Science Quiz / Transplantation & Tumor Immunology

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HintAnswerExtra
Alloantibodies (and production of new antibodies against the graft) and host CTLs against major and minor alloantigens cause what type of graft rejection?
What type of cell is critical in pregnancy to suppress alloreactivity to the fetus?
Antibodies present in blood group B
Antibodies present in blood group A
Tx in acute humoral rejection to remove anti-donor antibodies
Humanized mAb
Prophylactic tx of hemolytic disease of newborn
Inhibitor of acute humoral rejection
Antibodies present in blood group O
Antibodies present in blood group AB
HintAnswerExtra
Endothelium expresses class II MHC and sometimes B7 and starts to behave like a lymph node in what type of graft rejection?
Human antibody
Chimeric mAb
Half-life of a kidney even with immunosuppressants
Women suffering from this immunodeficiency cannot give birth
Antibodies in the recipient that are reactive with the foreign tissue or against MHC molecules of the graft is likely to cause what type of graft rejection?
Mouse mAb
Class II MHC molecule that helps NK cells convert to NK2 phenotype (pro-angiogenic, non-cytolytic)
Mechanism in acute humoral rejection in which the system stops reacting and tissue survives
Immunosuppressive cytokine that can be secreted by tumors to promote angiogenic environment

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