Science Quiz / Derm Pharmacology

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Can you name the Derm Pharmacology ?

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Enhances transdermal elimination
Highly liphophilic and keratophilic
Also used to treat Cushing’s syndrome and prostate cancer
______ (for psoriasis) is also Category X
Broad spectrum-IV (systemic infection) or topical use (lotion/cream/lozenges)
Active to many Gram(+) bacteria. Inhibit bacterial protein synthesis. Useful for treatment of impetigo caused by Staph aureus.
MOA: Inhibit squalene epoxidase
A fusion protein (TNFR-2 fused with IgG Fc). MOA: Binds to and inhibit TNF-alpha
Nucleoside (guanosine) analogs. Activated by phosphorylations (Viral Thymidine Kinase and host kinases). Inhibit viral DNA polymerase and cause chain termination. Treat HSV-1, HSV-
Use: Treat atopic dermatitis (a type of eczema)
Used to treat vulvovaginal candidiasis
Inhibit cytochrome P450 14 alpha-demethylase (P45014DM) involved in the biosynthesis of ergosterol
Side Effects: Life-threatening liver toxicity, nausea, vomiting, gynecomastia
Side effects: Burning sensation, potential risk of malignancy on skin and lymph nodes
Use: Treat external genital and perianal warts, keratoses, primary basal cell carcinomas
_______ is photochemically stable and less irritating
Acne Medication: Not recommended during pregnancy or breast-feeding (potentially carcinogenic)
Acne Medication: Competitive Inhibitor of PABA
Major Side Effects: IV - chills, fever, renal toxicity.
A fusion protein of CD2 binding domain of LFA-3 and IgG Fc.
MOA: Calcineurin inhibitors (Inhibit T cell activation and prevent the release of inflammatory cytokines)
1st Generation Retinoic Acid Derivatives
Protein synthesis inhibitor (aminoglycoside). Active against Gram (-) bacteria
Narrow spectrum- only topical use (lozenges/ suspension/cream) for treating cutaneous or mucosal candidiasis
Acne Preparation: Pregnancy Category X
xxx
The drug of choice for chronic infections caused by dermatophytes (used for months)
Acne Preparation: Pregnancy Category C
More active against C. albicans infections (less effective against dermatophyte). Poor GI absorption.
Also used for the treatment of systemic mucocutaneous fungal infections (potential liver toxicity)
Used to treat athlete's foot
3rd Generation Retinoid Acid Derivatives
Active against Gram(-) bacteria (target LPS)
A p450 inducer and substrate
Name a drug that increases clearance of azoles.
MOA: Acts on Toll-like receptor TLR7 (Stimulate release of IFN-alpha, TNF-α and interleukins)
Cell wall synthesis inhibitor. Gram (+) only
Acne Medication: Protein synthesis inhibitor. Active against anaerobes.
Retinoic Acid Side Effects
May reverse back to etretinate which is more toxic & has a longer t1/2
Lipid formulations are less toxic
MOA: Bind to CD2, blocking CD2/LFA3 interaction, leading to inhibition of T cell activation
Major Side Effects: Oral - GI irritation (nausea, vomiting, diarrhea)
Acne Medication: Protein synthesis inhibitor (Macrolide)
Inhibit Beta 1-3 Glycan Synthesis
Most of the topical azole antifungal agents belong to the _______ family
A p450 inhibitor and substrate
MOA: Bind to nuclear retinoic acid receptor (RAR). Mediate gene transcription.
A synthetic vitamin D3 derivative. MOA: Binds to Vitamin D receptor.
After discontinuing therapy: Avoid pregnancy for 3 years, donating blood for 3 years, alcohol for 2 months.
Inhibits mitosis in fungi

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