Science Quiz / Blood Brain Barrier and CSF

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Can you name the concepts concerning Blood Brain Barrier and CSF?

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QuestionAnswer
True or False: CSF is a combination of NaCl, bicarbonate, and water.
What is the main structural component of the BBB?
blood clot in or on the brain is known as a _____.
An increase in intracranial pressure can cause an increase in Cerebral vascular resistance, which causes a ______ in cerebral blood flow.
A tissue characterized by leaky capillaries and modified ependymal cells
This Circumventricular organ regulates the anterior pituitary.
What acts as a conduit for polypeptide hypothalamic hormones?
True or False: The Lamina Terminalis has an extensive blood brain barrier.
Where is CSF produced?
If there is a hemorrhage in the brain, then the CSF will be what color?
How do metabolites (glucose), vitamins, and minerals enter the brain?
True or False: The BBB acts as a selectively permeable barrier restricting entry of some hormones and NT, microorganisms, and immunoeffector cells.
A patent ventricular system characterized by impaired absorption into the venous system is known a _______ hydrocephalus.
True or False: The Trojan Horse Method for brain delivery includes targeting energy-dependent or facilitative transport to gain access to CNS
True or False: The endothelial cells of the BBB have a high concentration of mitochondria because the mitochondria are needed to power energy dependent mechanisms that allow specif
An increase in what 2 molecules or ions leads to vasodilation in cerebral resistance vessels?
organs with no BBB... line the ventricles
True or False: The CSF is essential in the removal of harmful substances or waste from the brain
True or False: Tight junctions are found in most endothelial cells in the body.
True or False: Normal CSF has a cloudy consistency.
What percentage of the Brain is water?
What cell is thought to influence the formation of endothelial tight junctions as well as influence the proliferation of endothelial cells?
This molecule is thought to play a big role in regulating the permeability of endothelial cells of the BBB
This Circumventricular organ regulates circadian rhythm via melatonin release
QuestionAnswer
proteins that form pores for water transport required for the production of CSF
What mediates the transport of glucose into the brain?
Complete the Equation: _____=CPP/CVR
the ______ the lipid solubility (i.e. ability to pass through endothelial membranes), the greater the delivery rate into the brain.
CSF occupies what percentage of the total brain weight?
___% of the blood from the heart goes to the brain.
True or False. The Area Postrema is a CVO.
a buildup of fluid inside the skull, leading to brain swelling. Can occur early in development preventing normal cranial development
What enzyme drives the gradient needed for bicarbonate production used in CSF?
This circumventricular organ releases glycoprotein into the CSF
High synaptic activity leads to an increase in extracellular Potassium, which leads to ______ of cerebral resistance vessels.
If there is an increase in proteins or leukocytes, what color with the CSF be?
an increase in optic disc swelling that can be secondary to intracranial pressure
what type of substance typically passes the BBB?
How much CSF is produced per day?
coughing, sneezing, hematomas, ateriovenous malformations, and edema can all be causes of increased _______ ______.
What structures act as one way valves, allowing CSF to exit the ventricular system into the venous system?
What is the characteristic of endothelial cells of CVOs?
What is the turnover rate for the production of CSF?
circumventricular organ that is chemoreceptive to angiotensin II, and regulates the water balance in the body
An obstruction of CSF flow (no free passage from lateral ventricles to subarachnoid space) is known as a ________ hydrocephalus.
The removal of wastes from the brain is mediated by ______.
The BBB is permeable to substances with a molecular weight upto about ___ daltons.
Circumventricular Organ involved in the secretion of vasopressin and oxytocin

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