| Clue | Answer |
|---|
| Cofactor of all aminotransferase reactions because amino group is first transferred to this molecule. | |
| Deficiency of this enzyme would lead to increased levels of orotic acid | |
| What amino acid donates an amino group to PRPP? | |
| Increased BUN usually indicates ________________ disease. | |
| Phenylpyruvate and phenylacetate are _____________. | |
| What type of reaction can create non-essential amino acids from essential amino acids or non-essential AAs from non-essential AAs. | |
| This disease causes increased levels of histidine in the blood and urine and causes mental retardation | |
| This isoform of creatine kinase is found in smooth muscle and brain tissue and makes up only 1% of total CK. | |
| This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily activated | |
| One type of this autosomal recessive disease stems from a deficiency of phenylalanine hydroxylase | |
| Creatine phosphate 'buffers' ___________ during exercise so it doesn't significantly drop. | |
| Lacking OMP decarboxylase or orotate phosphoribosyltransferase causes this rare metabolic condition. Patients often have aneamia, leukopenia and retarded development. | |
| This enzyme removes an ammonium ion from glutamate to make alpha-ketoglutarate. | |
| This enzyme converts dihydrofolate to tetrahydrofolate | |
| A deficiency of this enzyme would be indicated by citrullinemia. | |
| This type of base is sythesized piece by piece directly on the ribose | |
| 20% of SCID cases are due to this enzyme deficiency | |
| PRPP synthase is negatively regulated by ________________ | |
| This amino acid has two amino groups and is thus the most efficient carrier of ammonia | |
| This enzyme catalyzes the formation of IMP and GMP from Hypoxanthine and Guanine and PRPP | |
| What type of amino acids are not principally oxidized in the liver? | |
| Deamination occurs primarily on this amino acid because it is the end produce of many transamination reactions. | |
| What immune cell carries out de novo synthesis of nucleotides? | |
| Aminotransferase put the amino group from alanine on alpha-ketoglutarate to form glutamate and ___________________. | |
| This small, basic protein tags proteins for degradation | |
| Purine nucleosides are converted to free bases by what enzyme? | |
| This isoform of creatine kinase is in skeletal muscle and makes up 95% of the CK in the body. | |
| Pyrophosphates are the basis of this drug class which is used to treat osteoporosis. | |
| What enzyme synthesizes PRPP? | |
| In PKU which amino acid becomes essential? | |
| Enzyme that converts thymidine to TMP | |
| This enzyme converts neucleotides to nucleosides | |
| If the CK found in the heart is greater than ______ U/L then an MI is probable. | |
| This amino acid is used in the production of melanin | |
| Coverts dihydroorotate to orotate with FAD | |
| Enzyme that converts dUMP to dMP | |
| This drug binds to glutamine and is then excreted from the body in order to reduce the ammonia in the body | |
| With what disease would a patient have high levels of valine, leucine and isoleucine in their blood? | |
| Segments rich in what amino acids are rapidly degraded? (acronym) | |
| What molecule is at the branch point of de novo purine synthesis? | |
| During periods of growth, pregnancy and convalescence the nitrogen balance is _________________. | |
| Lysosomal proteases that degrade protein in the lysosomal pathway | |
| The cofactor required for transamination reaction is a derivative of ______________. | |
| A polymer of this chemical creates a black-brown pigment that deposits in connective tissue and can be seen in standing urine in people with alkoptonuria. | |
| This genetic disease is characterized by self-mutilating behavior | |
| The methyl group needed for the conversion of dUMP to dTMP comes from... | |
| Branched chain ketoacid dehydrogenase requires what cofactor? | |
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