This 100-1 shot took on undefeated Man O' War and came out on top.
Won the Kentucky Derby at 50-1 odds in 2009.
The 18-0 Patriots came into Super Bowl XLII as 12 point favorites, but this team ruined New England's perfect season.
This 14 point underdog won Super Bowl XXXVI over the St. Louis Rams.
This team defeated the Soviet Union, gold medal winners the previous four Olympics, in 1980.
Defeated the United States, winners of 63 straight, to win the gold medal in 1972, though controversy remains as clock issues gave the winning team multiple chances at a last shot
Coach Jim Valvano's 6th seeded underdogs beat the high flying Houston Cougars in the 1983 NCAA Basketball Championship game.
This 8 seed in the NCAA tournament was thought to have no chance against top seeded Georgetown, but they shot 78% from the field and won.
This boxer was given 42-1 odds against Mike Tyson in 1990, but beat won the bout in 10 rounds.
This team became the first 8 seed to beat a 1 seed in NBA playoff history when they beat the Sonics in 1994.
This 8th seeded team beat the top seeded Dallas Mavericks in a best of 7 series in 2007.
Russian wrestler Alexander Kerelin came into the 2000 Olympics undefeated in 13 years of competiton, but fell to this US competitor.
27 point underdogs on the road at Michigan, this FCS school pulled off the surprising upset in the first week of the 2007 season.
Despite being a 41 point favorite, USC fell to this team in 2007 by one point.
The first 16 seed to beat a 1 seed in NCAA history, this women's team beat Stanford in 1998.
This AL Wild Card team came back from 3 games down against the Yankees in 2004 to win the Pennant.
Beat the top-ranked Kentucky Wildcats with the first all-black starting line up in NCAA Championship history.
The NFL's Baltimore Colts were the overwhelming favorite in Super Bowl III, but this team and their brash quarterback surprised everyone.
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