Science Quiz / 8b GUG

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Can you name the 8b GUG?

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QuestionAnswerNotes
tx: stress urinary incontinence that inc sphincter tone
MC trisomy in spontaneous abortion
Still a cause of maternal and fetal death
HTN after 20 wk w/o proteinuria
Tx: stimulate ovary - induce endogenous FSH release
Type of cancer after tx for mediastinal mass in college age woman
Condition during lactation, mimics inflammatory breast cancer
MC renal tumor
breast path - clown face
Targeted therapy for HER2+ breast CA
C/I for anticholinergic therapy
Cells that convert adrenal steroids to estrone
Thin, long unilocular mass, associated with period
Hallmark pathological finding of granulosa cell tumots
Progestin in BCPs derived from spironolactone
Most important RF for uterine CA
Chromosome 17, 85% lifetime breast Ca risk
MC method of contraception
Kidney CA stage T4, invades
amenorrhea w/ high serum androgens, nl estrogen, low progesterone
2nd most common primary site of mets to ovary
Tumor marker of seminoma
acute infection w/ obstruction -1st step?
Zone sampled in pap smear and biopsy
Stage: detected from elevated PSA alone, normal DRE & TRUS
Infection causing bladder CA
Tumor marker of stromal cell tumors
postmenopausal, complex hyperplasia w/ atypia - tx?
MC STI
Tx: antagonist in breast; agonist in endometrium
Oral contraceptive in breastfeeding woman
MC infiltrating breast Ca
How to stage endometrial CA
Any condition irritating the periotoneal lining inc which marker?
Targeted therapy for ER+ breast CA
Induce fetal lung maturity - give mom ?
Name: loss of cell polarity, inc N:C, irreg shape, prominent nucleoli
monoclonal ab to HER-2 neu
Papillary projections surrounded by Schiller-Duval bodies
Mutation in mucinous ovarian tumors
screening for nonpalpable breast masses
sudden huge increase in PSA likely due to?
MCC testis CA >50yo
MC location of transitional cell cancer
dilatation of ducts, inspissated (thick) secretions
Dz: epidermis of nipple contains tumor cells
MCC abnml uterine bleeding in adolescence
MC site to endometriosis
testicular torsion perinatal only
Tx: tubal factor infertility
bleeding but os is open or closed, but still viable pregnancy
Lowest contraceptive failure rates
Bilateral ovarian mets w/ signet ring
most prostate CA develops in which zone?
'blue dot' sign and pain related to inflammation
HPV: Degrades p53 in the host cell
Breast duct/lobule cells that produce milk
hypogonadotropic hypogonadism and anosmia
Composition of staghorn stone
MC group of aneuploidy in spont ab
#1 killer of neonates
male contraceptive = exogenous hormone?
Given to prevent CW recurrence at mastectomy site
reflex test to triage ASCUS pap smear in women > 21
MCC UTO in male children
Molecular? Type I, proliferative - simple hyperplasia
Tumor marker for endodermal sinus tumor, embryonal carcinoma
MC histology of cervival CA
e of incontinence: unstable bladder
trophoblastic proliferation, cystic villi, no fetal tissue
MC testicular tumor
Tumor from dense fibroconnective tissue of the breast
QuestionAnswerNotes
malignant germ cell tumor: AFP
% of simple atypical hyperplasia that progressed to cancer
beta 2 receptors cause uterine ?
implantation into cornu of uterus or lower uterine segment
MC cystic mass in reproductive-age women
Tx PUV: Incise valve to damage leaflet
medical tx: urge incontinence
pau d' orange, cancer cells in dermal lymphatics
MC type of endometrial carcinoma
proliferation marker in endometrial cycle
Assoc w/ uterine hyperplasia/CA in postmenopausal women
L1 proteins from HPV strains self-assemble into non-infectious units called?
Antigen that lyses seminal coagulum
exogenous testosterone leads to ? type of kidney stones
antepartum hemorrhage after 20 wks
BPH Rx SE: orthostasis, dizziness, fall risk
Syndrome w/ inc risk of colon, ovarian, endometrial, breast and uroepithelial CA
HTN after 20 wk gestation assoc w/ proteinuria
Higher percent of free PSA (25%+)
Rx SE: PSA drops in half, ED, loss of libido
Major SE of contraceptive implants
pain with sex
umbilical cord inserts into the fetal membranes
Permanent cessation of menses x1yr w/ high FSH, low E2
MC breast carcinoma in situ
MC composition of kidney stones
Penile CA 0% in men who are ?
Bladder cancer sx in 85% of cases
twins share chorion but one gets more blood flow
Molecular? Type I, simple - complex hyperplasia
intraurethral Rx for ED
Signet ring cells in ovary = ?
HPV: Binds rB allowing for cell immortalization
Abnormally deep implantation onto the myometrium
highest risk of prostate CA starting at what age?
MC aneuploidy in abortuses
'powder burn' lesions
Tumor marker for dysgerminoma
HTN dx in first 20 weeks of pregnancy
Syndrome: AD w/ 85% penetrance, BRCA
Most important reason fertility dec w/ female age is increasing ?
Contraception w/ dec efficacy at higher BMI i.e. >198 lbs
MC gynecological CA worldwide
MC tumor of myometrium
Tx of choice for vaginal atrophy
MC ovarian germ cell tumor
Malignant tumor of admixed proliferating trophoblasts, no villi
Renal CA assoc w/ Von Hippel-Lindau
class of Rx for urge incontinence to tighten outlet
Best available protection against STIs
Rx: adjuvant therapy for ER+ premenopausal breast Ca
Special type breast CA, high grade but good prognosis
MC benign growth in breast
Classic path change - failure of conversion of maternal vessels from low volume-high resistance to a high volume-low resistance system
Type II endometrial carcinoma assoc w/ ?
lobular (breast) carcinoma in situ is assoc w/ invasive cancer where ?
ovarian neoplasm w/ 3 germinal layers
MCC abnml uterine bleeding in postmenopausal
Perimenopausal uterine bleeding, first step?
HRT: w/ uterus, need estrogen and ?
MCC male infertility in the world
Most common estrogenic ovarian tumor
Flow of urine in retrograde fashion (to kidney) w/ voiding
Mech: Change in transport speed of the ovum
Endometrium that has been hormonally influenced by pregnancy
Chemo combo for advanced bladder CA
malignant germ cell tumor: beta HCG
Type of incontinence: neurogenic dysfunction
normal strict morphology required to bind to?
IUD c/i in Wilson's disease
Uterine size discrepant from dates
If surgery unavailable for testicular torson, reduce by twisting?
QuestionAnswerNotes
Long acting Rx for ED
Appendix testes remnant of ?
Grading scheme for prostatic adenocarcinoma
first line hormonal therapy of metastatic breast Ca in postmeno
abnormal dev of chorionic villi in pregnancy can become?
% of simple hyperplasia that progressed to cancer
Type of incontinence: outlet obstruction
Rx w/ SE: endometrial polyps
oligohydramnios and 'key hole' sign
Proper name for 'chocolate cyst'
division of ovum after 13 days
MC neoplasm in young men
trophoblastic proliferation, fetus or fetal tissue present
Colposcopy: cells w/ inc collagen turn white w/ ?
Lady on tamoxifen w/ post-menopausal bleeding - next step?
MC site of mets in metastatic breast cancer
hormonal therapy of metastatic breast Ca causing chemical castration
Most important prognostic factor in breast Ca
Main mode of spread of ovarian cancer
Why is stage I breast Ca 10-year survival only 75%?
intraabdominal pregnancy, later found in a 60yo woman
Call-Exner bodies, Inhibin+
Chromosome of BRCA-2
Amniotic Fluid Index >90th %ile
CA most strongly associated w/ obesity
first line hormonal therapy of metastatic breast Ca in premenopausal
mech of finasteride, dutasteride
measure seminal vesciles - dilated due to?
Removal of breast, pec minor and axillary lymph node
Tx symptomatic bone mets (prostate CA)
MC histiological subtype of endometrial CA
6 months w/o period
Tumor, sx: precocious puberty, hyperandrogenism, pelvic mass/pain
MC ovarian tumor (and cancer)
best imaging modality for tubal infertility
Hemangioblastoma of cerebellum and retina, renal cysts and RCC
Deletion or unbalanced translocation of chromosome 3 (VKL gene)
CA w/ high rate of extra-uterine dz, NO myometrial invasion of tumor
Sv consequence of anovulatory cycle
% of complex atypical hyperplasia that progressed to cancer
low value w/ anovulation: failure to centrally stimulate follicular growth
Appendix epididymis remnant of ?
% of complex hyperplasia that progressed to cancer
MC gynecologic CA
Mutation assoc w/ high grade endometrioid tumors
Ovarian tumor w/ KRAS and BRAF mutations
Rx: adjuvant therapy for postmenopausal breast Ca
Other name for ovarian fibroma
Prevent sz in preeclampsia
MCC of amenorrhea (after pregnancy)
Tumor marker for choriocarcinoma, embryonal carcinoma
presence of endometrial glands in uterine myometrium
Marker WT-1
Lab value inc if patient is not making sperm
20-25% of adnexal masses, dx b/t age 10-30yo
Inc prolif of glands rel to stroma 2/2 inactivation of ? gene
Origin of 90% ovarian cancers (aka MC form)
malignant germ cell tumor: PLAP, Oct 3/4, cKIT
MC site of involvement in endometriosis
Endometrial glands/stroma implanted outside uterine cavity/walls
Varicocele finding on U/S
MC site of ectopic pregnant
elevated seminal leukocyte count aka?
Converts androgens to estrogen
MCC Epididymal Orchitis in young men
hormone causing ovulation
Class of Rx for urge incontinence to dec contractility
Worst SE of Magnesium sulfate
MC Tx of superficial bladder cancer
Sperm with DNA damage is assoc w/ ?
Adnexal mass in reproductive age female, first r/o?
Contraceptive w/ SE: irregular bleeding, weight gain, bone loss

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