Just For Fun Quiz / MDTI - ALL OF RHEUMATOLOGY

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Can you name the MDTI - ALL OF RHEUMATOLOGY?

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Score 0/119 Timer 20:00
PromptsDiseases
early, early disseminated, late disseminated spread
Fibrosis leading to ischemia and organ damage
fibroblasts turn to myofibroblasts
90% male, correlated with obesity and alcohol use
cholinesterase
fibrinoid kidney necrosis causes hypertension
slow progression over time
environmental triggers are UV exposure/DNA or RNA viruses/Medication
African Americans have particularly high anti-SCL70, bad prognosis
Tophi in olecranon bursa
msu crystals
focus
IFN-g/TNFa both inhibit SMAD activity
Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha
Defect in clearance of apoptosis
2000-100,000 white cells in joint fluid
subchondral sclerosis
osteophytes
Vital Dye test
Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha, with TNF-alpha being the boss
40% twin concordance
cppd
URAT1
hypertrophy of chondrocytes, but decrease in collagen production
polymorphisms in C2/C4 genes
TGFb/CTGF sensitize fibroblasts and increases collagen production
Oxypurinol
renal hypertension due to medium vessel closure
Type I/III collagen production
HLA DQ7/DR5 associated
IFNalpha upregulates TLR7/IRF7 to help uptake of DNA/RNA containing complexes
cytoplasmic and perinuclear antibodies
BAFF
20-200 white cells in joint fluid
Heberden's Node
3 stages, last one develops B cell Lymphoma
Occurrence linked to ingestion of purine/pyrimidines, endogenous production of urate, and breakdown of tissues
anti-ANA are first important sign
cells express Bax, lymphocytes express BCLxl
IFN signal induced by DNA/RNA containing complexes
PromptsDiseases
Sex hormones/chromosomes are important
CXCL 13 - B-cells
two causal reasons: highly vascularized synovium, no basement membrane
NALP3
Belimumab (1)
Alcohol increases conversion of ATP to AMP; produces lactate that acts on URAT1
Defect in Complement Receptor 1, FCyR
ectopic lymphoid follicles in salivary glands
sicca
treat acute flair up with NSAIDs, colchicine, corticosteroids
monoarthritic arthritis, usually 1st MTP/Knee/Ankle
associated with previous damage (RA, OA), diabetes mellitus, immunosuppression
discoid rash
Allopurinol
Inflammasomes
interferon signature connects viral infection to lymphocyte invasion
anti-ssa/ssb (not lupus)
TGFb downregulated metalloproteinase release
Belimumab (2)
Can be caused by increase in enzyme APRT
environmental influence of vinyl plastics, hair dyes
sialadenitis
karryohexis
cells inappropriately express both MHC1 and 2
Pathway: Nalp3 -> IL-1b -> NfkB -> attracting of neutrophils
Febuxostat
Uric Acid Kidney Stones
Raynaud's Phenomenon precedes it
spares lung/kidneys
cast nephritis
Vascular injury may be initiating factor
Cytokines: IL-6, IL-17, IFN-alpha
cartilage fragments mediate inflammation
200-2000 white cells in joint fluid
30% associated with HepB infection
Characterized by immune dysregulation/vascular dysfunction/fibrosis
Bouchard's Node
ANA test involves permeabilizing cells
Acute Uric Acid nephropathy (especially in cancer patients with chemo drugs)
A20 mutation leads to too much NfKb
PromptsDiseases
fibroblasts upregulate PDGFr in response to TGFb
Anti-Smith, Anti-dsDNA, Anti-SSB
>50,000 cells, >95% PMN's
Interferon Signature (1)
CREST
treat with physical therapy, braces, NSAIDs
fibrillations
6% concordance among MZ twins
Can be caused by increase in enzyme XO
Possible mimicry between retroviruses and anti-SCL70
TGFb/SMAD signaling
Can be caused by increase in enzyme PRPP
lack of DHEA
anti-M3
Anti-SCl-70 (Topoisomerase 1)
estrogen and prolactin cause activation/proliferation of lymphocytes
4:1 female to male ratio
Can be caused by deficiency of HGPRT
malar rash
Pyrazinamide, Nicotinate, Lactate all stimulate URAT1
Blys
Genetic defect in COL1A2, TGFb, Fibrillin 1
transmural inflammation
HLADRB1 association
CXCL 12 - T-cells
75% of people get this
problems in the WNT pathway
Mainly affects DIP, Knee, and 1st MCP joints
increase vascularization of cartilage which allows cytokine spread
Comes in both diffuse/limited versions
Interferon Signature (2)
Schirmer's test
cytokines: TGFb, CTGF, PDGF(r)
antibiotic resistant arthritis possibly due to mimcry between OspA and LFA
polymorphisms in HLA DR2/DR3
crescentic glomerulonephritis
Anti-centromere antibodies seen in limited version
lymphepithelial lesion
Probenecid

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