Science Quiz / Immunology Vaccines, Microbes, Immunosuppressants

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Can you name the vaccine, virus, bacteria, or immunosuppressant??

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Fully human monoclonal antibody against TNF
Inhibits IMP dehydrogenase, lowers dGTP levels
Chimeric anti-TNF monoclonal antibody
Virus that inhibits proteasomal activity, produces IL-10, inhibits macrophage and DC activation
Synthesizes modified LPS that resists peptide antibiotics
Inhibits purine synthesis
Inhibits IL-10 synthesis, good for tx EBV
Virus that blocks effector cell activation and produces soluble IL-1 or IFN-y receptors
Anti-TNF with chimeric receptor
Microbe that moves from cell to cell without going extracellular
Metabolite of cyclophosphamide that has a toxicity damaging bladder mucosa
SAP protein in XLP cannot bind this molecule
Flu vaccine that should not be given to children under the age of 8 except in certain circumstances
Capsular polysaccharide inhibits phagocytosis
Alkylating agent that crosslinks DNA-DNA and DNA-protein, blocking DNA replication and inducing cell death
Fungus that escapes phagolysosomes and resides in the cytoplasm of a macrophage
Anti-CD20 chimeric monoclonal antibody
Tx of methotrexate toxicity
Tx of acrolein toxicity
Microbe that inhibits phagolysosome fusion
Expresses NK inhibitor factor and blocks killing by NK cells
Fusion protein on macrophages upregulated in mycobacterial infection that cuases formation of giant cells
HintAnswerExtra
Microbe that crosses the placenta and can cause meningitis in newborns
Immunosuppressant that inhibits T-independent B cell activation
Lowers pyrimidine nucleotide levels
Expresses sialic acid which inhibits C3 and C5 convertases
Inhibits calcineurin and prevents NFAT migration to the nucleus by binding cyclophilin
Inhibits mTOR and prevents T cells from making proteins for proliferation
X-linked proliferative syndrome results in EBV and lymphomas due to lack of this signaling protein
When producing monoclonal antibodies, the fusion partner is a tumor B cell lacking what enzyme?
Recombinant fully human TNF-a receptor mAb that has ligand-binding portion fused to IgG
Inhibits DHFR, lowers purine levels
Lose depot and stranger signals/adjuvant effect in this type of vaccine
Virus that inhibits antigen presentation by interfering with TAP transporter
Humanized mAb
Human antibody
Virus that inhibits proteasomal activity and removes class I MHC molecules from the ER
Chimeric mAb
M protein blocks C3 binding to organism and C3b binding to complement receptors
Mouse mAb
Monoclonal antibody indicated for B lymphomas
Inhibits cyclosporine by binding FKBP
Produces catalase, resisting ROS in phagocytes

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