Science Quiz / 8b Endocrine1

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Can you name the 8b Endocrine1?

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male w/ female phenotype, lack axillary/pubic hair
Old test used to evalutate binding proteins
AR dz involving epithelial Na channel
Type of DI w/ high ADH
mediates most of the effects of GH on somatic growth
DM, optic atrophy, deafness - also expect what sx?
Gynecomastia w/ Inc LH, Dec T
Test to dx papillary thyroid Ca
First test to check for acromegaly
elderly w/ weight loss, anorexia, constipation, tachy, afib, cognitive dysfunction
Lack of ?results in impermeability of collecting duct to water/marked diuresis
low 8am cortisol, high ACTH
aging causes which testicular deficiency?
Gynecomastia w/ inc hcg - concern for ?
Satiety signal
Painless woody goiter and sclerosing cholangitis
Hyperthalamic temp instability w/ alt fevers
Abnml migration of GnRH and olfactory neurons
High estrogen states effect on TBG?
Reduction in thyroid hormone levels from ingesting large amt iodine
Way to measure central ACTH
Tx: goiter w/ compressive sx in unhealthy individuals
dx: tufting of terminal phalanges
iodide is stored w/i thyroid as?
dopamine receptor agonist
Hormone - dev of epididymis, vas def, seminal vesicle
skeleton type - androgen deficient before puberty?
Useful for thyroid Ca surveillance post surgery and radioiodine ablation
In which gender is thyroid malignancy w/ nodule more likely?
dopamine agonist w/ SE: nausea, orthostasis
Acts via cyclic AMP to inc permability of the tubular cell to water
Neoplasia of the parafollicular cell
Elevated GH/IGF-1 not suppressed by oral glucose tolerance test
Inhibin from sertoli cells inhibits GnRH and ?
Visual field defect w/ pituitary mass
Measured to release vasopressin at carotid sinus and aortic arch
anosmia and lack of secual development
Tumor from Rathke's pouch
Elevated prolactin w/o clinical sx, lab should do?
Test to assess functional status of thyroid tissue
The only pituitary adenoma where surgery is not considered first-line
Adrenal layer - aldosterone
Size of adrenals w/ autoimmune dz
Marijuana and methadone cause gynecomastia by dec ?
Adrenalytic Rx that can elevate liver enzymes
testosterone level in androgen resistance syndromes
1st tx for Thyroid Storm
unique enzyme in glomerularis
Persistent hyperkalemia w/o obv cause
Prolactin is excreted by ?
weakness, N/V, weight loss, hyperpigmentation, vitiligo, orthostatic hypotension
Baby w/ Na wasting, hypovolemia, hyperkalemia, very high aldo
Rx that greatly increases iodine
Hypothyroidism w/ very high mortality
only synthetic corticosteroid not tested by the cortisol assay
ADH secreted by the ?
Hyponatremia w/ hypoosmolarity, euvolemic
Endogenous cause for low RAIU w/ hyperthyroid sx
T3/T4 are bound by albumin, TBG, and ?
Small but firm testicles - dx?
Blue nevi, cardiac myxomas, schwannoma, testicle/ovary tumor
unexplained hyperkalemia, age > 60
5-alpha-reductase converts testosterone to ?
Gynecomastia w/ Inc LH, Inc T, nml TSH
acid base disturbance caused by 2nd hypoaldosteronism
Pituitary adenoma, Parathyroid hyperplasia, Pancreatic neuroendocrine tumors
21-hydroxylase deficiency aka?
phenotype switches from female to male at puberty
Exophthalmos, lytic bone lesions, DI
2nd adrenal insufficiency lacks?
MC pituitary lesion
ACTH dependent - next test?
Abnormal bend of penis during erection
hyperpigmentation, striae, truncal obesity, hyperandrogenism
Measured to release vasopressin at anterolateral hypothalamus
Tx for central DI
SE: 2nd aldosterone deficiency - besides BB and NSAID
Rx: Graves Dz (non-compressive)
endocrine condition w/ absolute eosinophilia
SE: prim aldosterone deficiency - besides ACEI/ARBs
Adrenal layer - cortisol (less), DHEA, androstenedione
Insulin tolerance test c/i in pt w/ sz and ?
Stimulates w/ CRH, suppresses w/ high dose Dex
Painless hyperthyroid -> hypothyroid that resolves after a year
MCC thyrotoxicosis
p450 cleaves cholesterol side chains to make?
men, permanent virilization of the hypothalamus occurs?
polydipsia, polyuria, large urine volume, inappropriately dilute urine
Adrenal layer - cortisol (more)
MCC acute thyroiditis (category)
toxic adenoma: tx in US w/ cure rate > 80%
primary AI effect on renin?
MCC tertiary adrenal insufficiency
After pituitary surgery, change in water balance due to no?
Ending of Rx to tx: SIADH
prolactinoma sx but low serum prolactin due to?
Adrenal dz caused by sarcoidosis
Psychoactive agent that can cause gynecomastia
Gynecomastia w/ Inc LH, Inc T, dec TSH
Tx acromegaly, failing somatostatin analogues
primary testicular failure - low testosterone, ? LH
MCC painful thyroid goiter
Hemorrhage into pituitary - aka?
cafe-au-lait spots, precocious puberty, acromegaly, thyrotoxicosis
Rx: Inhibits growth hormone
escutcheon type - androgen deficient after puberty
Inheritance of Kallman's syndrome
post adrenalectomy - risk of ?
Worst form of Thyroid Ca
how to tell organic from psychogenic ED
Psych Rx w/ SE of nephrogenic DI
MCC primary adrenal insuff in western world
how does hyperprolactinemia cause gynecomastia
DI-like sx but inc AVP w/ water deprivation and doesnt respond to DDAVP
Secondary amenorrhea after D&C
Thyroid Ca that invades blood vessels early
Cortisol + 11-beta-hydroxysteroid dehydrogenase = ?
MCC goiter and hypothyroid in US
Common precursor increases prolactin due to decreased?
Test for lack of diurnal rhythm of cortisol
High androgen states effect on TBG?
MC thyroid Ca
Dx: CRH stim -> exaggerated rise in ACTH
hormone - dev of prostate, ext genitalia
Acute or subacute thyroiditis: RAIU normal
Test to eval thyroid nodule/mass for malignancy
AMH, inhibin, activins, and aromatase secreted by?
male breast enlargement caused by inc dipose tissue
Gynecomastia w/ nml LH, Dec T, nl PRL
growth of lower jaw
effect of insulin resistance on sex hormone binding globulin (SHBG)
testicle in inguinal canal, undeveloped
Vaccine preventable cause of acquired testicular damage
Hormone imp for parturation and lactation?
HTN in Cushing's b/c cortisol activates the ? receptor
primary adrenal insuff - Na goes ?
Effect of amiodarone on RAIU
Rate limiting step for thyroid hormone synthesis
CRH does not stimulate, High Dose Dex does not suppress
Leydig cells produce which hormone?
hypothalamus is derived from the ?
androgen deficient in third trimester - sx?
Rx class: flutamide, finasteride, dutasteride
Tx: secondary and tertiry AI
Test for overproduction of cortisol
Gold standard for dx of adrenal insufficiency
Hyperthryoidism w/ very high mortality
Test to evaluate thyroid nodularity
Test to Dx DI
Rx that causes goiter in 6% of chronic users
Test for non-toxic MNG
Diffuse toxic goiter on RAIU (hot) - dx?
ID Rx w/ SE of nephrogenic DI
Test for HPA axis or GH axis deficiency
MCC secondary aldosterone deficiency
Dx: high ESR, low TSH, High T4 >T3, Low anti=TPO/Tgb
Acromegaly - MCC death due to enlargement of?
adenohypophysis (ant pit) develops from?
48 hrs of Dex differentiates Cushing's from ?
Test for dec feedback inhibition of cortisol
bioavailable testosterone is NOT bound to?
Rx: block MR receptor
priamry adrenal insuff - BUN goes ?
2nd adrenal insuff at delivery, in women w/ significant blood loss

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