Science Quiz / Endocrine Pharmacology

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HintAnswer
This drug class blocks potassium channels and depolarized calcium channels in the beta cell which stimulates insulin release
Exogenous androgens would (increase/decrease) levothyroxine needs
Iodine induced hyperthyroidism
This can be heard when auscultating the thyroid and is pathognomonic for Graves disease
Exogenous estrogen therapy would (increase/decrease) levothyroxine needs
Most active form of vitamin D
This class of secretagogue causes release of insulin but is shorter acting than SUs and its action depends on glucose levels in the blood
When supplementing calcium it is important to check the level of this, as opposed to just strength of the product
Rapid acting insulins have (more/less) Zn.
MoA: Causes release of acetylcholine and inhibits cholinesterase; acts as a depolarizing neuromuscular blocker, paralyzing helminths
Taking this compound after exposure to radioctive iodine can help prevent long term side-effects
This calcium salt is not affected by food
Trade name: Metronidazole
Preferred phosphate binder in the treatment of hyperphosphatemia
Lantus is less likely to cause this condition than other insulins
Preferred drug for intestinal and extraintestinal amebic infections but up to 50% relapse when used alone
THis drug class inhibits coupling iodotyrosines in the thyroid
After taking this type of drug you must remain upright for at least 30 minutes
HbA1c of 7% represents what concentration of glucose
Hallmark sign of acute hypocalcemia
This class of drug has been linked to osteonecrosis of the jaw (especially in cancer patients and patient with a history of dental procedure)
HintAnswer
Levothyroxine should be given based on what metric of body size
Anti-parasitic that increases permeability of parasite membrane to chloride ion, which hyperpolarizes nerve and muscle and causes paralysis
Drug class that delays the absorption of glucose
This class of drug causes insulin release regardless of glucose level which can be a risk or hypoglycemia
This diabetes drug is naturally cosecreted with insulin and inhibits glucagon secretion
Non-hormonal agent that mimics effects of estrogen on bone without the stimulating effects of estrogen
This class of drug causes chemically induced esohpagitis
True/False: Levothyroxine should be taken with food.
What is the half life of levothyroxine
High doses of this compound block synthesis and release of thyroid hormone
MoA: Inhibits microtubule formation in broad spectrum of nematodes, leading to deterioration
This therapy used to be considered the cold standard for osteoporosis treatment because it maintains appropriate levels of osteoclasts
This drug increases serum calcium and phosphate
Aminoglyciside that is used in the tx of parasitic infection
This calcium salt is best absorbed with food
Range of time (in hours) that intermediate acting insulins peak
Drug class: Raloxifene
Each percentage above of below 7% for HbA1c represents how many mg/dL of glucose
This rare, congenital defect has been associate with methimazole given during pregnancy
This drug works by inhibiting dipeptidyl peptidase-4
Flagyl should not be taken with alcohol due to risk of this
HintAnswer
Patients on a TSH suppressive dose of levothyroxine have a 5 times increased risk of this complication
'Peakless' insulin
This drug is recombinant human PTH
Exenatide mimics the action of what hormone?
Range of time (in minutes) that short acting insulins peak
High dose IV bisphosphonates are used in the case of hypercalcemia with what underlying condition
TSH suppressive doses of levothyroxine stimulate this bone-cell type
In addition to stopping iodityrosine coupling, this drug also inhibits conversion of T4-T3
This is the only drug for osteoporosis that can increase the number of osteoblasts
What range of time (in weeks) does it take for levothyroxine to reach steady state?
MoA: Nitro group of metronidazole is reduced by ferredoxin, promoting formation of intermediate compounds and free radicals that are toxic to organisms
Last resort for severe cases of hypercalcemia
Type of diabetic that lacks endogenous amylin
Major contraindication of metformin use
Detemir is what type of insulin
This diabetes drug class causes increased osteoclastic activity so people taking it have an increased fracture risk
Two drugs that enhance sensitivity of muscle and fat to insulin and decrease hepatic gluconeogenesis
This drug class has a very slow onset because they are trascription factors
Drug class that works by inhibiting FPPS which generates lipids essential for osteoclastic function
Major side effects of this drug include flatulence, diarrhea and abdominal pain
Newly diagnosed diabetic patients respond best on this drug because it depends on the beta cells intrinsic function
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Created Oct 14, 2013ReportNominate
Tags:endocrine, Pharmacology

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