Science Quiz / 8b GUG

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Can you name the 8b GUG?

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Syndrome: AD w/ 85% penetrance, BRCA
MC composition of kidney stones
Deletion or unbalanced translocation of chromosome 3 (VKL gene)
twins share chorion but one gets more blood flow
Sperm with DNA damage is assoc w/ ?
HTN dx in first 20 weeks of pregnancy
Infection causing bladder CA
L1 proteins from HPV strains self-assemble into non-infectious units called?
#1 killer of neonates
Perimenopausal uterine bleeding, first step?
Most common estrogenic ovarian tumor
Still a cause of maternal and fetal death
Oral contraceptive in breastfeeding woman
pain with sex
Tx symptomatic bone mets (prostate CA)
Type of incontinence: outlet obstruction
Zone sampled in pap smear and biopsy
breast path - clown face
Uterine size discrepant from dates
Rx SE: PSA drops in half, ED, loss of libido
amenorrhea w/ high serum androgens, nl estrogen, low progesterone
Ovarian tumor w/ KRAS and BRAF mutations
Most important prognostic factor in breast Ca
Molecular? Type I, simple - complex hyperplasia
ovarian neoplasm w/ 3 germinal layers
Molecular? Type I, proliferative - simple hyperplasia
Amniotic Fluid Index >90th %ile
MC site of involvement in endometriosis
MC group of aneuploidy in spont ab
Tx PUV: Incise valve to damage leaflet
Tumor marker of seminoma
trophoblastic proliferation, cystic villi, no fetal tissue
% of simple hyperplasia that progressed to cancer
Contraceptive w/ SE: irregular bleeding, weight gain, bone loss
Penile CA 0% in men who are ?
Marker WT-1
Tx: stimulate ovary - induce endogenous FSH release
Most important RF for uterine CA
20-25% of adnexal masses, dx b/t age 10-30yo
MC infiltrating breast Ca
MC histiological subtype of endometrial CA
MC site of ectopic pregnant
Signet ring cells in ovary = ?
Main mode of spread of ovarian cancer
measure seminal vesciles - dilated due to?
Given to prevent CW recurrence at mastectomy site
Tumor, sx: precocious puberty, hyperandrogenism, pelvic mass/pain
Chemo combo for advanced bladder CA
Endometrial glands/stroma implanted outside uterine cavity/walls
Tumor marker of stromal cell tumors
MC tumor of myometrium
MC histology of cervival CA
If surgery unavailable for testicular torson, reduce by twisting?
elevated seminal leukocyte count aka?
Composition of staghorn stone
MC breast carcinoma in situ
acute infection w/ obstruction -1st step?
% of simple atypical hyperplasia that progressed to cancer
pau d' orange, cancer cells in dermal lymphatics
Converts androgens to estrogen
class of Rx for urge incontinence to tighten outlet
Condition during lactation, mimics inflammatory breast cancer
Tumor marker for endodermal sinus tumor, embryonal carcinoma
Rx: adjuvant therapy for postmenopausal breast Ca
Lady on tamoxifen w/ post-menopausal bleeding - next step?
MC neoplasm in young men
hypogonadotropic hypogonadism and anosmia
Bilateral ovarian mets w/ signet ring
Class of Rx for urge incontinence to dec contractility
MC benign growth in breast
Type of incontinence: neurogenic dysfunction
BPH Rx SE: orthostasis, dizziness, fall risk
Antigen that lyses seminal coagulum
MCC male infertility in the world
trophoblastic proliferation, fetus or fetal tissue present
'powder burn' lesions
Best available protection against STIs
exogenous testosterone leads to ? type of kidney stones
abnormal dev of chorionic villi in pregnancy can become?
Syndrome w/ inc risk of colon, ovarian, endometrial, breast and uroepithelial CA
MC testicular tumor
Call-Exner bodies, Inhibin+
Rx: adjuvant therapy for ER+ premenopausal breast Ca
Type II endometrial carcinoma assoc w/ ?
Progestin in BCPs derived from spironolactone
'blue dot' sign and pain related to inflammation
Contraception w/ dec efficacy at higher BMI i.e. >198 lbs
Inc prolif of glands rel to stroma 2/2 inactivation of ? gene
IUD c/i in Wilson's disease
screening for nonpalpable breast masses
6 months w/o period
Classic path change - failure of conversion of maternal vessels from low volume-high resistance to a high volume-low resistance system
Mech: Change in transport speed of the ovum
Cells that convert adrenal steroids to estrone
Thin, long unilocular mass, associated with period
Higher percent of free PSA (25%+)
beta 2 receptors cause uterine ?
Papillary projections surrounded by Schiller-Duval bodies
2nd most common primary site of mets to ovary
intraabdominal pregnancy, later found in a 60yo woman
Dz: epidermis of nipple contains tumor cells
first line hormonal therapy of metastatic breast Ca in postmeno
Sv consequence of anovulatory cycle
Special type breast CA, high grade but good prognosis
malignant germ cell tumor: PLAP, Oct 3/4, cKIT
Why is stage I breast Ca 10-year survival only 75%?
Permanent cessation of menses x1yr w/ high FSH, low E2
Grading scheme for prostatic adenocarcinoma
MC ovarian tumor (and cancer)
Assoc w/ uterine hyperplasia/CA in postmenopausal women
Lab value inc if patient is not making sperm
Stage: detected from elevated PSA alone, normal DRE & TRUS
malignant germ cell tumor: beta HCG
Mutation assoc w/ high grade endometrioid tumors
Removal of breast, pec minor and axillary lymph node
Chromosome 17, 85% lifetime breast Ca risk
hormonal therapy of metastatic breast Ca causing chemical castration
Colposcopy: cells w/ inc collagen turn white w/ ?
antepartum hemorrhage after 20 wks
Varicocele finding on U/S
CA w/ high rate of extra-uterine dz, NO myometrial invasion of tumor
Adnexal mass in reproductive age female, first r/o?
testicular torsion perinatal only
Tumor marker for dysgerminoma
Renal CA assoc w/ Von Hippel-Lindau
MC renal tumor
Targeted therapy for ER+ breast CA
MC gynecologic CA
HPV: Degrades p53 in the host cell
best imaging modality for tubal infertility
division of ovum after 13 days
Appendix epididymis remnant of ?
Flow of urine in retrograde fashion (to kidney) w/ voiding
normal strict morphology required to bind to?
low value w/ anovulation: failure to centrally stimulate follicular growth
MC trisomy in spontaneous abortion
Prevent sz in preeclampsia
postmenopausal, complex hyperplasia w/ atypia - tx?
Major SE of contraceptive implants
Mutation in mucinous ovarian tumors
C/I for anticholinergic therapy
Tx of choice for vaginal atrophy
MCC of amenorrhea (after pregnancy)
MCC abnml uterine bleeding in postmenopausal
Type of cancer after tx for mediastinal mass in college age woman
MCC Epididymal Orchitis in young men
Long acting Rx for ED
lobular (breast) carcinoma in situ is assoc w/ invasive cancer where ?
Origin of 90% ovarian cancers (aka MC form)
most prostate CA develops in which zone?
Proper name for 'chocolate cyst'
Name: loss of cell polarity, inc N:C, irreg shape, prominent nucleoli
mech of finasteride, dutasteride
Rx w/ SE: endometrial polyps
Tx: antagonist in breast; agonist in endometrium
malignant germ cell tumor: AFP
Endometrium that has been hormonally influenced by pregnancy
Lowest contraceptive failure rates
Induce fetal lung maturity - give mom ?
Chromosome of BRCA-2
MC ovarian germ cell tumor
Bladder cancer sx in 85% of cases
hormone causing ovulation
MC cystic mass in reproductive-age women
intraurethral Rx for ED
Tumor marker for choriocarcinoma, embryonal carcinoma
presence of endometrial glands in uterine myometrium
MC type of endometrial carcinoma
implantation into cornu of uterus or lower uterine segment
highest risk of prostate CA starting at what age?
monoclonal ab to HER-2 neu
bleeding but os is open or closed, but still viable pregnancy
Appendix testes remnant of ?
sudden huge increase in PSA likely due to?
MC location of transitional cell cancer
Kidney CA stage T4, invades
tx: stress urinary incontinence that inc sphincter tone
medical tx: urge incontinence
Hemangioblastoma of cerebellum and retina, renal cysts and RCC
umbilical cord inserts into the fetal membranes
Breast duct/lobule cells that produce milk
Hallmark pathological finding of granulosa cell tumots
Other name for ovarian fibroma
CA most strongly associated w/ obesity
male contraceptive = exogenous hormone?
MCC abnml uterine bleeding in adolescence
How to stage endometrial CA
first line hormonal therapy of metastatic breast Ca in premenopausal
Worst SE of Magnesium sulfate
proliferation marker in endometrial cycle
reflex test to triage ASCUS pap smear in women > 21
Malignant tumor of admixed proliferating trophoblasts, no villi
MC gynecological CA worldwide
HPV: Binds rB allowing for cell immortalization
MC site to endometriosis
MC Tx of superficial bladder cancer
% of complex atypical hyperplasia that progressed to cancer
Most important reason fertility dec w/ female age is increasing ?
HRT: w/ uterus, need estrogen and ?
Tx: tubal factor infertility
Any condition irritating the periotoneal lining inc which marker?
MCC UTO in male children
dilatation of ducts, inspissated (thick) secretions
e of incontinence: unstable bladder
Tumor from dense fibroconnective tissue of the breast
Targeted therapy for HER2+ breast CA
MC aneuploidy in abortuses
HTN after 20 wk gestation assoc w/ proteinuria
Abnormally deep implantation onto the myometrium
MC site of mets in metastatic breast cancer
MCC testis CA >50yo
HTN after 20 wk w/o proteinuria
% of complex hyperplasia that progressed to cancer
MC method of contraception
oligohydramnios and 'key hole' sign

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