Science Quiz / Coagulation Cascade

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Almost everything you need to know about the Coagulation cascade in humans.

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activates II, forms prothrombinase complex with factor V
cleaves non-enzymatic factors
gamma-carboxy glutamate synthesis cofactor
its product lyses fibrin
inhibits IIa (and other proteases)
inactivates Va and VIIIa
a membrane protein of endothelium, activates VII
vasodilatator, inhibits platelet activation
cleaves I, but also V, X, VII, VIII, XI, XIII, protein C
activates IX
stimulates platelets and their aggregation
forms APC
essential reaction of II, VII, IX, X & protein C
cofactor of protein C
activates ATIII
co-factor of X with which it forms the prothrombinase complex
lyses fibrin (and other proteins)
activates XII and prekallikrein
co-factor of IX with which it forms the tenase complex
required for coagulation factors to bind to phospholipid
vitamine K antagonists
activates X, forms tenase complex with factor VIII
activates factor XI (also VII and prekallikrein)
cleaves X; output of the exogenous pathway
crosslinks fibrin
mediates platelet adhesion
bacterial activator of plasminogen
forms clot
inhibits plasmin

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