Biochemistry: Protein and Nucleotide Metabolism

Can you name the Biochemistry: Protein and Nucleotide Metabolism?

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This isoform of creatine kinase is found in smooth muscle and brain tissue and makes up only 1% of total CK.
This enzyme combines ornithine and carbamoyl phosphate to make citrulline
The methyl group needed for the conversion of dUMP to dTMP comes from...
Since humans can't store purines we must get rid of them in this form
CTP Synthase aminates UTP with an amino group from where?
The glycine residue at the carboxyl end of ubiquitin attaches to what residue on the target protein?
This enzyme is deficient in histidinemia
This enzyme converts Argininosuccinate to Arginine and Fumarate.
Enzyme that converts deoyuridine to dUMP
What product builds up in ADA deficient SCID that inhibits deoxynucleotide synthesis
Deficient enzyme in maple syrup urine disease
Lacking OMP decarboxylase or orotate phosphoribosyltransferase causes this rare metabolic condition. Patients often have aneamia, leukopenia and retarded development.
Cofactor of all aminotransferase reactions because amino group is first transferred to this molecule.
Presence of creatine kinase in the blood can indicate ___________________.
Aminotransferase put the amino group from alanine on alpha-ketoglutarate to form glutamate and ___________________.
This amino acid is used in the production of melanin
________________ have a maple/cheesy smell.
Ketogenic amino acids yield which compound(s)?
PRPP synthase is negatively regulated by ________________
This transaminase enzyme helps the urea cycle by being involved in the recycling of fumarate to aspartate.
Aspartate, Arginine, Leucine, Lysine and Phenylalanine are which type of N-Terminal amino acids?
A deficiency of this enzyme would be indicated by Argininosuccinic Acidemia
People with hyperammonemia are given ________________ so the body uses it for energy of protein
If the CK found in the heart is greater than ______ U/L then an MI is probable.
This enzyme catalyzes the formation of IMP and GMP from Hypoxanthine and Guanine and PRPP
20% of SCID cases are due to this enzyme deficiency
A muscle cell that is fully charged with CP has a __________:1 ratio of CP:ATP
CPS-II is most sensitive to PRPP during what cell phase?
What immune cell carries out de novo synthesis of nucleotides?
What amino acid is added to IMP to make AMP?
This enzyme catalyzes the conversion of bicarbonate and ammonia (from glutamine) to carbomoyl phosphate, releasing glutamate.
One type of this autosomal recessive disease stems from a deficiency of phenylalanine hydroxylase
A genetic mutation in what enzyme can cause increased de novo synthesis of purines and hyperuricemia
GMP, GDP, GTP, AMP, ADP and ATP all inhibit what enzyme?
Deamination reactions create this highly toxic chemical that must be removed from the body.
Pyrophosphates are the basis of this drug class which is used to treat osteoporosis.
Branched chain ketoacid dehydrogenase requires what cofactor?
This genetic disease is characterized by self-mutilating behavior
Ribose-5-Phostphate is an intermediary in what pathway?
Glycine, arginine and methionine are used to synthesize what?
This molecule allosterically activates CPS-I
What substrate is used to synthesize PRPP?
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily activated
In a healthy person ketovaline is broken down into ______________>
CPS-II is most sensitive to UTP during the end of which cell phase?
The commited step of de novo purine synthesis is conversion of PRPP to ____________________.
This enzyme converts carbomoyl phosphate to carbomoyl aspartate
With what disease would a patient have high levels of valine, leucine and isoleucine in their blood?
This enzyme combines citrulline and aspartate to argininosuccinate
This enzyme converts UTP to CTP
What amino acid is added to IMP to make GMP?
Deamination occurs primarily on this amino acid because it is the end produce of many transamination reactions.
Decreased BUN usually indicates ______________ disease.
How is maple syrup urine disease treated?
What type of amino acids are not principally oxidized in the liver?
Creatine phosphate 'buffers' ___________ during exercise so it doesn't significantly drop.
The most effective treatment for SCID
Increased BUN usually indicates ________________ disease.
What is the product of the rate limiting step of the urea cycle
What enzyme synthesizes PRPP?
What amino acid donates an amino group to PRPP?
This small, basic protein tags proteins for degradation
Enzyme that converts dUMP to dMP
This enzyme converts dihydrofolate to tetrahydrofolate
A very high protein diet or starvation would lead to __________________ (induction/repression) of urea cycle enzymes.
Homocystinuria results from a deficiency of this enzyme
Lysosomal degradation activity is ______________ during starvation? (Increased/Decreased)
Creatine kinase is only made in muscle cells that are _________________.
What molecule is at the branch point of de novo purine synthesis?
A genetic mutation leading to a deficiency in HGPRT leads to what condition?
Creatine phosphate donates its phosphate group to ADP after _________________.
Most de novo nucleotide synthesis occurs where?
What immune cell uses primarily the salvage pathway for nucleotide synthesis?
This type of base is sythesized piece by piece directly on the ribose
Converts OMP to UMP
This enzyme catalyzes formation of AMP from adenine and PRPP
Treatment for Lesch-Nyhan Sydrome?
Transfer of an amino group from one amino acid to an amino acid carbon skeleton or alpha ketoacid.
Condition when uric acid crystals precipitate out of the blood
This type of base is assembled completely first then attached to a ribose
Segments rich in what amino acids are rapidly degraded? (acronym)
During periods of growth, pregnancy and convalescence the nitrogen balance is _________________.
This amino acid has two amino groups and is thus the most efficient carrier of ammonia
This metabolite inhibites ribonucleotide reductase leading to the inability of cells to synthesize deoxyribonucleotides and therefore DNA.
What enzyme converts ribonucleotides to deoxyribonucleotides
This enzyme converts creatine to creatine phosphate.
Deficiency of this enzyme would lead to increased levels of orotic acid
What are uric acid crystals interacting with in gouty arthritis?
Phenylpyruvate and phenylacetate are _____________.
This enzyme converts Carbamoyl aspartate to Dihydroorotate
Coverts dihydroorotate to orotate with FAD
________________ cause poor myelination and mental retardation.
Alanine, glycine, methionine, serine, threonine and valine are which type of N-terminal residues?
In hereditary hyperammonemia the administration or citrulline and arginine is usually effective except in the case of _______________.
This enzyme can convert Adenosine to Inosine
The deficient enzyme in alkaptonuria breaks down tyrosine to form _____________.
What amino acids are purely ketogenic?
This drug binds to glutamine and is then excreted from the body in order to reduce the ammonia in the body
This molecule inhibits CPS-II
This enzyme removes an ammonium ion from glutamate to make alpha-ketoglutarate.
Ezyme that transaminates aspartate
This enzyme converts hypoxanthine to xanthine
This drug binds to glycine in the liver and is excreted in order to reduce ammonia in the body.
The most commonly inherited urea enzyme deficiency
This isoform of creatine kinase is in skeletal muscle and makes up 95% of the CK in the body.
In PKU which amino acid becomes essential?
Normal BUN:Creatinine level is ____________:1
Elimination of an amino group
What is the base in IMP?
During periods of malnutrition, starvation, cachexia and after traumatic injury the nitrogen balance is _________________.
This enzyme is deficient in albinism.
A deficiency of this enzyme would be indicated by Argininemia
This is the first enzyme to rise following a myocardial infarction and may only rise transiently and normalize in less thatn 3 days.
Homocystein and methionine levels are increased in this disease that causes mental retardation and dislocation of the lens of the eye.
Purine nucleosides are converted to free bases by what enzyme?
The cofactor required for transamination reaction is a derivative of ______________.
This molecule inhibits thymidine kinase
Bicarbonate, aspartate and ammonia are used to make what?
A polymer of this chemical creates a black-brown pigment that deposits in connective tissue and can be seen in standing urine in people with alkoptonuria.
Enzyme that converts thymidine to TMP
This molecule activtivates CPS-II
Enzyme that transaminates alanine
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily inhibited
Lysosomal proteases that degrade protein in the lysosomal pathway
This enzyme adds an ammonium ion to glutamate to make glutamine
HGPRT ___________________ causes an increase in the rate of purine synthesis. (Deficiency/Hyperactivity)
This enzyme converts neucleotides to nucleosides
This disease causes increased levels of histidine in the blood and urine and causes mental retardation
Converts orotate to OMP
This enzyme found in the gut cleaves urea to get carbon dioxide and ammonia.
What enzyme is deficient in alkaptonuria?
This isoform of CK is found in the heart and is important in diagnosing MIs.
This enzyme converts 5-phosphoribosyl-1-pyrophosphate to 5-phosphoribosyl-1-amine
A deposit of urate crystals in someone with gout
What type of reaction can create non-essential amino acids from essential amino acids or non-essential AAs from non-essential AAs.
A deficiency of this enzyme would be indicated by citrullinemia.
Enzyme that converts THF to N5, N10-methylene THF
What is molecule is 'activated ribose'?
This is a common cause of acquired hyperammonemia.
This single bifunctional enzyme has the properties of orotate phosphotranfserase and OMP decaboxylase
This enzyme converts Xanthine to Uric Acid

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