Science Quiz / Blood Brain Barrier and CSF

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Can you name the concepts concerning Blood Brain Barrier and CSF?

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QuestionAnswer
Circumventricular Organ involved in the secretion of vasopressin and oxytocin
True or False: Tight junctions are found in most endothelial cells in the body.
An increase in what 2 molecules or ions leads to vasodilation in cerebral resistance vessels?
If there is a hemorrhage in the brain, then the CSF will be what color?
organs with no BBB... line the ventricles
What is the main structural component of the BBB?
True or False. The Area Postrema is a CVO.
blood clot in or on the brain is known as a _____.
___% of the blood from the heart goes to the brain.
CSF occupies what percentage of the total brain weight?
what type of substance typically passes the BBB?
What is the turnover rate for the production of CSF?
This circumventricular organ releases glycoprotein into the CSF
True or False: The endothelial cells of the BBB have a high concentration of mitochondria because the mitochondria are needed to power energy dependent mechanisms that allow specif
How do metabolites (glucose), vitamins, and minerals enter the brain?
What cell is thought to influence the formation of endothelial tight junctions as well as influence the proliferation of endothelial cells?
True or False: The Trojan Horse Method for brain delivery includes targeting energy-dependent or facilitative transport to gain access to CNS
What enzyme drives the gradient needed for bicarbonate production used in CSF?
An increase in intracranial pressure can cause an increase in Cerebral vascular resistance, which causes a ______ in cerebral blood flow.
proteins that form pores for water transport required for the production of CSF
What acts as a conduit for polypeptide hypothalamic hormones?
Where is CSF produced?
What is the characteristic of endothelial cells of CVOs?
circumventricular organ that is chemoreceptive to angiotensin II, and regulates the water balance in the body
QuestionAnswer
The removal of wastes from the brain is mediated by ______.
A tissue characterized by leaky capillaries and modified ependymal cells
the ______ the lipid solubility (i.e. ability to pass through endothelial membranes), the greater the delivery rate into the brain.
A patent ventricular system characterized by impaired absorption into the venous system is known a _______ hydrocephalus.
This Circumventricular organ regulates circadian rhythm via melatonin release
What mediates the transport of glucose into the brain?
This Circumventricular organ regulates the anterior pituitary.
High synaptic activity leads to an increase in extracellular Potassium, which leads to ______ of cerebral resistance vessels.
How much CSF is produced per day?
Complete the Equation: _____=CPP/CVR
The BBB is permeable to substances with a molecular weight upto about ___ daltons.
What structures act as one way valves, allowing CSF to exit the ventricular system into the venous system?
coughing, sneezing, hematomas, ateriovenous malformations, and edema can all be causes of increased _______ ______.
True or False: Normal CSF has a cloudy consistency.
If there is an increase in proteins or leukocytes, what color with the CSF be?
True or False: The Lamina Terminalis has an extensive blood brain barrier.
What percentage of the Brain is water?
an increase in optic disc swelling that can be secondary to intracranial pressure
An obstruction of CSF flow (no free passage from lateral ventricles to subarachnoid space) is known as a ________ hydrocephalus.
a buildup of fluid inside the skull, leading to brain swelling. Can occur early in development preventing normal cranial development
This molecule is thought to play a big role in regulating the permeability of endothelial cells of the BBB
True or False: The CSF is essential in the removal of harmful substances or waste from the brain
True or False: CSF is a combination of NaCl, bicarbonate, and water.
True or False: The BBB acts as a selectively permeable barrier restricting entry of some hormones and NT, microorganisms, and immunoeffector cells.

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