Science Quiz / Biochemistry: Protein and Nucleotide Metabolism

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Can you name the Biochemistry: Protein and Nucleotide Metabolism?

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Enzyme that converts THF to N5, N10-methylene THF
This molecule allosterically activates CPS-I
This type of base is assembled completely first then attached to a ribose
Deficiency of this enzyme would lead to increased levels of orotic acid
What amino acid donates an amino group to PRPP?
What is the base in IMP?
This enzyme catalyzes the formation of IMP and GMP from Hypoxanthine and Guanine and PRPP
Aminotransferase put the amino group from alanine on alpha-ketoglutarate to form glutamate and ___________________.
Homocystinuria results from a deficiency of this enzyme
This isoform of CK is found in the heart and is important in diagnosing MIs.
The methyl group needed for the conversion of dUMP to dTMP comes from...
Lysosomal proteases that degrade protein in the lysosomal pathway
Ezyme that transaminates aspartate
Normal BUN:Creatinine level is ____________:1
CPS-II is most sensitive to UTP during the end of which cell phase?
Bicarbonate, aspartate and ammonia are used to make what?
Decreased BUN usually indicates ______________ disease.
This drug binds to glycine in the liver and is excreted in order to reduce ammonia in the body.
The deficient enzyme in alkaptonuria breaks down tyrosine to form _____________.
This disease causes increased levels of histidine in the blood and urine and causes mental retardation
What product builds up in ADA deficient SCID that inhibits deoxynucleotide synthesis
The cofactor required for transamination reaction is a derivative of ______________.
Converts orotate to OMP
Condition when uric acid crystals precipitate out of the blood
This enzyme converts creatine to creatine phosphate.
This enzyme adds an ammonium ion to glutamate to make glutamine
A very high protein diet or starvation would lead to __________________ (induction/repression) of urea cycle enzymes.
What immune cell carries out de novo synthesis of nucleotides?
This isoform of creatine kinase is in skeletal muscle and makes up 95% of the CK in the body.
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily inhibited
Enzyme that transaminates alanine
Ribose-5-Phostphate is an intermediary in what pathway?
This enzyme catalyzes the conversion of bicarbonate and ammonia (from glutamine) to carbomoyl phosphate, releasing glutamate.
The commited step of de novo purine synthesis is conversion of PRPP to ____________________.
This molecule inhibits thymidine kinase
Creatine kinase is only made in muscle cells that are _________________.
Converts OMP to UMP
One type of this autosomal recessive disease stems from a deficiency of phenylalanine hydroxylase
This single bifunctional enzyme has the properties of orotate phosphotranfserase and OMP decaboxylase
Lysosomal degradation activity is ______________ during starvation? (Increased/Decreased)
Elimination of an amino group
Enzyme that converts deoyuridine to dUMP
What substrate is used to synthesize PRPP?
What is molecule is 'activated ribose'?
People with hyperammonemia are given ________________ so the body uses it for energy of protein
PRPP synthase is negatively regulated by ________________
This isoform of creatine kinase is found in smooth muscle and brain tissue and makes up only 1% of total CK.
Ketogenic amino acids yield which compound(s)?
CTP Synthase aminates UTP with an amino group from where?
If the CK found in the heart is greater than ______ U/L then an MI is probable.
20% of SCID cases are due to this enzyme deficiency
Purine nucleosides are converted to free bases by what enzyme?
This enzyme found in the gut cleaves urea to get carbon dioxide and ammonia.
This enzyme converts hypoxanthine to xanthine
Branched chain ketoacid dehydrogenase requires what cofactor?
What amino acid is added to IMP to make AMP?
In hereditary hyperammonemia the administration or citrulline and arginine is usually effective except in the case of _______________.
During periods of growth, pregnancy and convalescence the nitrogen balance is _________________.
Alanine, glycine, methionine, serine, threonine and valine are which type of N-terminal residues?
Most de novo nucleotide synthesis occurs where?
A deficiency of this enzyme would be indicated by citrullinemia.
This type of base is sythesized piece by piece directly on the ribose
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily activated
What enzyme converts ribonucleotides to deoxyribonucleotides
This small, basic protein tags proteins for degradation
The most effective treatment for SCID
The most commonly inherited urea enzyme deficiency
What are uric acid crystals interacting with in gouty arthritis?
HGPRT ___________________ causes an increase in the rate of purine synthesis. (Deficiency/Hyperactivity)
This enzyme converts neucleotides to nucleosides
A genetic mutation in what enzyme can cause increased de novo synthesis of purines and hyperuricemia
Since humans can't store purines we must get rid of them in this form
This molecule activtivates CPS-II
What immune cell uses primarily the salvage pathway for nucleotide synthesis?
This enzyme removes an ammonium ion from glutamate to make alpha-ketoglutarate.
Pyrophosphates are the basis of this drug class which is used to treat osteoporosis.
Lacking OMP decarboxylase or orotate phosphoribosyltransferase causes this rare metabolic condition. Patients often have aneamia, leukopenia and retarded development.
Transfer of an amino group from one amino acid to an amino acid carbon skeleton or alpha ketoacid.
Deamination occurs primarily on this amino acid because it is the end produce of many transamination reactions.
Increased BUN usually indicates ________________ disease.
________________ cause poor myelination and mental retardation.
This enzyme is deficient in albinism.
This drug binds to glutamine and is then excreted from the body in order to reduce the ammonia in the body
What enzyme synthesizes PRPP?
What molecule is at the branch point of de novo purine synthesis?
Cofactor of all aminotransferase reactions because amino group is first transferred to this molecule.
This metabolite inhibites ribonucleotide reductase leading to the inability of cells to synthesize deoxyribonucleotides and therefore DNA.
This enzyme converts 5-phosphoribosyl-1-pyrophosphate to 5-phosphoribosyl-1-amine
Phenylpyruvate and phenylacetate are _____________.
This enzyme converts Carbamoyl aspartate to Dihydroorotate
Creatine phosphate donates its phosphate group to ADP after _________________.
Coverts dihydroorotate to orotate with FAD
This enzyme can convert Adenosine to Inosine
Deficient enzyme in maple syrup urine disease
________________ have a maple/cheesy smell.
A deposit of urate crystals in someone with gout
This is the first enzyme to rise following a myocardial infarction and may only rise transiently and normalize in less thatn 3 days.
This is a common cause of acquired hyperammonemia.
This amino acid is used in the production of melanin
This enzyme converts Argininosuccinate to Arginine and Fumarate.
With what disease would a patient have high levels of valine, leucine and isoleucine in their blood?
This enzyme is deficient in histidinemia
How is maple syrup urine disease treated?
This enzyme catalyzes formation of AMP from adenine and PRPP
What amino acids are purely ketogenic?
The glycine residue at the carboxyl end of ubiquitin attaches to what residue on the target protein?
Presence of creatine kinase in the blood can indicate ___________________.
What type of reaction can create non-essential amino acids from essential amino acids or non-essential AAs from non-essential AAs.
This enzyme converts Xanthine to Uric Acid
A deficiency of this enzyme would be indicated by Argininosuccinic Acidemia
Treatment for Lesch-Nyhan Sydrome?
Homocystein and methionine levels are increased in this disease that causes mental retardation and dislocation of the lens of the eye.
Enzyme that converts thymidine to TMP
CPS-II is most sensitive to PRPP during what cell phase?
In PKU which amino acid becomes essential?
What is the product of the rate limiting step of the urea cycle
This enzyme combines ornithine and carbamoyl phosphate to make citrulline
What amino acid is added to IMP to make GMP?
This amino acid has two amino groups and is thus the most efficient carrier of ammonia
This genetic disease is characterized by self-mutilating behavior
Creatine phosphate 'buffers' ___________ during exercise so it doesn't significantly drop.
This transaminase enzyme helps the urea cycle by being involved in the recycling of fumarate to aspartate.
GMP, GDP, GTP, AMP, ADP and ATP all inhibit what enzyme?
This enzyme converts dihydrofolate to tetrahydrofolate
A genetic mutation leading to a deficiency in HGPRT leads to what condition?
This molecule inhibits CPS-II
Glycine, arginine and methionine are used to synthesize what?
This enzyme combines citrulline and aspartate to argininosuccinate
Enzyme that converts dUMP to dMP
A polymer of this chemical creates a black-brown pigment that deposits in connective tissue and can be seen in standing urine in people with alkoptonuria.
Aspartate, Arginine, Leucine, Lysine and Phenylalanine are which type of N-Terminal amino acids?
Segments rich in what amino acids are rapidly degraded? (acronym)
A muscle cell that is fully charged with CP has a __________:1 ratio of CP:ATP
What type of amino acids are not principally oxidized in the liver?
A deficiency of this enzyme would be indicated by Argininemia
This enzyme converts carbomoyl phosphate to carbomoyl aspartate
What enzyme is deficient in alkaptonuria?
During periods of malnutrition, starvation, cachexia and after traumatic injury the nitrogen balance is _________________.
In a healthy person ketovaline is broken down into ______________>
Deamination reactions create this highly toxic chemical that must be removed from the body.
This enzyme converts UTP to CTP
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Created Dec 17, 2012ReportNominate
Tags:biochemistry, nucleotide, protein

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