Science Quiz / MDTI - Dale Frank Lectures

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Can you name the MDTI NHL buzzwords?

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most common lymphoid malignancy in African Americans
interstitial aggregates
fish-flesh appearance
BCL6+, CD10+, BCL2-
morphology (centroblastic/immunoblastic) not important
arises from chronic inflammation (h.pylori, campy, burrelia, HepC?)
spread quickly to other mucosal sites but may be treated with antibiotics early
mott cells
t(8;14) cMYC translocation
can evolve or start de novo
15-30% become prolymphocytic leukemia
diagnosis (immunophenotype) of exclusion; BCL2+, CD10-, BCL6-
express CD56 (NCAM)
grading based on centroblast number/nodular vs. diffuse growth
Ki67 100%
huge expansion of marginal zone
diffuse effacement/psuedofollicles
60% nodal, 40% extranodal in GI (unlike indolent lymphomas)
peripheral blood involvement very common
50% IgG, 25% IgA
presents at single site, bring patients in early
lipid vacuoles in cells
MUM1 (IRF4), BCL6, BCL10 positive
paratrabecular aggregates
severe immunodeficiency due to paraprotein
smudge cells
osteoclast activation leads to hypercalcemia
aggressive extranodal with CNS involvement
three separate diseases: nodal, extranodal, splenic
pleiomorphic and heterogenous, difficult to predict behavior
EBV positive is sometimes seen (not burkitt's!)
most common leukemia in adults
Toughie: tumor inhibiting miR-15a/MiR-16-1 lost with 13q deletion
30-50% transform to DLBCL
spectrum from monoclonal gammopathy of undetermined significance
Zap 70+ or Zap 70 -
Most common NHL
10-15% get AIHA caused by benign cells
deletion 13q/11q/trisomy 12/17p
Observation/Rituximab/CHOP as treatment
t(11:18) common/ also t(1:14) and t(14:18)
not technically a lymphoma, but does involve mature B cells
uncommon, less than 5 percent
lymphoepithelial lesions
85% Bone Marrow involvement
proliferation rate is high, Ki67+ 40-90%
most common lymphoid malignancy in childhood
Ki67 rate is low
treatment must begin IMMEDIATELY
male to female ratio is 2:1
starry sky
serum hyperviscosity
three main types: endemic, sporadic, everyone has aids
two main types: germinal center or activated b cell
paraprotein production (sometimes)
marrow replacement leads to severe anemia
10% undergo Richter's transformation
abdominal (ileocecal) masses more common
plasma cells account for 10% of cellularity
extreme paraprotein production
hypovolemia due to hypercalcemia
renal failure (casting) due to paraprotein
age>60, LDH levels up, multiple extranodal involvement are all bad prognostic signs
really attacks facial bones
Does dale frank hate medical students? (T/F)
1/3 of all NHL's
Bence Jones protein
extranodal involvement uncommon
3 cardinal features: small mature lymphos, monocytoid B cells, plasma cells
flame cell
multifocal, destroys bone

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Created Feb 5, 2012ReportNominate
Tags:NHL Quiz, buzzard, dale, frank

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