Just For Fun Quiz / MDTI - ALL OF RHEUMATOLOGY

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Can you name the MDTI - ALL OF RHEUMATOLOGY?

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PromptsDiseases
fibrillations
40% twin concordance
renal hypertension due to medium vessel closure
msu crystals
cholinesterase
transmural inflammation
karryohexis
CXCL 12 - T-cells
CXCL 13 - B-cells
Pyrazinamide, Nicotinate, Lactate all stimulate URAT1
cartilage fragments mediate inflammation
treat acute flair up with NSAIDs, colchicine, corticosteroids
90% male, correlated with obesity and alcohol use
Schirmer's test
antibiotic resistant arthritis possibly due to mimcry between OspA and LFA
malar rash
Belimumab (1)
fibrinoid kidney necrosis causes hypertension
Characterized by immune dysregulation/vascular dysfunction/fibrosis
Genetic defect in COL1A2, TGFb, Fibrillin 1
200-2000 white cells in joint fluid
cells express Bax, lymphocytes express BCLxl
Raynaud's Phenomenon precedes it
lack of DHEA
75% of people get this
interferon signature connects viral infection to lymphocyte invasion
Type I/III collagen production
problems in the WNT pathway
Febuxostat
spares lung/kidneys
Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha, with TNF-alpha being the boss
treat with physical therapy, braces, NSAIDs
30% associated with HepB infection
4:1 female to male ratio
polymorphisms in HLA DR2/DR3
Probenecid
cytoplasmic and perinuclear antibodies
Vascular injury may be initiating factor
associated with previous damage (RA, OA), diabetes mellitus, immunosuppression
BAFF
PromptsDiseases
estrogen and prolactin cause activation/proliferation of lymphocytes
Interferon Signature (2)
environmental triggers are UV exposure/DNA or RNA viruses/Medication
hypertrophy of chondrocytes, but decrease in collagen production
focus
Defect in clearance of apoptosis
slow progression over time
anti-ssa/ssb (not lupus)
Uric Acid Kidney Stones
CREST
anti-ANA are first important sign
ectopic lymphoid follicles in salivary glands
Tophi in olecranon bursa
Occurrence linked to ingestion of purine/pyrimidines, endogenous production of urate, and breakdown of tissues
Cytokines: IL-6, IL-17, IFN-alpha
Fibrosis leading to ischemia and organ damage
increase vascularization of cartilage which allows cytokine spread
Blys
TGFb/CTGF sensitize fibroblasts and increases collagen production
Anti-centromere antibodies seen in limited version
fibroblasts turn to myofibroblasts
IFNalpha upregulates TLR7/IRF7 to help uptake of DNA/RNA containing complexes
TGFb/SMAD signaling
Alcohol increases conversion of ATP to AMP; produces lactate that acts on URAT1
environmental influence of vinyl plastics, hair dyes
IFN signal induced by DNA/RNA containing complexes
cppd
>50,000 cells, >95% PMN's
Vital Dye test
Oxypurinol
anti-M3
Heberden's Node
discoid rash
Can be caused by increase in enzyme PRPP
Can be caused by increase in enzyme XO
Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha
Allopurinol
sicca
A20 mutation leads to too much NfKb
Can be caused by deficiency of HGPRT
PromptsDiseases
HLA DQ7/DR5 associated
fibroblasts upregulate PDGFr in response to TGFb
sialadenitis
crescentic glomerulonephritis
African Americans have particularly high anti-SCL70, bad prognosis
Interferon Signature (1)
cells inappropriately express both MHC1 and 2
Anti-Smith, Anti-dsDNA, Anti-SSB
TGFb downregulated metalloproteinase release
Defect in Complement Receptor 1, FCyR
two causal reasons: highly vascularized synovium, no basement membrane
polymorphisms in C2/C4 genes
early, early disseminated, late disseminated spread
Comes in both diffuse/limited versions
Inflammasomes
ANA test involves permeabilizing cells
cytokines: TGFb, CTGF, PDGF(r)
cast nephritis
Belimumab (2)
Mainly affects DIP, Knee, and 1st MCP joints
Pathway: Nalp3 -> IL-1b -> NfkB -> attracting of neutrophils
NALP3
subchondral sclerosis
Sex hormones/chromosomes are important
HLADRB1 association
6% concordance among MZ twins
Acute Uric Acid nephropathy (especially in cancer patients with chemo drugs)
monoarthritic arthritis, usually 1st MTP/Knee/Ankle
Can be caused by increase in enzyme APRT
Possible mimicry between retroviruses and anti-SCL70
osteophytes
Anti-SCl-70 (Topoisomerase 1)
URAT1
2000-100,000 white cells in joint fluid
20-200 white cells in joint fluid
lymphepithelial lesion
Bouchard's Node
IFN-g/TNFa both inhibit SMAD activity
3 stages, last one develops B cell Lymphoma

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Created Feb 5, 2012ReportNominate
Tags:disease, prompt

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