Science Quiz / Derm Pharmacology

Random Science Quiz

Can you name the Derm Pharmacology ?

Quiz not verified by Sporcle

Forced Order
Also try: Flood Escape!
Score 0/50 Timer 10:00
Also used for the treatment of systemic mucocutaneous fungal infections (potential liver toxicity)
Inhibit cytochrome P450 14 alpha-demethylase (P45014DM) involved in the biosynthesis of ergosterol
MOA: Calcineurin inhibitors (Inhibit T cell activation and prevent the release of inflammatory cytokines)
Active against Gram(-) bacteria (target LPS)
May reverse back to etretinate which is more toxic & has a longer t1/2
MOA: Bind to CD2, blocking CD2/LFA3 interaction, leading to inhibition of T cell activation
The drug of choice for chronic infections caused by dermatophytes (used for months)
Acne Medication: Competitive Inhibitor of PABA
Protein synthesis inhibitor (aminoglycoside). Active against Gram (-) bacteria
Inhibit Beta 1-3 Glycan Synthesis
Nucleoside (guanosine) analogs. Activated by phosphorylations (Viral Thymidine Kinase and host kinases). Inhibit viral DNA polymerase and cause chain termination. Treat HSV-1, HSV-
Acne Preparation: Pregnancy Category C
Used to treat athlete's foot
______ (for psoriasis) is also Category X
Use: Treat atopic dermatitis (a type of eczema)
Name a drug that increases clearance of azoles.
Side effects: Burning sensation, potential risk of malignancy on skin and lymph nodes
MOA: Acts on Toll-like receptor TLR7 (Stimulate release of IFN-alpha, TNF-α and interleukins)
Cell wall synthesis inhibitor. Gram (+) only
Side Effects: Life-threatening liver toxicity, nausea, vomiting, gynecomastia
Acne Medication: Protein synthesis inhibitor. Active against anaerobes.
Highly liphophilic and keratophilic
Major Side Effects: IV - chills, fever, renal toxicity.
Major Side Effects: Oral - GI irritation (nausea, vomiting, diarrhea)
Inhibits mitosis in fungi
MOA: Bind to nuclear retinoic acid receptor (RAR). Mediate gene transcription.
Retinoic Acid Side Effects
Acne Preparation: Pregnancy Category X
A p450 inducer and substrate
Lipid formulations are less toxic
3rd Generation Retinoid Acid Derivatives
A fusion protein (TNFR-2 fused with IgG Fc). MOA: Binds to and inhibit TNF-alpha
1st Generation Retinoic Acid Derivatives
Use: Treat external genital and perianal warts, keratoses, primary basal cell carcinomas
After discontinuing therapy: Avoid pregnancy for 3 years, donating blood for 3 years, alcohol for 2 months.
Also used to treat Cushing’s syndrome and prostate cancer
A fusion protein of CD2 binding domain of LFA-3 and IgG Fc.
A p450 inhibitor and substrate
MOA: Inhibit squalene epoxidase
Active to many Gram(+) bacteria. Inhibit bacterial protein synthesis. Useful for treatment of impetigo caused by Staph aureus.
Most of the topical azole antifungal agents belong to the _______ family
_______ is photochemically stable and less irritating
More active against C. albicans infections (less effective against dermatophyte). Poor GI absorption.
Enhances transdermal elimination
A synthetic vitamin D3 derivative. MOA: Binds to Vitamin D receptor.
Used to treat vulvovaginal candidiasis
Acne Medication: Protein synthesis inhibitor (Macrolide)
Narrow spectrum- only topical use (lozenges/ suspension/cream) for treating cutaneous or mucosal candidiasis
Broad spectrum-IV (systemic infection) or topical use (lotion/cream/lozenges)
Acne Medication: Not recommended during pregnancy or breast-feeding (potentially carcinogenic)

You're not logged in!

Compare scores with friends on all Sporcle quizzes.
Join for Free
Log In

You Might Also Like...

Show Comments


Top Quizzes Today

Score Distribution

Your Account Isn't Verified!

In order to create a playlist on Sporcle, you need to verify the email address you used during registration. Go to your Sporcle Settings to finish the process.

Report this User

Report this user for behavior that violates our Community Guidelines.