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Biochemistry: Protein and Nucleotide Metabolism Quiz Stats

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Clue Answer % Correct
Deamination reactions create this highly toxic chemical that must be removed from the body.Ammonia
23.1%
Since humans can't store purines we must get rid of them in this formUric Acid
23.1%
This amino acid has two amino groups and is thus the most efficient carrier of ammoniaGlutamine
22.4%
What amino acid donates an amino group to PRPP?Glutamine
21.8%
What substrate is used to synthesize PRPP?Ribose-5-Phosphate
20.5%
A very high protein diet or starvation would lead to __________________ (induction/repression) of urea cycle enzymes.Induction
19.9%
In PKU which amino acid becomes essential?Tyrosine
19.2%
Lysosomal degradation activity is ______________ during starvation? (Increased/Decreased)Increased
18.6%
This amino acid is used in the production of melaninTyrosine
18.6%
Transfer of an amino group from one amino acid to an amino acid carbon skeleton or alpha ketoacid.Transamination
18.6%
Elimination of an amino groupDeamination
18.6%
Condition when uric acid crystals precipitate out of the bloodGout
16.7%
Aminotransferase put the amino group from alanine on alpha-ketoglutarate to form glutamate and ___________________.Pyruvate
16%
This enzyme converts creatine to creatine phosphate.Creatine kinase
16%
What amino acid is added to IMP to make AMP?Aspartate
16%
What amino acid is added to IMP to make GMP?Glutamine
16%
This enzyme converts Xanthine to Uric AcidXanthine Oxidase
16%
Most de novo nucleotide synthesis occurs where?Liver
15.4%
HGPRT ___________________ causes an increase in the rate of purine synthesis. (Deficiency/Hyperactivity)Deficiency
15.4%
This enzyme removes an ammonium ion from glutamate to make alpha-ketoglutarate.Glutamate dehydrogenase
14.7%
A deficiency of this enzyme would be indicated by ArgininemiaArginase
14.7%
This type of base is sythesized piece by piece directly on the ribosePurine
14.7%
This enzyme converts hypoxanthine to xanthineXanthine Oxidase
14.7%
This small, basic protein tags proteins for degradationUbiquitin
14.1%
Ezyme that transaminates aspartateAspartate Aminotransferase (AST)
14.1%
Deamination occurs primarily on this amino acid because it is the end produce of many transamination reactions.Glutamate
14.1%
This enzyme is deficient in albinism.Tyrosinase
13.5%
What molecule is at the branch point of de novo purine synthesis?Inosine Monophosphate
13.5%
CPS-II is most sensitive to PRPP during what cell phase?S-Phase
13.5%
The cofactor required for transamination reaction is a derivative of ______________.Vitamin B6
12.8%
Ribose-5-Phostphate is an intermediary in what pathway?Pentose Pathway
12.8%
This enzyme can convert Adenosine to InosineAdenosine deaminase
12.8%
What amino acids are purely ketogenic?Leucine and Lysine
12.2%
What enzyme synthesizes PRPP?PRPP Synthase
12.2%
A genetic mutation leading to a deficiency in HGPRT leads to what condition?Lesch-Nyhan Syndrome
12.2%
CTP Synthase aminates UTP with an amino group from where?Glutamine
11.5%
During periods of growth, pregnancy and convalescence the nitrogen balance is _________________. Positive
10.9%
During periods of malnutrition, starvation, cachexia and after traumatic injury the nitrogen balance is _________________. Negative
10.9%
This enzyme combines citrulline and aspartate to argininosuccinateArgininosuccinate Synthase
10.9%
This enzyme converts Argininosuccinate to Arginine and Fumarate.Argininosuccinate Lyase
10.9%
This enzyme catalyzes the formation of IMP and GMP from Hypoxanthine and Guanine and PRPPHypoxanthine-guanine phosphoribosyltransferase (HGPRT)
10.9%
This genetic disease is characterized by self-mutilating behaviorLesch-Nyhan Syndrome
10.9%
This enzyme converts carbomoyl phosphate to carbomoyl aspartateAspartate transcarbamoylase
10.3%
This enzyme converts UTP to CTPCTP synthase
10.3%
A polymer of this chemical creates a black-brown pigment that deposits in connective tissue and can be seen in standing urine in people with alkoptonuria.Homogentisate
9.6%
Enzyme that transaminates alanineAlanine Aminotransferase (ALT)
9.6%
What is the base in IMP?Hypoxanthine
9.6%
Clue Answer % Correct
This enzyme catalyzes formation of AMP from adenine and PRPPAdenine phosphoribosyltransferase (APRT)
9.6%
This metabolite inhibites ribonucleotide reductase leading to the inability of cells to synthesize deoxyribonucleotides and therefore DNA.dATP
9.6%
This enzyme catalyzes the conversion of bicarbonate and ammonia (from glutamine) to carbomoyl phosphate, releasing glutamate.Carbomoyl Phosphate Synthase II
9.6%
This molecule activtivates CPS-II5-Phosphoribosyl-1-Pyrophosphate (PRPP)
9.6%
One type of this autosomal recessive disease stems from a deficiency of phenylalanine hydroxylasePhenylketonuria (PKU)
9%
Homocystein and methionine levels are increased in this disease that causes mental retardation and dislocation of the lens of the eye.Homocystinuria
9%
This enzyme adds an ammonium ion to glutamate to make glutamineGlutamine synthase
9%
This enzyme combines ornithine and carbamoyl phosphate to make citrullineOrnithine transcarbamoylase
9%
Converts OMP to UMPOMP decarboxylase
9%
Phenylpyruvate and phenylacetate are _____________.Phenylketones
8.3%
This enzyme is deficient in histidinemiaHistidase
8.3%
What type of reaction can create non-essential amino acids from essential amino acids or non-essential AAs from non-essential AAs.Transamination
8.3%
This molecule allosterically activates CPS-IN-acetyl-glutamate
8.3%
Increased BUN usually indicates ________________ disease.Kidney
8.3%
With what disease would a patient have high levels of valine, leucine and isoleucine in their blood?Maple Syrup Urine Disease
7.7%
This isoform of creatine kinase is found in smooth muscle and brain tissue and makes up only 1% of total CK.CK-I or CK-BB
7.7%
Cofactor of all aminotransferase reactions because amino group is first transferred to this molecule.Pyridoxal Phosphate
7.1%
This transaminase enzyme helps the urea cycle by being involved in the recycling of fumarate to aspartate.Aspartate Aminotransferase (AST)
7.1%
The methyl group needed for the conversion of dUMP to dTMP comes from...N5, N10-methylene tetrahydrofolate
7.1%
This disease causes increased levels of histidine in the blood and urine and causes mental retardationHistidinemia
6.4%
Creatine phosphate 'buffers' ___________ during exercise so it doesn't significantly drop.ATP
6.4%
What immune cell uses primarily the salvage pathway for nucleotide synthesis?Lymphocytes
6.4%
What product builds up in ADA deficient SCID that inhibits deoxynucleotide synthesisdATP
6.4%
Enzyme that converts thymidine to TMPThymidine kinase
6.4%
CPS-II is most sensitive to UTP during the end of which cell phase?S-Phase
6.4%
________________ cause poor myelination and mental retardation.Ketoacids
5.8%
How is maple syrup urine disease treated?Diet
5.8%
What is the product of the rate limiting step of the urea cycle Carbomoyl Phosphate
5.8%
This enzyme found in the gut cleaves urea to get carbon dioxide and ammonia.Bacterial urease
5.8%
A deficiency of this enzyme would be indicated by Argininosuccinic AcidemiaArgininosuccinate Lyase
5.8%
Purine nucleosides are converted to free bases by what enzyme?Purine nucleoside phosphorylase
5.8%
Treatment for Lesch-Nyhan Sydrome?Diet
5.8%
The glycine residue at the carboxyl end of ubiquitin attaches to what residue on the target protein?Lysine
5.1%
This isoform of CK is found in the heart and is important in diagnosing MIs.CK-II or CK-MB
5.1%
Decreased BUN usually indicates ______________ disease.Liver
5.1%
This enzyme converts neucleotides to nucleosides5'-Nucleotidase
5.1%
Lacking OMP decarboxylase or orotate phosphoribosyltransferase causes this rare metabolic condition. Patients often have aneamia, leukopenia and retarded development.Orotic Aciduria
5.1%
This molecule inhibits CPS-IIUTP
5.1%
Deficient enzyme in maple syrup urine diseaseBranched Chain alpha Ketoacid Dehydrogenase
4.5%
A deposit of urate crystals in someone with goutGouty Tophus
4.5%
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily inhibitedProtein Kinase A
4.5%
Homocystinuria results from a deficiency of this enzymecystathione synthase
3.8%
Glycine, arginine and methionine are used to synthesize what?Creatine
3.8%
A muscle cell that is fully charged with CP has a __________:1 ratio of CP:ATP3
3.8%
What type of amino acids are not principally oxidized in the liver?Branched Chain Amino Acids
3.8%
Bicarbonate, aspartate and ammonia are used to make what?Pyrimidines
3.8%
Presence of creatine kinase in the blood can indicate ___________________. Myocardial infarction
3.2%
Clue Answer % Correct
Creatine kinase is only made in muscle cells that are _________________.Resting
3.2%
This isoform of creatine kinase is in skeletal muscle and makes up 95% of the CK in the body.CK-III or CK-MM
3.2%
This is a common cause of acquired hyperammonemia.Liver Disease
3.2%
This drug binds to glycine in the liver and is excreted in order to reduce ammonia in the body.Benzoic Acid
3.2%
This drug binds to glutamine and is then excreted from the body in order to reduce the ammonia in the bodyPhenylacetate
3.2%
People with hyperammonemia are given ________________ so the body uses it for energy of proteinIV Glucose
3.2%
PRPP synthase is negatively regulated by ________________GTP and ATP
3.2%
A genetic mutation in what enzyme can cause increased de novo synthesis of purines and hyperuricemiaPRPP Synthase
3.2%
This enzyme converts dihydrofolate to tetrahydrofolateDihydrofolate Dehydrogenase
3.2%
This molecule inhibits thymidine kinasedTTP
3.2%
This single bifunctional enzyme has the properties of orotate phosphotranfserase and OMP decaboxylaseUMP Synthase
3.2%
Alanine, glycine, methionine, serine, threonine and valine are which type of N-terminal residues?Stabilizing
2.6%
What enzyme is deficient in alkaptonuria?Homogentisic Acid Oxidase
2.6%
This type of base is assembled completely first then attached to a ribosePyrimadine
2.6%
This enzyme converts 5-phosphoribosyl-1-pyrophosphate to 5-phosphoribosyl-1-amineGlutamine phosphoribosyl amidotransferase
2.6%
What immune cell carries out de novo synthesis of nucleotides?Neutrophils
2.6%
The most effective treatment for SCIDBone Marrow Transplant
2.6%
Aspartate, Arginine, Leucine, Lysine and Phenylalanine are which type of N-Terminal amino acids?Destabilizing
1.9%
This is the first enzyme to rise following a myocardial infarction and may only rise transiently and normalize in less thatn 3 days.Creatine Kinase II
1.9%
Deficiency of this enzyme would lead to increased levels of orotic acidOrnithine Transcarbamoylase
1.9%
Pyrophosphates are the basis of this drug class which is used to treat osteoporosis.Bisphosphonates
1.9%
What is molecule is 'activated ribose'?5-phosphoribosyl-1-pyrophosphate (PRPP)
1.9%
What enzyme converts ribonucleotides to deoxyribonucleotidesRibonucleoreductase
1.9%
Segments rich in what amino acids are rapidly degraded? (acronym)PEST (Proline, Serine, Glutamate, Threonine)
1.3%
The deficient enzyme in alkaptonuria breaks down tyrosine to form _____________.Fumarate
1.3%
In hereditary hyperammonemia the administration or citrulline and arginine is usually effective except in the case of _______________.Argininemia
1.3%
GMP, GDP, GTP, AMP, ADP and ATP all inhibit what enzyme?Glutamine phosphoribosyl amidotransferase
1.3%
Coverts dihydroorotate to orotate with FADDihyrdoorotate dehydrogenase
1.3%
Lysosomal proteases that degrade protein in the lysosomal pathwayCathepsins
0.6%
In a healthy person ketovaline is broken down into ______________>Proprionyl CoA
0.6%
The most commonly inherited urea enzyme deficiencyOrnithine Transcaramoylase
0.6%
Normal BUN:Creatinine level is ____________:110-20
0.6%
Ketogenic amino acids yield which compound(s)?Acetyl CoA and Acetoacyl CoA
0.6%
Branched chain ketoacid dehydrogenase requires what cofactor?Thiamine pyrophosphate
0.6%
The commited step of de novo purine synthesis is conversion of PRPP to ____________________.5-phosphoribosyl-1-amine
0.6%
What are uric acid crystals interacting with in gouty arthritis?Neutrophils
0.6%
This enzyme converts Carbamoyl aspartate to DihydroorotateDihyrdroorotase
0.6%
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily activatedMAP Kinase
0.6%
________________ have a maple/cheesy smell.Ketoacids
0%
Creatine phosphate donates its phosphate group to ADP after _________________.Cross-Bridge Cycling
0%
If the CK found in the heart is greater than ______ U/L then an MI is probable.12
0%
A deficiency of this enzyme would be indicated by citrullinemia.Argininosuccinate Sythase
0%
20% of SCID cases are due to this enzyme deficiencyAdeonsine deaminase
0%
Converts orotate to OMPOrotate phophoribosyltransferase
0%
Enzyme that converts dUMP to dMPThymidylate cyclase
0%
Enzyme that converts THF to N5, N10-methylene THFSerine hydroxymethyl transferase
0%
Enzyme that converts deoyuridine to dUMPThymidine kinase
0%

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Created Dec 17, 2012ReportNominate
Tags:Biochemistry, nucleotide, protein

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