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Overview of epilepsy drug mechanisms Stats
Can you name the Overview of epilepsy drug mechanisms
By
cptp
20m
23 Questions
3 Plays
3 Plays
3 Plays
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Score
0/23
Timer
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Hint
Answer
% Correct
Some drugs inhibit _
_
involved in neuronal excitability
Ionic channels
66.7%
These drugs bind preferentially to inactivated (closed) _
_
, preventing them from opening
Sodium channels
66.7%
Ethosuximide inhibits_
_
, low-
threshold, fast-
inactivating calcium
T-type
66.7%
Lamotrigine inhibits the release of _
_
as one of its actions
Glutamate
66.7%
Drugs such as phenytoin, carbamazepine & valproate inhibit the _
_
'Fast' sodium current
33.3%
The high-
frequency repetitive _
_
of neurons during a seizure increases the proportion of sodium channels in the inactivated state susceptible to blockage
Depolarisation
33.3%
Eventually, sufficient sodium channels become blocked so that the _
_
is insufficient to cause a depolarisation
'Fast' neuronal sodium current
33.3%
Note that neuronal transmission at normal frequencies is relatively unaffected because a much smaller proportion of the sodium channels are in the _
_
state
Inactivated
33.3%
Absence seizures involve oscillatory neuronal activity between the _
_
& the _
_
, which produce low-
threshold spokes, thus allowing groups of cells to fire in bursts
Thamalus, calcium channels
33.3%
It appears that the anti-
absence drug Ethosuximide reduces this _
_
, dampening the thalamocortical oscillations that are critical in the generation of such absence seizures
'Fast' inactivating calcium current
33.3%
Some drugs inhibit _
_
Excitatory transmission
33.3%
Drugs that block amino acid receptors (_
_
) have been shown to be antiepileptic in animal models
N-methyl-D-aspirate (NMDA) antagonists
33.3%
Hint
Answer
% Correct
Some drugs enhance _
_
inhibition
GABA-mediated
33.3%
This can be by enhancement by direct _
_
properties
GABA agonist
33.3%
For example by _
_
Gabapentin
33.3%
This can be by potentiation of chloride currents through the _
_
channel complex
GABAa|CL-
33.3%
For example by _
_
Benzodiazepines & barbiturates
33.3%
The increased _
_
at GABAa receptors, hyperpolarises neurons & makes them refractory to excitation
Postsynaptic inhibitory chloride current
33.3%
This can be by inhibition of _
_
degradation in the CNS
GABA
33.3%
For example by _
_
Vigabatrin
33.3%
Which is an irreversible inhibitor of _
_
GABA transaminase (GABAt)
33.3%
Which is the enzyme normally responsible for metabolism of _
_
in the neuron
GABA
33.3%
Inhibition of GABAt, therefore, leads to an increase in _
_
levels of GABA & so enhances GABA-
mediated inhibition
Synaptic
33.3%
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