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Biochemistry
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Biochemistry
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Biomineralization
Can you name the Steps of Biomineralization
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biochem_17
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Oct 12, 2013
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Step
Answer
Hint
Pre 1
Epithelium and mesenchyme cells migrate and form what cell types?
Pre 1
What forms when the ondontoblasts and ameloblasts separate?
Pre 1
What cell types have Matrix Vesicles?
Pre 1
Where does ACP formation start?
Pre 1
Where are Matrix Vesicles made in the cell? Where do they rupture?
Pre 1
What does a typical matrix vessel contain?
Pre 1
What do the contents of the MV do?
Pre 1
What cell type releases components using excocytotic vesicles instead of MVs?
1
What happens in step 1 of biomineralization?
1A
MVs break open at ECM releasing...
1B
Upon release,
1C
What binds inside? outside?
1D
Type I collagen controls?
1D
SIBLING and Proteoglycans control?
1E
What else helps the ACP-HAP conversion?
1E
Ondontoblasts that are 're-awakened' make ECM know as?
Protein types
SIBLING stands for?
Protein types
Where are these proteins found?
Protein types
Dentin Matrix Phosphoprotein 1 (DMP-1)
Protein types
Dentin Matrix Phosphoprotein 1 (DMP-1)
Protein types
Dentin Matrix Phosphoprotein 1 (DMP-1)
Protein types
Mutations in DMP-1 lead to?
Protein types
Dentin matrix phosphoprotein 2 (DMP-2)
Protein types
Dentin matrix phosphoprotein 2 (DMP-2)
Protein types
Dentin matrix phosphoprotein 2 (DMP-2)
Protein types
Mutations in DMP-2 lead to?
Step
Answer
Hint
Protein types
Dentin sialoprotein (DSPP) is a cleavage product of
Protein types
Dentin sialoprotein (DSPP)
Protein types
Dentin sialoprotein (DSPP) ALSO
Protein types
Osteopontin (OPN) is also called
Protein types
Osteopontin (OPN) regulates
Protein types
Osteopontin (OPN) plays role in
2
Step 2 of biomineralization
2A
What is secreted to the ECM
2B
What does amelogenin self-assemble into?
2B
What do they do?
2C
In the next step,
2C
where does it go?
2D
After ACP crystalizes to HAP, what forms?
2E
When tooth matures,
Proteins
Amelogenin is an analog of
Proteins
Amelogenin guides formation of
Proteins
Amelogenin is removed by
Proteins
Amelogenin gene
Proteins
Enamelin prevents
Proteins
Enamelin allows elongation of
Proteins
Enamelin present in mature enamel?
Proteins
Enamelin gene
Proteins
Tuftelin located at
Proteins
Tuftelin initiates crystal formation of _____ in enamel
Proteins
Tuftelin does what to enamel rods?
Proteins
Is tuftelin removed by proteases? What is it's gene?
Step
Answer
Hint
Proteins
Ameloblastin defines
Proteins
Ameloblastin controls
Proteins
Ameloblastin is or is not removed by proteases?
Proteins
Ameloblastin gene?
Diseases
Defects in what genes cause dentinogenesis imperfecta?
Diseases
How do you treat dentinogenesis imperfecta and amelogenesis imperfecta?
Diseases
Amelogenesis imperfecta caused by mutations in what genes?
Diseases
Amelogenin used in Xelma to treat
Diseases
Amelogenin used in Emdogain to
Enamel
Pro of enamel
Enamel
Pro of enamel
Enamel
Pro of enamel
Enamel
Pro of enamel
Enamel
Con of enamel
Enamel
Con of enamel
Dentin
Pro of dentin
Dentin
Pro of dentin
Dentin
Con of dentin
Dentin
Con of dentin
Dentin
Con of dentin
Dentin
Con of dentin
Bone mineralization
control cell of BONE mineralization
Bone mineralization
Osteoblasts migrate
Bone mineralization
osteoblasts expand after
Bone mineralization
Which proteins have sequence differences between osteoblasts and dentoblasts?
Bone mineralization
Bone can be resorbed more readily, providing a good
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