Science Quiz / 8b GUG

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QuestionAnswerNotes
screening for nonpalpable breast masses
mech of finasteride, dutasteride
Signet ring cells in ovary = ?
Ovarian tumor w/ KRAS and BRAF mutations
first line hormonal therapy of metastatic breast Ca in postmeno
male contraceptive = exogenous hormone?
antepartum hemorrhage after 20 wks
Tumor marker for choriocarcinoma, embryonal carcinoma
Uterine size discrepant from dates
Type of cancer after tx for mediastinal mass in college age woman
C/I for anticholinergic therapy
Sperm with DNA damage is assoc w/ ?
most prostate CA develops in which zone?
trophoblastic proliferation, cystic villi, no fetal tissue
Perimenopausal uterine bleeding, first step?
Malignant tumor of admixed proliferating trophoblasts, no villi
exogenous testosterone leads to ? type of kidney stones
malignant germ cell tumor: PLAP, Oct 3/4, cKIT
presence of endometrial glands in uterine myometrium
MC Tx of superficial bladder cancer
MC neoplasm in young men
CA w/ high rate of extra-uterine dz, NO myometrial invasion of tumor
MC method of contraception
Abnormally deep implantation onto the myometrium
highest risk of prostate CA starting at what age?
Infection causing bladder CA
Lab value inc if patient is not making sperm
Deletion or unbalanced translocation of chromosome 3 (VKL gene)
sudden huge increase in PSA likely due to?
Class of Rx for urge incontinence to dec contractility
abnormal dev of chorionic villi in pregnancy can become?
HTN after 20 wk w/o proteinuria
MC histiological subtype of endometrial CA
% of complex hyperplasia that progressed to cancer
MC cystic mass in reproductive-age women
Composition of staghorn stone
BPH Rx SE: orthostasis, dizziness, fall risk
MC site of mets in metastatic breast cancer
division of ovum after 13 days
Given to prevent CW recurrence at mastectomy site
2nd most common primary site of mets to ovary
Rx w/ SE: endometrial polyps
amenorrhea w/ high serum androgens, nl estrogen, low progesterone
Breast duct/lobule cells that produce milk
Type II endometrial carcinoma assoc w/ ?
Best available protection against STIs
Adnexal mass in reproductive age female, first r/o?
MCC testis CA >50yo
Oral contraceptive in breastfeeding woman
Molecular? Type I, proliferative - simple hyperplasia
Most common estrogenic ovarian tumor
Targeted therapy for HER2+ breast CA
Tumor, sx: precocious puberty, hyperandrogenism, pelvic mass/pain
Tx of choice for vaginal atrophy
IUD c/i in Wilson's disease
MC type of endometrial carcinoma
Tumor marker for dysgerminoma
HRT: w/ uterus, need estrogen and ?
Worst SE of Magnesium sulfate
HPV: Binds rB allowing for cell immortalization
Dz: epidermis of nipple contains tumor cells
tx: stress urinary incontinence that inc sphincter tone
Condition during lactation, mimics inflammatory breast cancer
Marker WT-1
malignant germ cell tumor: beta HCG
oligohydramnios and 'key hole' sign
MC ovarian tumor (and cancer)
MC breast carcinoma in situ
Papillary projections surrounded by Schiller-Duval bodies
postmenopausal, complex hyperplasia w/ atypia - tx?
Stage: detected from elevated PSA alone, normal DRE & TRUS
Appendix epididymis remnant of ?
QuestionAnswerNotes
malignant germ cell tumor: AFP
Special type breast CA, high grade but good prognosis
MC composition of kidney stones
Grading scheme for prostatic adenocarcinoma
Hallmark pathological finding of granulosa cell tumots
bleeding but os is open or closed, but still viable pregnancy
Tx PUV: Incise valve to damage leaflet
MCC abnml uterine bleeding in adolescence
6 months w/o period
HTN after 20 wk gestation assoc w/ proteinuria
trophoblastic proliferation, fetus or fetal tissue present
Type of incontinence: outlet obstruction
MCC abnml uterine bleeding in postmenopausal
MCC male infertility in the world
% of complex atypical hyperplasia that progressed to cancer
MC tumor of myometrium
Most important prognostic factor in breast Ca
MC gynecologic CA
Call-Exner bodies, Inhibin+
Zone sampled in pap smear and biopsy
Long acting Rx for ED
Rx: adjuvant therapy for postmenopausal breast Ca
Varicocele finding on U/S
Main mode of spread of ovarian cancer
beta 2 receptors cause uterine ?
L1 proteins from HPV strains self-assemble into non-infectious units called?
Proper name for 'chocolate cyst'
Chemo combo for advanced bladder CA
MCC Epididymal Orchitis in young men
normal strict morphology required to bind to?
MC histology of cervival CA
Tumor marker of seminoma
e of incontinence: unstable bladder
Hemangioblastoma of cerebellum and retina, renal cysts and RCC
MC renal tumor
MC trisomy in spontaneous abortion
Sv consequence of anovulatory cycle
intraurethral Rx for ED
hormonal therapy of metastatic breast Ca causing chemical castration
HPV: Degrades p53 in the host cell
How to stage endometrial CA
Rx SE: PSA drops in half, ED, loss of libido
umbilical cord inserts into the fetal membranes
best imaging modality for tubal infertility
CA most strongly associated w/ obesity
Classic path change - failure of conversion of maternal vessels from low volume-high resistance to a high volume-low resistance system
Most important RF for uterine CA
Contraception w/ dec efficacy at higher BMI i.e. >198 lbs
Removal of breast, pec minor and axillary lymph node
intraabdominal pregnancy, later found in a 60yo woman
MC location of transitional cell cancer
acute infection w/ obstruction -1st step?
Thin, long unilocular mass, associated with period
Tx: antagonist in breast; agonist in endometrium
Other name for ovarian fibroma
Most important reason fertility dec w/ female age is increasing ?
MC site of involvement in endometriosis
pain with sex
Mutation in mucinous ovarian tumors
MC STI
Penile CA 0% in men who are ?
Higher percent of free PSA (25%+)
monoclonal ab to HER-2 neu
MC benign growth in breast
Inc prolif of glands rel to stroma 2/2 inactivation of ? gene
measure seminal vesciles - dilated due to?
If surgery unavailable for testicular torson, reduce by twisting?
Lady on tamoxifen w/ post-menopausal bleeding - next step?
Tumor marker of stromal cell tumors
Major SE of contraceptive implants
Progestin in BCPs derived from spironolactone
Type of incontinence: neurogenic dysfunction
QuestionAnswerNotes
Name: loss of cell polarity, inc N:C, irreg shape, prominent nucleoli
dilatation of ducts, inspissated (thick) secretions
Lowest contraceptive failure rates
#1 killer of neonates
Contraceptive w/ SE: irregular bleeding, weight gain, bone loss
Tx symptomatic bone mets (prostate CA)
HTN dx in first 20 weeks of pregnancy
hypogonadotropic hypogonadism and anosmia
Permanent cessation of menses x1yr w/ high FSH, low E2
Antigen that lyses seminal coagulum
MCC of amenorrhea (after pregnancy)
'blue dot' sign and pain related to inflammation
Mutation assoc w/ high grade endometrioid tumors
Prevent sz in preeclampsia
Rx: adjuvant therapy for ER+ premenopausal breast Ca
Tumor marker for endodermal sinus tumor, embryonal carcinoma
Converts androgens to estrogen
Endometrium that has been hormonally influenced by pregnancy
first line hormonal therapy of metastatic breast Ca in premenopausal
ovarian neoplasm w/ 3 germinal layers
% of simple hyperplasia that progressed to cancer
Any condition irritating the periotoneal lining inc which marker?
MC ovarian germ cell tumor
Still a cause of maternal and fetal death
MC aneuploidy in abortuses
twins share chorion but one gets more blood flow
Bilateral ovarian mets w/ signet ring
Chromosome of BRCA-2
Colposcopy: cells w/ inc collagen turn white w/ ?
MC testicular tumor
MC gynecological CA worldwide
lobular (breast) carcinoma in situ is assoc w/ invasive cancer where ?
Tx: tubal factor infertility
breast path - clown face
Flow of urine in retrograde fashion (to kidney) w/ voiding
Syndrome: AD w/ 85% penetrance, BRCA
Mech: Change in transport speed of the ovum
Assoc w/ uterine hyperplasia/CA in postmenopausal women
elevated seminal leukocyte count aka?
Kidney CA stage T4, invades
MC site to endometriosis
Targeted therapy for ER+ breast CA
Bladder cancer sx in 85% of cases
proliferation marker in endometrial cycle
reflex test to triage ASCUS pap smear in women > 21
Tumor from dense fibroconnective tissue of the breast
MC site of ectopic pregnant
pau d' orange, cancer cells in dermal lymphatics
Molecular? Type I, simple - complex hyperplasia
Induce fetal lung maturity - give mom ?
Endometrial glands/stroma implanted outside uterine cavity/walls
MC group of aneuploidy in spont ab
Appendix testes remnant of ?
testicular torsion perinatal only
Renal CA assoc w/ Von Hippel-Lindau
Cells that convert adrenal steroids to estrone
MCC UTO in male children
'powder burn' lesions
hormone causing ovulation
implantation into cornu of uterus or lower uterine segment
% of simple atypical hyperplasia that progressed to cancer
Amniotic Fluid Index >90th %ile
Why is stage I breast Ca 10-year survival only 75%?
Chromosome 17, 85% lifetime breast Ca risk
low value w/ anovulation: failure to centrally stimulate follicular growth
class of Rx for urge incontinence to tighten outlet
20-25% of adnexal masses, dx b/t age 10-30yo
MC infiltrating breast Ca
medical tx: urge incontinence
Tx: stimulate ovary - induce endogenous FSH release
Syndrome w/ inc risk of colon, ovarian, endometrial, breast and uroepithelial CA
Origin of 90% ovarian cancers (aka MC form)

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