Science Quiz / 8b Endocrine1

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Can you name the 8b Endocrine1?

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unique enzyme in glomerularis
hyperpigmentation, striae, truncal obesity, hyperandrogenism
Way to measure central ACTH
Tx for central DI
priamry adrenal insuff - BUN goes ?
Hormone imp for parturation and lactation?
Dx: high ESR, low TSH, High T4 >T3, Low anti=TPO/Tgb
Test for dec feedback inhibition of cortisol
Pituitary adenoma, Parathyroid hyperplasia, Pancreatic neuroendocrine tumors
MCC painful thyroid goiter
Marijuana and methadone cause gynecomastia by dec ?
Rx class: flutamide, finasteride, dutasteride
Cortisol + 11-beta-hydroxysteroid dehydrogenase = ?
polydipsia, polyuria, large urine volume, inappropriately dilute urine
skeleton type - androgen deficient before puberty?
Size of adrenals w/ autoimmune dz
Adrenal layer - cortisol (more)
Effect of amiodarone on RAIU
Worst form of Thyroid Ca
Rx: Inhibits growth hormone
Leydig cells produce which hormone?
primary AI effect on renin?
Elevated GH/IGF-1 not suppressed by oral glucose tolerance test
Abnormal bend of penis during erection
MC pituitary lesion
Test for non-toxic MNG
Psychoactive agent that can cause gynecomastia
MCC thyrotoxicosis
iodide is stored w/i thyroid as?
CRH does not stimulate, High Dose Dex does not suppress
MCC tertiary adrenal insufficiency
Tx: secondary and tertiry AI
Gynecomastia w/ nml LH, Dec T, nl PRL
unexplained hyperkalemia, age > 60
Inheritance of Kallman's syndrome
dopamine receptor agonist
p450 cleaves cholesterol side chains to make?
Vaccine preventable cause of acquired testicular damage
High estrogen states effect on TBG?
Hormone - dev of epididymis, vas def, seminal vesicle
Hyperthryoidism w/ very high mortality
Hyponatremia w/ hypoosmolarity, euvolemic
low 8am cortisol, high ACTH
Persistent hyperkalemia w/o obv cause
Test to dx papillary thyroid Ca
Elevated prolactin w/o clinical sx, lab should do?
Measured to release vasopressin at carotid sinus and aortic arch
aging causes which testicular deficiency?
5-alpha-reductase converts testosterone to ?
Test for overproduction of cortisol
Hyperthalamic temp instability w/ alt fevers
1st tx for Thyroid Storm
The only pituitary adenoma where surgery is not considered first-line
First test to check for acromegaly
MC thyroid Ca
primary testicular failure - low testosterone, ? LH
21-hydroxylase deficiency aka?
Rx that greatly increases iodine
toxic adenoma: tx in US w/ cure rate > 80%
Acute or subacute thyroiditis: RAIU normal
SE: prim aldosterone deficiency - besides ACEI/ARBs
Type of DI w/ high ADH
DI-like sx but inc AVP w/ water deprivation and doesnt respond to DDAVP
mediates most of the effects of GH on somatic growth
Rx: block MR receptor
acid base disturbance caused by 2nd hypoaldosteronism
Endogenous cause for low RAIU w/ hyperthyroid sx
MCC primary adrenal insuff in western world
Hypothyroidism w/ very high mortality
Gynecomastia w/ Inc LH, Inc T, nml TSH
Painless woody goiter and sclerosing cholangitis
In which gender is thyroid malignancy w/ nodule more likely?
Useful for thyroid Ca surveillance post surgery and radioiodine ablation
cafe-au-lait spots, precocious puberty, acromegaly, thyrotoxicosis
Abnml migration of GnRH and olfactory neurons
Test for lack of diurnal rhythm of cortisol
effect of insulin resistance on sex hormone binding globulin (SHBG)
testosterone level in androgen resistance syndromes
MCC acute thyroiditis (category)
Rx that causes goiter in 6% of chronic users
prolactinoma sx but low serum prolactin due to?
ACTH dependent - next test?
primary adrenal insuff - Na goes ?
Thyroid Ca that invades blood vessels early
High androgen states effect on TBG?
endocrine condition w/ absolute eosinophilia
Satiety signal
how to tell organic from psychogenic ED
Test to eval thyroid nodule/mass for malignancy
Tumor from Rathke's pouch
Measured to release vasopressin at anterolateral hypothalamus
Acts via cyclic AMP to inc permability of the tubular cell to water
Adrenal layer - cortisol (less), DHEA, androstenedione
MCC goiter and hypothyroid in US
After pituitary surgery, change in water balance due to no?
Secondary amenorrhea after D&C
dx: tufting of terminal phalanges
Small but firm testicles - dx?
Test to assess functional status of thyroid tissue
AMH, inhibin, activins, and aromatase secreted by?
Lack of ?results in impermeability of collecting duct to water/marked diuresis
ID Rx w/ SE of nephrogenic DI
men, permanent virilization of the hypothalamus occurs?
Visual field defect w/ pituitary mass
Reduction in thyroid hormone levels from ingesting large amt iodine
male w/ female phenotype, lack axillary/pubic hair
Painless hyperthyroid -> hypothyroid that resolves after a year
elderly w/ weight loss, anorexia, constipation, tachy, afib, cognitive dysfunction
Exophthalmos, lytic bone lesions, DI
dopamine agonist w/ SE: nausea, orthostasis
SE: 2nd aldosterone deficiency - besides BB and NSAID
Inhibin from sertoli cells inhibits GnRH and ?
2nd adrenal insufficiency lacks?
escutcheon type - androgen deficient after puberty
Gynecomastia w/ inc hcg - concern for ?
post adrenalectomy - risk of ?
testicle in inguinal canal, undeveloped
male breast enlargement caused by inc dipose tissue
Psych Rx w/ SE of nephrogenic DI
Blue nevi, cardiac myxomas, schwannoma, testicle/ovary tumor
AR dz involving epithelial Na channel
Insulin tolerance test c/i in pt w/ sz and ?
Hemorrhage into pituitary - aka?
Stimulates w/ CRH, suppresses w/ high dose Dex
Adrenal layer - aldosterone
Gynecomastia w/ Inc LH, Dec T
Gynecomastia w/ Inc LH, Inc T, dec TSH
Tx acromegaly, failing somatostatin analogues
Old test used to evalutate binding proteins
ADH secreted by the ?
how does hyperprolactinemia cause gynecomastia
HTN in Cushing's b/c cortisol activates the ? receptor
growth of lower jaw
Diffuse toxic goiter on RAIU (hot) - dx?
adenohypophysis (ant pit) develops from?
2nd adrenal insuff at delivery, in women w/ significant blood loss
T3/T4 are bound by albumin, TBG, and ?
only synthetic corticosteroid not tested by the cortisol assay
Dx: CRH stim -> exaggerated rise in ACTH
anosmia and lack of secual development
phenotype switches from female to male at puberty
hypothalamus is derived from the ?
Rate limiting step for thyroid hormone synthesis
Adrenal dz caused by sarcoidosis
Prolactin is excreted by ?
48 hrs of Dex differentiates Cushing's from ?
weakness, N/V, weight loss, hyperpigmentation, vitiligo, orthostatic hypotension
Neoplasia of the parafollicular cell
MCC secondary aldosterone deficiency
Gold standard for dx of adrenal insufficiency
hormone - dev of prostate, ext genitalia
androgen deficient in third trimester - sx?
Common precursor increases prolactin due to decreased?
bioavailable testosterone is NOT bound to?
Test to Dx DI
Tx: goiter w/ compressive sx in unhealthy individuals
DM, optic atrophy, deafness - also expect what sx?
Acromegaly - MCC death due to enlargement of?
Test to evaluate thyroid nodularity
Ending of Rx to tx: SIADH
Baby w/ Na wasting, hypovolemia, hyperkalemia, very high aldo
Test for HPA axis or GH axis deficiency
Adrenalytic Rx that can elevate liver enzymes
Rx: Graves Dz (non-compressive)

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