Science Quiz / Derm Pharmacology

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Can you name the Derm Pharmacology ?

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Acne Preparation: Pregnancy Category C
Acne Medication: Not recommended during pregnancy or breast-feeding (potentially carcinogenic)
Used to treat vulvovaginal candidiasis
3rd Generation Retinoid Acid Derivatives
Acne Medication: Protein synthesis inhibitor. Active against anaerobes.
Acne Medication: Protein synthesis inhibitor (Macrolide)
A fusion protein of CD2 binding domain of LFA-3 and IgG Fc.
The drug of choice for chronic infections caused by dermatophytes (used for months)
Cell wall synthesis inhibitor. Gram (+) only
Also used for the treatment of systemic mucocutaneous fungal infections (potential liver toxicity)
May reverse back to etretinate which is more toxic & has a longer t1/2
Active to many Gram(+) bacteria. Inhibit bacterial protein synthesis. Useful for treatment of impetigo caused by Staph aureus.
Enhances transdermal elimination
MOA: Calcineurin inhibitors (Inhibit T cell activation and prevent the release of inflammatory cytokines)
A synthetic vitamin D3 derivative. MOA: Binds to Vitamin D receptor.
Name a drug that increases clearance of azoles.
Retinoic Acid Side Effects
After discontinuing therapy: Avoid pregnancy for 3 years, donating blood for 3 years, alcohol for 2 months.
Side Effects: Life-threatening liver toxicity, nausea, vomiting, gynecomastia
______ (for psoriasis) is also Category X
Also used to treat Cushing’s syndrome and prostate cancer
Side effects: Burning sensation, potential risk of malignancy on skin and lymph nodes
Acne Preparation: Pregnancy Category X
Major Side Effects: Oral - GI irritation (nausea, vomiting, diarrhea)
Used to treat athlete's foot
Inhibits mitosis in fungi
MOA: Bind to nuclear retinoic acid receptor (RAR). Mediate gene transcription.
Acne Medication: Competitive Inhibitor of PABA
Active against Gram(-) bacteria (target LPS)
MOA: Bind to CD2, blocking CD2/LFA3 interaction, leading to inhibition of T cell activation
Highly liphophilic and keratophilic
1st Generation Retinoic Acid Derivatives
Inhibit Beta 1-3 Glycan Synthesis
MOA: Acts on Toll-like receptor TLR7 (Stimulate release of IFN-alpha, TNF-α and interleukins)
More active against C. albicans infections (less effective against dermatophyte). Poor GI absorption.
MOA: Inhibit squalene epoxidase
Major Side Effects: IV - chills, fever, renal toxicity.
A fusion protein (TNFR-2 fused with IgG Fc). MOA: Binds to and inhibit TNF-alpha
_______ is photochemically stable and less irritating
A p450 inhibitor and substrate
Use: Treat atopic dermatitis (a type of eczema)
Most of the topical azole antifungal agents belong to the _______ family
Broad spectrum-IV (systemic infection) or topical use (lotion/cream/lozenges)
Lipid formulations are less toxic
Use: Treat external genital and perianal warts, keratoses, primary basal cell carcinomas
Nucleoside (guanosine) analogs. Activated by phosphorylations (Viral Thymidine Kinase and host kinases). Inhibit viral DNA polymerase and cause chain termination. Treat HSV-1, HSV-
Inhibit cytochrome P450 14 alpha-demethylase (P45014DM) involved in the biosynthesis of ergosterol
Narrow spectrum- only topical use (lozenges/ suspension/cream) for treating cutaneous or mucosal candidiasis
A p450 inducer and substrate
Protein synthesis inhibitor (aminoglycoside). Active against Gram (-) bacteria

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Created Apr 11, 2012ReportNominate

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