Science Quiz / 8b GUG

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Can you name the 8b GUG?

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QuestionAnswerNotes
postmenopausal, complex hyperplasia w/ atypia - tx?
breast path - clown face
trophoblastic proliferation, fetus or fetal tissue present
Tx symptomatic bone mets (prostate CA)
Signet ring cells in ovary = ?
trophoblastic proliferation, cystic villi, no fetal tissue
C/I for anticholinergic therapy
Mech: Change in transport speed of the ovum
Tumor marker for choriocarcinoma, embryonal carcinoma
MC breast carcinoma in situ
Tumor marker of stromal cell tumors
Progestin in BCPs derived from spironolactone
2nd most common primary site of mets to ovary
MC testicular tumor
Oral contraceptive in breastfeeding woman
tx: stress urinary incontinence that inc sphincter tone
Special type breast CA, high grade but good prognosis
Endometrial glands/stroma implanted outside uterine cavity/walls
Tx PUV: Incise valve to damage leaflet
Long acting Rx for ED
Tx: tubal factor infertility
Rx SE: PSA drops in half, ED, loss of libido
Appendix epididymis remnant of ?
HTN dx in first 20 weeks of pregnancy
proliferation marker in endometrial cycle
Any condition irritating the periotoneal lining inc which marker?
elevated seminal leukocyte count aka?
Flow of urine in retrograde fashion (to kidney) w/ voiding
20-25% of adnexal masses, dx b/t age 10-30yo
division of ovum after 13 days
MC benign growth in breast
L1 proteins from HPV strains self-assemble into non-infectious units called?
Worst SE of Magnesium sulfate
reflex test to triage ASCUS pap smear in women > 21
Tumor from dense fibroconnective tissue of the breast
Targeted therapy for HER2+ breast CA
Tx of choice for vaginal atrophy
Tumor marker for endodermal sinus tumor, embryonal carcinoma
Rx: adjuvant therapy for ER+ premenopausal breast Ca
ovarian neoplasm w/ 3 germinal layers
Cells that convert adrenal steroids to estrone
malignant germ cell tumor: AFP
Breast duct/lobule cells that produce milk
abnormal dev of chorionic villi in pregnancy can become?
MC location of transitional cell cancer
intraurethral Rx for ED
highest risk of prostate CA starting at what age?
MC gynecologic CA
Appendix testes remnant of ?
'blue dot' sign and pain related to inflammation
mech of finasteride, dutasteride
Permanent cessation of menses x1yr w/ high FSH, low E2
MCC UTO in male children
exogenous testosterone leads to ? type of kidney stones
measure seminal vesciles - dilated due to?
most prostate CA develops in which zone?
sudden huge increase in PSA likely due to?
pain with sex
% of simple atypical hyperplasia that progressed to cancer
oligohydramnios and 'key hole' sign
hormone causing ovulation
MC method of contraception
pau d' orange, cancer cells in dermal lymphatics
Converts androgens to estrogen
MC Tx of superficial bladder cancer
'powder burn' lesions
Higher percent of free PSA (25%+)
malignant germ cell tumor: beta HCG
amenorrhea w/ high serum androgens, nl estrogen, low progesterone
Most important reason fertility dec w/ female age is increasing ?
umbilical cord inserts into the fetal membranes
Endometrium that has been hormonally influenced by pregnancy
QuestionAnswerNotes
Stage: detected from elevated PSA alone, normal DRE & TRUS
MC infiltrating breast Ca
Antigen that lyses seminal coagulum
implantation into cornu of uterus or lower uterine segment
MCC testis CA >50yo
CA most strongly associated w/ obesity
MC site to endometriosis
Inc prolif of glands rel to stroma 2/2 inactivation of ? gene
MC aneuploidy in abortuses
Kidney CA stage T4, invades
MCC abnml uterine bleeding in adolescence
twins share chorion but one gets more blood flow
Syndrome w/ inc risk of colon, ovarian, endometrial, breast and uroepithelial CA
Deletion or unbalanced translocation of chromosome 3 (VKL gene)
Assoc w/ uterine hyperplasia/CA in postmenopausal women
Lab value inc if patient is not making sperm
MC ovarian germ cell tumor
Targeted therapy for ER+ breast CA
monoclonal ab to HER-2 neu
testicular torsion perinatal only
Tx: stimulate ovary - induce endogenous FSH release
Molecular? Type I, proliferative - simple hyperplasia
MC cystic mass in reproductive-age women
Origin of 90% ovarian cancers (aka MC form)
first line hormonal therapy of metastatic breast Ca in premenopausal
Abnormally deep implantation onto the myometrium
MC STI
How to stage endometrial CA
e of incontinence: unstable bladder
Proper name for 'chocolate cyst'
If surgery unavailable for testicular torson, reduce by twisting?
Most common estrogenic ovarian tumor
Uterine size discrepant from dates
Zone sampled in pap smear and biopsy
class of Rx for urge incontinence to tighten outlet
Ovarian tumor w/ KRAS and BRAF mutations
Amniotic Fluid Index >90th %ile
malignant germ cell tumor: PLAP, Oct 3/4, cKIT
Rx w/ SE: endometrial polyps
dilatation of ducts, inspissated (thick) secretions
Adnexal mass in reproductive age female, first r/o?
Varicocele finding on U/S
bleeding but os is open or closed, but still viable pregnancy
Type of cancer after tx for mediastinal mass in college age woman
Given to prevent CW recurrence at mastectomy site
MC trisomy in spontaneous abortion
Perimenopausal uterine bleeding, first step?
MC group of aneuploidy in spont ab
normal strict morphology required to bind to?
Chromosome of BRCA-2
MC type of endometrial carcinoma
Removal of breast, pec minor and axillary lymph node
Contraception w/ dec efficacy at higher BMI i.e. >198 lbs
Molecular? Type I, simple - complex hyperplasia
hormonal therapy of metastatic breast Ca causing chemical castration
Most important prognostic factor in breast Ca
Tumor marker of seminoma
Colposcopy: cells w/ inc collagen turn white w/ ?
low value w/ anovulation: failure to centrally stimulate follicular growth
CA w/ high rate of extra-uterine dz, NO myometrial invasion of tumor
Syndrome: AD w/ 85% penetrance, BRCA
Best available protection against STIs
MCC Epididymal Orchitis in young men
Hallmark pathological finding of granulosa cell tumots
Composition of staghorn stone
Hemangioblastoma of cerebellum and retina, renal cysts and RCC
Sv consequence of anovulatory cycle
MC renal tumor
MCC male infertility in the world
Bladder cancer sx in 85% of cases
Dz: epidermis of nipple contains tumor cells
presence of endometrial glands in uterine myometrium
QuestionAnswerNotes
% of simple hyperplasia that progressed to cancer
Thin, long unilocular mass, associated with period
MC gynecological CA worldwide
Bilateral ovarian mets w/ signet ring
HPV: Degrades p53 in the host cell
Still a cause of maternal and fetal death
screening for nonpalpable breast masses
Call-Exner bodies, Inhibin+
Lady on tamoxifen w/ post-menopausal bleeding - next step?
Renal CA assoc w/ Von Hippel-Lindau
intraabdominal pregnancy, later found in a 60yo woman
Mutation assoc w/ high grade endometrioid tumors
Name: loss of cell polarity, inc N:C, irreg shape, prominent nucleoli
HRT: w/ uterus, need estrogen and ?
Tumor marker for dysgerminoma
% of complex atypical hyperplasia that progressed to cancer
HPV: Binds rB allowing for cell immortalization
Type of incontinence: neurogenic dysfunction
6 months w/o period
Malignant tumor of admixed proliferating trophoblasts, no villi
MC tumor of myometrium
BPH Rx SE: orthostasis, dizziness, fall risk
Rx: adjuvant therapy for postmenopausal breast Ca
Other name for ovarian fibroma
Mutation in mucinous ovarian tumors
acute infection w/ obstruction -1st step?
Type II endometrial carcinoma assoc w/ ?
Tx: antagonist in breast; agonist in endometrium
Most important RF for uterine CA
MC site of ectopic pregnant
Main mode of spread of ovarian cancer
MC site of involvement in endometriosis
Papillary projections surrounded by Schiller-Duval bodies
first line hormonal therapy of metastatic breast Ca in postmeno
best imaging modality for tubal infertility
medical tx: urge incontinence
HTN after 20 wk gestation assoc w/ proteinuria
antepartum hemorrhage after 20 wks
Classic path change - failure of conversion of maternal vessels from low volume-high resistance to a high volume-low resistance system
Lowest contraceptive failure rates
Why is stage I breast Ca 10-year survival only 75%?
#1 killer of neonates
MCC abnml uterine bleeding in postmenopausal
Sperm with DNA damage is assoc w/ ?
Class of Rx for urge incontinence to dec contractility
male contraceptive = exogenous hormone?
Infection causing bladder CA
Contraceptive w/ SE: irregular bleeding, weight gain, bone loss
MC histology of cervival CA
Condition during lactation, mimics inflammatory breast cancer
Chromosome 17, 85% lifetime breast Ca risk
Chemo combo for advanced bladder CA
MC composition of kidney stones
MCC of amenorrhea (after pregnancy)
MC histiological subtype of endometrial CA
MC ovarian tumor (and cancer)
% of complex hyperplasia that progressed to cancer
Major SE of contraceptive implants
Tumor, sx: precocious puberty, hyperandrogenism, pelvic mass/pain
MC neoplasm in young men
Grading scheme for prostatic adenocarcinoma
Induce fetal lung maturity - give mom ?
Penile CA 0% in men who are ?
lobular (breast) carcinoma in situ is assoc w/ invasive cancer where ?
Type of incontinence: outlet obstruction
beta 2 receptors cause uterine ?
HTN after 20 wk w/o proteinuria
hypogonadotropic hypogonadism and anosmia
MC site of mets in metastatic breast cancer
IUD c/i in Wilson's disease
Marker WT-1
Prevent sz in preeclampsia

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