Science Quiz / 8b Endocrine2

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Can you name the 8b Endocrine Wk2?

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Necrobiosis Lipoidica Diabeticorum - send pt to?
DKA Tx - 1st step?
Hurthle cells and lymphoid follicles
CPT-1 transports the FFA into ?
low HCO3 in DKA means ?
bacteremia + adrenal hemorrhage
Impaired mineralization of new bone matrix in adults
malignancy - high ca, low p, low pth due to?
how to measure dehydration?
CAH pathway: defective conversion of 17-OH progesterone to 11-deoxycortisol
Effect of alkalosis on ionized Calcium
Converts D-glucose to sorbitol
MCC primary hyperparathyroidism
class: Acarbose, miglitol
type of PO calcium to give for Severe hypocalcemia
MC bacteria assoc w/ Waterhouse-Friderichsen Syndrome
Urinary and serum N-telopeptide are increased
17-alpha hydroxylase/ 17,20 lyase deficiency results in excess ?
volume depletion/dehydration in DM due to ?
Follicular cells of thyroid derived from?
ketoacidosis from adipocytes + ?
thyroid carcinoma w/ empty nuclei and psamomma bodies
DM type I + hypothyroid + hyperpigmentation, likely dx?
MCC primary hyperaldosteronism
pituitary infarct from postpartum hemorrhage
Inflate BP 10mmHg above systolic and hold -> carpal spasm
C-cells derived from?
Why you stop metformin before surgery etc
Bilateral streak gonads, Eunuchoid proportions
nml PTH but kidney resistance to PTH
Extremely slow release (peak-less) insulin analogue
hirsutism - 1st r/o ?
Effect of acidosis on ionized Calcium
Milkman's fractures/'Looser's Zone'/pseudofractures
HNF - 1alpha assoc w/ which monogenic syndrome?
Reversible schiff base to irreversible?
oncocytic metaplasia of follicular cells
currently, MCC Addison's disease
Rx: dec hepatic glucose production
historically, MCC Addison's disease
Dense fibrosis replacement of thyroid gland w/ extension into adjacent tissues
Tx: vitamin D intoxication
infant w/ big tongue, umbilical hernia, open fontanelle, poor feeding and growth, lethargy
band keratopathy, HTN, cardiac arrhythmia, short QT interval
BMD c/w someone your own age, gender, and ethnicity
Give ACEI and GFR plunges - block in ?
Medullary thyroid CA, pheo, parathyroid hyperplasia
Give w/ thiazide diuretic to treat hypocalcemia
parathyroid hyperplasia - hereditary due to ?
follicular hyperplasia of thymus assoc w/ ?
hypogonadotropic hypogonadism and anosmia
T score between -1 and -2.5
elevated urinary VMA, HVA
parathyroid, pancrease, pituitary ?
fewer than 6-8 cycles/year
Tx: Paget's
'brown tumors' and severe hypercalcemia
MCC ectopic ACTH production
Rx: blocks conversion of T4 to T3 and used in pregnancy
systemic and adreogenic sx in female, testosterone > 200, DHEAS > 700 - tumor?
Part of 'polyol pathway' that results in neuropathy
Rx that is RF for fx
- thickened cortical/trabecular bone
Rachitis rosary on CXR
Silent dz until fracture occurs
Measure of how much beta cell dysfunction there is
High ACTH, High Cortisol, no suppression w/ high dose Dex
Differentiation of ovarian interstitial cells into steroidogenically active luteinized stromal cells
DM I with blunted neuro sx; first sx of hypoglycemia?
Tx: diabetic retinopathy
co-localized w/ insulin in granules, co-secreted
Effect of PTH on kidney excretion of phos
highest power Rx: Inc beta cell insulin secretion
Proliferative stage of diabetic retinopathy defined by?
Test - familial hypercalcemia v. primary hyperparathyroidism
Tx: refractory hypercalcemia
decoy receptor that prevents RANKL binding to RANK
keratin pearls - histologically characteristic of ?
high alk phos, low (calcium x phos) product
High ACTH, High Cortisol, Suppression of 17OH-corticosteroid w/ high dose Dex
Inactivating mutation of CaSR - presents at ?
knuckle knuckle dimple knuckle
Syndrome - toxic nodule in multinodular goiter
Abscence of uterus, externally female, serum T and LH inc
human monoclonal antibody against RANKL
Predictor of CHD in Type II DM
gland - tumor causes precocious puberty
Gene assoc w/ APS1
hyperprolactinemia 2/2 stalk effect is due to decrease of?
ambiguous genitalia at birth + salt-wasting
DM, fasting plasma glucose > ?
MCC of hyperandrogenic anovulation
Product of kidney - neg feedback to suppress PTH
Intermediate acting insulin aka ?
Treat DKA - effect on potassium?
Major worldwide cause of hypocalcemia
MC deficient enzyme in CAH
Turns dark brown in Zenker's fixative
Tx lactic acidosis - 1st step?
Nucleus - 24hr cycle timekeeper
Medullary thyroid CA, pheo, mucosal neuromas, marfanoid features
Absence of uterus, CN 8 deafness, renal abnormalities
Low ACTH, High Cortisol, no suppression w/ high dose Dex
Tx osteoporosis: anabolic agents
MCC: effacement of acinar pattern in pituitary
Tx hypercalcemia: fluids, then ?
Hypernatremia, hypokalemia, HTN, high renin
Statin + fibrates: risk of?
DM: postprandial lipema b/c insulin regulates?
MODY2 assoc w/ which enzyme mutation?
hypogonadotropic hypogonadism is a problem of the?
46XY Complete Gonadal Dysgenesis
Tetany, chvostek's, trousseau's etc
HHNS Tx - 1st step?
leonine facies, edema of extremities due to CHF
how to measure volume depletion?
Tap facial nerve -> ipsi facial muscles contract
Activating mutation of CaSR causes?
resorption of distal phalanx
Osteoclast derived TRAP is elevated
sella tumor w/ biphasic peak in children and middle aged adults
MCC hypercalcemia
MC pineal region mass
Test to eval cornification of vaginal epithelium
Osteoporosis - excess RANKL and not enough ?
estradiol less than 5; FSH > 40; dx ?
MC autoimmune endocrine dz
cardiac, abnormal facies, thymic hypoplasia, cleft palate, hypocalemia
heart condition assoc w/ Turner's
CAH pathway: defective conversion of progesterone to 11-deoxycorticosterone
DM: eruptive xanthomas due to high?
DM: Albuminuria >? mg/24 h
Effect of cytosolic Ca++ on PTH
DM - Rx to lower triglycerides
Infection during infancy assoc w/ higher rate of DM type I
Tx for lactic acidosis: bypass formation of lactate
First line tx for osteoporosis
Rx: block GTPase binding, flatten ruffled border
MCC adrenogenital synrome
infiltrative cause of hypopituitarism
MC hormonal abnormality assoc w/ pituitary adenomas
BMD 2.5+ SD below young adult female
mitochondrial disease = early onset diabetes + ?
hyperglycemia, absence of ketosis and hyperosmolar state
adipocytes dont develop properly, fat goes into organs
Painful thyroid - multinucleated giant cells and acute inflammation w/ destruction of follicles
worst outcome of diabetic retinopathy?
Flattened weight chart: IGF-1 low but IGF BP3 is normal ?
women's basal body temp rises due to?
AD, inactivating heterozygous mutation, hypercalcemia w/ no sequelae
Hypernatremia, hypokalemia, HTN, low renin
corpus luteum secretes?
Class: Inc tissue respose to insulin by activating PPAR
Diabetic autonomic dz - ED correlates w/ ?
DM or DI: dehydration only?

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