Science Quiz / Anti HIV agents

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Can you name the Anti HIV drugs?

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Descriptionagentclass
Can cause severe, potentially fatal hepatotoxicityNNRTI
Adverse reactions: GI discomfort, rhinitis. Given once dailyPI
Blocks DNA strand transfer from viral to host genomeIntegrase inhibitor
Most potent cyp3A4 inhibitor of the protease inhibitors. Used to prolong half life of other PIsPI
Prevents vertical transmission, adverse reactions: myelosuppression, gi intolerance, hematologic toxicity when given with ganciclovir or ribavirinNRTI
NucleoTIDE analogueNRTI
Adverse reactions: hypersensitivity, increased risk of CVDNRTI
Contraindicated in patients with allergies to sulfanomidesPI
Adverse reaction: skin rash; drug interactions: inhibits cyp3A4 and cyp2C9NNRTI
Co-administration with TMP-SMZ increases bioavailabilityNRTI
Descriptionagentclass
Contraindicated in children, adverse reactions: hypersensitivity of palmsNRTI
Blocks CCR5 co-receptorEntry inhibitor
Avoid in patients with PKU, adverse reactions: pancreatitis, retinal changesNRTI
Inhibits and induces cyp3A4; adverse reactions: CNS toxicity, Gi intolerance, skin rashNNRTI
Given to pregnant womenPI
Adverse reaction: peripheral neuropathyNRTI
binds to and inhibits gp41 of HIVFusion inhibitor
Adverse reaction: nephrolithiasis, patient must be adequately hydratedPI
Adverse reactions: jaundice, increased QT intervalPI

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