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cns
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CNS Biochem Stats
Can you name the CNS Biochem
By
eddywcwwong
10m
40 Questions
2 Plays
2 Plays
2 Plays
Comments
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Avg Score
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Score Distribution
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Score
0/40
Timer
10:00
0
Plays Today
Hint
Answer
% Correct
Huntington's disease/
area
Caudate, Putamen
100%
Gene?
Htt
100%
Chromosome?
4
100%
What's wrong with the gene?
>36 CAG
100%
Morphological feature? /
Huntington
Striatal atrophy
100%
MS/
full name?
Multiple Sclerosis
100%
Gene?
HLA-DRB1
100%
Pathogenesis?
Autoimmune
100%
Charcot's Triad? 1?
Scanning speech
100%
2?
Incontinence, Internuclear ophthalmoplegia, Intention tremor
100%
3?
Nystagmus
100%
ALS/
Full name?
Amyotrophic lateral sclerosis
100%
Aka?
Motor neurone disease
100%
Gene?
Superoxide dismutase 1
100%
Pathogensesis
Oxidative damage
100%
Who got this disease? /
ALS
Stephen Hawking
100%
Macrophage feature?
Foam cell
100%
Parkinson's/
Area
Substantia nigra, locus caeruleus
100%
Gene? (2)
Parkin, alpha-synuclein
100%
Parkin work with another enzyme called?
E3 ubiquitin ligase
100%
Hint
Answer
% Correct
Alpha-
synuclein locus?
PARK1
100%
Alpha-
synuclein normal function?
Packing dopamine
100%
Alpha-
synuclein inclusion bodies? /
Parkinson's
Lewy Bodies
100%
Precursor to Beta-
amyloid?
APP
100%
What turns the precursor into beta-
amyloid?
beta-secretase, gamma-secretase
100%
What breaks down beta-
amyloid?
ApoE
100%
Which ApoE isoform is the weakest in breaking beta-
amyloid?
ApoE4
100%
What is the gene affecting gamma-
secretase
Presenilin 1, Presenilin 2
100%
Beta-
amyloid forms?
Amyloid plaque
100%
Postmortem staging concerning Tau fragment/
Neurofibrillary tangles extensiveness
Braak staging
100%
Amyloid plaque can cause intracranial haemorrhage by?
Amyloid angiopathy
100%
Down syndrome is related to which gene?
APP
100%
Inheritance pattern?
Autosomal dominant
100%
Immunomodulatory treatment?/
MS
Beta-interferon
100%
Humanized monoclonal antibodies treatment?
Natalizumab
100%
Treatment?
Riluzole
100%
Spinal onset percentage?
75%
100%
Bulbar onset percentage?
25%
100%
Any cognitive impairment?
No
100%
AD/
Full name?
Alzheimer's Disease
50%
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Last Updated: Feb 16, 2017
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