of simple hyperplasia that progressed to cancer
Ovarian tumor w/ KRAS and BRAF mutations
Class of Rx for urge incontinence to dec contractility
Tx: stimulate ovary - induce endogenous FSH release
Special type breast CA, high grade but good prognosis
sudden huge increase in PSA likely due to?
Chromosome 17, 85% lifetime breast Ca risk
MC gynecologic CA
Tumor marker for choriocarcinoma, embryonal carcinoma
Endometrium that has been hormonally influenced by pregnancy
beta 2 receptors cause uterine ?
HPV: Binds rB allowing for cell immortalization
malignant germ cell tumor: PLAP, Oct 3/4, cKIT
Rx w/ SE: endometrial polyps
Best available protection against STIs
Tumor, sx: precocious puberty, hyperandrogenism, pelvic mass/pain
Dz: epidermis of nipple contains tumor cells
Worst SE of Magnesium sulfate
Mutation in mucinous ovarian tumors
Penile CA 0% in men who are ?
Malignant tumor of admixed proliferating trophoblasts, no villi
MC aneuploidy in abortuses
twins share chorion but one gets more blood flow
presence of endometrial glands in uterine myometrium
MC testicular tumor
HTN after 20 wk w/o proteinuria
Progestin in BCPs derived from spironolactone
Deletion or unbalanced translocation of chromosome 3 (VKL gene)
MC group of aneuploidy in spont ab
Endometrial glands/stroma implanted outside uterine cavity/walls
hypogonadotropic hypogonadism and anosmia
Infection causing bladder CA
Tx PUV: Incise valve to damage leaflet
proliferation marker in endometrial cycle
pau d' orange, cancer cells in dermal lymphatics
Call-Exner bodies, Inhibin+
Molecular? Type I, proliferative - simple hyperplasia
Kidney CA stage T4, invades
Removal of breast, pec minor and axillary lymph node
medical tx: urge incontinence
Type of cancer after tx for mediastinal mass in college age woman
Grading scheme for prostatic adenocarcinoma
ovarian neoplasm w/ 3 germinal layers
Antigen that lyses seminal coagulum
MC type of endometrial carcinoma
class of Rx for urge incontinence to tighten outlet
Lowest contraceptive failure rates
BPH Rx SE: orthostasis, dizziness, fall risk
dilatation of ducts, inspissated (thick) secretions
Higher percent of free PSA (25%+)
MC Tx of superficial bladder cancer
MC site of ectopic pregnant
implantation into cornu of uterus or lower uterine segment
Hallmark pathological finding of granulosa cell tumots
bleeding but os is open or closed, but still viable pregnancy
Inc prolif of glands rel to stroma 2/2 inactivation of ? gene
Tx symptomatic bone mets (prostate CA)
e of incontinence: unstable bladder
most prostate CA develops in which zone?
20-25% of adnexal masses, dx b/t age 10-30yo
measure seminal vesciles - dilated due to?
HRT: w/ uterus, need estrogen and ?
umbilical cord inserts into the fetal membranes
Perimenopausal uterine bleeding, first step?
Marker WT-1
Syndrome w/ inc risk of colon, ovarian, endometrial, breast and uroepithelial CA
Composition of staghorn stone
If surgery unavailable for testicular torson, reduce by twisting?
MC cystic mass in reproductive-age women
Lab value inc if patient is not making sperm
screening for nonpalpable breast masses
Rx: adjuvant therapy for postmenopausal breast Ca
Cells that convert adrenal steroids to estrone
MC benign growth in breast
MC site of mets in metastatic breast cancer
intraabdominal pregnancy, later found in a 60yo woman
acute infection w/ obstruction -1st step?
Stage: detected from elevated PSA alone, normal DRE & TRUS
Sv consequence of anovulatory cycle
Name: loss of cell polarity, inc N:C, irreg shape, prominent nucleoli
MCC testis CA >50yo
Type of incontinence: outlet obstruction
Origin of 90% ovarian cancers (aka MC form)
MC neoplasm in young men
Still a cause of maternal and fetal death
Chemo combo for advanced bladder CA
Syndrome: AD w/ 85% penetrance, BRCA
IUD c/i in Wilson's disease
Rx: adjuvant therapy for ER+ premenopausal breast Ca
MC composition of kidney stones
Renal CA assoc w/ Von Hippel-Lindau
trophoblastic proliferation, cystic villi, no fetal tissue
abnormal dev of chorionic villi in pregnancy can become?
Adnexal mass in reproductive age female, first r/o?
Molecular? Type I, simple - complex hyperplasia
Rx SE: PSA drops in half, ED, loss of libido
male contraceptive = exogenous hormone?
HPV: Degrades p53 in the host cell
Hemangioblastoma of cerebellum and retina, renal cysts and RCC
Chromosome of BRCA-2
exogenous testosterone leads to ? type of kidney stones
Bilateral ovarian mets w/ signet ring
Other name for ovarian fibroma
% of complex atypical hyperplasia that progressed to cancer
Most important prognostic factor in breast Ca
first line hormonal therapy of metastatic breast Ca in premenopausal
MCC Epididymal Orchitis in young men
How to stage endometrial CA
Proper name for 'chocolate cyst'
6 months w/o period
Tx: antagonist in breast; agonist in endometrium
MC ovarian germ cell tumor
elevated seminal leukocyte count aka?
Given to prevent CW recurrence at mastectomy site
Flow of urine in retrograde fashion (to kidney) w/ voiding
MC method of contraception
Tumor marker for endodermal sinus tumor, embryonal carcinoma
trophoblastic proliferation, fetus or fetal tissue present
Most important reason fertility dec w/ female age is increasing ?
MC renal tumor
mech of finasteride, dutasteride
Any condition irritating the periotoneal lining inc which marker?
Type II endometrial carcinoma assoc w/ ?
amenorrhea w/ high serum androgens, nl estrogen, low progesterone
Long acting Rx for ED
malignant germ cell tumor: beta HCG
Major SE of contraceptive implants
MC ovarian tumor (and cancer)
monoclonal ab to HER-2 neu
Contraception w/ dec efficacy at higher BMI i.e. >198 lbs
MC infiltrating breast Ca
Targeted therapy for ER+ breast CA
Tx of choice for vaginal atrophy
Breast duct/lobule cells that produce milk
Tumor marker of stromal cell tumors
Oral contraceptive in breastfeeding woman

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