Science Quiz / Endocrine Pharmacology

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Can you name the Endocrine Pharmacology

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This drug class has a very slow onset because they are trascription factors
'Peakless' insulin
Most active form of vitamin D
Major contraindication of metformin use
Flagyl should not be taken with alcohol due to risk of this
When supplementing calcium it is important to check the level of this, as opposed to just strength of the product
Type of diabetic that lacks endogenous amylin
This can be heard when auscultating the thyroid and is pathognomonic for Graves disease
Two drugs that enhance sensitivity of muscle and fat to insulin and decrease hepatic gluconeogenesis
This drug increases serum calcium and phosphate
This class of drug has been linked to osteonecrosis of the jaw (especially in cancer patients and patient with a history of dental procedure)
High doses of this compound block synthesis and release of thyroid hormone
What is the half life of levothyroxine
Preferred phosphate binder in the treatment of hyperphosphatemia
Range of time (in hours) that intermediate acting insulins peak
TSH suppressive doses of levothyroxine stimulate this bone-cell type
Aminoglyciside that is used in the tx of parasitic infection
Preferred drug for intestinal and extraintestinal amebic infections but up to 50% relapse when used alone
After taking this type of drug you must remain upright for at least 30 minutes
Levothyroxine should be given based on what metric of body size
This diabetes drug class causes increased osteoclastic activity so people taking it have an increased fracture risk
MoA: Inhibits microtubule formation in broad spectrum of nematodes, leading to deterioration
Drug class: Raloxifene
MoA: Nitro group of metronidazole is reduced by ferredoxin, promoting formation of intermediate compounds and free radicals that are toxic to organisms
Rapid acting insulins have (more/less) Zn.
This calcium salt is best absorbed with food
Trade name: Metronidazole
Exogenous estrogen therapy would (increase/decrease) levothyroxine needs
Taking this compound after exposure to radioctive iodine can help prevent long term side-effects
Exenatide mimics the action of what hormone?
Hallmark sign of acute hypocalcemia
In addition to stopping iodityrosine coupling, this drug also inhibits conversion of T4-T3
High dose IV bisphosphonates are used in the case of hypercalcemia with what underlying condition
This drug works by inhibiting dipeptidyl peptidase-4
THis drug class inhibits coupling iodotyrosines in the thyroid
MoA: Causes release of acetylcholine and inhibits cholinesterase; acts as a depolarizing neuromuscular blocker, paralyzing helminths
Lantus is less likely to cause this condition than other insulins
Each percentage above of below 7% for HbA1c represents how many mg/dL of glucose
Iodine induced hyperthyroidism
This class of drug causes insulin release regardless of glucose level which can be a risk or hypoglycemia
Patients on a TSH suppressive dose of levothyroxine have a 5 times increased risk of this complication
This class of drug causes chemically induced esohpagitis
Major side effects of this drug include flatulence, diarrhea and abdominal pain
Detemir is what type of insulin
This rare, congenital defect has been associate with methimazole given during pregnancy
HbA1c of 7% represents what concentration of glucose
This therapy used to be considered the cold standard for osteoporosis treatment because it maintains appropriate levels of osteoclasts
This class of secretagogue causes release of insulin but is shorter acting than SUs and its action depends on glucose levels in the blood
This drug class blocks potassium channels and depolarized calcium channels in the beta cell which stimulates insulin release
True/False: Levothyroxine should be taken with food.
Range of time (in minutes) that short acting insulins peak
This diabetes drug is naturally cosecreted with insulin and inhibits glucagon secretion
Newly diagnosed diabetic patients respond best on this drug because it depends on the beta cells intrinsic function
This calcium salt is not affected by food
This is the only drug for osteoporosis that can increase the number of osteoblasts
Anti-parasitic that increases permeability of parasite membrane to chloride ion, which hyperpolarizes nerve and muscle and causes paralysis
This drug is recombinant human PTH
Drug class that works by inhibiting FPPS which generates lipids essential for osteoclastic function
What range of time (in weeks) does it take for levothyroxine to reach steady state?
Drug class that delays the absorption of glucose
Exogenous androgens would (increase/decrease) levothyroxine needs
Non-hormonal agent that mimics effects of estrogen on bone without the stimulating effects of estrogen
Last resort for severe cases of hypercalcemia

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