Science Quiz / Plasma Glucose Regulation

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T/F: Insulin's response to persistent hyperglycemia is characterized by a sharp initial increase in insulin secretion, then a fall and gradual rise in insulin (due to increase in i
these cells of the pancreas make somatostatin
T/F: Influx of glucose in a hepatocyte activates glucokinase which increase ATP levels, activating ATP dependent K channel. This causes a depolarization of the cell causing an incr
insulin independent diabetes
these cells of the pancreas make glucagon
T/F: Acute hypoglycemia cause neurological problems, coma, and death because the brain is dependent upon glucose as a source of energy.
T/F: C peptide has no biological funtion.
Dr. Benting won the nobel prize for insulin in ____.
insulin dependent diabetes
acetylcholine acts to _____ insulin secretion
This protein is important for the activation of glucose transport and it is phophorylated by the B subunit of the insulin receptor.
The B subunit of the insulin receptor acts to bind and recognize insulin.
IRS mediates the translaocation of what glucose transporter to the cellular membrane?
How much oral glucose is administered during a glucose tolerance test? (grams)
T/F: An increase in sympathetic activity, increases production and synthesis of insulin.
persistent hyperglycemia causes perisistent _______.
insulin dependent transporter
What other 2 molecules can be found in mature insulin granules besides insulin?
Major targets of insulin include liver, _____ and _____
Blood glucose levels must be maintained at ___mg/ 100ml.
T/F: Hepatocytes contain GLUT4 transporters.
T/F: Proinsulin is composed of 2 subunits.
The liver degrades ___% of the insulin released.
QuestionAnswer
T/F: Glucose enters the cell via active transport.
T/F: Basal glucose levels in a diabetic patient are equivalent to non-diabetic patient.
T/F: 98% of the pancreas has endocrine function.
T/F: Insulin receptor is a tyrosine kinase receptor thats acts to autophosphorylate itself.
percentage of alpha cells in the pancreas
GI hormones that are released in response to a meal containing glucose
percentage of delta cells in the pancreas
T/F: Insulin is protein hormone and is synthesized from pro-insulin.
used as a measure of insulin secretion
production of glucose from non-carbohydrate sources
Normal blood glucose levels are ___mg/ dl
T/F: Norepinephrine and epinephrine act to inhibit insulin release.
Currently used in the treatment of diabetes and they act by binding to their G-protein coupled receptor to increase intracellular Ca activating insulin release.
T/F: Chronic hyperinsulinemia causes a downregulation of insulin receptors due to an imbalance of receptor internalization and recycling.
In liver, glucose stimulates which enzyme?
percentage of beta cells in the pancreas
These drugs act on the ATP dependent K channel to activate insulin secretion
Muscle and adipocytes contain GLUT4.
these cells of the pancreas make insulin
insulin independent transporter
insulin deficiency causes a (an) _____ in plasma glucose
low levels of glucose stimulates the release of _____.

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Created Feb 27, 2012ReportFavoriteNominate
Tags:concept, regulation

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