Science Quiz / Dermatopathology

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Can you name the Dermatopathology

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This terms refers to itchy skin caused by stimulation of C fibres extending into the epidermis.
May be stimulated directly or through insect bites or histamine from mast cells. 
If lymphocytes are the cause of pruritus, what is the likely condition?
 
What Immunoglobulin type mediates a type I hypersensitivity reaction causing degranulation of mast cells?
 
What aspect of the vasoactive amine response to histamine prompts the development of edema and wheals?
Both this and the next question form part of superficial perivascular dermatitis, a common generic reaction of the skin to injury featuring endothelial hypertrophy as well. 
What aspect of the response to histamine prompts erythema?
 
Which of the following is not involves in the regulation of normal epidermis?
a)cytokines b)growth factors c)vitamin C d)Zn and Cu e)fatty acids f)CCS, thyroid, sex and growth hormones 
This is the keratinized outermost layer of the epidermis.
 
This layer of the epidermis is composed of keratinocytes with intercellular bridges (desmosomes)
 
The stratum basale is the basement membrane, featuring these connections between cells?
 
These are the granules present in the stratum granulosum?
 
Which of the following terms is not essentially synonymous (although some are histological, others are clinical!!!)
a)scale b)acanthosis c)seborrhea d)hyperkeratosis e)parakeratosis f)dandruff 
_______ refers to an increase in the thickness of a normally differentiated stratum corneum. If there is incomplete differentiation and retention of nuclei, it is termed _____.
 
Associated with Zn, vitamin A deficiencies. 
Histologically this condition is known as epidermal hyperplasia, and colloquially as elephant skin?
Thickening of skin, exaggeration of normal superficial skin markings, often hyperpigmentation? 
This is a flat topped lesion over 1 cm in size on the surface of skin?
 
______ refers to hyperplasia of the stratum spinosum?
 
This is the term for follicles plugged with keratin, often colloquially called blackheads.
 
A neutrophilic superficial perivascular dermatitis typically is caused by this type of agent?
 
Name a cause of lymphocytic plasmacytic superifcial perivascular dermatitis?
 
Crusting skin diseases might more scientifically be referred to as _______ dermatitis?
 
Name a viral cause of vesiculopustular dermatitis?
 
A bacterial cause of a vesiculopustular disease would likely be referred to as?
Involves damage to intercellular bridges by neutrophilic enzymes. 
If damage is caused to intercellular bridges as a result of antibodies to desmoglein (humans) or desmocolin-1 (dogs) , the cause of the vesiculopustular disease is?
 
If a vesicle (formed within or just underneath the epidermis) grows to be larger than 1cm diameter, it is termed? If they fill with pus?
 
 
Which of the following is not a cause of subepidermal vesiculopustular dermatitis?
a)bullous pemphigoid b)mucous membrane phemphigoid c)epidermolysis bulosa d)IgA dermatosis e)bacterial pyoderma 
If there is nodular inflammatory reaction following a rupture of the hair follicle, this is not folliculitis, but?
 
If there is specific targetting and inflammation of the sebaceous glands, this is termed?
Common in Standard Poodles 
This is a small (under 1cm diameter) elevation of skin palpable as a solid mass.
 
This is a circumscribed solid elevation in skin greater than 1 cm diameter, extending deeper into the dermis.
Accumulations of inflammatory cells, neoplastic cells or crystalline material in dermis and subcutis. 
True or false: a tumour is always neoplastic.
 
Name a sterile cause of nodular and diffuse dermatitis?
 
Panniculitis is inflammation restricted to the ________ ___
Can be feline nutritional, or secondary to pancreatitis. 
Vesiculopustular diseases, epidermal cytotoxic diseases and vasculitis may all lead to ____ and _____ diseases.
 
This is a circumscribed non-palpable up to 1cm diameter lesion which results from alteration of skin pigmentation.
Histologically= localized hyperpigmentation 
What is another term for depigmentation, vitiligo or pigmentary incontinence.
 
Name a term for loss of pigmentation of hair?
 
Name another term for an erosion? What does an erosion become when it goes fully through epidermis?
 
 
Name a cause of epidermal cytotoxic interface dermatitis?
Often presents as depigmenting conditions (leukoderma) 
Which of the following targets more than the stratum basale?
a)cutaneous lupus erythematosus b)erythema multiforme c)discoid lupus erythematosis d)systemic lupus erythematosus e)all of the above target all skin layers 
Name a breed of dog with an associated vasculitis?
 
Which of the following would not be a strong indicator of vasculitis?
a)marginal footpad ulcers b)marginal ear lesions c)diamond skin disease of pigs d)purpura hemorrhagica e)none of the above 
What is the histological term for alopecia?
 
Name a secondary etiology of alopecia?
 
Which of hte following relates to the normal hair cycle, not a halted hair cycle?
a)catagen alopecia b)telogen alopecia c)anagen alopecia d)kenogen alopecia 
True or false: castration may result in halted hair cycle alopecias?
 
Name a diagnostic test you'd likely attempt before skin biopsy?
 
True or false: to prevent infection it is vital that you surgically prep a biopsy site?
 
What size Baker punch is best for most skin biopsies?
 
What type of biopsy should you do on a large lesion?
 
True or false: there is no fixed rule for center vs. periphery of lesion when biopsying?
 
Which of the following is not a good indication for biopsy?
a)unsuccessful clinical work up b)appears to be immune mediated c)no response to apparently appropriate therapy d)really unusual or really serious e)chronic itch 
In what age group is atopy most typical?
 
Name a structure on the skin that might commonly be confused with a neoplastic tumor?
 
True or false: most epithelial neoplasia are malignant?
 
What is a malignant tumour originating from basal cells called?
 
This papilloma virus commonly can progress from viral plaques to squamous cell carcinoma?
 
What is the name for a follicular epithelial tumour originating in the infundibulum of the follicle (superficial)?
 
Name a tumour that originates in the isthmus (middle) or deep in the follicle?
 
This is a tumour of the follicular bulb.
 
This is a combination tumour of epithelial cells and hair follicle.
 
Name the three tumours that can develop from sebaceous glands?
 
 
 
Only adenoma or carcinoma may result form this type of skin gland?
 
Name a source cell for a canine soft tissue sarcoma?
 
True or false: mesenchymal tumours generally are not metastatic?
 
At what sites do 60% of fibrosarcomas occur?
Highly infiltrative with late metastasis. 
Name a round cell tumour?
 
What is the name for a benign cutaneous melanoma? Malignant?
 
Over 3 mitotic figures per 10 high power fields. 
True or false: you may have carcinoma or epithelioma of the hepatoid glands?
 
This commonly metastatic tumour type is commonly associated with humoral hypercalcemia of malignancy, a paraneoplastic effect.
 
Which of the following subungual (nailbed) tumors would you not associate with epithelial origins?
a)keratoacanthoma b)melanoma c)osteosarcoma d)squamous cell carcinoma e)b and c 
Canine mast cell tumours are easy to diagnose, but difficult to ____
Feline mast cells are pleiomorphic in appearnace and often accompanied by eosinophils. 
These tumours normally present in young dogs, occasionally older ones. Non-haired raised lesions, full of histiocytes, often regress without treatment.
Proliferaitn of dysregulated immune cells, not malignant tumour. 
You need to biopsy this cutaneous form of lymphoma to diagnose. It usually shows up in older animals.
Usually affects paws, mucosa, skin. Made of T-lymphocytes. 
This is a tumour of mature plasma cells found in the skin, oral mucosa or rectum. Usually benign in dogs, variable in cats.
 
This tumour is transmissible, histiocytic cell origin, and affects face and genitals of dogs, primarily in S. hemisphere.
You'll see extra chromosomes, it originates from Schwann cells. 
When it appears at this site in dogs, melanoma is typically benign?
 
Cats are most often affected by melanoma at this location. (May be locally infiltrative or metastatic)
 
True or false: in horses, older greys are mainly affected by a malignant melanoma?
 
Name a slow growing, rarely metastatic soft tissue stromal cell tumour?
Can usually get adequate samples by FNA, can often tell origin by extracellular matrix, may not be able to classify beyond spindle cell neoplasm. 
A tumor's ____ is based on cytological features and mitoses.
 
True or false: epithelial tumours are usually aspirated readily and identified by cytopathology?
 
Which is not a distinctive feature of SCC?
a)keratin in the cytoplasm on cytology b)nuclear to cytoplasmic asynchrony c)anisocytosis and anisokaryosis d)all of the above are true 
If there is follicular differentiation in a basal cell tumour, it is termed?
 
Ceruminous glands at the base of feline ears can give rise to these tumor types?
 
With which domestic species would you associate malignant mammary tumours, and hyperplasia after MPA treatment?
 
A young dog presents to your clinic with a small mass on the leg. It is full on aspiration of a chalky fluid. What is this?
 
The primary content of an abscess?
 
This looks like a tumor. It is full of macrophages with hemosidern and phagocytosed RBCs, no platelets.
 
What are the few cells found amongst the high protein environment of a seroma or hygroma?
 
What is the term for edema of the epidermis (fluid between cells) which in extreme forms leads to vesicle or bulla formation?
 
This is the term for the release of melanin into the dermis due to damage to the basal layer?
 
This term refers to aporcine glands, eccrine glands, sebaceous glands and hair follicles together?
 
Which of the following is NOT a secondary lesion?
a) wheal b)epidermal collarette c)lichenification d)scar e)fissure f)erosion or ulcer 
Superficial perviascular dermatitis becomes _______ when pruritic, vitamin A or zinc deficient or ichthyosis.
 
Purpura hemorrhagica in horse legs is usually a reaction to this bacteria.
 
An intraepidermal vesiculopustular pattern is typically characteristic of this immune mediated disease, but may be mimicked by this condition?
 
 

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