Science Quiz / DMARDs

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Can you name the DMARDs?

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Endogenous ligand for CTLA4. Prevents APC from activating T cells.
Gold salt given IV/IM. Toxicity- dermatitis (15-20%), cytopenias, proteinuria, diarrhea
DMARD of first choice. Folic acid analogue. Toxicity - inhibiting all fast growing cells and hepatotoxicity
Efficacy similar to Methotrexate. Inhibits dihydroorate dehydrogenase. Stops B cell function and T cell proliferation. Toxicity- Diarrhea (25%) and elevated liver enzymes
Suppress IL-2 and TNF-alpha. Used for transplant rejection. Toxicity- hyperkalemia, hypertension, and may be teratogenic and oncogenic
TNF-alpha receptors linked to IgG1. Given SC
Monoclonal against TNF-alpha. IV weekly
Antimalarial. Toxicity- GI distress, ototoxicity, headache, myopathy, and neuropathy.
Inhibits inosinic acid synthesis and inhibits B and T cell function. Bone marrow toxicity, oncogenesis, teratogenesis, and increased infection risk.
Used for ulcerative colitis.
Monoclonal against TNF-alpha. IV monthly
Metal chelator used for Wilson's disease and copper poisoning
Binds CD20 on B cells. B cell depletion
Oral Gold Salt

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