Science Quiz / MDTI - Dale Frank Lectures

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Can you name the MDTI NHL buzzwords?

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hypovolemia due to hypercalcemia
three main types: endemic, sporadic, everyone has aids
arises from chronic inflammation (h.pylori, campy, burrelia, HepC?)
abdominal (ileocecal) masses more common
Ki67 100%
mott cells
uncommon, less than 5 percent
smudge cells
30-50% transform to DLBCL
spectrum from monoclonal gammopathy of undetermined significance
most common lymphoid malignancy in childhood
60% nodal, 40% extranodal in GI (unlike indolent lymphomas)
osteoclast activation leads to hypercalcemia
Observation/Rituximab/CHOP as treatment
15-30% become prolymphocytic leukemia
Bence Jones protein
male to female ratio is 2:1
3 cardinal features: small mature lymphos, monocytoid B cells, plasma cells
renal failure (casting) due to paraprotein
pleiomorphic and heterogenous, difficult to predict behavior
extreme paraprotein production
two main types: germinal center or activated b cell
diffuse effacement/psuedofollicles
spread quickly to other mucosal sites but may be treated with antibiotics early
lipid vacuoles in cells
interstitial aggregates
peripheral blood involvement very common
Does dale frank hate medical students? (T/F)
Ki67 rate is low
lymphoepithelial lesions
diagnosis (immunophenotype) of exclusion; BCL2+, CD10-, BCL6-
Toughie: tumor inhibiting miR-15a/MiR-16-1 lost with 13q deletion
not technically a lymphoma, but does involve mature B cells
50% IgG, 25% IgA
10% undergo Richter's transformation
aggressive extranodal with CNS involvement
presents at single site, bring patients in early
grading based on centroblast number/nodular vs. diffuse growth
serum hyperviscosity
morphology (centroblastic/immunoblastic) not important
marrow replacement leads to severe anemia
most common lymphoid malignancy in African Americans
huge expansion of marginal zone
t(11:18) common/ also t(1:14) and t(14:18)
Most common NHL
MUM1 (IRF4), BCL6, BCL10 positive
flame cell
age>60, LDH levels up, multiple extranodal involvement are all bad prognostic signs
85% Bone Marrow involvement
multifocal, destroys bone
plasma cells account for 10% of cellularity
three separate diseases: nodal, extranodal, splenic
1/3 of all NHL's
extranodal involvement uncommon
proliferation rate is high, Ki67+ 40-90%
paratrabecular aggregates
can evolve or start de novo
severe immunodeficiency due to paraprotein
treatment must begin IMMEDIATELY
EBV positive is sometimes seen (not burkitt's!)
really attacks facial bones
starry sky
express CD56 (NCAM)
BCL6+, CD10+, BCL2-
Zap 70+ or Zap 70 -
paraprotein production (sometimes)
fish-flesh appearance
10-15% get AIHA caused by benign cells
t(8;14) cMYC translocation
deletion 13q/11q/trisomy 12/17p
most common leukemia in adults

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