Science Quiz / Plasma Glucose Regulation

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QuestionAnswer
used as a measure of insulin secretion
insulin deficiency causes a (an) _____ in plasma glucose
GI hormones that are released in response to a meal containing glucose
T/F: Basal glucose levels in a diabetic patient are equivalent to non-diabetic patient.
T/F: Proinsulin is composed of 2 subunits.
T/F: Norepinephrine and epinephrine act to inhibit insulin release.
In liver, glucose stimulates which enzyme?
Muscle and adipocytes contain GLUT4.
these cells of the pancreas make somatostatin
IRS mediates the translaocation of what glucose transporter to the cellular membrane?
T/F: Insulin's response to persistent hyperglycemia is characterized by a sharp initial increase in insulin secretion, then a fall and gradual rise in insulin (due to increase in i
T/F: Insulin is protein hormone and is synthesized from pro-insulin.
How much oral glucose is administered during a glucose tolerance test? (grams)
The B subunit of the insulin receptor acts to bind and recognize insulin.
low levels of glucose stimulates the release of _____.
these cells of the pancreas make insulin
T/F: Acute hypoglycemia cause neurological problems, coma, and death because the brain is dependent upon glucose as a source of energy.
Normal blood glucose levels are ___mg/ dl
Dr. Benting won the nobel prize for insulin in ____.
Blood glucose levels must be maintained at ___mg/ 100ml.
percentage of delta cells in the pancreas
percentage of beta cells in the pancreas
T/F: 98% of the pancreas has endocrine function.
QuestionAnswer
these cells of the pancreas make glucagon
persistent hyperglycemia causes perisistent _______.
T/F: Influx of glucose in a hepatocyte activates glucokinase which increase ATP levels, activating ATP dependent K channel. This causes a depolarization of the cell causing an incr
Major targets of insulin include liver, _____ and _____
T/F: Chronic hyperinsulinemia causes a downregulation of insulin receptors due to an imbalance of receptor internalization and recycling.
T/F: C peptide has no biological funtion.
T/F: Insulin receptor is a tyrosine kinase receptor thats acts to autophosphorylate itself.
These drugs act on the ATP dependent K channel to activate insulin secretion
acetylcholine acts to _____ insulin secretion
T/F: Hepatocytes contain GLUT4 transporters.
T/F: Glucose enters the cell via active transport.
insulin independent transporter
percentage of alpha cells in the pancreas
Currently used in the treatment of diabetes and they act by binding to their G-protein coupled receptor to increase intracellular Ca activating insulin release.
What other 2 molecules can be found in mature insulin granules besides insulin?
insulin dependent diabetes
insulin independent diabetes
production of glucose from non-carbohydrate sources
The liver degrades ___% of the insulin released.
insulin dependent transporter
T/F: An increase in sympathetic activity, increases production and synthesis of insulin.
This protein is important for the activation of glucose transport and it is phophorylated by the B subunit of the insulin receptor.

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