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Can you name the MDTI - ALL OF RHEUMATOLOGY?

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PromptsDiseases
Alcohol increases conversion of ATP to AMP; produces lactate that acts on URAT1
crescentic glomerulonephritis
cells express Bax, lymphocytes express BCLxl
hypertrophy of chondrocytes, but decrease in collagen production
Pathway: Nalp3 -> IL-1b -> NfkB -> attracting of neutrophils
Characterized by immune dysregulation/vascular dysfunction/fibrosis
anti-M3
Can be caused by increase in enzyme APRT
Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha
NALP3
environmental influence of vinyl plastics, hair dyes
Oxypurinol
ANA test involves permeabilizing cells
TGFb downregulated metalloproteinase release
Belimumab (1)
discoid rash
Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha, with TNF-alpha being the boss
4:1 female to male ratio
cholinesterase
associated with previous damage (RA, OA), diabetes mellitus, immunosuppression
Can be caused by deficiency of HGPRT
estrogen and prolactin cause activation/proliferation of lymphocytes
CREST
Interferon Signature (2)
75% of people get this
sialadenitis
renal hypertension due to medium vessel closure
Blys
Anti-Smith, Anti-dsDNA, Anti-SSB
cells inappropriately express both MHC1 and 2
Schirmer's test
BAFF
environmental triggers are UV exposure/DNA or RNA viruses/Medication
two causal reasons: highly vascularized synovium, no basement membrane
Anti-centromere antibodies seen in limited version
early, early disseminated, late disseminated spread
Uric Acid Kidney Stones
TGFb/SMAD signaling
fibrinoid kidney necrosis causes hypertension
lack of DHEA
PromptsDiseases
30% associated with HepB infection
polymorphisms in HLA DR2/DR3
Belimumab (2)
Interferon Signature (1)
URAT1
Can be caused by increase in enzyme XO
sicca
problems in the WNT pathway
cppd
CXCL 12 - T-cells
200-2000 white cells in joint fluid
Possible mimicry between retroviruses and anti-SCL70
Probenecid
transmural inflammation
Vascular injury may be initiating factor
Inflammasomes
IFN-g/TNFa both inhibit SMAD activity
cast nephritis
fibroblasts turn to myofibroblasts
antibiotic resistant arthritis possibly due to mimcry between OspA and LFA
IFN signal induced by DNA/RNA containing complexes
Vital Dye test
Comes in both diffuse/limited versions
treat with physical therapy, braces, NSAIDs
cytokines: TGFb, CTGF, PDGF(r)
CXCL 13 - B-cells
Fibrosis leading to ischemia and organ damage
Occurrence linked to ingestion of purine/pyrimidines, endogenous production of urate, and breakdown of tissues
TGFb/CTGF sensitize fibroblasts and increases collagen production
increase vascularization of cartilage which allows cytokine spread
Can be caused by increase in enzyme PRPP
HLA DQ7/DR5 associated
karryohexis
Tophi in olecranon bursa
slow progression over time
6% concordance among MZ twins
>50,000 cells, >95% PMN's
ectopic lymphoid follicles in salivary glands
90% male, correlated with obesity and alcohol use
anti-ssa/ssb (not lupus)
PromptsDiseases
subchondral sclerosis
treat acute flair up with NSAIDs, colchicine, corticosteroids
20-200 white cells in joint fluid
Cytokines: IL-6, IL-17, IFN-alpha
Mainly affects DIP, Knee, and 1st MCP joints
monoarthritic arthritis, usually 1st MTP/Knee/Ankle
Heberden's Node
malar rash
Defect in Complement Receptor 1, FCyR
Anti-SCl-70 (Topoisomerase 1)
cartilage fragments mediate inflammation
Raynaud's Phenomenon precedes it
Defect in clearance of apoptosis
40% twin concordance
2000-100,000 white cells in joint fluid
Genetic defect in COL1A2, TGFb, Fibrillin 1
Acute Uric Acid nephropathy (especially in cancer patients with chemo drugs)
African Americans have particularly high anti-SCL70, bad prognosis
A20 mutation leads to too much NfKb
Pyrazinamide, Nicotinate, Lactate all stimulate URAT1
msu crystals
3 stages, last one develops B cell Lymphoma
Bouchard's Node
IFNalpha upregulates TLR7/IRF7 to help uptake of DNA/RNA containing complexes
spares lung/kidneys
osteophytes
Sex hormones/chromosomes are important
Allopurinol
polymorphisms in C2/C4 genes
focus
interferon signature connects viral infection to lymphocyte invasion
cytoplasmic and perinuclear antibodies
lymphepithelial lesion
Febuxostat
Type I/III collagen production
fibroblasts upregulate PDGFr in response to TGFb
fibrillations
HLADRB1 association
anti-ANA are first important sign

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Created Feb 5, 2012ReportNominate
Tags:disease, prompt

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