Just For Fun Quiz / MDTI - ALL OF RHEUMATOLOGY

Random Just For Fun Quiz

Can you name the MDTI - ALL OF RHEUMATOLOGY?

Quiz not verified by Sporcle

Forced Order
Challenge
Share
Tweet
Embed
Score 0/119 Timer 20:00
PromptsDiseases
cytoplasmic and perinuclear antibodies
early, early disseminated, late disseminated spread
treat with physical therapy, braces, NSAIDs
Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha, with TNF-alpha being the boss
90% male, correlated with obesity and alcohol use
anti-ssa/ssb (not lupus)
CXCL 12 - T-cells
cppd
Comes in both diffuse/limited versions
20-200 white cells in joint fluid
2000-100,000 white cells in joint fluid
URAT1
BAFF
Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha
Anti-centromere antibodies seen in limited version
Vascular injury may be initiating factor
problems in the WNT pathway
A20 mutation leads to too much NfKb
Schirmer's test
Characterized by immune dysregulation/vascular dysfunction/fibrosis
Allopurinol
cells inappropriately express both MHC1 and 2
two causal reasons: highly vascularized synovium, no basement membrane
environmental triggers are UV exposure/DNA or RNA viruses/Medication
transmural inflammation
Can be caused by increase in enzyme PRPP
IFN-g/TNFa both inhibit SMAD activity
Anti-SCl-70 (Topoisomerase 1)
30% associated with HepB infection
monoarthritic arthritis, usually 1st MTP/Knee/Ankle
HLADRB1 association
associated with previous damage (RA, OA), diabetes mellitus, immunosuppression
Sex hormones/chromosomes are important
IFN signal induced by DNA/RNA containing complexes
subchondral sclerosis
Alcohol increases conversion of ATP to AMP; produces lactate that acts on URAT1
75% of people get this
increase vascularization of cartilage which allows cytokine spread
treat acute flair up with NSAIDs, colchicine, corticosteroids
Inflammasomes
PromptsDiseases
Interferon Signature (1)
Belimumab (2)
TGFb downregulated metalloproteinase release
Probenecid
Raynaud's Phenomenon precedes it
crescentic glomerulonephritis
Can be caused by increase in enzyme APRT
CXCL 13 - B-cells
Acute Uric Acid nephropathy (especially in cancer patients with chemo drugs)
cartilage fragments mediate inflammation
Oxypurinol
NALP3
environmental influence of vinyl plastics, hair dyes
spares lung/kidneys
Anti-Smith, Anti-dsDNA, Anti-SSB
TGFb/SMAD signaling
TGFb/CTGF sensitize fibroblasts and increases collagen production
cytokines: TGFb, CTGF, PDGF(r)
anti-M3
lack of DHEA
fibroblasts turn to myofibroblasts
HLA DQ7/DR5 associated
6% concordance among MZ twins
4:1 female to male ratio
cast nephritis
CREST
interferon signature connects viral infection to lymphocyte invasion
Can be caused by increase in enzyme XO
polymorphisms in HLA DR2/DR3
Occurrence linked to ingestion of purine/pyrimidines, endogenous production of urate, and breakdown of tissues
>50,000 cells, >95% PMN's
Bouchard's Node
osteophytes
Tophi in olecranon bursa
discoid rash
Defect in clearance of apoptosis
fibroblasts upregulate PDGFr in response to TGFb
200-2000 white cells in joint fluid
IFNalpha upregulates TLR7/IRF7 to help uptake of DNA/RNA containing complexes
Cytokines: IL-6, IL-17, IFN-alpha
PromptsDiseases
Type I/III collagen production
Heberden's Node
Pyrazinamide, Nicotinate, Lactate all stimulate URAT1
cholinesterase
sialadenitis
antibiotic resistant arthritis possibly due to mimcry between OspA and LFA
Febuxostat
Interferon Signature (2)
anti-ANA are first important sign
ANA test involves permeabilizing cells
hypertrophy of chondrocytes, but decrease in collagen production
Pathway: Nalp3 -> IL-1b -> NfkB -> attracting of neutrophils
renal hypertension due to medium vessel closure
Can be caused by deficiency of HGPRT
Blys
slow progression over time
Defect in Complement Receptor 1, FCyR
Vital Dye test
focus
African Americans have particularly high anti-SCL70, bad prognosis
karryohexis
cells express Bax, lymphocytes express BCLxl
fibrillations
40% twin concordance
Possible mimicry between retroviruses and anti-SCL70
malar rash
lymphepithelial lesion
sicca
Belimumab (1)
Fibrosis leading to ischemia and organ damage
3 stages, last one develops B cell Lymphoma
Genetic defect in COL1A2, TGFb, Fibrillin 1
fibrinoid kidney necrosis causes hypertension
polymorphisms in C2/C4 genes
Uric Acid Kidney Stones
msu crystals
ectopic lymphoid follicles in salivary glands
Mainly affects DIP, Knee, and 1st MCP joints
estrogen and prolactin cause activation/proliferation of lymphocytes

You're not logged in!

Compare scores with friends on all Sporcle quizzes.
Join for Free
OR
Log In

You Might Also Like...

Show Comments

Extras

Top Quizzes Today


Score Distribution

Your Account Isn't Verified!

In order to create a playlist on Sporcle, you need to verify the email address you used during registration. Go to your Sporcle Settings to finish the process.

Report this User

Report this user for behavior that violates our Community Guidelines.

Details: