Science Quiz / Wilbur Lectures Block 3 Spring 2011

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Can you name the Wilbur Lectures Block 3 Spring 2011?

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Robust cell wall and long life of TB bacteria contribute to _______ infectionRisk of infection is higher in small, enclosed areas, poor ventilation, or frequent/prolonged exposure
Secondary prevention of TB is early _______ and treatment of active or latent TB
Non-opioid, local anesthetic type cough suppressant. Chemically related to ester local anesthetics such as procaine. Related to PABA. Do not use if patient is allergic to PABA. For adults only, do not use in pediatrics
There are ____ million deaths a year from TB 1/3 of the world population is infected with TB.
Infective process from inhalation of oropharyngeal contents. Serious complication for hospital patients and patients in nursing homes or bedridden.
TB lymphadenopathy. Cutaneous TB that goes to the lymph nodes. Immune system has a hard time slowing this down.
What do you look for in Hospital Acquired Pneumonia?Can occur from aspiration, inhalation, or hematogenous causes
Name a DDx for pulmonary TB.Bronchopulmonary aspergillus, Other pulmonary fungal infections
Localized necrosis leading to a walled cavity. Characterized by a gradual onset of foul smelling sputum, cough, and fever. Can be a complication of aspiration pneumonia. Treat with antibiotics, including anaerobe coverage, surgical treatment for complicated cases
Acute Bronchitis is managed with _______ care. Antibiotics are not proven to be helpful.
_____TB: another name for disseminated TB or widely extra pulmonary tubeculosis infection. Very serious with high mortality.
Typically pediatric and viral as in RSV. Occurs in airways
Current recommendation for AECB is a short course of antibiotics such as ______.Typical pathogens are Haemophilus influenza, Strep pneumoniae, Moraxella catarrhalis
A calcified complex involving a Ghon focus and an adjacent hilar lymph node.
Name a risk for TB progression from latent to active TB Other medical conditions such as silicosis, diabetes mellitus, chronic renal failure, gastrectomy, jejunoileal bypass, solid organ transplant
______ Exacerbation of Chronic Bronchitis (AECB): when there is increased sputum, dyspnea, and purulence of sputum. Common cause of mortality in patients with Chronic Bronchitis type COPD
Primary prevention of TB is limiting the _____.
The rate of TB cases in California is ____ per 100,0002472 cases in 2009. 75% were foreign born.
Chronic lung disease leading to a permanent distortion of the lung architecture, usually secondary to infection. Imaging studies may show dilated and thickened medium sized bronchi. Characterized by daily cough and thick sputum production.
Acute inflammatory reaction from inhalation of gastric contents.
Name a risk factor for Pneumonia. Comorbidities include asthma, cerebrovascular disease, COPD, chronic renal failure, CHF, diabetes, liver disease, neoplastic disease
Hint AnswerExtra Information
Name a risk factor for Hosptial Acquired Pneumonia.
______ containing cough suppressants are very commonly prescribed in treating URI associated cough and bronchitis. Two formulations are Guiafenesin (Robitussin) and Promethazine
_______ Disease: Tuberculous Spondylitis. Check several areas of spinal x-rays for tumors and infection.
Name an advantage of Interference-Gamma Release Assay (Quantiferon TB-Gold)Cons are higher cost; Inadequate data for pregnant women, immunosuppressed or HIV infected patients, pediatric patients.
Walking pneumonia. Bullous myringitis can be an indicator. Can lead to exanthems such as erythema multiforme. Slow onset. 5-20yo most common, ranges up to 40yo. Tx typically with a macrolide such as azithromycin or a tetracycline such as doxycycline.
Children less than ____yo are more likely to develop active TB after infection and disseminate TB when actively infected.
_________ TB has insidous onset: cough, phlegm, weight loss, malaise, night sweats.
A person with active TB typically infects _____ other people. Transmited by droplet nuclei. Up to 3000 organisms per cough
______ Bronchitis: typically viral and self limited. Mucus color generally not indicative of bacterial cause. Antibiotics not proven to be helpful. Manage with supportive care.
A calcified pulmonary caseating granuloma in the lung from M. tuberculosis.
______ TB can occur in 25% of pulmonary TB cases. Difficult to diagnose.
Latent TB is treated with 9 months of daily ________ plus Vitamin B6. Vitamin B6 reduces the risk of neuropathy from INH
_______ TB: symptoms vary by location, often mistaken for another illness.
A cytokine-based immunoassay measuring cell-mediated immune responses to two M. tubeculosis cell proteins not found in BCG vaccine.
Common ingredient in OTC cold and cough meds. Works in the medulla by acting on the cough center to reduce cough.NMDA agonist, also affects the serotonin reuptake pump. Can lead to serotinergic syndrome when combined with SSRI medications.
Bacterial cause of Community Acquired Pneumonia (85% of the time)15% are caused by Mycoplasma pneumoniae, Chlamydia pneumoniae, and Legionella
Name a risk factor for Aspiration Pneumonia.
Acute cough is less than __ weeks
Greater than _____mm is considered positive for TB skin testing in California. This differs from CDC guidelines which list >15mm as positive in low risk patients.
Vaccine from an attenuated M. bovis strain, somewhat effective for preventing miliary TB and TB meningitis. Currently in use in over 100 countries. Limited use in the US
Tachypnea, Low O2 saturation, inability to clear secretions, fever, dusky skin color are clinical warning signs of what?

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