Science Quiz / DMARDs

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Can you name the DMARDs?

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Antimalarial. Toxicity- GI distress, ototoxicity, headache, myopathy, and neuropathy.
Metal chelator used for Wilson's disease and copper poisoning
DMARD of first choice. Folic acid analogue. Toxicity - inhibiting all fast growing cells and hepatotoxicity
Efficacy similar to Methotrexate. Inhibits dihydroorate dehydrogenase. Stops B cell function and T cell proliferation. Toxicity- Diarrhea (25%) and elevated liver enzymes
TNF-alpha receptors linked to IgG1. Given SC
Oral Gold Salt
Monoclonal against TNF-alpha. IV weekly
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Binds CD20 on B cells. B cell depletion
Monoclonal against TNF-alpha. IV monthly
Gold salt given IV/IM. Toxicity- dermatitis (15-20%), cytopenias, proteinuria, diarrhea
Inhibits inosinic acid synthesis and inhibits B and T cell function. Bone marrow toxicity, oncogenesis, teratogenesis, and increased infection risk.
Used for ulcerative colitis.
Endogenous ligand for CTLA4. Prevents APC from activating T cells.
Suppress IL-2 and TNF-alpha. Used for transplant rejection. Toxicity- hyperkalemia, hypertension, and may be teratogenic and oncogenic

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