Science Quiz / Pharm Drugs 2

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Can you name the Pharm Drugs 2

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Inhibits abl kinase - treatment of chronic myeloid leukemia - binds ATP binding site
Treats severe pain - causes euphoria, μ agonist
Severe pain - two OH groups of morphine acetylated - crosses bbb easily
Ether group and hydroxyl - converted to morphine by P450 in liver (CYP2D6)
Acts at nicotinic acetylcholine receptors
H1 antagonist, now used to treat depression. Lots of actions at different concs.
COX inhibitor - converted by P450 to reactive intermediate
β-adrenoceptor antagonist
Reversible antagonist of β2-adrenoceptor, covalently binds with UV irradiation
β-adrenoceptor antagonist - treatment of angina
β2-adrenoceptor agonist - treatment of asthma
α1-adrenoceptor antagonist - treatment of hypertension
H1 antagonist - treament of hayfever
H2 antagonist - treament of gastric ulcers
Specifically and irreversibly alkylates muscarinic receptor
Partial β1-adrenoceptor agonist, treatment of hypertension
partial μ-opiod agonist, treatment of heroin addiction
Powerful μ antagonist when injected, not orally active, prevents abuse by injection
Long acting μ antagonist
anti-histamine, crosses bbb, sedating and dry mouth
anti-histamine, non-sedating but cardiac arrhythmias, prodrug for fexofenadine, P450
non-sedating, no arrhythmia, anti-histamine
converted to sulfenamide, irreversibly inhibits stomach proton pump, treatment gastris ulcers
EP3 agonist, increases stomach mucus secretion - has side effects
High affinity (almost irreversible) antagonist for nicotinic receptor
2hr sulphonylurea, binds 4SUR1 subunit of KATP, causing closure, mimics glucose
8hr sulphonylurea, binds 4SUR1 subunit of KATP, causing closure, mimics glucose
10hr sulphonylurea, binds 4SUR1 subunit of KATP, causing closure, mimics glucose
36hr sulphonylurea, binds 4SUR1 subunit of KATP, causing closure, mimics glucose
opens KATP channels, treament of hperinsulinaemia
Stable analogue of GLP-1, incretin
orally active dipeptidyl peptidase (DPP-4), extends half lives of incretins
mimics effects of insulin, stimulates glucose uptake and reduces plasma lipids, activate AMP Kinase
high affinity agonist of PPARγ, stimulates adipogenesis, more uptake of fatty acids, inc. insulin sensitivity
plant diterpenoid, activates all AC except AC IX
inhibits IP to inositol conversion by IP phosphatase, treatment of bipolar disorder
Inhibits ER calcium influx pump
Cleaves synaptobrevin
Cleaves synaptobrevin, SNAP-25 and syntaxin
inhibits choline uptake mechanism
Blocks Ach transporter into vesicles
Nicotinic Ach receptor antagonist in ganglia
Nicotinic Ach receptor antagonist at NMJ
Nicotinic Ach receptor channel blocker - antihypertensive
Muscarinic agonist - parasympathomimetic, also Nic. a bit
Muscarinic agonist - parasympathomimetic
Muscarinic agonist - parasympathomimetic - lipophilic, treatment of glaucoma
Muscarinic agonist - parasympathomimetic, also Nic. a lot
Muscarinic antagonist - anaesthetic premed to dry secretion (M3), treatment of sinus bradycardia (M2)
M3 antagonist, relaxation of GI tract to facilitate endoscopy
M1 antagonist, relaxation of GI tract to facilitate endoscopy
M3 antagonist, long acting, dilation of pupil
Short-acting anticholinesterase, diagnostic purposes
Medium duration anticholinesterase
Medium duration anticholinesterase, orally active, Myasthenia Gravis
Medium duration anticholinesterase, penetrated bbb
irreversible anticholinesterase
long lasting anticholinesterase, treatment for glaucoma
inhibits tyrosine hydroxylase
inhibits DOPA decarboxylase, reduces side-effects of Parkinsons drugs
inhibits dopamine β-hydroxylase
taken up, metabolised and displaces noradrenaline from vesicles and released as false transmitter
binds tightly to the site of catecholamine recognition on storage vesicles, prevents packaging
Tricyclic antidepressant, inhibits uptake 1, accumulation noradrenaline at receptors
Inhibits uptake 1
antidepressant, inhibit seratonin uptake at presynaptic nerve terminal
COMT inhibitor, treatment of Parkinsons
inhibits MAO-A, increases catecholamine leakage
sympathomimetic, displaces NA from storage vesicles into cytosol
sympathomimetic, displaces NA from storage vesicles into cytosol
displaces NA from vesicles
β-adrenoceptor agonist, treatment of asthma
α2-adrenoceptor agonist, treatment of hypertension
α-adrenoceptor antagonist, treatment of Raynauds
β-adrenoceptor antagonist, treatment of hypertension
Peptide drug, treatment of diabetes insipidus
Peptide drug, immunosuppression
Blocks mast cell Ca channels, inhibits degranulation
3rd gen. antihistamine
H2- antagonist
antibiotic to treat Helicobacter pylori
antibiotic to treat Helicobacter pylori
kallikrein inhibitor
Non-selective COX inhibitor
Reversible COX inhibitor, non-selective
Non-selective COX inhibitor
COX-2 selective inhibitor
COX-2 selective inhibitor
5HT3 antagonist - anti-emetic
D2 antagonist, anti-emetic
Muscarinic antagonist used as anti-emetic
H1 antagonist used as anti-emetic
5HT1D agonist, control migraine
5HT1 agonist, control migraine
short-acting corticosteroid
Medium-action corticosteroid
longer-term action corticosteroid
binds TNF-α
binds TNF-α
Binds IgE
Binds CD52
Inhibits release of inflammatory mediators from mast cells
Muscarininc antagonist, treatment of asthma and COPD
Phosphodiesterase inhibitor
inhibits folic acid synthesis, arthritis
interferes with lymphocytes, arthritis
Metabolite of penicillin, treatment of arthritis
Alkylates DNA, inhibits B,T cell proliferation, immunosuppression
inhibits secretion of IL2, immunosuppressant
Ester bond local anaesthetic
Ester bond local anaesthetic
Amide bond local anaesthetic
Amide bond local anaesthetic
AMPA agonist - no desensitisation
AMPA agonist - no desensitisation
Blocks AMPA receptor desensitization
AMPA antagonist
NMDA antagonist
NMDA antagonist
NMDA antagonist - schizophrenic symptoms
Agonist for all mGluR receptors
GluR modulator
GABAB agonist
GABAB antagonist
GABAB antagonist
Glycine receptor agonist
Glycine receptor agonist
Glycine receptor agonist
Glycine receptor antagonist
GABAA receptor agonist
GABAA receptor antagonist
GABAA receptor antagonist
GABAA receptor modulator - increase affinity for GABA
GABAA receptor modulator - increase single channel open time
Valium - 1,4- Benzodiazepine
Z-drug - GABAA modulator
GABAA antagonist - for overdose
5HT1A agonist - anxoilytic
Sodium channel blocker - antiepileptic
Sodium channel blocker - antiepileptic
Sodium channel blocker - antiepileptic
Calcium channel blocker - treament of absence seizures
Calcium channel blocker - treament of absence seizures
GABA transminase inhibitor - antiepileptic
Inhibits VMAT2 - treament of depression - nor specific
Inhibits DAT - ADHD treatment
Dopamine receptor antagonist - antipsychotic
Sympathomimetic
Inhibits MAO-B in dopamine metabolism
Inhibits COMT in dopamine metabolism
Inhibits COMT in dopamine metabolism - crosses BBB
inhibits DOPA decarboxylase - prevents L-DOPA degradation
inhibits DOPA decarboxylase - prevents L-DOPA degradation
increases DOPA supply - Parkinsons
D2 receptor agonist - Parkinsons
Antiviral drug - antiviral drug, treatment of Parkinsons
Treatment of schizophrenia - D2 antagonist
Psychotic - 5-HT2A agonist
Antipsyshotic - causes loss of white blood cells
Muscarinic antagonist - Parkinsons
NMDA antagonist - treatment of Alzheimers
block aggregation of Aβ - treatment of Alzheimers
Causes more Aβ40 than 42 production - Alzheimers
NET inhibitor - antidepressant
SERT inhibitor - antidepressant
Bipolar disorder
H3 antagonist - wakefulness and memory
Inducer of CYP 1A1,1A2
Inducer od CYP 2C9, 3A4
Angina, antidote for cyanide poisoning
Immunosuppressant - inhaled
Rectal - suppresses vomiting
General anaesthetic - iv
General anaesthetic - iv
General anaesthetic - inhalation
General anaesthetic
General anaesthetic
Quarternary derivative of local anaesthetic
Toxic - binds to Na channel - binds neurotoxin receptor site 1
Toxic - binds to Na channel - binds neurotoxin receptor site 1
Intracellular Na channel binder - neurotoxin receptor site 2
Intracellular Na channel binder - neurotoxin receptor site 2
Slows the coupling of inactivation to activation of Na channel - NRS 3
A Dihydropyridine - L-type Ca channel blocker - vasodilator - slows caridac cell death
A Dihydropyridine - L-type Ca channel blocker - vasodilator
A Dihydropyridine - increases Ca channel opening
A Phenylalkylamine - L-type Ca channel blocker
A Benzothiazepine - L-type Ca channel blocker - antidysrhythmic
T-type Ca channel blocker - triggers pacemaker potentials
Class I antidysrhythmic - Na blocker - (IA - slow)
Class I antidysrhythmic - Na blocker - (IB -fast)
Class I antidysrhythmic - Na blocker - (IC - mid)
Class II antidysrhythmic - decreases sympathetic effect on heart
Class II and Class III antidysrhythmic
Class III antidysrhythmic - lengthens APD - K current inhibitor
Class IV antidysrhythmic - Ca channel blocker
KATP opener - cardiac preconditioning
Sulphonylurea - blocks KATP - inhibits preconditioning
Anti-coagulant - binds plasminogen - generates plasmin -degrades fibrin - causes thrombolysis
combo of anisoylated plasminogen and streptokinase
Plasminogen activator
Plasminogen activator - selective for plasminogen bound to fibrin
Plasminogen activator - selective for plasminogen bound to fibrin
Inhibits plasminogen activation
prevents clot formation - activates antithrombin III
Cyclic heptapeptide inhibitor of glycoprotein IIb/IIIa receptor
Monoclonal antibody against glycoprotein IIb/IIIa receptor
Inhibits platelet aggregation by inhibiting binding of ADP to its receptors
Oral anticoagulant - blocks Vit K epoxide cycle
Double pro-drug -thrombin inhibitor
Nitrovasodilator and K channel opener - angina treatment
Blocks if current - reduces pacemaker activity -angina
Immunosuppressant - used with stent treatment of angina
Hypolipidaemic agent - inhibits HMG-CoA - reduces cholestrol levels - atherosclerosis
Reduces cholestrol absorption from the gut
Reduces cholestrol absorption from the gut
a fibrate - lowers VLDL
ihibits VLDL secretion
ACE inhibitor - heart failure - also hypertension
β-blocker - heart failure
block Na pump - raises intracellular Ca - positive inotropic effect - heart failure
PDE inhibitor - treatment of heart failure
Calcium sensitiser - treatment of heart failure
endothelin antagonist - vasodilator - heart failure
Angiotensin receptor antagonist - antihypertensive
Renin inhibitor - antihypertensive
3rd generation β blocker
centrally acting antihypertensive - decrease sympathetic output
α1 adrenoceptor blocker - vasodilator - antihypertensive
KCO- inhibits ATP binding - efflux of K - vasodilation
KCO- inhibits ATP binding - efflux of K - vasodilation
metabolised to NO - vasodilator
Dilates arterioles
Loop diuretic - blocks co-transport of Na/K/Cl
Loop diuretic - blocks co-transport of Na/K/Cl
a thiazide -loop diuretic
increase secretion of uric acid - prevents gout
inhibitor of Xanthine oxidase - reduced production of uric acid
Aldosterone antagonist - potassium sparing diuretic
Epithelial Na channel blocker - Potassium sparing diuretic
Carbonic acid inhibitor - diuretic
Osmotic diuretic
Osmotic diuretic
 

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