Science Quiz / Russell Block 3 Spring 2011

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Can you name the Russell Block 3 Spring 2011 ?

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________ syndrome: primary ciliary dyskinesia, bronchiectasis, sinusitis, infertility. Autosomal recessive.
Detached solid, liquid, or gaseous intravascular mass. Carried by blood from the point of origin to a distant site. 99% represent a dislodged thrombus. Consequence is ischemic necrosis.
_______ Atelectasis: Bronchial obstruction by mucus plugs, foreign body, or endobronchial tumor. Mediastinum shifts toward atelectasis. Reversible.
Large vessel vasculitis causing granulomatous inflammation in patients younger than age 50.
Obstructive or Restrictive: Inflammation in alveolar walls, thickening of alveolar walls. Hyperplasia and metaplasia of alveolar epithelium.
Proliferation of smooth muscle in bronchiolar walls, alveolar septa, lymphatics, and perivascular spaces. Cyst formation leading to rupture and spontaneous pneumothorax. Looks like a honeycomb lung
Abnormal permanent enlargement of the air spaces distal to the terminal bronchioli accompanied by destruction of their walls. Etiology are smoking, air pollution, and alpha-1 antitrypsin deficiency
Obstructive or Restrictive: Inflammation in airway walls, thickening of airway walls. Hyperplasia and metaplasia of airway epithelium.
Curschmann spirals, massive eosinophilia and charcot-leyden crystals can be found in this disease.
Consolidation of the entire lobe. Caused by Streptococcus pneumoniae (95%) and Klebsiella pneumoniae.
________ emphysema: Air in the interstitial tissue stroma of the lung, mediastinum, or subcutaneous tissue. Causes alveolar tears, chest wounds that allow air to be sucked in.
Obstructive or Restrictive: Decrease of tissue mass. Irregular thin-walled spaces.
________ pneumonia is defined as interstitial pneumonia without consolidation. More common in children and young adults. Lab results are elevated cold-agglutinin titers.
Name a complication of pneumonia
Acute or Chronic Rejection: At least half of all lung transplanted patient get this by 3-5 years after transplantation. Patchy bronchiolitis obliterans.Manifested by cough, dyspnea, and an irreversible decrease in lung function tests.
Endothelial injury, hypercoagulability, and abnormal blood flow are part of Virchow's triangle and lead to _______.
Antemortem thrombus have Lines of _____ composed of RBC, platelets, and fibrin
Necrotizing inflammation typically involving renal arteries but sparing pulmonary vessels. Medium vessel vasculitis
Bronchitis or Emphysema: Mild dyspnea, early copious cough, repeated respiratory insufficiency, cor pulmonale, increased airway resistance, blue boater.
_________ emphysema: Associated with alpha-1 antitrypsin deficiency. Acini are uniformly enlarged from the level of the respiratory bronchioles to the terminal blind alveoli. Occurs most commonly in the lower zones and in the anterior margins of the lung. Usually most severe at the bases.
Atheromatous streaks in large pulmonary arteries, medial hypertrophy, and plexiform lesions are found in pulmonary ______
________ emphysema: The proximal portion of the acinus is normal, the distal part is predominantly affected. Probably underlies many cases of spontaneous pneumothorax in youth.
Classic stages of Lobar Pneumonia are Congestion, Red hepatization, Gray hepatization, and ________Macrophages mop up debris
Recurrent pulmonary thromboemboli, heart disease, vasospasm, adulterated olive oil, antiobesity drugs are part of the etiology of ______pulmonary HTN
________ emphysema: Acinus is irregularly involved. Almost invariable associated with scarring.
Common in smokers. The earliest manifestation of COPD. Airways less than 2-3mm diameter affected. Small airway disease. Infection does not play a primary role.
Most common cause of secondary pulmonary hypertension.
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_______ Atelectasis: Local or generalized fibrotic changes in the pleura or lung prevent full expansion. Irreversible.
Obstructive or Restrictive: Increase of tissue mass. Irregular thick walled spaces.
Granulomatous inflammation and necrotizing vasculitis with striking number of eosinophils affecting small vessels and perivascular tissues in upper respiratory tract, lung, heart.
Pulmonary HTN have a ________ lesion and thick intima and media.
Multiple emboli may cause pulmonary hypertension and __________ due to loss of vascular bed.
________ emphysema: Dilation of the alveoli but no destruction of septal walls in response to loss of lung substance elsewhere. Results from hyperexpansion of the residual lung.
_______ mortem clot in a pulmonary artery has separation of fibrin and cells.
Acute bacterial pneumonia presents with PMNs in alveoli, Hyperemia, and _______
Accumulation of surfactant in alveoli and bronchioli is typical in all forms of ______. Can be acquired or congenital. Secondary to hematopoietic disorders & malignancies.
Hemosiderin containing macrophages in Grey Hepatization of Lobar Pneumonia.
BMPR2 signaling is missing in _______ pulmonary HTNBMPR2 signaling causes inhibition of proliferation and favors apoptosis in vascular smooth muscle cells; when stimulus is missing, vascular smooth muscle cells proliferate
Multiple cavitary lesions, capillaritis, destroyed medium sized artery with necrotizing granulomatous inflammation.
Chronic necrotizing inflammation in bronchial wall leading to destruction of smooth muscle, elastic tissue, and cartilage resulting in cylindrical or saccular dilatation.
Arteritis with mucocutaneous lymph node syndrome. Coronary arteries can be involved with aneurysm formation and/or thrombosis. Usually occurs in children. Medium vessel vasculitis
________ emphysema: Descriptive term for large subpleural blebs or bullae. Can occur in any form of emphysema. Occurs near apex, sometimes in relation to old scars.
Acute or Chronic Rejection: Lung transplant rejection that occurs to some degree in all patients despite routine immunosuppression.Often during early weeks to months after surgery, but may occur years later whenever immunosuppression is decreased.
Coin lesion due to _____ causes Valley Fever
________ emphysema: Age related loss of lung mass (atrophy). Affects the entire lung but it is often more pronounced in the upper lobes.
Bronchitis or Emphysema: Early severe dyspnea, late scanty cough, terminal respiratory insufficiency, decreased elastic recoil, hyperinflation, small teardrop heart, pink puffer.
__________ emphysema: More than 95% of cases. The central or proximal parts of the acini, formed by respiratory bronchioles are affected, distal alveoli are spared.
The patient is diagnosed with Pulmonary arterial HTN (PAH), but the chest radiograph and CT scan raise the suggestion of pulmonary edema.
Scattered patchy consolidation centered around bronchioles. Caused by staph, strep, haemophilus influenza
Disease: increased irritability of the tracheobronchial tree with intermittent paroxysmal narrowing of the airways which may reverse spontaneously or with treatment.Genetic predisposition to type I hypersensitivity (atopy)
_______ Atelectasis: Fluid, tumor, air in pleural cavity (tension pneumothorax). Abnormal elevation of diaphragm. Mediastinum shifts away from the affected lung. Reversible.
Presenting triad of hemoptysis, anemia, and diffuse pulmonary infiltrates.
Characteristic linear pattern of immunoglobulin deposition is seen in immunofluorescence studies. >90% of patients have antibodies against the noncollagenous domain of the a3 chain of type IV collagen

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