Science Quiz / Derm Pharmacology

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QUIZ: Can you name the Derm Pharmacology ?

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Broad spectrum-IV (systemic infection) or topical use (lotion/cream/lozenges)
Inhibits mitosis in fungi
Acne Preparation: Pregnancy Category C
Active against Gram(-) bacteria (target LPS)
A fusion protein (TNFR-2 fused with IgG Fc). MOA: Binds to and inhibit TNF-alpha
Also used to treat Cushing’s syndrome and prostate cancer
Major Side Effects: IV - chills, fever, renal toxicity.
Use: Treat external genital and perianal warts, keratoses, primary basal cell carcinomas
Enhances transdermal elimination
Also used for the treatment of systemic mucocutaneous fungal infections (potential liver toxicity)
A synthetic vitamin D3 derivative. MOA: Binds to Vitamin D receptor.
MOA: Inhibit squalene epoxidase
Highly liphophilic and keratophilic
Used to treat athlete's foot
A p450 inducer and substrate
Major Side Effects: Oral - GI irritation (nausea, vomiting, diarrhea)
Use: Treat atopic dermatitis (a type of eczema)
Retinoic Acid Side Effects
Acne Medication: Protein synthesis inhibitor. Active against anaerobes.
MOA: Acts on Toll-like receptor TLR7 (Stimulate release of IFN-alpha, TNF-α and interleukins)
Used to treat vulvovaginal candidiasis
A p450 inhibitor and substrate
Most of the topical azole antifungal agents belong to the _______ family
Nucleoside (guanosine) analogs. Activated by phosphorylations (Viral Thymidine Kinase and host kinases). Inhibit viral DNA polymerase and cause chain termination. Treat HSV-1, HSV-
Cell wall synthesis inhibitor. Gram (+) only
xxx
Narrow spectrum- only topical use (lozenges/ suspension/cream) for treating cutaneous or mucosal candidiasis
More active against C. albicans infections (less effective against dermatophyte). Poor GI absorption.
The drug of choice for chronic infections caused by dermatophytes (used for months)
May reverse back to etretinate which is more toxic & has a longer t1/2
Protein synthesis inhibitor (aminoglycoside). Active against Gram (-) bacteria
Acne Medication: Not recommended during pregnancy or breast-feeding (potentially carcinogenic)
MOA: Calcineurin inhibitors (Inhibit T cell activation and prevent the release of inflammatory cytokines)
After discontinuing therapy: Avoid pregnancy for 3 years, donating blood for 3 years, alcohol for 2 months.
_______ is photochemically stable and less irritating
Acne Medication: Competitive Inhibitor of PABA
Acne Preparation: Pregnancy Category X
Lipid formulations are less toxic
______ (for psoriasis) is also Category X
Acne Medication: Protein synthesis inhibitor (Macrolide)
MOA: Bind to nuclear retinoic acid receptor (RAR). Mediate gene transcription.
MOA: Bind to CD2, blocking CD2/LFA3 interaction, leading to inhibition of T cell activation
3rd Generation Retinoid Acid Derivatives
Side Effects: Life-threatening liver toxicity, nausea, vomiting, gynecomastia
A fusion protein of CD2 binding domain of LFA-3 and IgG Fc.
Side effects: Burning sensation, potential risk of malignancy on skin and lymph nodes
Active to many Gram(+) bacteria. Inhibit bacterial protein synthesis. Useful for treatment of impetigo caused by Staph aureus.
Inhibit cytochrome P450 14 alpha-demethylase (P45014DM) involved in the biosynthesis of ergosterol
Inhibit Beta 1-3 Glycan Synthesis
1st Generation Retinoic Acid Derivatives
Name a drug that increases clearance of azoles.

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