Science Quiz / 8b Endocrine2

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Can you name the 8b Endocrine Wk2?

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QuestionAnswerNotes
resorption of distal phalanx
co-localized w/ insulin in granules, co-secreted
MCC primary hyperaldosteronism
infiltrative cause of hypopituitarism
nml PTH but kidney resistance to PTH
MCC primary hyperparathyroidism
Flattened weight chart: IGF-1 low but IGF BP3 is normal ?
hyperprolactinemia 2/2 stalk effect is due to decrease of?
currently, MCC Addison's disease
Hurthle cells and lymphoid follicles
elevated urinary VMA, HVA
keratin pearls - histologically characteristic of ?
CAH pathway: defective conversion of 17-OH progesterone to 11-deoxycortisol
oncocytic metaplasia of follicular cells
Tx lactic acidosis - 1st step?
DM or DI: dehydration only?
class: Acarbose, miglitol
BMD 2.5+ SD below young adult female
Urinary and serum N-telopeptide are increased
hyperglycemia, absence of ketosis and hyperosmolar state
HNF - 1alpha assoc w/ which monogenic syndrome?
parathyroid, pancrease, pituitary ?
cardiac, abnormal facies, thymic hypoplasia, cleft palate, hypocalemia
DM: eruptive xanthomas due to high?
hypogonadotropic hypogonadism is a problem of the?
decoy receptor that prevents RANKL binding to RANK
ketoacidosis from adipocytes + ?
Inflate BP 10mmHg above systolic and hold -> carpal spasm
Give w/ thiazide diuretic to treat hypocalcemia
AD, inactivating heterozygous mutation, hypercalcemia w/ no sequelae
high alk phos, low (calcium x phos) product
bacteremia + adrenal hemorrhage
DM: postprandial lipema b/c insulin regulates?
historically, MCC Addison's disease
fewer than 6-8 cycles/year
Tap facial nerve -> ipsi facial muscles contract
Tx for lactic acidosis: bypass formation of lactate
Give ACEI and GFR plunges - block in ?
Diabetic autonomic dz - ED correlates w/ ?
C-cells derived from?
Effect of alkalosis on ionized Calcium
estradiol less than 5; FSH > 40; dx ?
Impaired mineralization of new bone matrix in adults
Test to eval cornification of vaginal epithelium
Absence of uterus, CN 8 deafness, renal abnormalities
Effect of acidosis on ionized Calcium
MCC: effacement of acinar pattern in pituitary
thyroid carcinoma w/ empty nuclei and psamomma bodies
Activating mutation of CaSR causes?
Osteoporosis - excess RANKL and not enough ?
Effect of PTH on kidney excretion of phos
'brown tumors' and severe hypercalcemia
QuestionAnswerNotes
malignancy - high ca, low p, low pth due to?
DKA Tx - 1st step?
type of PO calcium to give for Severe hypocalcemia
DM I with blunted neuro sx; first sx of hypoglycemia?
human monoclonal antibody against RANKL
Gene assoc w/ APS1
MCC ectopic ACTH production
highest power Rx: Inc beta cell insulin secretion
High ACTH, High Cortisol, no suppression w/ high dose Dex
volume depletion/dehydration in DM due to ?
Rachitis rosary on CXR
Inactivating mutation of CaSR - presents at ?
Test - familial hypercalcemia v. primary hyperparathyroidism
Medullary thyroid CA, pheo, mucosal neuromas, marfanoid features
Osteoclast derived TRAP is elevated
pituitary infarct from postpartum hemorrhage
HHNS Tx - 1st step?
Turns dark brown in Zenker's fixative
Tx hypercalcemia: fluids, then ?
First line tx for osteoporosis
Tetany, chvostek's, trousseau's etc
CAH pathway: defective conversion of progesterone to 11-deoxycorticosterone
MODY2 assoc w/ which enzyme mutation?
Abscence of uterus, externally female, serum T and LH inc
MC autoimmune endocrine dz
low HCO3 in DKA means ?
parathyroid hyperplasia - hereditary due to ?
infant w/ big tongue, umbilical hernia, open fontanelle, poor feeding and growth, lethargy
Rx that is RF for fx
Tx: vitamin D intoxication
MC hormonal abnormality assoc w/ pituitary adenomas
Measure of how much beta cell dysfunction there is
Tx: refractory hypercalcemia
hypogonadotropic hypogonadism and anosmia
Hypernatremia, hypokalemia, HTN, low renin
Treat DKA - effect on potassium?
DM: Albuminuria >? mg/24 h
Proliferative stage of diabetic retinopathy defined by?
heart condition assoc w/ Turner's
MCC hypercalcemia
Product of kidney - neg feedback to suppress PTH
- thickened cortical/trabecular bone
MC deficient enzyme in CAH
ambiguous genitalia at birth + salt-wasting
Rx: dec hepatic glucose production
worst outcome of diabetic retinopathy?
BMD c/w someone your own age, gender, and ethnicity
46XY Complete Gonadal Dysgenesis
Tx osteoporosis: anabolic agents
knuckle knuckle dimple knuckle
DM, fasting plasma glucose > ?
leonine facies, edema of extremities due to CHF
QuestionAnswerNotes
Necrobiosis Lipoidica Diabeticorum - send pt to?
corpus luteum secretes?
CPT-1 transports the FFA into ?
follicular hyperplasia of thymus assoc w/ ?
MC pineal region mass
Statin + fibrates: risk of?
Nucleus - 24hr cycle timekeeper
band keratopathy, HTN, cardiac arrhythmia, short QT interval
Effect of cytosolic Ca++ on PTH
women's basal body temp rises due to?
mitochondrial disease = early onset diabetes + ?
Rx: block GTPase binding, flatten ruffled border
T score between -1 and -2.5
Reversible schiff base to irreversible?
Syndrome - toxic nodule in multinodular goiter
Painful thyroid - multinucleated giant cells and acute inflammation w/ destruction of follicles
systemic and adreogenic sx in female, testosterone > 200, DHEAS > 700 - tumor?
Class: Inc tissue respose to insulin by activating PPAR
DM type I + hypothyroid + hyperpigmentation, likely dx?
Dense fibrosis replacement of thyroid gland w/ extension into adjacent tissues
Rx: blocks conversion of T4 to T3 and used in pregnancy
Why you stop metformin before surgery etc
Silent dz until fracture occurs
Major worldwide cause of hypocalcemia
Infection during infancy assoc w/ higher rate of DM type I
Part of 'polyol pathway' that results in neuropathy
High ACTH, High Cortisol, Suppression of 17OH-corticosteroid w/ high dose Dex
MCC of hyperandrogenic anovulation
17-alpha hydroxylase/ 17,20 lyase deficiency results in excess ?
Tx: diabetic retinopathy
Medullary thyroid CA, pheo, parathyroid hyperplasia
adipocytes dont develop properly, fat goes into organs
Follicular cells of thyroid derived from?
Bilateral streak gonads, Eunuchoid proportions
hirsutism - 1st r/o ?
gland - tumor causes precocious puberty
Intermediate acting insulin aka ?
Predictor of CHD in Type II DM
how to measure volume depletion?
DM - Rx to lower triglycerides
Converts D-glucose to sorbitol
Extremely slow release (peak-less) insulin analogue
MC bacteria assoc w/ Waterhouse-Friderichsen Syndrome
Low ACTH, High Cortisol, no suppression w/ high dose Dex
Differentiation of ovarian interstitial cells into steroidogenically active luteinized stromal cells
sella tumor w/ biphasic peak in children and middle aged adults
MCC adrenogenital synrome
how to measure dehydration?
Tx: Paget's
Hypernatremia, hypokalemia, HTN, high renin
Milkman's fractures/'Looser's Zone'/pseudofractures

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Created Nov 18, 2012ReportNominate
Tags:endocrine, note

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