Science Quiz / Antiepileptics - Phenytoin

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Can you name the Antiepileptics - Phenytoin

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HintAnswer
Mechanism: involves use-dependent block of __
Phenytoin reduces the __ of a seizure
EEG recordings show that phenytoin does not stop the __ at a focus (i.e. it doesn't prevent the ignition of an epileptic discharge
But it does stop it spreading & causing __ clinical symptoms
Phenytoin is indicated in all forms of epilepsy except __
Also can be used for __
It has many contraindications, mainly because it induces the hepatic __ system
Thus, increasing the metabolism or __
The dosage-related adverse effects affect the cerebellovascular system, leading to __
Acute toxicity causes __
HintAnswer
The non-dosage-related effects include __ effects such as gum hypertrophy & coarsening of facial features
__ reactions, e.g. rash, hepatitis & lymphadenopathy
__ effects, e.g. hirsutism
And __ effects (it may cause congenital malformations)
Phenytoin has a __ therapeutic index
And the relationship is __
This is because phenytoin is metabolised by a __ that is saturated at therapeutic levels
Small dosage increase may, therefore, produce large rises in __ with acute side-effects
It is no longer a __ treatment for any of the seizure symptoms, due to its adverse effects and narrow therapeutic window

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