Science Quiz / 8b Endocrine2

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Can you name the 8b Endocrine Wk2?

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QuestionAnswerNotes
resorption of distal phalanx
highest power Rx: Inc beta cell insulin secretion
MCC of hyperandrogenic anovulation
type of PO calcium to give for Severe hypocalcemia
MCC adrenogenital synrome
Tap facial nerve -> ipsi facial muscles contract
MC autoimmune endocrine dz
Converts D-glucose to sorbitol
Measure of how much beta cell dysfunction there is
DKA Tx - 1st step?
Tx: diabetic retinopathy
Rx: blocks conversion of T4 to T3 and used in pregnancy
Differentiation of ovarian interstitial cells into steroidogenically active luteinized stromal cells
malignancy - high ca, low p, low pth due to?
Effect of cytosolic Ca++ on PTH
keratin pearls - histologically characteristic of ?
heart condition assoc w/ Turner's
elevated urinary VMA, HVA
thyroid carcinoma w/ empty nuclei and psamomma bodies
leonine facies, edema of extremities due to CHF
MC pineal region mass
Low ACTH, High Cortisol, no suppression w/ high dose Dex
Tx: vitamin D intoxication
adipocytes dont develop properly, fat goes into organs
Tx lactic acidosis - 1st step?
Syndrome - toxic nodule in multinodular goiter
co-localized w/ insulin in granules, co-secreted
MC deficient enzyme in CAH
ambiguous genitalia at birth + salt-wasting
Urinary and serum N-telopeptide are increased
Inactivating mutation of CaSR - presents at ?
DM: postprandial lipema b/c insulin regulates?
Why you stop metformin before surgery etc
decoy receptor that prevents RANKL binding to RANK
hypogonadotropic hypogonadism is a problem of the?
Diabetic autonomic dz - ED correlates w/ ?
Product of kidney - neg feedback to suppress PTH
currently, MCC Addison's disease
gland - tumor causes precocious puberty
Impaired mineralization of new bone matrix in adults
mitochondrial disease = early onset diabetes + ?
hyperprolactinemia 2/2 stalk effect is due to decrease of?
parathyroid, pancrease, pituitary ?
17-alpha hydroxylase/ 17,20 lyase deficiency results in excess ?
hypogonadotropic hypogonadism and anosmia
MCC primary hyperaldosteronism
HHNS Tx - 1st step?
MCC primary hyperparathyroidism
Tx hypercalcemia: fluids, then ?
DM: eruptive xanthomas due to high?
High ACTH, High Cortisol, no suppression w/ high dose Dex
Give ACEI and GFR plunges - block in ?
QuestionAnswerNotes
Medullary thyroid CA, pheo, parathyroid hyperplasia
Osteoclast derived TRAP is elevated
MCC hypercalcemia
Rx: dec hepatic glucose production
BMD c/w someone your own age, gender, and ethnicity
DM - Rx to lower triglycerides
ketoacidosis from adipocytes + ?
CAH pathway: defective conversion of 17-OH progesterone to 11-deoxycortisol
infant w/ big tongue, umbilical hernia, open fontanelle, poor feeding and growth, lethargy
Osteoporosis - excess RANKL and not enough ?
Abscence of uterus, externally female, serum T and LH inc
Bilateral streak gonads, Eunuchoid proportions
historically, MCC Addison's disease
Gene assoc w/ APS1
Class: Inc tissue respose to insulin by activating PPAR
how to measure volume depletion?
Tx for lactic acidosis: bypass formation of lactate
Infection during infancy assoc w/ higher rate of DM type I
- thickened cortical/trabecular bone
estradiol less than 5; FSH > 40; dx ?
hyperglycemia, absence of ketosis and hyperosmolar state
DM I with blunted neuro sx; first sx of hypoglycemia?
MC bacteria assoc w/ Waterhouse-Friderichsen Syndrome
Follicular cells of thyroid derived from?
Dense fibrosis replacement of thyroid gland w/ extension into adjacent tissues
Effect of alkalosis on ionized Calcium
Proliferative stage of diabetic retinopathy defined by?
follicular hyperplasia of thymus assoc w/ ?
Absence of uterus, CN 8 deafness, renal abnormalities
nml PTH but kidney resistance to PTH
knuckle knuckle dimple knuckle
Effect of PTH on kidney excretion of phos
Predictor of CHD in Type II DM
Rachitis rosary on CXR
DM, fasting plasma glucose > ?
'brown tumors' and severe hypercalcemia
Tetany, chvostek's, trousseau's etc
Hurthle cells and lymphoid follicles
MODY2 assoc w/ which enzyme mutation?
Intermediate acting insulin aka ?
HNF - 1alpha assoc w/ which monogenic syndrome?
low HCO3 in DKA means ?
band keratopathy, HTN, cardiac arrhythmia, short QT interval
Milkman's fractures/'Looser's Zone'/pseudofractures
parathyroid hyperplasia - hereditary due to ?
Reversible schiff base to irreversible?
fewer than 6-8 cycles/year
bacteremia + adrenal hemorrhage
DM: Albuminuria >? mg/24 h
volume depletion/dehydration in DM due to ?
women's basal body temp rises due to?
BMD 2.5+ SD below young adult female
QuestionAnswerNotes
High ACTH, High Cortisol, Suppression of 17OH-corticosteroid w/ high dose Dex
oncocytic metaplasia of follicular cells
Medullary thyroid CA, pheo, mucosal neuromas, marfanoid features
Activating mutation of CaSR causes?
Hypernatremia, hypokalemia, HTN, high renin
Statin + fibrates: risk of?
how to measure dehydration?
Rx that is RF for fx
pituitary infarct from postpartum hemorrhage
Extremely slow release (peak-less) insulin analogue
human monoclonal antibody against RANKL
AD, inactivating heterozygous mutation, hypercalcemia w/ no sequelae
systemic and adreogenic sx in female, testosterone > 200, DHEAS > 700 - tumor?
high alk phos, low (calcium x phos) product
infiltrative cause of hypopituitarism
MCC ectopic ACTH production
corpus luteum secretes?
hirsutism - 1st r/o ?
C-cells derived from?
Hypernatremia, hypokalemia, HTN, low renin
worst outcome of diabetic retinopathy?
Silent dz until fracture occurs
Tx: Paget's
Part of 'polyol pathway' that results in neuropathy
Flattened weight chart: IGF-1 low but IGF BP3 is normal ?
Give w/ thiazide diuretic to treat hypocalcemia
cardiac, abnormal facies, thymic hypoplasia, cleft palate, hypocalemia
Treat DKA - effect on potassium?
MCC: effacement of acinar pattern in pituitary
DM or DI: dehydration only?
Turns dark brown in Zenker's fixative
Test - familial hypercalcemia v. primary hyperparathyroidism
46XY Complete Gonadal Dysgenesis
Necrobiosis Lipoidica Diabeticorum - send pt to?
DM type I + hypothyroid + hyperpigmentation, likely dx?
Painful thyroid - multinucleated giant cells and acute inflammation w/ destruction of follicles
class: Acarbose, miglitol
T score between -1 and -2.5
CAH pathway: defective conversion of progesterone to 11-deoxycorticosterone
Effect of acidosis on ionized Calcium
CPT-1 transports the FFA into ?
Major worldwide cause of hypocalcemia
Test to eval cornification of vaginal epithelium
Rx: block GTPase binding, flatten ruffled border
MC hormonal abnormality assoc w/ pituitary adenomas
Nucleus - 24hr cycle timekeeper
Tx osteoporosis: anabolic agents
sella tumor w/ biphasic peak in children and middle aged adults
First line tx for osteoporosis
Inflate BP 10mmHg above systolic and hold -> carpal spasm
Tx: refractory hypercalcemia

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