Science Quiz / MDTI - Dale Frank Lectures

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Can you name the MDTI NHL buzzwords?

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plasma cells account for 10% of cellularity
age>60, LDH levels up, multiple extranodal involvement are all bad prognostic signs
presents at single site, bring patients in early
aggressive extranodal with CNS involvement
osteoclast activation leads to hypercalcemia
fish-flesh appearance
hypovolemia due to hypercalcemia
treatment must begin IMMEDIATELY
10-15% get AIHA caused by benign cells
interstitial aggregates
lymphoepithelial lesions
Zap 70+ or Zap 70 -
paratrabecular aggregates
starry sky
extreme paraprotein production
huge expansion of marginal zone
lipid vacuoles in cells
mott cells
uncommon, less than 5 percent
pleiomorphic and heterogenous, difficult to predict behavior
most common leukemia in adults
15-30% become prolymphocytic leukemia
flame cell
diagnosis (immunophenotype) of exclusion; BCL2+, CD10-, BCL6-
Most common NHL
can evolve or start de novo
really attacks facial bones
MUM1 (IRF4), BCL6, BCL10 positive
60% nodal, 40% extranodal in GI (unlike indolent lymphomas)
spread quickly to other mucosal sites but may be treated with antibiotics early
Ki67 100%
three main types: endemic, sporadic, everyone has aids
BCL6+, CD10+, BCL2-
t(11:18) common/ also t(1:14) and t(14:18)
arises from chronic inflammation (h.pylori, campy, burrelia, HepC?)
10% undergo Richter's transformation
3 cardinal features: small mature lymphos, monocytoid B cells, plasma cells
Observation/Rituximab/CHOP as treatment
1/3 of all NHL's
smudge cells
50% IgG, 25% IgA
Does dale frank hate medical students? (T/F)
deletion 13q/11q/trisomy 12/17p
renal failure (casting) due to paraprotein
t(8;14) cMYC translocation
multifocal, destroys bone
proliferation rate is high, Ki67+ 40-90%
two main types: germinal center or activated b cell
Toughie: tumor inhibiting miR-15a/MiR-16-1 lost with 13q deletion
three separate diseases: nodal, extranodal, splenic
85% Bone Marrow involvement
extranodal involvement uncommon
grading based on centroblast number/nodular vs. diffuse growth
severe immunodeficiency due to paraprotein
abdominal (ileocecal) masses more common
EBV positive is sometimes seen (not burkitt's!)
paraprotein production (sometimes)
male to female ratio is 2:1
30-50% transform to DLBCL
express CD56 (NCAM)
not technically a lymphoma, but does involve mature B cells
morphology (centroblastic/immunoblastic) not important
most common lymphoid malignancy in African Americans
spectrum from monoclonal gammopathy of undetermined significance
peripheral blood involvement very common
serum hyperviscosity
diffuse effacement/psuedofollicles
Ki67 rate is low
Bence Jones protein
marrow replacement leads to severe anemia
most common lymphoid malignancy in childhood

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Created Feb 5, 2012ReportNominate
Tags:NHL Quiz, buzzard, dale, frank

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