Science Quiz / MDTI - Dale Frank Lectures

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Can you name the MDTI NHL buzzwords?

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Most common NHL
Bence Jones protein
most common lymphoid malignancy in childhood
osteoclast activation leads to hypercalcemia
most common lymphoid malignancy in African Americans
not technically a lymphoma, but does involve mature B cells
paratrabecular aggregates
t(8;14) cMYC translocation
pleiomorphic and heterogenous, difficult to predict behavior
10% undergo Richter's transformation
arises from chronic inflammation (h.pylori, campy, burrelia, HepC?)
extranodal involvement uncommon
starry sky
plasma cells account for 10% of cellularity
lymphoepithelial lesions
presents at single site, bring patients in early
Ki67 100%
morphology (centroblastic/immunoblastic) not important
really attacks facial bones
60% nodal, 40% extranodal in GI (unlike indolent lymphomas)
multifocal, destroys bone
renal failure (casting) due to paraprotein
uncommon, less than 5 percent
Toughie: tumor inhibiting miR-15a/MiR-16-1 lost with 13q deletion
interstitial aggregates
EBV positive is sometimes seen (not burkitt's!)
age>60, LDH levels up, multiple extranodal involvement are all bad prognostic signs
treatment must begin IMMEDIATELY
express CD56 (NCAM)
grading based on centroblast number/nodular vs. diffuse growth
Zap 70+ or Zap 70 -
hypovolemia due to hypercalcemia
50% IgG, 25% IgA
Observation/Rituximab/CHOP as treatment
spread quickly to other mucosal sites but may be treated with antibiotics early
paraprotein production (sometimes)
two main types: germinal center or activated b cell
huge expansion of marginal zone
fish-flesh appearance
severe immunodeficiency due to paraprotein
Does dale frank hate medical students? (T/F)
lipid vacuoles in cells
can evolve or start de novo
flame cell
85% Bone Marrow involvement
three main types: endemic, sporadic, everyone has aids
three separate diseases: nodal, extranodal, splenic
proliferation rate is high, Ki67+ 40-90%
BCL6+, CD10+, BCL2-
t(11:18) common/ also t(1:14) and t(14:18)
Ki67 rate is low
1/3 of all NHL's
serum hyperviscosity
deletion 13q/11q/trisomy 12/17p
diagnosis (immunophenotype) of exclusion; BCL2+, CD10-, BCL6-
peripheral blood involvement very common
3 cardinal features: small mature lymphos, monocytoid B cells, plasma cells
abdominal (ileocecal) masses more common
male to female ratio is 2:1
spectrum from monoclonal gammopathy of undetermined significance
MUM1 (IRF4), BCL6, BCL10 positive
most common leukemia in adults
mott cells
aggressive extranodal with CNS involvement
10-15% get AIHA caused by benign cells
15-30% become prolymphocytic leukemia
marrow replacement leads to severe anemia
extreme paraprotein production
smudge cells
30-50% transform to DLBCL
diffuse effacement/psuedofollicles

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