Science Quiz / Plasma Glucose Regulation

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QuestionAnswer
these cells of the pancreas make insulin
T/F: Hepatocytes contain GLUT4 transporters.
Dr. Benting won the nobel prize for insulin in ____.
insulin dependent transporter
These drugs act on the ATP dependent K channel to activate insulin secretion
low levels of glucose stimulates the release of _____.
In liver, glucose stimulates which enzyme?
Normal blood glucose levels are ___mg/ dl
This protein is important for the activation of glucose transport and it is phophorylated by the B subunit of the insulin receptor.
T/F: Proinsulin is composed of 2 subunits.
The B subunit of the insulin receptor acts to bind and recognize insulin.
T/F: Chronic hyperinsulinemia causes a downregulation of insulin receptors due to an imbalance of receptor internalization and recycling.
percentage of delta cells in the pancreas
T/F: Insulin's response to persistent hyperglycemia is characterized by a sharp initial increase in insulin secretion, then a fall and gradual rise in insulin (due to increase in i
T/F: Norepinephrine and epinephrine act to inhibit insulin release.
T/F: 98% of the pancreas has endocrine function.
Currently used in the treatment of diabetes and they act by binding to their G-protein coupled receptor to increase intracellular Ca activating insulin release.
T/F: Acute hypoglycemia cause neurological problems, coma, and death because the brain is dependent upon glucose as a source of energy.
used as a measure of insulin secretion
Blood glucose levels must be maintained at ___mg/ 100ml.
persistent hyperglycemia causes perisistent _______.
insulin independent diabetes
Major targets of insulin include liver, _____ and _____
QuestionAnswer
insulin independent transporter
production of glucose from non-carbohydrate sources
percentage of beta cells in the pancreas
acetylcholine acts to _____ insulin secretion
T/F: Influx of glucose in a hepatocyte activates glucokinase which increase ATP levels, activating ATP dependent K channel. This causes a depolarization of the cell causing an incr
percentage of alpha cells in the pancreas
What other 2 molecules can be found in mature insulin granules besides insulin?
T/F: Insulin is protein hormone and is synthesized from pro-insulin.
insulin deficiency causes a (an) _____ in plasma glucose
Muscle and adipocytes contain GLUT4.
T/F: An increase in sympathetic activity, increases production and synthesis of insulin.
these cells of the pancreas make somatostatin
these cells of the pancreas make glucagon
GI hormones that are released in response to a meal containing glucose
T/F: C peptide has no biological funtion.
insulin dependent diabetes
T/F: Glucose enters the cell via active transport.
The liver degrades ___% of the insulin released.
T/F: Insulin receptor is a tyrosine kinase receptor thats acts to autophosphorylate itself.
How much oral glucose is administered during a glucose tolerance test? (grams)
T/F: Basal glucose levels in a diabetic patient are equivalent to non-diabetic patient.
IRS mediates the translaocation of what glucose transporter to the cellular membrane?

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