Hint | Answer |
If total cholesterol is raised, __ should be measured on a fasting sample | |
Specific diagnosis of the defect requires the measurement of individual lipoproteins by __, but this is not usually necessary | |
Disorders of __ can cause hypertriglyceridaemia | |
__ accounts for most cases of hypertriglyceridaemia | |
In which there are many __ both acting together & interacting with environmental factors to produce a modest elevation in serum triglyceride levels | |
Familial hypertriglyceridaemia is inherited in an __ fashion | |
The exact defect is not known & the only clinical feature is a history of __ in some individuals | |
__ & __ are rare diseases which usually present in childhood with severe hypertriglyceridaemia | |
This is usually complicated by ___ | |
Disorders of __ can cause hypercholesterolaemia | |
__ is the result of underproduction of the LDL cholesterol receptor in the liver | |
This results in high plasma concentrations of __ | |
__ may be asymptomatic or develop coronary artery disease in their late 40s | |
Typical clinical features include __ | |
__ have a total absenc of LDL receptors in the liver | |
They have grossly elevated plasma cholesterol levels (__) &, without treatment, die in their teens from coronary artery disease | |
Mutations in the __ gene result in a clinical picture resembling heterozygous familial hypercholesterolaemia | |
__ particles normally bind to their clearance receptor in the liver through apoprotein B-100, & the mutation results in high __ concentrations in the blood | |
__ aa=ccounts for those patients with a raised serum cholesterol concentration, but without one of the monogenic disorders above | |
__ & __ account for the vast majority of patients with combined hyperlipidaemia | |
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