Science Quiz / Neuromuscular Block Pharm

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Piperacillin is penicillinase: Sensitive or Resistant
Bacteriostatic or Bactericidal: Tetracyclines
Class of drug: Amikacin
Class of Drug: Indinavir
More potent, longer lasting COMT inhibitor
Block voltage-dependent sodium channels at high firing frequencies—use dependent
Mega spectrum penicillin that is very active against Pseudomonas
Bacteriostatic or Bactericidal: Spectinomycin
Prepared combination of clavulanic acid and amoxicillin
Binds to 50s mRNA subunit and prevents movement along mRNA
First successful drug type in the treatment for Alzheimer's Disease
Bacteriostatic or Bactericidal: Quinolones
Rapid Excretion/Slow Excretion/Poorly Absorbed: Sulfamethazine
Class of drug: Netilmicin
Drug that competes with xanthine oxidase to reduce uric acid production.
First generation penicillins are most effective against what kind of bacteria: Gram Positive or Gram Negative
Bacitracin interferes with the synthesis of _____________?
Class of drug that is very resistant to hydrolysis by beta lactamase
Triptan that has a tablet, suppository, subQ and nasal spray form
Rapid Excretion/Slow Excretion/Poorly Absorbed: Phthalysulfathiazole
Drug used in the treatment of TB that causes hemolytic anemia in patients with glucose-6-phosphate deficiency
Blocks voltage-dependent sodium channels at high firing frequencies AND effects K+ channels
Ticarcillin is penicillinase: Sensitive or Resistant
Prostaglandins that produce vasodilatory effects and promote edema
This drug should be used against serious gram positive infections like MRSA
Rapid Excretion/Slow Excretion/Poorly Absorbed: Sulfadiazine
Class of drug: bromocriptine mesylate
This drug (which intereferes with fungal RNA and DNA synthesis) has a synergistic effect with amphotericin. The combination is effective in treating severe systemic fungal infectio
Class of Drug: Ritonavir
If pyroxidine is not given concurrently with isoniazid there is a potential for this condition to arise
First line drug for absence seizures. Blocks T-type calcium channels in the thalamus
Type of tetracycline that is least affected by food.
Class of drug: Gemifloxacin
Nafcillin is penicillinase: Sensitive or Resistant
Aspirin shouldn't be given to children with a viral infection because this can develop.
Class of drug: Gentamicin
This drug is only used in ointments and powders because it is too systemically toxic
Bacteria can upregulate this compound to overcome/become resistant to sulfonamides
Prostaglandins that stimulate gastric mucosal secretion
Type of bacteria aminoglycosides are most effective against: Gram positive or Gram negative
This NSAID is used to treat gout and manage patent ductus arteriosis
Blocks voltage-dependent sodium channels and T-type calcium channels
Class of drugs that increase frequency of GABA-mediated chloride channel openings
Class of drug: -triptans
Class of drug that when mixed with alcohol can suppress breathing to the point of causing death
Drug that works by inhibiting GABA aminotransferase
Rapid Excretion/Slow Excretion/Poorly Absorbed: Sulfadimethoxime
Celecoxib shouldn't be given to patients with this condition
Parkinson's drug that is associated with livedo reticularis
Inhibits protein synthesis by binding to the 50S ribosome, blocking peptide formation at either A or P site.
Stage of AD that donepezil is used
Type of bacteria against which spectinomycin is most active
Class of drug: Donepezil HCl
Most common organ that experiences injury as a side effect of pyrazinamide
Class of drug: Norafloxacin
Generalized seizure disorder is usually treated with...
Streptogramins are effective against what type of bacteria: gram positive or gram negative
Anti-fungal agent that is used primarily topically and is particularly effective against vaginal candidiasis
Dicloxacillin is penicillinase: Sensitive or Resistant
Infliximab and etanercept target this cytokine
_____________ dose aspirin has antipyretic and analgesic effects. (Low or High)
Class of drug: Entacapone
Methicillin is acid: Labile or Stable
Class of drug: Erythromycin
Condition associated with erythema multiforme, exfoliative dermatitis and uticaria that is a potentially deadly adverse drug reaction
Site of binding for tetracycline
Resistance will occur if any TB drug is given alone: true or false
Stage of AD that galantamine is used
Piperacillin is particularly effective against this organism
Class of drug associated with yellow brown staining and fluorescence of teeth
Mega spectrum penicillin that is active against gram negative rods, especially Klebsiella
Enzyme that converts MPTP to MPP+
Rapid Excretion/Slow Excretion/Poorly Absorbed: Sulfamerazine
Drug that may modulate amino acid transport into brain may interfere with GABA re-uptake
Most effective antiviral in treating hepatitis B and hepatitis C
HintAnswer
This drug class interferes with the structure and function of DNA by preventing resealing of open strands of DNA
Class of Drug: Nelfinavir
Class of drug: Memantine HCl
Interferes with tRNA anticodon reading of mRNA codon
Drug that is given with Imipenem to slow renal inactivation
Class of drug: diazepam
Drug that is synergistic with sulfonamides
Dopamine agonists have (more/less) side effects than L-dopa
Type of bacteria aztreonam is active against: Gram Positive or Gram Negative
Potentially deadly adverse effect associated with clindamycin
Class of drug: Tolcapone
Enzyme that celecoxib selectively inhibits
Anti-fungal drug that works by inhibiting polymerization of microtubules.
Class of drug: pergolide mesylate
Bacteriostatic agent that reversibly binds to the 50S subunit of the bacterial 70S ribosome resulting in supression of peptidyl transferase activity. Peptide bond formation is inhi
Fourth generation penicillins are most effective against what kind of bacteria: Gram Positive or Gram Negative
Drug combination that causes increased urinary secretion of urate. Used if there have been several bouts of gout.
Most important side effect of ethambutol
Type of bacteria bacitracin is active against: Gram Positive or Gram Negative
Rapid Excretion/Slow Excretion/Poorly Absorbed: Sulfamethoxypyridazine
Severity of migraine treated by NSAIDs
Prostaglandin that is anti-aggregatory for platelets
Considered the primary drug in the treatment of tuberuculosis
Class of drug: Streptomycin
_____________ dose aspirin has anti-aggregatory effect on platelets. (Low or High)
Ticarcillin is particularly effective against this organism
Bacteriostatic or Bactericidal: Aminoglycosides
Main type of infection that sulfonamides are used to treat today
Antibiotic that essentially all gram negative and aerobes are resistant against
This drug is rarely used due to the potential for bone marrow damage
Quinolones are most effective against this type of bacteria (gram positive or gram negative)
Drug used for TB treatement that interferes with the folic acid pathway because it looks like p-ABA
Plasmodium species associated with the most serious complications and death
Class of Drug: Saquinavir
Drug that binds to beta lactamase and inactivates it.
_____________ dose aspirin has anti-inflammatory effects. (Low or High)
Disease modifying anti-rheumatic drug that is a folate analog
Drug that is analgesic and antipyretic and can be used in kids with viral infections
Potentially deadly adverse effect associated with sulfonamides
Drug that crystallizes in the urine if the urine isn't an alkaline pH.
This drug binds to tubulin in leukocytes preventing their migration and phagocytosis
This is the only available drug in the treatment of hemorrhagic fever
Class of drug: Galantamine
Class of drug: Tobramycin
Class of drug associated with bulging fontanelle syndrome
Class of drug: Moxifloxacin
Used in gouty arthritis if colchicine cannot be tolerated
Ampicillin is penicillinase: Sensitive or Resistant
Oxacillin is penicillinase: Sensitive or Resistant
Changes shape of 30s rRNA and causes mRNA to be read incorrectly
Drug that elevates GABA levels by irreversibly inhibiting its main catabolic enzyme, GABAtransaminase
Drug that is associated with gray baby syndrome because children don't have the appropriate liver enzymes to metabolize it
Anti-fungal drug that targets ergosterol synthesis and is teratogenic
Class of drug: Levofloxacin
Genus of bacteria against which spectinomycin is particularly effective.
Alloxanthine inhibits this enzyme
Vancomycin has the potential to cause possibly irreversible _____toxicity
Used in the treatement of acute gouty arthritis
Bacteriostatic or Bactericidal: Isoniazid with 'resting' organisms
Rapid Excretion/Slow Excretion/Poorly Absorbed: Sulfasalazine
Carbenicillin is particularly effective against this organism
This penicillinase resistant penicillin is used for prophylaxis before dental procedures and surgery
Class of drug: phenobarbital
Prepared combination of clavulanic acid and ticarcillin
Rapid Excretion/Slow Excretion/Poorly Absorbed: Sulfisoxazole
Severity of migraine treated by diclofenac
Powerful antibiotic isolated from shark tissue that has potential to be used in TB treatment
This class of antibiotics shouldn't be used during pregnancy (and shortly after), lactation and periods of growth (due to its effect on tendons)
Triptan with lowest rate of 24-hour relapse and highest percent of migraine-free patients after 24 hours
Streptogramins bind to which ribosomal subunit
The only antiepileptic drug with known actions on K+ channels
Best drug for the treatment of superficial yeast infection
Bacteriostatic or Bactericidal: Sulfonamides
This compound retards the renal excretion of penecillin
This drug is associated with 'red neck syndrome' caused by a local release of histamine
HintAnswer
Neurotoxin taken up by dopaminergic cells that kills them
Penicillin G is acid: Labile or Stable
Plasmodium species that is most prevalent cause of human malaria
Rapid Excretion/Slow Excretion/Poorly Absorbed: Sulfamethoxazole
Overall effect of this drug is to increase pre- and postsynaptic GABA
Prostaglandins that sensitize cutaneous pain receptors to bradykinin and histamine
Class of drug: Rivastigmine
Drug class: Aztreonam
This antiviral drug is the most effective antiviral in treating HSV infections and can also be used to treat RSV
Class of drugs that prolong GABA-mediated chloride channel openings and do some blockade of voltage-dependent sodium channels
Disease modifying anti-rheumatic drug that can decrease neutrophil chemotaxis and reduce function of macrophages and lymphocytes
Spectinomycin blocks protein synthesis by binding to this
Bacteriostatic or Bactericidal: Macrolides
Class of drug: Ciprofloxacin
Last line of defense against gram+ organisms
This class of drug causes irreversible ototoxicity
Class of drugs that is helpful in treating acne
First-line drug for generalized seizures that enhances GABA transmission, blocks Na+ channels, activates K+ channels
Bacteriostatic or Bactericidal: Isoniazid with actively dividing organisms
This class of drug causes irreversible ototoxicity
Slow release IM form of penicillin G is especially good for the treatement of patients with this type of infection since they are unlikely to come back for a follow-up visit.
Sensitive members are suppressed thereby removing inhibitory effects. Overgrowth and repopulation with resistant organisms may occur that, in turn lead to infection.
This drug is widely distributed through the tissues as demonstrated by orange-red color of the urine, feces, saliva, sputum, tears and sweat but this indicate a problem.
Severity of migraine treated by narcotics
Drug that works by activating glutamic acid decarboxylase
Class of drug: Nalidixic Acid
IM form of penicillin G is prepared with ____________________ (two compounds) which allows it to be more slowly released and therefore remain at a steady state longer in the blood.
Drug class that inhibits bacterial protein synthesis by binding to tthe 50s ribosomal subunit. The production of small peptides goes on normally but highly polymerized homopeptides
Which type of antiepileptic drug has fewer CNS sedative effects? (New or Classic)
Drug that inhibits recapture of dopamine
Bacteriostatic or Bactericidal: Penicillins
Bacteriostatic or Bactericidal: Chloramphenicol
NSAID with the least cardiovascular effects
Class of drug: ropinirole
Anti-rheumatic drug that can cause pancytopenia
Drug that reduces the adverse effects of L-dopa by preventing its peripheral conversion to dopamine by peripheral dopa decarboxylase. This drug does not cross the blood-brain barri
Plasmodium species that undergoes several lifecycles in the liver and therefore requires liver and RBC drugs
Severity of migraine treated by triptans
Drug that is inactivated by dihydropeptidase so it is given with cilastatin
Parkinson's pharmacotherapy that is a dopamine precursor that freely crosses the blood-brain barrier
Cloxacillin is penicillinase: Sensitive or Resistant
People with a deficiency of this enzyme can get lethal hemolysis when treated with certain anti-malarial drugs
Inhibition of bone growth caused by tetracyclines is: Reversible or Irreversible
Only anti-malarial drug that is effective against organisms in the liver
Class of drug: primidone
Type of bacteria vancomycin is mainly active against: Gram Positive or Gram Negative
Bind to 50s rRNA and inhibits formation or peptide bond
Bacteriostatic or Bactericidal: Vancomycin
Class of Drug: trihexyphenidyl
Stage of AD that rivastigmine is used
Class of drug: pamipexol
First line drug for partial seizures
Drug's mechanism of action is to inhibit the activity of RNA dependent RNA polymerase
Best drug for the treatment of systemic mycoses
Rapid Excretion/Slow Excretion/Poorly Absorbed: Succinylsulfathiazole
Which type of antiepileptic drug has fewer CNS sedative effects? (New or Classic)
Class of drug: Gatifloxacin
Class of drug: clonazapam
Penicillin crosses the placenta: True or False
Anti-fungal drug with 70% CNS penetration that can be used to treat meningeal crystococcus
Class of Drug: benztropine mesylate
One of the better drug classes for sepsis/septic shock
Celecoxib may reduce the effectiveness of what other drug class
Methicillin is penicillinase: Sensitive or Resistant
Type of bacteria macrolides are most effective against: Gram Positive or Gram Negative
Class of drugs that is very broad spectrum for fungi and works by inhibiting ergosterol synthesis while not affecting cholesterol synthesis
Type of antibiotic that aminoglycosides are synergistic with
All the antiviral nucleotide analogs are effective against this virus
Sulfonamide used to treat inflammatory bowel disease
This class of drug causes irreversible ototoxicity
Sulfonamide with particular specificity for P. carinii, Shigella, Salmonella, Serratia
Prostaglandins that increase body temperature when in the CNS
Target of trimethoprim
Bacteriostatic or Bactericidal: Cephalosporins

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