Science Quiz / Immunology Vaccines, Microbes, Immunosuppressants

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Can you name the vaccine, virus, bacteria, or immunosuppressant??

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Chimeric anti-TNF monoclonal antibody
Microbe that inhibits phagolysosome fusion
Fusion protein on macrophages upregulated in mycobacterial infection that cuases formation of giant cells
Inhibits DHFR, lowers purine levels
Virus that inhibits proteasomal activity and removes class I MHC molecules from the ER
Chimeric mAb
Inhibits IMP dehydrogenase, lowers dGTP levels
Monoclonal antibody indicated for B lymphomas
Inhibits IL-10 synthesis, good for tx EBV
Anti-TNF with chimeric receptor
Lose depot and stranger signals/adjuvant effect in this type of vaccine
Mouse mAb
Inhibits purine synthesis
Alkylating agent that crosslinks DNA-DNA and DNA-protein, blocking DNA replication and inducing cell death
Lowers pyrimidine nucleotide levels
SAP protein in XLP cannot bind this molecule
Capsular polysaccharide inhibits phagocytosis
Virus that blocks effector cell activation and produces soluble IL-1 or IFN-y receptors
Expresses NK inhibitor factor and blocks killing by NK cells
Human antibody
Microbe that moves from cell to cell without going extracellular
Inhibits mTOR and prevents T cells from making proteins for proliferation
Anti-CD20 chimeric monoclonal antibody
Expresses sialic acid which inhibits C3 and C5 convertases
Virus that inhibits proteasomal activity, produces IL-10, inhibits macrophage and DC activation
M protein blocks C3 binding to organism and C3b binding to complement receptors
Tx of methotrexate toxicity
Humanized mAb
Produces catalase, resisting ROS in phagocytes
Inhibits calcineurin and prevents NFAT migration to the nucleus by binding cyclophilin
Metabolite of cyclophosphamide that has a toxicity damaging bladder mucosa
Immunosuppressant that inhibits T-independent B cell activation
Fully human monoclonal antibody against TNF
Recombinant fully human TNF-a receptor mAb that has ligand-binding portion fused to IgG
Fungus that escapes phagolysosomes and resides in the cytoplasm of a macrophage
Virus that inhibits antigen presentation by interfering with TAP transporter
X-linked proliferative syndrome results in EBV and lymphomas due to lack of this signaling protein
Tx of acrolein toxicity
When producing monoclonal antibodies, the fusion partner is a tumor B cell lacking what enzyme?
Microbe that crosses the placenta and can cause meningitis in newborns
Flu vaccine that should not be given to children under the age of 8 except in certain circumstances
Inhibits cyclosporine by binding FKBP
Synthesizes modified LPS that resists peptide antibiotics

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