Science Quiz / Derm Pharmacology

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Can you name the Derm Pharmacology ?

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Also used for the treatment of systemic mucocutaneous fungal infections (potential liver toxicity)
Inhibit cytochrome P450 14 alpha-demethylase (P45014DM) involved in the biosynthesis of ergosterol
MOA: Calcineurin inhibitors (Inhibit T cell activation and prevent the release of inflammatory cytokines)
Active against Gram(-) bacteria (target LPS)
May reverse back to etretinate which is more toxic & has a longer t1/2
MOA: Bind to CD2, blocking CD2/LFA3 interaction, leading to inhibition of T cell activation
The drug of choice for chronic infections caused by dermatophytes (used for months)
Acne Medication: Competitive Inhibitor of PABA
Protein synthesis inhibitor (aminoglycoside). Active against Gram (-) bacteria
Inhibit Beta 1-3 Glycan Synthesis
Nucleoside (guanosine) analogs. Activated by phosphorylations (Viral Thymidine Kinase and host kinases). Inhibit viral DNA polymerase and cause chain termination. Treat HSV-1, HSV-
Acne Preparation: Pregnancy Category C
Used to treat athlete's foot
______ (for psoriasis) is also Category X
Use: Treat atopic dermatitis (a type of eczema)
Name a drug that increases clearance of azoles.
Side effects: Burning sensation, potential risk of malignancy on skin and lymph nodes
MOA: Acts on Toll-like receptor TLR7 (Stimulate release of IFN-alpha, TNF-α and interleukins)
Cell wall synthesis inhibitor. Gram (+) only
Side Effects: Life-threatening liver toxicity, nausea, vomiting, gynecomastia
Acne Medication: Protein synthesis inhibitor. Active against anaerobes.
Highly liphophilic and keratophilic
Major Side Effects: IV - chills, fever, renal toxicity.
Major Side Effects: Oral - GI irritation (nausea, vomiting, diarrhea)
Inhibits mitosis in fungi
xxx
MOA: Bind to nuclear retinoic acid receptor (RAR). Mediate gene transcription.
Retinoic Acid Side Effects
Acne Preparation: Pregnancy Category X
A p450 inducer and substrate
Lipid formulations are less toxic
3rd Generation Retinoid Acid Derivatives
A fusion protein (TNFR-2 fused with IgG Fc). MOA: Binds to and inhibit TNF-alpha
1st Generation Retinoic Acid Derivatives
Use: Treat external genital and perianal warts, keratoses, primary basal cell carcinomas
After discontinuing therapy: Avoid pregnancy for 3 years, donating blood for 3 years, alcohol for 2 months.
Also used to treat Cushing’s syndrome and prostate cancer
A fusion protein of CD2 binding domain of LFA-3 and IgG Fc.
A p450 inhibitor and substrate
MOA: Inhibit squalene epoxidase
Active to many Gram(+) bacteria. Inhibit bacterial protein synthesis. Useful for treatment of impetigo caused by Staph aureus.
Most of the topical azole antifungal agents belong to the _______ family
_______ is photochemically stable and less irritating
More active against C. albicans infections (less effective against dermatophyte). Poor GI absorption.
Enhances transdermal elimination
A synthetic vitamin D3 derivative. MOA: Binds to Vitamin D receptor.
Used to treat vulvovaginal candidiasis
Acne Medication: Protein synthesis inhibitor (Macrolide)
Narrow spectrum- only topical use (lozenges/ suspension/cream) for treating cutaneous or mucosal candidiasis
Broad spectrum-IV (systemic infection) or topical use (lotion/cream/lozenges)
Acne Medication: Not recommended during pregnancy or breast-feeding (potentially carcinogenic)

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