Growth Hormone Physiology

Can you name the Growth Hormone Physiology?

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T/F: The chronic release of GH causes an increase in plasma glucose and increase in plasma insulin, leading to hyperglycemia and insulin resistance.
short stature or form of dwarfism caused by a lack of GH receptors.
fasting _____ the release of GH
Which nucleus of the hypothalamus produces Growth Hormone releasing hormone?
obesity ______ the release of GH
The GH receptor at the liver is a unique receptor coupled to the JAK/ STAT pathway which causes production of _____ and its binding protein.
T/F: Growth hormone acts to increase glucose availability for energy purposes.
T/F: When GHRH binds to its receptor intracellularly, it increases cAMP levels and causes an influx of calcium and release of secretory vesicles containing GH.
this pathological condition is caused by a deficiency of GH or IGF-1 during childhood. Patients are short (but proportional) with no mental retardation.
Main target organ for growth hormone that causes its long term effect related to growth
Where is somatostatin produced in the hypothalamus?
this condition is caused by excessive GH after adolescence. It does not increase the length of bones but does increase the growth of soft tissues.
Main role of GH on hepatocytes is to induce the formation of ___.
The GHRH _____ the release of growth hormone.
T/F: Levels of GH increase significantly during the day.
QuestionAnswer
T/F: Maximum secretion of GH during life occurs at puberty.
This receptor is a clearance receptor that removes its ligand out of circulation and into the cell to undergo lysosomal degradation?
T/F: pvGH is produced by the placenta. It binds to hGH receptor and is extremely important for the development of the fetus.
T/F: GH is a protein hormone that has 2 biologically active isoforms
this condition is caused by excessive GH before adolescence, which causes increased body size and hyperglycemia.
Insulin and IGF-1 receptors are apart of what class of receptors?
IGF-1 travels in the blood bound to which protein?
inhibits the release of GH
T/F: GH acts on proteins by increasing the amino acid intake, increasing protein synthesis, increasing transcription, and decreasing protein degradation.
True or False: IGF acts as a negative feedback regulator of GH release. and acts as a positive feedback regulator of somatostatin release.
T/F: Somatostatin can only be made in the hypothalamus.
T/F: Growth hormone acts to increase glucose uptake.
A decrease in blood sugar (hypoglycemia) would ______ the release of GH.
glucagon acts to _______ the release of GH.
Growth hormone _____ lipolysis.

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