| Start/End (S/W, N/E) | Interstate Number |
|---|
| Concord, NH/Highgate Springs, VT | |
| Middletown, VA/Washington, DC | |
| Raleigh, NC/Wendell, NC | |
| Annapolis, MD/Baltimore, MD | |
| Hannibal, MO/Champaign, IL | |
| near Dandridge, TN/Alexandria Bay, NY | |
| Mobile, AL/Gary, IN | |
| Seville, OH/Camden, NJ (East) | |
| Seattle, WA/Boston, MA | |
| San Diego, CA/Sweetgrass, MT | |
| Macon, GA/Savannah, GA | |
| Wichita Falls, TX/St. Louis, MO | |
| Kansas City, MO/Pembina, ND | |
| LaPlace, LA/Chicago, IL | |
| Beloit, WI/Green Bay, WI | |
| Baton Rouge, LA/Slidell, LA | |
| Baltimore, MD/Colonial Park, PA | |
| Barstow, CA/Wilmington, NC | |
| O'Fallon, MO/Chesapeake, VA | |
| Penitas, TX/Harlingen, TX | |
| Ellensburg, WA/Hermiston, OR | |
| Nogales, AZ/Tucson, AZ | |
| Sikeston, MO/Chicago, IL | |
| Laredo, TX/Duluth, MN | |
| Queens, NY/Rouses Point, NY (North) | |
| | Start/End (S/W, N/E) | Interstate Number |
|---|
| Louisville, KY/Cleveland, OH | |
| Slidell, LA/Lookout Mountain, GA | |
| near Kent, TX/Florence, SC | |
| Halawa Heights, HI/Kanoehe Marine Corps Base, HI | |
| New Haven, CT/Derby Line, VT | |
| near Byhalia, MS/Birmingham, AL | |
| Lubbock, TX/Amarillo, TX | |
| San Diego, CA/Casa Grande, AZ | |
| Phoenix, AZ/Flagstaff, AZ | |
| Las Cruces, NM/Buffalo, WY | |
| Normal, IL/Wausau, WI (Merrill, WI) | |
| near Candor, NC/Greensboro, NC | |
| Galveston, TX/Dallas, TX | |
| Dunmore, PA/near Sturbridge, MA (East) | |
| Bedford, PA/Painted Post, NY | |
| Columbia, SC/Cleveland, OH | |
| San Ysidro, CA/Blaine, WA | |
| near Moline, IL/Chicago, IL (West) | |
| near Boulder City, NV/near Henderson, NV | |
| near Boulder City, NV/Henderson, NV | |
| Virginia State Line/Lumberton, NC (East-Disconnected Segments) | |
| near Lickdale, PA/Manhattan, NY | |
| Cove Fort, UT/Baltimore, MD | |
| Montgomery, AL/Petersburg, VA | |
| Wheat Ridge, CO/near Big Spring, NE (West) | |
| | Start/End (S/W, N/E) | Interstate Number |
|---|
| Davenport, IA/Cincinnati, OH (West) | |
| Pulleys Mill, IL/Chattanooga, TN | |
| San Francisco, CA/Ridgefield Park, NJ | |
| Charleston, WV/Erie, PA | |
| Rosenburg, TX/Port Huron, MI (Incomplete) | |
| Tampa, FL/Daytona Beach, FL | |
| Makakilo, HI/Honolulu, HI | |
| near Erie, PA/Elmira, NY (East) | |
| Santa Monica, CA/Jacksonville, FL | |
| Portland, OR/Echo, UT (West) | |
| Lafayette, LA/Kansas City, MO | |
| Morgantown, WV/Hancock, MD | |
| Morrison City, TN/Charleston, SC | |
| Billings, MT/Port Huron, MI | |
| Pearl City, HI/Wahiawa, HI | |
| Miami, FL/Houlton, ME | |
| Russell, IL/Howard, WI | |
| Canton, MA/St. Johnsbury, VT | |
| Heyburn, ID/Pocatello, ID (West) | |
| Muskegon, MI/Detroit, MI | |
| Binghamton, NY/Schenectady, NY (East) | |
| Copperas Cove, TX/Belton, TX | |
| Hialeah, FL/Sault Ste. Marie, MI | |
| Fort Worth, TX/Little Rock, AR | |
| Corpus Christi, TX/San Antonio, TX | |
|
