Science Quiz / Biochemistry: Protein and Nucleotide Metabolism

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Can you name the Biochemistry: Protein and Nucleotide Metabolism?

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ClueAnswer
________________ have a maple/cheesy smell.
This enzyme can convert Adenosine to Inosine
This enzyme converts Xanthine to Uric Acid
Transfer of an amino group from one amino acid to an amino acid carbon skeleton or alpha ketoacid.
CPS-II is most sensitive to PRPP during what cell phase?
Creatine kinase is only made in muscle cells that are _________________.
Enzyme that transaminates alanine
This enzyme catalyzes formation of AMP from adenine and PRPP
What is molecule is 'activated ribose'?
A deposit of urate crystals in someone with gout
Deficient enzyme in maple syrup urine disease
A genetic mutation in what enzyme can cause increased de novo synthesis of purines and hyperuricemia
A deficiency of this enzyme would be indicated by Argininemia
Elimination of an amino group
HGPRT ___________________ causes an increase in the rate of purine synthesis. (Deficiency/Hyperactivity)
Lysosomal degradation activity is ______________ during starvation? (Increased/Decreased)
Treatment for Lesch-Nyhan Sydrome?
This type of base is assembled completely first then attached to a ribose
GMP, GDP, GTP, AMP, ADP and ATP all inhibit what enzyme?
People with hyperammonemia are given ________________ so the body uses it for energy of protein
This enzyme converts UTP to CTP
This enzyme converts 5-phosphoribosyl-1-pyrophosphate to 5-phosphoribosyl-1-amine
This enzyme converts hypoxanthine to xanthine
Presence of creatine kinase in the blood can indicate ___________________.
Deamination reactions create this highly toxic chemical that must be removed from the body.
In hereditary hyperammonemia the administration or citrulline and arginine is usually effective except in the case of _______________.
Bicarbonate, aspartate and ammonia are used to make what?
This single bifunctional enzyme has the properties of orotate phosphotranfserase and OMP decaboxylase
This enzyme converts creatine to creatine phosphate.
During periods of malnutrition, starvation, cachexia and after traumatic injury the nitrogen balance is _________________.
Since humans can't store purines we must get rid of them in this form
This transaminase enzyme helps the urea cycle by being involved in the recycling of fumarate to aspartate.
This molecule allosterically activates CPS-I
A very high protein diet or starvation would lead to __________________ (induction/repression) of urea cycle enzymes.
Enzyme that converts deoyuridine to dUMP
This enzyme converts carbomoyl phosphate to carbomoyl aspartate
In a healthy person ketovaline is broken down into ______________>
This is a common cause of acquired hyperammonemia.
A genetic mutation leading to a deficiency in HGPRT leads to what condition?
The deficient enzyme in alkaptonuria breaks down tyrosine to form _____________.
This molecule activtivates CPS-II
This molecule inhibits CPS-II
What amino acid is added to IMP to make GMP?
The glycine residue at the carboxyl end of ubiquitin attaches to what residue on the target protein?
This enzyme is deficient in histidinemia
Converts OMP to UMP
Glycine, arginine and methionine are used to synthesize what?
ClueAnswer
Cofactor of all aminotransferase reactions because amino group is first transferred to this molecule.
Deficiency of this enzyme would lead to increased levels of orotic acid
What amino acid donates an amino group to PRPP?
Increased BUN usually indicates ________________ disease.
Phenylpyruvate and phenylacetate are _____________.
What type of reaction can create non-essential amino acids from essential amino acids or non-essential AAs from non-essential AAs.
This disease causes increased levels of histidine in the blood and urine and causes mental retardation
This isoform of creatine kinase is found in smooth muscle and brain tissue and makes up only 1% of total CK.
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily activated
One type of this autosomal recessive disease stems from a deficiency of phenylalanine hydroxylase
Creatine phosphate 'buffers' ___________ during exercise so it doesn't significantly drop.
Lacking OMP decarboxylase or orotate phosphoribosyltransferase causes this rare metabolic condition. Patients often have aneamia, leukopenia and retarded development.
This enzyme removes an ammonium ion from glutamate to make alpha-ketoglutarate.
This enzyme converts dihydrofolate to tetrahydrofolate
A deficiency of this enzyme would be indicated by citrullinemia.
This type of base is sythesized piece by piece directly on the ribose
20% of SCID cases are due to this enzyme deficiency
PRPP synthase is negatively regulated by ________________
This amino acid has two amino groups and is thus the most efficient carrier of ammonia
This enzyme catalyzes the formation of IMP and GMP from Hypoxanthine and Guanine and PRPP
What type of amino acids are not principally oxidized in the liver?
Deamination occurs primarily on this amino acid because it is the end produce of many transamination reactions.
What immune cell carries out de novo synthesis of nucleotides?
Aminotransferase put the amino group from alanine on alpha-ketoglutarate to form glutamate and ___________________.
This small, basic protein tags proteins for degradation
Purine nucleosides are converted to free bases by what enzyme?
This isoform of creatine kinase is in skeletal muscle and makes up 95% of the CK in the body.
Pyrophosphates are the basis of this drug class which is used to treat osteoporosis.
What enzyme synthesizes PRPP?
In PKU which amino acid becomes essential?
Enzyme that converts thymidine to TMP
This enzyme converts neucleotides to nucleosides
If the CK found in the heart is greater than ______ U/L then an MI is probable.
This amino acid is used in the production of melanin
Coverts dihydroorotate to orotate with FAD
Enzyme that converts dUMP to dMP
This drug binds to glutamine and is then excreted from the body in order to reduce the ammonia in the body
With what disease would a patient have high levels of valine, leucine and isoleucine in their blood?
Segments rich in what amino acids are rapidly degraded? (acronym)
What molecule is at the branch point of de novo purine synthesis?
During periods of growth, pregnancy and convalescence the nitrogen balance is _________________.
Lysosomal proteases that degrade protein in the lysosomal pathway
The cofactor required for transamination reaction is a derivative of ______________.
A polymer of this chemical creates a black-brown pigment that deposits in connective tissue and can be seen in standing urine in people with alkoptonuria.
This genetic disease is characterized by self-mutilating behavior
The methyl group needed for the conversion of dUMP to dTMP comes from...
Branched chain ketoacid dehydrogenase requires what cofactor?
ClueAnswer
Alanine, glycine, methionine, serine, threonine and valine are which type of N-terminal residues?
Enzyme that converts THF to N5, N10-methylene THF
________________ cause poor myelination and mental retardation.
This isoform of CK is found in the heart and is important in diagnosing MIs.
This molecule inhibits thymidine kinase
The most commonly inherited urea enzyme deficiency
Ribose-5-Phostphate is an intermediary in what pathway?
This enzyme converts Argininosuccinate to Arginine and Fumarate.
This enzyme combines ornithine and carbamoyl phosphate to make citrulline
Normal BUN:Creatinine level is ____________:1
This enzyme catalyzes the conversion of bicarbonate and ammonia (from glutamine) to carbomoyl phosphate, releasing glutamate.
Converts orotate to OMP
What amino acid is added to IMP to make AMP?
CPS-II is most sensitive to UTP during the end of which cell phase?
A muscle cell that is fully charged with CP has a __________:1 ratio of CP:ATP
Homocystinuria results from a deficiency of this enzyme
This metabolite inhibites ribonucleotide reductase leading to the inability of cells to synthesize deoxyribonucleotides and therefore DNA.
Ezyme that transaminates aspartate
This enzyme combines citrulline and aspartate to argininosuccinate
Ketogenic amino acids yield which compound(s)?
This enzyme converts Carbamoyl aspartate to Dihydroorotate
What substrate is used to synthesize PRPP?
What product builds up in ADA deficient SCID that inhibits deoxynucleotide synthesis
What is the product of the rate limiting step of the urea cycle
Homocystein and methionine levels are increased in this disease that causes mental retardation and dislocation of the lens of the eye.
This enzyme is deficient in albinism.
Most de novo nucleotide synthesis occurs where?
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily inhibited
Condition when uric acid crystals precipitate out of the blood
Decreased BUN usually indicates ______________ disease.
What enzyme converts ribonucleotides to deoxyribonucleotides
What is the base in IMP?
This enzyme adds an ammonium ion to glutamate to make glutamine
This enzyme found in the gut cleaves urea to get carbon dioxide and ammonia.
This drug binds to glycine in the liver and is excreted in order to reduce ammonia in the body.
Creatine phosphate donates its phosphate group to ADP after _________________.
How is maple syrup urine disease treated?
What enzyme is deficient in alkaptonuria?
This is the first enzyme to rise following a myocardial infarction and may only rise transiently and normalize in less thatn 3 days.
What amino acids are purely ketogenic?
The most effective treatment for SCID
A deficiency of this enzyme would be indicated by Argininosuccinic Acidemia
What immune cell uses primarily the salvage pathway for nucleotide synthesis?
The commited step of de novo purine synthesis is conversion of PRPP to ____________________.
Aspartate, Arginine, Leucine, Lysine and Phenylalanine are which type of N-Terminal amino acids?
CTP Synthase aminates UTP with an amino group from where?
What are uric acid crystals interacting with in gouty arthritis?

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