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Science Quiz / Biomineralization

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Can you name the Steps of Biomineralization

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StepAnswerHint
Pre 1Epithelium and mesenchyme cells migrate and form what cell types?
Pre 1What forms when the ondontoblasts and ameloblasts separate?
Pre 1What cell types have Matrix Vesicles?
Pre 1Where does ACP formation start?
Pre 1Where are Matrix Vesicles made in the cell? Where do they rupture?
Pre 1What does a typical matrix vessel contain?
Pre 1What do the contents of the MV do?
Pre 1What cell type releases components using excocytotic vesicles instead of MVs?
1What happens in step 1 of biomineralization?
1AMVs break open at ECM releasing...
1BUpon release,
1CWhat binds inside? outside?
1DType I collagen controls?
1DSIBLING and Proteoglycans control?
1EWhat else helps the ACP-HAP conversion?
1EOndontoblasts that are 're-awakened' make ECM know as?
Protein typesSIBLING stands for?
Protein typesWhere are these proteins found?
Protein typesDentin Matrix Phosphoprotein 1 (DMP-1)
Protein typesDentin Matrix Phosphoprotein 1 (DMP-1)
Protein typesDentin Matrix Phosphoprotein 1 (DMP-1)
Protein typesMutations in DMP-1 lead to?
Protein typesDentin matrix phosphoprotein 2 (DMP-2)
Protein typesDentin matrix phosphoprotein 2 (DMP-2)
Protein typesDentin matrix phosphoprotein 2 (DMP-2)
Protein typesMutations in DMP-2 lead to?
StepAnswerHint
Protein typesDentin sialoprotein (DSPP) is a cleavage product of
Protein typesDentin sialoprotein (DSPP)
Protein typesDentin sialoprotein (DSPP) ALSO
Protein typesOsteopontin (OPN) is also called
Protein typesOsteopontin (OPN) regulates
Protein typesOsteopontin (OPN) plays role in
2Step 2 of biomineralization
2AWhat is secreted to the ECM
2BWhat does amelogenin self-assemble into?
2BWhat do they do?
2CIn the next step,
2Cwhere does it go?
2DAfter ACP crystalizes to HAP, what forms?
2EWhen tooth matures,
ProteinsAmelogenin is an analog of
ProteinsAmelogenin guides formation of
ProteinsAmelogenin is removed by
ProteinsAmelogenin gene
ProteinsEnamelin prevents
ProteinsEnamelin allows elongation of
ProteinsEnamelin present in mature enamel?
ProteinsEnamelin gene
ProteinsTuftelin located at
ProteinsTuftelin initiates crystal formation of _____ in enamel
ProteinsTuftelin does what to enamel rods?
ProteinsIs tuftelin removed by proteases? What is it's gene?
StepAnswerHint
ProteinsAmeloblastin defines
ProteinsAmeloblastin controls
ProteinsAmeloblastin is or is not removed by proteases?
ProteinsAmeloblastin gene?
DiseasesDefects in what genes cause dentinogenesis imperfecta?
DiseasesHow do you treat dentinogenesis imperfecta and amelogenesis imperfecta?
DiseasesAmelogenesis imperfecta caused by mutations in what genes?
DiseasesAmelogenin used in Xelma to treat
DiseasesAmelogenin used in Emdogain to
EnamelPro of enamel
EnamelPro of enamel
EnamelPro of enamel
EnamelPro of enamel
EnamelCon of enamel
EnamelCon of enamel
DentinPro of dentin
DentinPro of dentin
DentinCon of dentin
DentinCon of dentin
DentinCon of dentin
DentinCon of dentin
Bone mineralizationcontrol cell of BONE mineralization
Bone mineralizationOsteoblasts migrate
Bone mineralizationosteoblasts expand after
Bone mineralizationWhich proteins have sequence differences between osteoblasts and dentoblasts?
Bone mineralizationBone can be resorbed more readily, providing a good
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