Just For Fun Quiz / MDTI - ALL OF RHEUMATOLOGY

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QUIZ: Can you name the MDTI - ALL OF RHEUMATOLOGY?

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Score 0/119 Timer 20:00
PromptsDiseases
Vascular injury may be initiating factor
30% associated with HepB infection
African Americans have particularly high anti-SCL70, bad prognosis
lymphepithelial lesion
cytoplasmic and perinuclear antibodies
Blys
Vital Dye test
Anti-SCl-70 (Topoisomerase 1)
URAT1
interferon signature connects viral infection to lymphocyte invasion
Bouchard's Node
focus
karryohexis
TGFb downregulated metalloproteinase release
polymorphisms in C2/C4 genes
Characterized by immune dysregulation/vascular dysfunction/fibrosis
estrogen and prolactin cause activation/proliferation of lymphocytes
spares lung/kidneys
Comes in both diffuse/limited versions
cholinesterase
IFNalpha upregulates TLR7/IRF7 to help uptake of DNA/RNA containing complexes
Belimumab (1)
antibiotic resistant arthritis possibly due to mimcry between OspA and LFA
CXCL 12 - T-cells
discoid rash
two causal reasons: highly vascularized synovium, no basement membrane
environmental influence of vinyl plastics, hair dyes
anti-ssa/ssb (not lupus)
cells express Bax, lymphocytes express BCLxl
Heberden's Node
Acute Uric Acid nephropathy (especially in cancer patients with chemo drugs)
Oxypurinol
treat acute flair up with NSAIDs, colchicine, corticosteroids
Can be caused by increase in enzyme XO
sialadenitis
monoarthritic arthritis, usually 1st MTP/Knee/Ankle
HLADRB1 association
Anti-Smith, Anti-dsDNA, Anti-SSB
slow progression over time
6% concordance among MZ twins
PromptsDiseases
msu crystals
osteophytes
increase vascularization of cartilage which allows cytokine spread
Can be caused by increase in enzyme APRT
Schirmer's test
cells inappropriately express both MHC1 and 2
Type I/III collagen production
cast nephritis
fibroblasts turn to myofibroblasts
75% of people get this
crescentic glomerulonephritis
Occurrence linked to ingestion of purine/pyrimidines, endogenous production of urate, and breakdown of tissues
CREST
Uric Acid Kidney Stones
Probenecid
Sex hormones/chromosomes are important
subchondral sclerosis
NALP3
problems in the WNT pathway
Inflammasomes
90% male, correlated with obesity and alcohol use
Interferon Signature (2)
fibroblasts upregulate PDGFr in response to TGFb
malar rash
cartilage fragments mediate inflammation
ectopic lymphoid follicles in salivary glands
IFN signal induced by DNA/RNA containing complexes
fibrinoid kidney necrosis causes hypertension
Tophi in olecranon bursa
sicca
Allopurinol
Fibrosis leading to ischemia and organ damage
Febuxostat
renal hypertension due to medium vessel closure
Can be caused by increase in enzyme PRPP
anti-M3
Pathway: Nalp3 -> IL-1b -> NfkB -> attracting of neutrophils
HLA DQ7/DR5 associated
fibrillations
Raynaud's Phenomenon precedes it
PromptsDiseases
transmural inflammation
lack of DHEA
2000-100,000 white cells in joint fluid
Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha, with TNF-alpha being the boss
associated with previous damage (RA, OA), diabetes mellitus, immunosuppression
Interferon Signature (1)
3 stages, last one develops B cell Lymphoma
Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha
hypertrophy of chondrocytes, but decrease in collagen production
Alcohol increases conversion of ATP to AMP; produces lactate that acts on URAT1
TGFb/SMAD signaling
IFN-g/TNFa both inhibit SMAD activity
ANA test involves permeabilizing cells
polymorphisms in HLA DR2/DR3
cppd
40% twin concordance
CXCL 13 - B-cells
TGFb/CTGF sensitize fibroblasts and increases collagen production
Belimumab (2)
cytokines: TGFb, CTGF, PDGF(r)
Cytokines: IL-6, IL-17, IFN-alpha
Anti-centromere antibodies seen in limited version
>50,000 cells, >95% PMN's
Pyrazinamide, Nicotinate, Lactate all stimulate URAT1
4:1 female to male ratio
Genetic defect in COL1A2, TGFb, Fibrillin 1
environmental triggers are UV exposure/DNA or RNA viruses/Medication
early, early disseminated, late disseminated spread
200-2000 white cells in joint fluid
anti-ANA are first important sign
Defect in clearance of apoptosis
Mainly affects DIP, Knee, and 1st MCP joints
Can be caused by deficiency of HGPRT
20-200 white cells in joint fluid
treat with physical therapy, braces, NSAIDs
Possible mimicry between retroviruses and anti-SCL70
Defect in Complement Receptor 1, FCyR
A20 mutation leads to too much NfKb
BAFF

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