Science Quiz / Systemic Lupus Erythematosus

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Can you name the Systemic Lupus Erythematosus

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HintAnswer
Inflammatory __ disease
Characterised by the presence of __ against nuclear components
It is a disease mostly of __
With a peak age of onset between __ years
There is a higher concordance rate in __ (up to 25%)
Compared to __ (3%)
Genes linked to the development of SLE include __
Also deficiencies of the complement genes __
Higher incidence in males with __
This suggests an __ hormonal effect
Drugs such as __ can cause a mild lipus-like syndrome
__ can trigger flares of SLE, especially in the skin
Exposure to __ virus has been suggested as a trigger for SLE
__ & cell fragments are cleared inefficienctly by phagocytes
This results in transfer to __
Where they are taken up by __
These self-antigens are presented to __
Which in turn stimulate __ to produce autoantibodies against the antigens
The clinical manifestations of SLE are mediated by __
And the development & deposition of __
As well as __ activation
HintAnswer
Influx of __
And abnormal __ production
Common presenting features are a __ small joint arthralgia & skin manifestations
Non-specific features such as __ can dominate the clinical picture
__ is a benign variant of the disease
In which only the __ is involved
There is characteristic __ rash
With __ plaques which progress to scarring & pigmentation
Blood count usually shows a __ anaemia
Often with __
The __ is raised
But the __ is usually normal unless the patient has a coexistent infection
__ only rise when renal disease is advenced
Early indicators of lupus nephritis include low serum __
Or high __
__ is specific for SLE & is positive in 70% of cases
Serum complement __ & __ levels are reduced in active disease
Characteristic histological & __ abnormalities
Deposition of __ are seen in biopsies from the kidney or skin
The disease is characterised by __ even in severe disease
The 10-year survival is about __, although much lower if there is major organ involvement

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