Science Quiz / CSIM & CPTP - Disorders of lipid metabolism

Random Science Quiz

Can you name the Schizophrenia treatment

 Plays Quiz not verified by Sporcle

Forced Order
Score 0/41 Timer 20:00
Fats are transported in the bloodstream as __ particles
These are composed of __
These proteins exert a stabilising function & allow the particles to be recognised by receptors in the __
__ are synthesised in the small intestine postprandially
They serve to transport the digestion of dietary __ to the liver & peripheral tissues
__ are synthesised & secreted & secreted by the liver
They transport endogenously synthesised __ to the periphery
In fat & muscle, triglycerides are removed from chylomicrons & VLDLs by the tissue enzyme __ & the essential cofactor __
__ are derived from the peripheral breakdown of VLDLs
And are transported back to the liver & metabolised to yield the cholesterol rich particles - __
LDLs deliver most __ to the periphery & liver with subsequent binding to LDL receptors in these tissues
__ transport cholesterol from peripheral tissues to the liver
HDL particles carry __ of the total quantity of cholesterol in the blood
The major clinical significance of hypercholesterolaemia is as a risk factor for __
The risk is greater in those with other __ risk factors
Severe hypertriglyceridaemia is above __
And this is associated with a greatly increased risk of __
__ particles, which transport cholesterol away from the periphery, appear to protect against atheroma
Most patients with hyperlipidaemia are __
A __ is necessary to test for hypertriglyceridaemia
__ is sufficient for cholesterol
If total cholesterol is raised, __ should be measured on a fasting sample
Specific diagnosis of the defect requires the measurement of individual lipoproteins by __, but this is not usually necessary
Disorders of __ can cause hypertriglyceridaemia
__ accounts for most cases of hypertriglyceridaemia
In which there are many __ both acting together & interacting with environmental factors to produce a modest elevation in serum triglyceride levels
Familial hypertriglyceridaemia is inherited in an __ fashion
The exact defect is not known & the only clinical feature is a history of __ in some individuals
__ & __ are rare diseases which usually present in childhood with severe hypertriglyceridaemia
This is usually complicated by ___
Disorders of __ can cause hypercholesterolaemia
__ is the result of underproduction of the LDL cholesterol receptor in the liver
This results in high plasma concentrations of __
__ may be asymptomatic or develop coronary artery disease in their late 40s
Typical clinical features include __
__ have a total absenc of LDL receptors in the liver
They have grossly elevated plasma cholesterol levels (__) &, without treatment, die in their teens from coronary artery disease
Mutations in the __ gene result in a clinical picture resembling heterozygous familial hypercholesterolaemia
__ particles normally bind to their clearance receptor in the liver through apoprotein B-100, & the mutation results in high __ concentrations in the blood
__ aa=ccounts for those patients with a raised serum cholesterol concentration, but without one of the monogenic disorders above
__ & __ account for the vast majority of patients with combined hyperlipidaemia

You're not logged in!

Compare scores with friends on all Sporcle quizzes.
Log In

Sporcle TV

Today on Sporcle TV

Watch our educational content, quiz creation guides, and fun videos on Sporcle TV.

Show Comments


Created Dec 10, 2014ReportNominate
Tags:disorder, treatment

Top Quizzes Today

Score Distribution

Your Account Isn't Verified!

In order to create a playlist on Sporcle, you need to verify the email address you used during registration. Go to your Sporcle Settings to finish the process.

Report this User

Report this user for behavior that violates our Community Guidelines.