Science Quiz / Coagulation Cascade

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Almost everything you need to know about the Coagulation cascade in humans.

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crosslinks fibrin
inhibits IIa (and other proteases)
vitamine K antagonists
activates factor XI (also VII and prekallikrein)
cleaves non-enzymatic factors
gamma-carboxy glutamate synthesis cofactor
lyses fibrin (and other proteins)
mediates platelet adhesion
activates ATIII
activates X, forms tenase complex with factor VIII
forms APC
activates XII and prekallikrein
forms clot
cofactor of protein C
co-factor of X with which it forms the prothrombinase complex
activates II, forms prothrombinase complex with factor V
cleaves I, but also V, X, VII, VIII, XI, XIII, protein C
cleaves X; output of the exogenous pathway
stimulates platelets and their aggregation
co-factor of IX with which it forms the tenase complex
inactivates Va and VIIIa
bacterial activator of plasminogen
essential reaction of II, VII, IX, X & protein C
inhibits plasmin
a membrane protein of endothelium, activates VII
vasodilatator, inhibits platelet activation
its product lyses fibrin
required for coagulation factors to bind to phospholipid
activates IX

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