Science Quiz / Immunology Vaccines, Microbes, Immunosuppressants

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Can you name the vaccine, virus, bacteria, or immunosuppressant??

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HintAnswerExtra
Inhibits IL-10 synthesis, good for tx EBV
Recombinant fully human TNF-a receptor mAb that has ligand-binding portion fused to IgG
Tx of acrolein toxicity
Inhibits calcineurin and prevents NFAT migration to the nucleus by binding cyclophilin
Anti-CD20 chimeric monoclonal antibody
Chimeric anti-TNF monoclonal antibody
Metabolite of cyclophosphamide that has a toxicity damaging bladder mucosa
X-linked proliferative syndrome results in EBV and lymphomas due to lack of this signaling protein
Mouse mAb
Human antibody
Inhibits IMP dehydrogenase, lowers dGTP levels
Alkylating agent that crosslinks DNA-DNA and DNA-protein, blocking DNA replication and inducing cell death
Virus that inhibits proteasomal activity, produces IL-10, inhibits macrophage and DC activation
Capsular polysaccharide inhibits phagocytosis
SAP protein in XLP cannot bind this molecule
Flu vaccine that should not be given to children under the age of 8 except in certain circumstances
Humanized mAb
Produces catalase, resisting ROS in phagocytes
Immunosuppressant that inhibits T-independent B cell activation
Microbe that inhibits phagolysosome fusion
Fusion protein on macrophages upregulated in mycobacterial infection that cuases formation of giant cells
Inhibits purine synthesis
HintAnswerExtra
Tx of methotrexate toxicity
Virus that inhibits antigen presentation by interfering with TAP transporter
Virus that inhibits proteasomal activity and removes class I MHC molecules from the ER
Microbe that moves from cell to cell without going extracellular
Expresses sialic acid which inhibits C3 and C5 convertases
M protein blocks C3 binding to organism and C3b binding to complement receptors
Chimeric mAb
Inhibits cyclosporine by binding FKBP
Synthesizes modified LPS that resists peptide antibiotics
Inhibits mTOR and prevents T cells from making proteins for proliferation
Fungus that escapes phagolysosomes and resides in the cytoplasm of a macrophage
Microbe that crosses the placenta and can cause meningitis in newborns
Expresses NK inhibitor factor and blocks killing by NK cells
Lose depot and stranger signals/adjuvant effect in this type of vaccine
Virus that blocks effector cell activation and produces soluble IL-1 or IFN-y receptors
Inhibits DHFR, lowers purine levels
Fully human monoclonal antibody against TNF
Monoclonal antibody indicated for B lymphomas
Lowers pyrimidine nucleotide levels
When producing monoclonal antibodies, the fusion partner is a tumor B cell lacking what enzyme?
Anti-TNF with chimeric receptor

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