Science Quiz / Anti HIV agents

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Descriptionagentclass
Inhibits and induces cyp3A4; adverse reactions: CNS toxicity, Gi intolerance, skin rashNNRTI
Given to pregnant womenPI
Most potent cyp3A4 inhibitor of the protease inhibitors. Used to prolong half life of other PIsPI
binds to and inhibits gp41 of HIVFusion inhibitor
Adverse reaction: skin rash; drug interactions: inhibits cyp3A4 and cyp2C9NNRTI
Can cause severe, potentially fatal hepatotoxicityNNRTI
Avoid in patients with PKU, adverse reactions: pancreatitis, retinal changesNRTI
Contraindicated in patients with allergies to sulfanomidesPI
Adverse reaction: peripheral neuropathyNRTI
Blocks DNA strand transfer from viral to host genomeIntegrase inhibitor
Descriptionagentclass
Prevents vertical transmission, adverse reactions: myelosuppression, gi intolerance, hematologic toxicity when given with ganciclovir or ribavirinNRTI
NucleoTIDE analogueNRTI
Adverse reactions: jaundice, increased QT intervalPI
Co-administration with TMP-SMZ increases bioavailabilityNRTI
Contraindicated in children, adverse reactions: hypersensitivity of palmsNRTI
Adverse reaction: nephrolithiasis, patient must be adequately hydratedPI
Adverse reactions: GI discomfort, rhinitis. Given once dailyPI
Blocks CCR5 co-receptorEntry inhibitor
Adverse reactions: hypersensitivity, increased risk of CVDNRTI
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