Science Quiz / Neuromuscular Block Pharm

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HintAnswer
The only antiepileptic drug with known actions on K+ channels
This drug class interferes with the structure and function of DNA by preventing resealing of open strands of DNA
Prostaglandins that produce vasodilatory effects and promote edema
Only anti-malarial drug that is effective against organisms in the liver
Most common organ that experiences injury as a side effect of pyrazinamide
If pyroxidine is not given concurrently with isoniazid there is a potential for this condition to arise
Plasmodium species that is most prevalent cause of human malaria
First successful drug type in the treatment for Alzheimer's Disease
Class of drug: ropinirole
Neurotoxin taken up by dopaminergic cells that kills them
Bacteriostatic or Bactericidal: Macrolides
This penicillinase resistant penicillin is used for prophylaxis before dental procedures and surgery
Fourth generation penicillins are most effective against what kind of bacteria: Gram Positive or Gram Negative
Drug that reduces the adverse effects of L-dopa by preventing its peripheral conversion to dopamine by peripheral dopa decarboxylase. This drug does not cross the blood-brain barri
Bacteriostatic or Bactericidal: Sulfonamides
Class of drug: Gentamicin
Resistance will occur if any TB drug is given alone: true or false
Prostaglandin that is anti-aggregatory for platelets
Class of drug: pamipexol
Drug that works by inhibiting GABA aminotransferase
Bacteriostatic or Bactericidal: Cephalosporins
This is the only available drug in the treatment of hemorrhagic fever
Used in the treatement of acute gouty arthritis
Class of drug that when mixed with alcohol can suppress breathing to the point of causing death
Class of drug: Erythromycin
Best drug for the treatment of superficial yeast infection
Class of drug: Gatifloxacin
Rapid Excretion/Slow Excretion/Poorly Absorbed: Sulfadiazine
Slow release IM form of penicillin G is especially good for the treatement of patients with this type of infection since they are unlikely to come back for a follow-up visit.
Piperacillin is particularly effective against this organism
All the antiviral nucleotide analogs are effective against this virus
Drug that works by activating glutamic acid decarboxylase
This drug (which intereferes with fungal RNA and DNA synthesis) has a synergistic effect with amphotericin. The combination is effective in treating severe systemic fungal infectio
First line drug for absence seizures. Blocks T-type calcium channels in the thalamus
Class of drug: Ciprofloxacin
Drug that is analgesic and antipyretic and can be used in kids with viral infections
Site of binding for tetracycline
Class of drug: Tolcapone
Streptogramins bind to which ribosomal subunit
Plasmodium species associated with the most serious complications and death
Rapid Excretion/Slow Excretion/Poorly Absorbed: Sulfisoxazole
Prostaglandins that sensitize cutaneous pain receptors to bradykinin and histamine
Oxacillin is penicillinase: Sensitive or Resistant
Prostaglandins that increase body temperature when in the CNS
Sensitive members are suppressed thereby removing inhibitory effects. Overgrowth and repopulation with resistant organisms may occur that, in turn lead to infection.
Class of drug: Nalidixic Acid
Alloxanthine inhibits this enzyme
Drug class that inhibits bacterial protein synthesis by binding to tthe 50s ribosomal subunit. The production of small peptides goes on normally but highly polymerized homopeptides
Stage of AD that rivastigmine is used
Mega spectrum penicillin that is very active against Pseudomonas
Drug that is inactivated by dihydropeptidase so it is given with cilastatin
Block voltage-dependent sodium channels at high firing frequencies—use dependent
Class of drugs that increase frequency of GABA-mediated chloride channel openings
Type of bacteria vancomycin is mainly active against: Gram Positive or Gram Negative
_____________ dose aspirin has anti-inflammatory effects. (Low or High)
Drug that is given with Imipenem to slow renal inactivation
Class of Drug: Nelfinavir
This NSAID is used to treat gout and manage patent ductus arteriosis
Most important side effect of ethambutol
Sulfonamide used to treat inflammatory bowel disease
Rapid Excretion/Slow Excretion/Poorly Absorbed: Sulfamethoxypyridazine
Type of bacteria bacitracin is active against: Gram Positive or Gram Negative
Class of drug: Donepezil HCl
Rapid Excretion/Slow Excretion/Poorly Absorbed: Succinylsulfathiazole
Class of drug: Galantamine
Class of drug: clonazapam
Anti-fungal drug that targets ergosterol synthesis and is teratogenic
Anti-fungal drug with 70% CNS penetration that can be used to treat meningeal crystococcus
Bacteria can upregulate this compound to overcome/become resistant to sulfonamides
Piperacillin is penicillinase: Sensitive or Resistant
Class of drug: Levofloxacin
_____________ dose aspirin has antipyretic and analgesic effects. (Low or High)
Potentially deadly adverse effect associated with sulfonamides
Type of bacteria against which spectinomycin is most active
Rapid Excretion/Slow Excretion/Poorly Absorbed: Sulfamethazine
HintAnswer
Class of drug: primidone
Class of drugs that is helpful in treating acne
Celecoxib may reduce the effectiveness of what other drug class
One of the better drug classes for sepsis/septic shock
Anti-fungal agent that is used primarily topically and is particularly effective against vaginal candidiasis
Blocks voltage-dependent sodium channels at high firing frequencies AND effects K+ channels
Rapid Excretion/Slow Excretion/Poorly Absorbed: Phthalysulfathiazole
Drug class: Aztreonam
Considered the primary drug in the treatment of tuberuculosis
Anti-rheumatic drug that can cause pancytopenia
Inhibits protein synthesis by binding to the 50S ribosome, blocking peptide formation at either A or P site.
Disease modifying anti-rheumatic drug that can decrease neutrophil chemotaxis and reduce function of macrophages and lymphocytes
Parkinson's pharmacotherapy that is a dopamine precursor that freely crosses the blood-brain barrier
IM form of penicillin G is prepared with ____________________ (two compounds) which allows it to be more slowly released and therefore remain at a steady state longer in the blood.
Class of drug: bromocriptine mesylate
Class of drug: diazepam
Class of drug: Amikacin
Enzyme that converts MPTP to MPP+
Penicillin crosses the placenta: True or False
This drug is associated with 'red neck syndrome' caused by a local release of histamine
Class of drug: Tobramycin
Which type of antiepileptic drug has fewer CNS sedative effects? (New or Classic)
Anti-fungal drug that works by inhibiting polymerization of microtubules.
Rapid Excretion/Slow Excretion/Poorly Absorbed: Sulfamerazine
Class of drug: Moxifloxacin
Class of drug: Memantine HCl
Prostaglandins that stimulate gastric mucosal secretion
Prepared combination of clavulanic acid and ticarcillin
Drug that competes with xanthine oxidase to reduce uric acid production.
Drug combination that causes increased urinary secretion of urate. Used if there have been several bouts of gout.
Class of drug: Rivastigmine
Used in gouty arthritis if colchicine cannot be tolerated
Class of drug associated with bulging fontanelle syndrome
Methicillin is penicillinase: Sensitive or Resistant
Bind to 50s rRNA and inhibits formation or peptide bond
This antiviral drug is the most effective antiviral in treating HSV infections and can also be used to treat RSV
Type of bacteria aztreonam is active against: Gram Positive or Gram Negative
Parkinson's drug that is associated with livedo reticularis
Class of Drug: Indinavir
Inhibition of bone growth caused by tetracyclines is: Reversible or Irreversible
This drug should be used against serious gram positive infections like MRSA
Bacteriostatic or Bactericidal: Vancomycin
Drug's mechanism of action is to inhibit the activity of RNA dependent RNA polymerase
Stage of AD that galantamine is used
Class of drug: Netilmicin
Severity of migraine treated by triptans
Condition associated with erythema multiforme, exfoliative dermatitis and uticaria that is a potentially deadly adverse drug reaction
Interferes with tRNA anticodon reading of mRNA codon
Type of tetracycline that is least affected by food.
Drug used for TB treatement that interferes with the folic acid pathway because it looks like p-ABA
Best drug for the treatment of systemic mycoses
Ticarcillin is penicillinase: Sensitive or Resistant
Disease modifying anti-rheumatic drug that is a folate analog
Ticarcillin is particularly effective against this organism
Type of bacteria aminoglycosides are most effective against: Gram positive or Gram negative
Ampicillin is penicillinase: Sensitive or Resistant
Mega spectrum penicillin that is active against gram negative rods, especially Klebsiella
More potent, longer lasting COMT inhibitor
Type of antibiotic that aminoglycosides are synergistic with
Sulfonamide with particular specificity for P. carinii, Shigella, Salmonella, Serratia
Bacteriostatic or Bactericidal: Isoniazid with actively dividing organisms
NSAID with the least cardiovascular effects
Drug that binds to beta lactamase and inactivates it.
This class of drug causes irreversible ototoxicity
Penicillin G is acid: Labile or Stable
Severity of migraine treated by narcotics
Class of drug: Streptomycin
Which type of antiepileptic drug has fewer CNS sedative effects? (New or Classic)
Overall effect of this drug is to increase pre- and postsynaptic GABA
Enzyme that celecoxib selectively inhibits
Rapid Excretion/Slow Excretion/Poorly Absorbed: Sulfamethoxazole
Blocks voltage-dependent sodium channels and T-type calcium channels
Triptan that has a tablet, suppository, subQ and nasal spray form
Class of drug: -triptans
Prepared combination of clavulanic acid and amoxicillin
HintAnswer
Drug that may modulate amino acid transport into brain may interfere with GABA re-uptake
This drug is widely distributed through the tissues as demonstrated by orange-red color of the urine, feces, saliva, sputum, tears and sweat but this indicate a problem.
Nafcillin is penicillinase: Sensitive or Resistant
Rapid Excretion/Slow Excretion/Poorly Absorbed: Sulfasalazine
Target of trimethoprim
This class of drug causes irreversible ototoxicity
Genus of bacteria against which spectinomycin is particularly effective.
Bacteriostatic agent that reversibly binds to the 50S subunit of the bacterial 70S ribosome resulting in supression of peptidyl transferase activity. Peptide bond formation is inhi
This drug binds to tubulin in leukocytes preventing their migration and phagocytosis
Severity of migraine treated by diclofenac
First line drug for partial seizures
Last line of defense against gram+ organisms
Class of Drug: Ritonavir
This drug is rarely used due to the potential for bone marrow damage
Class of drugs that prolong GABA-mediated chloride channel openings and do some blockade of voltage-dependent sodium channels
Severity of migraine treated by NSAIDs
Antibiotic that essentially all gram negative and aerobes are resistant against
Bacteriostatic or Bactericidal: Tetracyclines
Most effective antiviral in treating hepatitis B and hepatitis C
Bacteriostatic or Bactericidal: Isoniazid with 'resting' organisms
Quinolones are most effective against this type of bacteria (gram positive or gram negative)
Triptan with lowest rate of 24-hour relapse and highest percent of migraine-free patients after 24 hours
Class of drug: phenobarbital
Bacteriostatic or Bactericidal: Spectinomycin
Bacteriostatic or Bactericidal: Penicillins
Class of Drug: benztropine mesylate
Class of drug: Gemifloxacin
Methicillin is acid: Labile or Stable
Plasmodium species that undergoes several lifecycles in the liver and therefore requires liver and RBC drugs
Bacteriostatic or Bactericidal: Quinolones
Class of drug associated with yellow brown staining and fluorescence of teeth
Type of bacteria macrolides are most effective against: Gram Positive or Gram Negative
Class of drug: Norafloxacin
Streptogramins are effective against what type of bacteria: gram positive or gram negative
First-line drug for generalized seizures that enhances GABA transmission, blocks Na+ channels, activates K+ channels
Dopamine agonists have (more/less) side effects than L-dopa
First generation penicillins are most effective against what kind of bacteria: Gram Positive or Gram Negative
Class of Drug: Saquinavir
Changes shape of 30s rRNA and causes mRNA to be read incorrectly
Drug that is associated with gray baby syndrome because children don't have the appropriate liver enzymes to metabolize it
This compound retards the renal excretion of penecillin
Carbenicillin is particularly effective against this organism
Class of drug: Entacapone
This class of drug causes irreversible ototoxicity
Class of drugs that is very broad spectrum for fungi and works by inhibiting ergosterol synthesis while not affecting cholesterol synthesis
Drug that is synergistic with sulfonamides
Binds to 50s mRNA subunit and prevents movement along mRNA
Main type of infection that sulfonamides are used to treat today
Vancomycin has the potential to cause possibly irreversible _____toxicity
Dicloxacillin is penicillinase: Sensitive or Resistant
Drug that crystallizes in the urine if the urine isn't an alkaline pH.
Drug that inhibits recapture of dopamine
Class of drug: pergolide mesylate
This drug is only used in ointments and powders because it is too systemically toxic
Bacitracin interferes with the synthesis of _____________?
Drug that elevates GABA levels by irreversibly inhibiting its main catabolic enzyme, GABAtransaminase
Bacteriostatic or Bactericidal: Chloramphenicol
Aspirin shouldn't be given to children with a viral infection because this can develop.
Class of Drug: trihexyphenidyl
Rapid Excretion/Slow Excretion/Poorly Absorbed: Sulfadimethoxime
Generalized seizure disorder is usually treated with...
Celecoxib shouldn't be given to patients with this condition
Infliximab and etanercept target this cytokine
Potentially deadly adverse effect associated with clindamycin
Drug used in the treatment of TB that causes hemolytic anemia in patients with glucose-6-phosphate deficiency
Cloxacillin is penicillinase: Sensitive or Resistant
_____________ dose aspirin has anti-aggregatory effect on platelets. (Low or High)
Bacteriostatic or Bactericidal: Aminoglycosides
Powerful antibiotic isolated from shark tissue that has potential to be used in TB treatment
This class of antibiotics shouldn't be used during pregnancy (and shortly after), lactation and periods of growth (due to its effect on tendons)
Stage of AD that donepezil is used
Spectinomycin blocks protein synthesis by binding to this
People with a deficiency of this enzyme can get lethal hemolysis when treated with certain anti-malarial drugs
Class of drug that is very resistant to hydrolysis by beta lactamase

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