Science Quiz / Autosomal Dominant Polycystic Kidney Disease

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Can you name the Autosomal Dominant Polycystic Kidney Disease

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HintAnswer
Affects __ of the population
Cysts increase in size over time & lead to renal __
And the progressive destruction of normal __
With gradual loss of __
Most cases are due to a mutation in the __ gene
Which is the short arm of chromosome __
Which encodes for a protein __
An integral membrane protein which regulates __ development in the kidneys & other organs
A second gene, __
On chromosome __ accounts for the remaining cases
The disease presents at any age after the __ decade
There is acute __ pain
Due to cyst __ or infection
Or due to urinary tract __ formation
HintAnswer
Uric acid __ occur more commonly
There is abdo discomfort caused by __
End-stage renal failure develops in about __ of patients by 50-60 years of age
There is also __
__ cysts are usually clinically insignificant
There are rarely cysts in the __
Intracranial aneurysms are more common & can cause __
__ prolapse in 20%
Clinical examination commonly reveals __ kidneys
There is sometimes __megaly
A definitive diagnosis is established by __
Criteria for diagnosis are at least __ renal cysts in patients aged under 30
__ cysts in each kidney in patients aged 30-59
__ cysts in each kidney in patients aged over 60

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