Science Quiz / 8b Endocrine1

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Can you name the 8b Endocrine1?

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Abnml migration of GnRH and olfactory neurons
Adrenal layer - aldosterone
MCC primary adrenal insuff in western world
aging causes which testicular deficiency?
Rx: Graves Dz (non-compressive)
DM, optic atrophy, deafness - also expect what sx?
Persistent hyperkalemia w/o obv cause
Test for dec feedback inhibition of cortisol
Dx: high ESR, low TSH, High T4 >T3, Low anti=TPO/Tgb
prolactinoma sx but low serum prolactin due to?
Baby w/ Na wasting, hypovolemia, hyperkalemia, very high aldo
Test to eval thyroid nodule/mass for malignancy
Measured to release vasopressin at carotid sinus and aortic arch
Pituitary adenoma, Parathyroid hyperplasia, Pancreatic neuroendocrine tumors
unexplained hyperkalemia, age > 60
mediates most of the effects of GH on somatic growth
endocrine condition w/ absolute eosinophilia
Adrenal layer - cortisol (more)
polydipsia, polyuria, large urine volume, inappropriately dilute urine
how to tell organic from psychogenic ED
2nd adrenal insufficiency lacks?
First test to check for acromegaly
Test for lack of diurnal rhythm of cortisol
2nd adrenal insuff at delivery, in women w/ significant blood loss
primary adrenal insuff - Na goes ?
21-hydroxylase deficiency aka?
MCC tertiary adrenal insufficiency
anosmia and lack of secual development
MC pituitary lesion
Abnormal bend of penis during erection
Rx that causes goiter in 6% of chronic users
Hyponatremia w/ hypoosmolarity, euvolemic
Test to Dx DI
testicle in inguinal canal, undeveloped
Gynecomastia w/ Inc LH, Inc T, nml TSH
Test to dx papillary thyroid Ca
Gynecomastia w/ inc hcg - concern for ?
Inhibin from sertoli cells inhibits GnRH and ?
Insulin tolerance test c/i in pt w/ sz and ?
DI-like sx but inc AVP w/ water deprivation and doesnt respond to DDAVP
dopamine agonist w/ SE: nausea, orthostasis
High estrogen states effect on TBG?
Neoplasia of the parafollicular cell
Endogenous cause for low RAIU w/ hyperthyroid sx
Worst form of Thyroid Ca
Stimulates w/ CRH, suppresses w/ high dose Dex
escutcheon type - androgen deficient after puberty
androgen deficient in third trimester - sx?
After pituitary surgery, change in water balance due to no?
testosterone level in androgen resistance syndromes
Psych Rx w/ SE of nephrogenic DI
Adrenal layer - cortisol (less), DHEA, androstenedione
ID Rx w/ SE of nephrogenic DI
MCC secondary aldosterone deficiency
CRH does not stimulate, High Dose Dex does not suppress
48 hrs of Dex differentiates Cushing's from ?
how does hyperprolactinemia cause gynecomastia
Measured to release vasopressin at anterolateral hypothalamus
SE: 2nd aldosterone deficiency - besides BB and NSAID
Lack of ?results in impermeability of collecting duct to water/marked diuresis
Prolactin is excreted by ?
primary testicular failure - low testosterone, ? LH
Acute or subacute thyroiditis: RAIU normal
Painless hyperthyroid -> hypothyroid that resolves after a year
Small but firm testicles - dx?
bioavailable testosterone is NOT bound to?
Rx: Inhibits growth hormone
male w/ female phenotype, lack axillary/pubic hair
hyperpigmentation, striae, truncal obesity, hyperandrogenism
Test to assess functional status of thyroid tissue
Rate limiting step for thyroid hormone synthesis
T3/T4 are bound by albumin, TBG, and ?
Common precursor increases prolactin due to decreased?
MC thyroid Ca
iodide is stored w/i thyroid as?
dx: tufting of terminal phalanges
adenohypophysis (ant pit) develops from?
MCC goiter and hypothyroid in US
Dx: CRH stim -> exaggerated rise in ACTH
Gynecomastia w/ Inc LH, Dec T
unique enzyme in glomerularis
MCC acute thyroiditis (category)
Satiety signal
Acromegaly - MCC death due to enlargement of?
Useful for thyroid Ca surveillance post surgery and radioiodine ablation
Tx: secondary and tertiry AI
Old test used to evalutate binding proteins
acid base disturbance caused by 2nd hypoaldosteronism
Test to evaluate thyroid nodularity
Adrenal dz caused by sarcoidosis
Rx that greatly increases iodine
Test for overproduction of cortisol
Exophthalmos, lytic bone lesions, DI
Way to measure central ACTH
Blue nevi, cardiac myxomas, schwannoma, testicle/ovary tumor
only synthetic corticosteroid not tested by the cortisol assay
Visual field defect w/ pituitary mass
Psychoactive agent that can cause gynecomastia
Gynecomastia w/ nml LH, Dec T, nl PRL
Hormone - dev of epididymis, vas def, seminal vesicle
post adrenalectomy - risk of ?
Type of DI w/ high ADH
Inheritance of Kallman's syndrome
Thyroid Ca that invades blood vessels early
Secondary amenorrhea after D&C
Effect of amiodarone on RAIU
Leydig cells produce which hormone?
Test for non-toxic MNG
Rx class: flutamide, finasteride, dutasteride
Adrenalytic Rx that can elevate liver enzymes
SE: prim aldosterone deficiency - besides ACEI/ARBs
men, permanent virilization of the hypothalamus occurs?
Ending of Rx to tx: SIADH
growth of lower jaw
Marijuana and methadone cause gynecomastia by dec ?
Elevated GH/IGF-1 not suppressed by oral glucose tolerance test
Gold standard for dx of adrenal insufficiency
Reduction in thyroid hormone levels from ingesting large amt iodine
toxic adenoma: tx in US w/ cure rate > 80%
Vaccine preventable cause of acquired testicular damage
primary AI effect on renin?
Tx for central DI
Hormone imp for parturation and lactation?
Tx: goiter w/ compressive sx in unhealthy individuals
Tx acromegaly, failing somatostatin analogues
weakness, N/V, weight loss, hyperpigmentation, vitiligo, orthostatic hypotension
In which gender is thyroid malignancy w/ nodule more likely?
Test for HPA axis or GH axis deficiency
Tumor from Rathke's pouch
1st tx for Thyroid Storm
p450 cleaves cholesterol side chains to make?
Hyperthryoidism w/ very high mortality
Painless woody goiter and sclerosing cholangitis
Elevated prolactin w/o clinical sx, lab should do?
male breast enlargement caused by inc dipose tissue
Rx: block MR receptor
skeleton type - androgen deficient before puberty?
MCC painful thyroid goiter
HTN in Cushing's b/c cortisol activates the ? receptor
Acts via cyclic AMP to inc permability of the tubular cell to water
cafe-au-lait spots, precocious puberty, acromegaly, thyrotoxicosis
Hyperthalamic temp instability w/ alt fevers
Diffuse toxic goiter on RAIU (hot) - dx?
effect of insulin resistance on sex hormone binding globulin (SHBG)
ACTH dependent - next test?
Gynecomastia w/ Inc LH, Inc T, dec TSH
Hypothyroidism w/ very high mortality
Cortisol + 11-beta-hydroxysteroid dehydrogenase = ?
Size of adrenals w/ autoimmune dz
MCC thyrotoxicosis
The only pituitary adenoma where surgery is not considered first-line
Hemorrhage into pituitary - aka?
5-alpha-reductase converts testosterone to ?
dopamine receptor agonist
hypothalamus is derived from the ?
hormone - dev of prostate, ext genitalia
AMH, inhibin, activins, and aromatase secreted by?
phenotype switches from female to male at puberty
priamry adrenal insuff - BUN goes ?
High androgen states effect on TBG?
ADH secreted by the ?
elderly w/ weight loss, anorexia, constipation, tachy, afib, cognitive dysfunction
AR dz involving epithelial Na channel
low 8am cortisol, high ACTH

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