Science Quiz / Immunodeficiencies & Autoimmunities

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Can you name the immunodeficiency or autoimmunity?

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Cytokine produced by basophils and Th2 cells
Deficiency in this can result in hereditary angioneurotic edema
HIV envelope glycoprotein that binds to CD4 co-receptor on class II MHC-restricted T cells
What cytokine might prime endothelial antigens to be exposed, bringing in anti-neutrophil cytoplasmic antibodies in vasculitis?
Signaling subunit that undergoes a mutation in X-linked SCID
Anti-phospholipid syndrome, or an autoimmune hypercoagulative state, is characterized by what?
Most important gene in current research for lupus
Cytokine that activates Ig class switching to non-cytolytic IgG2 and IgG4
Mutated enzyme in X-linked agammaglobulinemia
G-protein coupled receptor on T cells, B cells, and hematopoietic stem cells for SDF-1/CXCL-12; important co-receptor for HIV in late infection
Main steroidal treatment of lupus
Patients with drug-induced lupus usually test positive for what?
What antibody is very SENSITIVE for lupus?
Immunodeficiency characterized by recurrent intracellular bacterial and fungal infections
Cytokine secreted by Th1 cells and NK cells, growth factor for T cells and B cells
Patients lacking this enzyme cannot make either T cells or B cells
Important distinguishing feature of malar rash in lupus (spares what?)
Absent molecule in leukocyte adhesion deficiency
Ligand on T cells for its costimulatory receptor on B cells and dendritic cells
Biologic therapy for lupus Belimumab stops B cell activity by inhibiting what?
Defective enzyme in chronic granulomatous disease
Cleavage product of iC3b that binds CD21 on B cells to help stimulate them
Gene that permits receptor editing in peripheral tissues
What bacterial infection can recur in patients with deficiencies in late-acting complement components?
Cytokine in psoriasis that drives keratinocyte hyperplasia and secretion of IL-17
Rapid onset of wrist drop or foot drop is a nervous system manifestation characteristic of what?
T cell deficiency due to congenital malformation resulting in defective development of the thymus, PT glands, and the heart
Immunodeficiency in which phagocytosis is impaired
Major co-receptor for HIV found on T cells and macrophages, initial entry point
Deficiency in this can result in paroxysmal nocturnal hemoglobinuria
Cytokine in psoriasis that causes T cells to differentiate into Th17 and Th22 cells
Receptor for iC3b on macrophages
Rapid onset dypsnea is characteristic of what type of vasculitis?
Characteristic clinical presentation of SCID
CD4+ T cell count in which a patient infected with HIV is considered to be suffering from AIDS
Activation of this receptor co-stimulates and upregulates AID, responsible for Ig class switching and affinity maturation
DAF deficiency can result in
IPEX (immune dysregulation polyendocrinopathy enteropathy x-linked disease) is caused by loss of what?
Neutrophils release what in response to carbon black?
Deficiency of this enzyme leads to accumulation of toxic purine metabolites in cells that are actively synthesizing DNA
Most common skin manifestation of lupus
What therapy clears bullous pemphigus?
Innate receptor that may be responsible for mechanism of emphysema
Antibody associated with spontaneous abortions in lupus
Chimeric anti-CD20 monoclonal antibody indicated for lupus
Most common gene mutation in CVID
Chief cytokine for proliferation of lymphocytes, deficiency in this cytokine strongly resembles SCID
C1 INH deficiency results in
Hormone or hormone derivative that stimulates thymocytes, lymphocytes, cytokines, and VCAM/ICAM
What antibody is very SPECIFIC for lupus?
Cytokine that can induce promiscuous killing by CTLs, activate killing by NK cells, and overcome T cell anergy
Irreversible blindness can occur in what type of vasculitis?
Most common clinical presentation of XLA
Patients that are homozygous deficient in this receptor are virtually immune to HIV
Enzyme that undergoes mutation in autosomal SCID
Patients with active hepatitis B might develop what type of vasculitis?
Most common treatment for XLA
20 yo Asian female presents with weight loss, fever, one arm 10mmHg in BP less than the other, diastolic murmur in aortic area. What is the tx?
What antibody is useful for measuring disease activity of lupus?
Gene that mediates VDJ recombination of TCR and BCR
Possible infectious cause of lupus in children
Watery diarrhea & failure to thrive, dermatitis and infant-onset IDDM are typical features of what immunodeficiency?
Deficiency in this receptor results in macrophages being unable to control mycobacterial infections
Mutations in this ligand cause X-linked hyper-IgM syndrome
Immunodeficiency that often does not present until the patient is in his/her 20s or 30s
Hormone or hormone derivative that reduces apoptosis in self-reactive B cells
Substance that activates neutrophils and macrophages in emphysema
Component of receptors for IL-2, IL-4, IL-7, IL-9, and IL-15

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Created Feb 9, 2013ReportNominate

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