Science Quiz / Biochemistry: Protein and Nucleotide Metabolism

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QUIZ: Can you name the Biochemistry: Protein and Nucleotide Metabolism?

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Pyrophosphates are the basis of this drug class which is used to treat osteoporosis.
The most effective treatment for SCID
A very high protein diet or starvation would lead to __________________ (induction/repression) of urea cycle enzymes.
In a healthy person ketovaline is broken down into ______________>
Branched chain ketoacid dehydrogenase requires what cofactor?
This drug binds to glutamine and is then excreted from the body in order to reduce the ammonia in the body
This isoform of creatine kinase is in skeletal muscle and makes up 95% of the CK in the body.
A polymer of this chemical creates a black-brown pigment that deposits in connective tissue and can be seen in standing urine in people with alkoptonuria.
What are uric acid crystals interacting with in gouty arthritis?
What is the product of the rate limiting step of the urea cycle
This enzyme catalyzes formation of AMP from adenine and PRPP
Lysosomal proteases that degrade protein in the lysosomal pathway
Elimination of an amino group
This molecule allosterically activates CPS-I
Since humans can't store purines we must get rid of them in this form
The cofactor required for transamination reaction is a derivative of ______________.
A deposit of urate crystals in someone with gout
Alanine, glycine, methionine, serine, threonine and valine are which type of N-terminal residues?
What amino acid donates an amino group to PRPP?
Homocystinuria results from a deficiency of this enzyme
This is a common cause of acquired hyperammonemia.
Creatine phosphate donates its phosphate group to ADP after _________________.
This enzyme converts creatine to creatine phosphate.
This enzyme converts dihydrofolate to tetrahydrofolate
GMP, GDP, GTP, AMP, ADP and ATP all inhibit what enzyme?
This is the first enzyme to rise following a myocardial infarction and may only rise transiently and normalize in less thatn 3 days.
This enzyme found in the gut cleaves urea to get carbon dioxide and ammonia.
This single bifunctional enzyme has the properties of orotate phosphotranfserase and OMP decaboxylase
A muscle cell that is fully charged with CP has a __________:1 ratio of CP:ATP
This amino acid has two amino groups and is thus the most efficient carrier of ammonia
What is the base in IMP?
Coverts dihydroorotate to orotate with FAD
________________ have a maple/cheesy smell.
This enzyme combines citrulline and aspartate to argininosuccinate
Deficiency of this enzyme would lead to increased levels of orotic acid
Most de novo nucleotide synthesis occurs where?
This molecule inhibits thymidine kinase
What immune cell uses primarily the salvage pathway for nucleotide synthesis?
This enzyme converts hypoxanthine to xanthine
People with hyperammonemia are given ________________ so the body uses it for energy of protein
Deamination reactions create this highly toxic chemical that must be removed from the body.
With what disease would a patient have high levels of valine, leucine and isoleucine in their blood?
Increased BUN usually indicates ________________ disease.
Aminotransferase put the amino group from alanine on alpha-ketoglutarate to form glutamate and ___________________.
What molecule is at the branch point of de novo purine synthesis?
The most commonly inherited urea enzyme deficiency
Lysosomal degradation activity is ______________ during starvation? (Increased/Decreased)
Ketogenic amino acids yield which compound(s)?
Enzyme that converts thymidine to TMP
This enzyme converts carbomoyl phosphate to carbomoyl aspartate
Deamination occurs primarily on this amino acid because it is the end produce of many transamination reactions.
Glycine, arginine and methionine are used to synthesize what?
This enzyme converts UTP to CTP
The methyl group needed for the conversion of dUMP to dTMP comes from...
Converts OMP to UMP
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily activated
Creatine phosphate 'buffers' ___________ during exercise so it doesn't significantly drop.
What amino acid is added to IMP to make GMP?
What enzyme converts ribonucleotides to deoxyribonucleotides
The glycine residue at the carboxyl end of ubiquitin attaches to what residue on the target protein?
This isoform of creatine kinase is found in smooth muscle and brain tissue and makes up only 1% of total CK.
How is maple syrup urine disease treated?
________________ cause poor myelination and mental retardation.
Condition when uric acid crystals precipitate out of the blood
This enzyme removes an ammonium ion from glutamate to make alpha-ketoglutarate.
PRPP synthase is negatively regulated by ________________
20% of SCID cases are due to this enzyme deficiency
Transfer of an amino group from one amino acid to an amino acid carbon skeleton or alpha ketoacid.
CTP Synthase aminates UTP with an amino group from where?
This enzyme converts neucleotides to nucleosides
One type of this autosomal recessive disease stems from a deficiency of phenylalanine hydroxylase
During periods of growth, pregnancy and convalescence the nitrogen balance is _________________.
Deficient enzyme in maple syrup urine disease
If the CK found in the heart is greater than ______ U/L then an MI is probable.
A deficiency of this enzyme would be indicated by Argininosuccinic Acidemia
What product builds up in ADA deficient SCID that inhibits deoxynucleotide synthesis
This enzyme converts 5-phosphoribosyl-1-pyrophosphate to 5-phosphoribosyl-1-amine
This metabolite inhibites ribonucleotide reductase leading to the inability of cells to synthesize deoxyribonucleotides and therefore DNA.
This enzyme converts Xanthine to Uric Acid
What type of amino acids are not principally oxidized in the liver?
In PKU which amino acid becomes essential?
Presence of creatine kinase in the blood can indicate ___________________.
This enzyme converts Carbamoyl aspartate to Dihydroorotate
Converts orotate to OMP
What substrate is used to synthesize PRPP?
This type of base is sythesized piece by piece directly on the ribose
Lacking OMP decarboxylase or orotate phosphoribosyltransferase causes this rare metabolic condition. Patients often have aneamia, leukopenia and retarded development.
A genetic mutation in what enzyme can cause increased de novo synthesis of purines and hyperuricemia
This enzyme can convert Adenosine to Inosine
This genetic disease is characterized by self-mutilating behavior
This type of base is assembled completely first then attached to a ribose
What enzyme is deficient in alkaptonuria?
Cofactor of all aminotransferase reactions because amino group is first transferred to this molecule.
Enzyme that converts dUMP to dMP
This drug binds to glycine in the liver and is excreted in order to reduce ammonia in the body.
Phenylpyruvate and phenylacetate are _____________.
In hereditary hyperammonemia the administration or citrulline and arginine is usually effective except in the case of _______________.
CPS-II is most sensitive to PRPP during what cell phase?
During periods of malnutrition, starvation, cachexia and after traumatic injury the nitrogen balance is _________________.
Segments rich in what amino acids are rapidly degraded? (acronym)
What immune cell carries out de novo synthesis of nucleotides?
Normal BUN:Creatinine level is ____________:1
Enzyme that converts deoyuridine to dUMP
Enzyme that transaminates alanine
This enzyme combines ornithine and carbamoyl phosphate to make citrulline
This enzyme is deficient in albinism.
HGPRT ___________________ causes an increase in the rate of purine synthesis. (Deficiency/Hyperactivity)
CPS-II is most sensitive to UTP during the end of which cell phase?
Enzyme that converts THF to N5, N10-methylene THF
The deficient enzyme in alkaptonuria breaks down tyrosine to form _____________.
Aspartate, Arginine, Leucine, Lysine and Phenylalanine are which type of N-Terminal amino acids?
This enzyme converts Argininosuccinate to Arginine and Fumarate.
Ezyme that transaminates aspartate
Treatment for Lesch-Nyhan Sydrome?
This transaminase enzyme helps the urea cycle by being involved in the recycling of fumarate to aspartate.
This enzyme adds an ammonium ion to glutamate to make glutamine
Ribose-5-Phostphate is an intermediary in what pathway?
Homocystein and methionine levels are increased in this disease that causes mental retardation and dislocation of the lens of the eye.
What is molecule is 'activated ribose'?
Bicarbonate, aspartate and ammonia are used to make what?
What amino acids are purely ketogenic?
This enzyme catalyzes the conversion of bicarbonate and ammonia (from glutamine) to carbomoyl phosphate, releasing glutamate.
A deficiency of this enzyme would be indicated by citrullinemia.
This isoform of CK is found in the heart and is important in diagnosing MIs.
This enzyme is deficient in histidinemia
This amino acid is used in the production of melanin
This enzyme catalyzes the formation of IMP and GMP from Hypoxanthine and Guanine and PRPP
The commited step of de novo purine synthesis is conversion of PRPP to ____________________.
What enzyme synthesizes PRPP?
What amino acid is added to IMP to make AMP?
What type of reaction can create non-essential amino acids from essential amino acids or non-essential AAs from non-essential AAs.
This molecule inhibits CPS-II
This disease causes increased levels of histidine in the blood and urine and causes mental retardation
A deficiency of this enzyme would be indicated by Argininemia
Creatine kinase is only made in muscle cells that are _________________.
Decreased BUN usually indicates ______________ disease.
Purine nucleosides are converted to free bases by what enzyme?
This small, basic protein tags proteins for degradation
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily inhibited
This molecule activtivates CPS-II
A genetic mutation leading to a deficiency in HGPRT leads to what condition?

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