Science Quiz / Derm Pharmacology

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Can you name the Derm Pharmacology ?

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Broad spectrum-IV (systemic infection) or topical use (lotion/cream/lozenges)
A fusion protein (TNFR-2 fused with IgG Fc). MOA: Binds to and inhibit TNF-alpha
Most of the topical azole antifungal agents belong to the _______ family
Used to treat athlete's foot
MOA: Bind to CD2, blocking CD2/LFA3 interaction, leading to inhibition of T cell activation
Inhibits mitosis in fungi
Acne Medication: Protein synthesis inhibitor. Active against anaerobes.
Also used to treat Cushing’s syndrome and prostate cancer
MOA: Calcineurin inhibitors (Inhibit T cell activation and prevent the release of inflammatory cytokines)
______ (for psoriasis) is also Category X
Inhibit Beta 1-3 Glycan Synthesis
Side Effects: Life-threatening liver toxicity, nausea, vomiting, gynecomastia
Nucleoside (guanosine) analogs. Activated by phosphorylations (Viral Thymidine Kinase and host kinases). Inhibit viral DNA polymerase and cause chain termination. Treat HSV-1, HSV-
After discontinuing therapy: Avoid pregnancy for 3 years, donating blood for 3 years, alcohol for 2 months.
Name a drug that increases clearance of azoles.
MOA: Inhibit squalene epoxidase
3rd Generation Retinoid Acid Derivatives
Use: Treat atopic dermatitis (a type of eczema)
Acne Medication: Not recommended during pregnancy or breast-feeding (potentially carcinogenic)
Major Side Effects: IV - chills, fever, renal toxicity.
Also used for the treatment of systemic mucocutaneous fungal infections (potential liver toxicity)
Acne Medication: Protein synthesis inhibitor (Macrolide)
A fusion protein of CD2 binding domain of LFA-3 and IgG Fc.
Inhibit cytochrome P450 14 alpha-demethylase (P45014DM) involved in the biosynthesis of ergosterol
Acne Preparation: Pregnancy Category C
xxx
A p450 inducer and substrate
Major Side Effects: Oral - GI irritation (nausea, vomiting, diarrhea)
Acne Medication: Competitive Inhibitor of PABA
Enhances transdermal elimination
Protein synthesis inhibitor (aminoglycoside). Active against Gram (-) bacteria
Active to many Gram(+) bacteria. Inhibit bacterial protein synthesis. Useful for treatment of impetigo caused by Staph aureus.
_______ is photochemically stable and less irritating
MOA: Acts on Toll-like receptor TLR7 (Stimulate release of IFN-alpha, TNF-α and interleukins)
A p450 inhibitor and substrate
Narrow spectrum- only topical use (lozenges/ suspension/cream) for treating cutaneous or mucosal candidiasis
Highly liphophilic and keratophilic
Use: Treat external genital and perianal warts, keratoses, primary basal cell carcinomas
May reverse back to etretinate which is more toxic & has a longer t1/2
Used to treat vulvovaginal candidiasis
Side effects: Burning sensation, potential risk of malignancy on skin and lymph nodes
A synthetic vitamin D3 derivative. MOA: Binds to Vitamin D receptor.
1st Generation Retinoic Acid Derivatives
The drug of choice for chronic infections caused by dermatophytes (used for months)
Retinoic Acid Side Effects
Active against Gram(-) bacteria (target LPS)
Acne Preparation: Pregnancy Category X
MOA: Bind to nuclear retinoic acid receptor (RAR). Mediate gene transcription.
Cell wall synthesis inhibitor. Gram (+) only
More active against C. albicans infections (less effective against dermatophyte). Poor GI absorption.
Lipid formulations are less toxic

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Created Apr 11, 2012ReportNominate
Tags:pharmacology

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