Science Quiz / Heart Failure treatment - Cardiac Glycosides

Random Science Quiz

Can you name the Heart Failure treatment - Digoxin

Quiz not verified by Sporcle

Forced Order
Challenge
Share
Tweet
Embed
Score 0/46 Timer 20:00
HintAnswer
Example of cardiac glycosides
They possess an __ nucleus
They have an __ which conveys cardiotonic activity
They also have __, which are able to modulate potency & pharmacokinetic distribution
Although the __ actions of cardiac glycosides shift the __ ventricular function curve to a more favourable position
Thus improving the symptoms of
There is no evidence that they have a beneficial effect on the __ of patients with CCF
Cardiac glycosides act by inhibiting the membrane __ pump
This increases intracellular __ concentration
Thus reducing the __ gradient across the membrane
And decreasing the amount of __ pumped out the cell
By the __ exchanger
During __
Consequently, the intracellular __ concentration rises
Thus increasing the force of cardiac __
And maintaining normal
In addition, cardiac glycosides alter the __ of the heart, both directly & indirectly
At therapeutic doses they indirectly decrease the __
Slow __ conductance
And shorten the __
By stimulating __ activity
This is useful in __
At toxic doses they indirectly increase the __ activity of the heart
HintAnswer
And cause __
Including __
The direct effects are mainly due to loss of intracellular __
And are most pronounced at __ doses
The resting membrane potential is __
Causing enhanced __
Slowed cardiac __
And increased __ refractory period
The increased cytosolic __ concentration may reach toxic levels
Thereby saturating the __
And causingoscillations in calcium owing to __
This results in oscillatory after-potentials & subsequent __
In addition, cardiac glycosides have a direct effect on __
Causing __
And a consequent increase in __
With is further enhanced by a centrally mediated increase in __
Indications are
Contraindications include __ associated with the use of diuretics
And __
Adverse effects
The cardiac glycosides have a very __ therapeutic index
If toxicity occurs the drug should be withdrawn & if necessary __ supplements & __ drugs administered
For severe intoxication, __ specific to cardiac glycosides are available

You're not logged in!

Compare scores with friends on all Sporcle quizzes.
Sign Up with Email
OR
Log In

You Might Also Like...

Show Comments

Extras

Top Quizzes Today


Score Distribution

Your Account Isn't Verified!

In order to create a playlist on Sporcle, you need to verify the email address you used during registration. Go to your Sporcle Settings to finish the process.