Science Quiz / MDTI - Dale Frank Lectures

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Can you name the MDTI NHL buzzwords?

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Toughie: tumor inhibiting miR-15a/MiR-16-1 lost with 13q deletion
treatment must begin IMMEDIATELY
extranodal involvement uncommon
smudge cells
paratrabecular aggregates
1/3 of all NHL's
MUM1 (IRF4), BCL6, BCL10 positive
abdominal (ileocecal) masses more common
serum hyperviscosity
huge expansion of marginal zone
EBV positive is sometimes seen (not burkitt's!)
multifocal, destroys bone
mott cells
deletion 13q/11q/trisomy 12/17p
three separate diseases: nodal, extranodal, splenic
t(8;14) cMYC translocation
15-30% become prolymphocytic leukemia
most common lymphoid malignancy in African Americans
flame cell
60% nodal, 40% extranodal in GI (unlike indolent lymphomas)
lymphoepithelial lesions
30-50% transform to DLBCL
pleiomorphic and heterogenous, difficult to predict behavior
proliferation rate is high, Ki67+ 40-90%
not technically a lymphoma, but does involve mature B cells
t(11:18) common/ also t(1:14) and t(14:18)
peripheral blood involvement very common
Observation/Rituximab/CHOP as treatment
Most common NHL
Zap 70+ or Zap 70 -
marrow replacement leads to severe anemia
renal failure (casting) due to paraprotein
age>60, LDH levels up, multiple extranodal involvement are all bad prognostic signs
three main types: endemic, sporadic, everyone has aids
plasma cells account for 10% of cellularity
grading based on centroblast number/nodular vs. diffuse growth
most common leukemia in adults
presents at single site, bring patients in early
arises from chronic inflammation (h.pylori, campy, burrelia, HepC?)
10% undergo Richter's transformation
really attacks facial bones
85% Bone Marrow involvement
fish-flesh appearance
spread quickly to other mucosal sites but may be treated with antibiotics early
3 cardinal features: small mature lymphos, monocytoid B cells, plasma cells
10-15% get AIHA caused by benign cells
extreme paraprotein production
Does dale frank hate medical students? (T/F)
interstitial aggregates
spectrum from monoclonal gammopathy of undetermined significance
osteoclast activation leads to hypercalcemia
50% IgG, 25% IgA
starry sky
aggressive extranodal with CNS involvement
can evolve or start de novo
severe immunodeficiency due to paraprotein
male to female ratio is 2:1
BCL6+, CD10+, BCL2-
lipid vacuoles in cells
Ki67 rate is low
hypovolemia due to hypercalcemia
morphology (centroblastic/immunoblastic) not important
express CD56 (NCAM)
two main types: germinal center or activated b cell
diagnosis (immunophenotype) of exclusion; BCL2+, CD10-, BCL6-
Bence Jones protein
most common lymphoid malignancy in childhood
diffuse effacement/psuedofollicles
uncommon, less than 5 percent
paraprotein production (sometimes)
Ki67 100%

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