Science Quiz / Derm Pharmacology

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Can you name the Derm Pharmacology ?

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A fusion protein (TNFR-2 fused with IgG Fc). MOA: Binds to and inhibit TNF-alpha
Highly liphophilic and keratophilic
A p450 inducer and substrate
Use: Treat external genital and perianal warts, keratoses, primary basal cell carcinomas
Also used for the treatment of systemic mucocutaneous fungal infections (potential liver toxicity)
Inhibit Beta 1-3 Glycan Synthesis
Acne Preparation: Pregnancy Category C
MOA: Inhibit squalene epoxidase
Inhibits mitosis in fungi
Narrow spectrum- only topical use (lozenges/ suspension/cream) for treating cutaneous or mucosal candidiasis
Cell wall synthesis inhibitor. Gram (+) only
MOA: Bind to nuclear retinoic acid receptor (RAR). Mediate gene transcription.
Acne Medication: Protein synthesis inhibitor (Macrolide)
Protein synthesis inhibitor (aminoglycoside). Active against Gram (-) bacteria
Retinoic Acid Side Effects
Broad spectrum-IV (systemic infection) or topical use (lotion/cream/lozenges)
MOA: Acts on Toll-like receptor TLR7 (Stimulate release of IFN-alpha, TNF-α and interleukins)
Lipid formulations are less toxic
Active against Gram(-) bacteria (target LPS)
Side effects: Burning sensation, potential risk of malignancy on skin and lymph nodes
Most of the topical azole antifungal agents belong to the _______ family
Major Side Effects: Oral - GI irritation (nausea, vomiting, diarrhea)
Name a drug that increases clearance of azoles.
Used to treat vulvovaginal candidiasis
Used to treat athlete's foot
xxx
The drug of choice for chronic infections caused by dermatophytes (used for months)
Inhibit cytochrome P450 14 alpha-demethylase (P45014DM) involved in the biosynthesis of ergosterol
A synthetic vitamin D3 derivative. MOA: Binds to Vitamin D receptor.
Major Side Effects: IV - chills, fever, renal toxicity.
Use: Treat atopic dermatitis (a type of eczema)
Acne Preparation: Pregnancy Category X
______ (for psoriasis) is also Category X
3rd Generation Retinoid Acid Derivatives
1st Generation Retinoic Acid Derivatives
MOA: Bind to CD2, blocking CD2/LFA3 interaction, leading to inhibition of T cell activation
Enhances transdermal elimination
Also used to treat Cushing’s syndrome and prostate cancer
Acne Medication: Not recommended during pregnancy or breast-feeding (potentially carcinogenic)
_______ is photochemically stable and less irritating
More active against C. albicans infections (less effective against dermatophyte). Poor GI absorption.
Acne Medication: Competitive Inhibitor of PABA
MOA: Calcineurin inhibitors (Inhibit T cell activation and prevent the release of inflammatory cytokines)
A fusion protein of CD2 binding domain of LFA-3 and IgG Fc.
A p450 inhibitor and substrate
Nucleoside (guanosine) analogs. Activated by phosphorylations (Viral Thymidine Kinase and host kinases). Inhibit viral DNA polymerase and cause chain termination. Treat HSV-1, HSV-
After discontinuing therapy: Avoid pregnancy for 3 years, donating blood for 3 years, alcohol for 2 months.
Acne Medication: Protein synthesis inhibitor. Active against anaerobes.
Active to many Gram(+) bacteria. Inhibit bacterial protein synthesis. Useful for treatment of impetigo caused by Staph aureus.
May reverse back to etretinate which is more toxic & has a longer t1/2
Side Effects: Life-threatening liver toxicity, nausea, vomiting, gynecomastia

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