Science Quiz / Immunology Vaccines, Microbes, Immunosuppressants

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Can you name the vaccine, virus, bacteria, or immunosuppressant??

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HintAnswerExtra
Capsular polysaccharide inhibits phagocytosis
SAP protein in XLP cannot bind this molecule
Mouse mAb
Immunosuppressant that inhibits T-independent B cell activation
Tx of acrolein toxicity
Expresses sialic acid which inhibits C3 and C5 convertases
Inhibits calcineurin and prevents NFAT migration to the nucleus by binding cyclophilin
Metabolite of cyclophosphamide that has a toxicity damaging bladder mucosa
Produces catalase, resisting ROS in phagocytes
Microbe that inhibits phagolysosome fusion
Virus that blocks effector cell activation and produces soluble IL-1 or IFN-y receptors
Inhibits IMP dehydrogenase, lowers dGTP levels
Synthesizes modified LPS that resists peptide antibiotics
Inhibits DHFR, lowers purine levels
Inhibits IL-10 synthesis, good for tx EBV
Inhibits cyclosporine by binding FKBP
Recombinant fully human TNF-a receptor mAb that has ligand-binding portion fused to IgG
Humanized mAb
When producing monoclonal antibodies, the fusion partner is a tumor B cell lacking what enzyme?
Fungus that escapes phagolysosomes and resides in the cytoplasm of a macrophage
Chimeric anti-TNF monoclonal antibody
Tx of methotrexate toxicity
HintAnswerExtra
Human antibody
Flu vaccine that should not be given to children under the age of 8 except in certain circumstances
Virus that inhibits proteasomal activity and removes class I MHC molecules from the ER
Inhibits purine synthesis
Anti-CD20 chimeric monoclonal antibody
Lowers pyrimidine nucleotide levels
Anti-TNF with chimeric receptor
Virus that inhibits antigen presentation by interfering with TAP transporter
Fusion protein on macrophages upregulated in mycobacterial infection that cuases formation of giant cells
Monoclonal antibody indicated for B lymphomas
Fully human monoclonal antibody against TNF
X-linked proliferative syndrome results in EBV and lymphomas due to lack of this signaling protein
Microbe that moves from cell to cell without going extracellular
Lose depot and stranger signals/adjuvant effect in this type of vaccine
Microbe that crosses the placenta and can cause meningitis in newborns
Alkylating agent that crosslinks DNA-DNA and DNA-protein, blocking DNA replication and inducing cell death
Expresses NK inhibitor factor and blocks killing by NK cells
Inhibits mTOR and prevents T cells from making proteins for proliferation
Chimeric mAb
M protein blocks C3 binding to organism and C3b binding to complement receptors
Virus that inhibits proteasomal activity, produces IL-10, inhibits macrophage and DC activation

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