| Clue | Answer |
|---|
| What amino acids are purely ketogenic? | |
| Alanine, glycine, methionine, serine, threonine and valine are which type of N-terminal residues? | |
| Deamination occurs primarily on this amino acid because it is the end produce of many transamination reactions. | |
| This transaminase enzyme helps the urea cycle by being involved in the recycling of fumarate to aspartate. | |
| A genetic mutation in what enzyme can cause increased de novo synthesis of purines and hyperuricemia | |
| This small, basic protein tags proteins for degradation | |
| A genetic mutation leading to a deficiency in HGPRT leads to what condition? | |
| Converts orotate to OMP | |
| What type of amino acids are not principally oxidized in the liver? | |
| In hereditary hyperammonemia the administration or citrulline and arginine is usually effective except in the case of _______________. | |
| What enzyme converts ribonucleotides to deoxyribonucleotides | |
| What product builds up in ADA deficient SCID that inhibits deoxynucleotide synthesis | |
| This enzyme catalyzes the conversion of bicarbonate and ammonia (from glutamine) to carbomoyl phosphate, releasing glutamate. | |
| HGPRT ___________________ causes an increase in the rate of purine synthesis. (Deficiency/Hyperactivity) | |
| Condition when uric acid crystals precipitate out of the blood | |
| People with hyperammonemia are given ________________ so the body uses it for energy of protein | |
| This drug binds to glycine in the liver and is excreted in order to reduce ammonia in the body. | |
| Presence of creatine kinase in the blood can indicate ___________________. | |
| Lysosomal degradation activity is ______________ during starvation? (Increased/Decreased) | |
| The most effective treatment for SCID | |
| Transfer of an amino group from one amino acid to an amino acid carbon skeleton or alpha ketoacid. | |
| A deficiency of this enzyme would be indicated by citrullinemia. | |
| A very high protein diet or starvation would lead to __________________ (induction/repression) of urea cycle enzymes. | |
| One type of this autosomal recessive disease stems from a deficiency of phenylalanine hydroxylase | |
| This isoform of CK is found in the heart and is important in diagnosing MIs. | |
| This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily inhibited | |
| Normal BUN:Creatinine level is ____________:1 | |
| During periods of malnutrition, starvation, cachexia and after traumatic injury the nitrogen balance is _________________. | |
| This molecule activtivates CPS-II | |
| This is the first enzyme to rise following a myocardial infarction and may only rise transiently and normalize in less thatn 3 days. | |
| What is the product of the rate limiting step of the urea cycle | |
| Creatine phosphate donates its phosphate group to ADP after _________________. | |
| This single bifunctional enzyme has the properties of orotate phosphotranfserase and OMP decaboxylase | |
| This is a common cause of acquired hyperammonemia. | |
| This isoform of creatine kinase is found in smooth muscle and brain tissue and makes up only 1% of total CK. | |
| CTP Synthase aminates UTP with an amino group from where? | |
| If the CK found in the heart is greater than ______ U/L then an MI is probable. | |
| The commited step of de novo purine synthesis is conversion of PRPP to ____________________. | |
| This type of base is assembled completely first then attached to a ribose | |
| What type of reaction can create non-essential amino acids from essential amino acids or non-essential AAs from non-essential AAs. | |
| The cofactor required for transamination reaction is a derivative of ______________. | |
| This enzyme converts creatine to creatine phosphate. | |
| This enzyme combines ornithine and carbamoyl phosphate to make citrulline | |
| Most de novo nucleotide synthesis occurs where? | |
| Lysosomal proteases that degrade protein in the lysosomal pathway | |
| This enzyme catalyzes the formation of IMP and GMP from Hypoxanthine and Guanine and PRPP | |
| What is molecule is 'activated ribose'? | |
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