Science Quiz / Plasma Glucose Regulation

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QuestionAnswer
The B subunit of the insulin receptor acts to bind and recognize insulin.
What other 2 molecules can be found in mature insulin granules besides insulin?
these cells of the pancreas make glucagon
This protein is important for the activation of glucose transport and it is phophorylated by the B subunit of the insulin receptor.
percentage of alpha cells in the pancreas
IRS mediates the translaocation of what glucose transporter to the cellular membrane?
production of glucose from non-carbohydrate sources
Major targets of insulin include liver, _____ and _____
T/F: Hepatocytes contain GLUT4 transporters.
Muscle and adipocytes contain GLUT4.
Currently used in the treatment of diabetes and they act by binding to their G-protein coupled receptor to increase intracellular Ca activating insulin release.
T/F: Basal glucose levels in a diabetic patient are equivalent to non-diabetic patient.
T/F: Glucose enters the cell via active transport.
The liver degrades ___% of the insulin released.
these cells of the pancreas make insulin
Normal blood glucose levels are ___mg/ dl
T/F: 98% of the pancreas has endocrine function.
insulin independent diabetes
percentage of delta cells in the pancreas
T/F: Chronic hyperinsulinemia causes a downregulation of insulin receptors due to an imbalance of receptor internalization and recycling.
T/F: C peptide has no biological funtion.
T/F: Insulin's response to persistent hyperglycemia is characterized by a sharp initial increase in insulin secretion, then a fall and gradual rise in insulin (due to increase in i
T/F: Influx of glucose in a hepatocyte activates glucokinase which increase ATP levels, activating ATP dependent K channel. This causes a depolarization of the cell causing an incr
QuestionAnswer
T/F: Acute hypoglycemia cause neurological problems, coma, and death because the brain is dependent upon glucose as a source of energy.
acetylcholine acts to _____ insulin secretion
GI hormones that are released in response to a meal containing glucose
T/F: Insulin receptor is a tyrosine kinase receptor thats acts to autophosphorylate itself.
persistent hyperglycemia causes perisistent _______.
low levels of glucose stimulates the release of _____.
T/F: Insulin is protein hormone and is synthesized from pro-insulin.
percentage of beta cells in the pancreas
insulin dependent transporter
T/F: Proinsulin is composed of 2 subunits.
T/F: Norepinephrine and epinephrine act to inhibit insulin release.
insulin deficiency causes a (an) _____ in plasma glucose
these cells of the pancreas make somatostatin
T/F: An increase in sympathetic activity, increases production and synthesis of insulin.
These drugs act on the ATP dependent K channel to activate insulin secretion
How much oral glucose is administered during a glucose tolerance test? (grams)
used as a measure of insulin secretion
insulin dependent diabetes
In liver, glucose stimulates which enzyme?
Dr. Benting won the nobel prize for insulin in ____.
Blood glucose levels must be maintained at ___mg/ 100ml.
insulin independent transporter

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