Science Quiz / USMLE First Aid Rapid Review - Classic Labs / Findings

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Can you name the USMLE First Aid Rapid Review - Classic Labs / Findings?

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Clinical presentationDiagnosis / diseasecharacteristic features
Dysplastic squamous cervical cells with enlargement and hyperchromasia
“Brown” tumor of bone
Antiplatelet antibodies
“boot shaped heart on X-ray
Bloody tap on LP
Mucin-filled cell with peripheral nucleus
Polished, “ivory-like appearance of bone at cartilage erosion
Monoclonal antibody spike (normal consequences of aging)
Honeycomb lung on x-ray
Periosteum raised from bone, creating triangular area
Hexagonal, double-pointed, needle-like crystals in bronchial secretions
Nodular hyaline deposits in glomeruli
Antihistone antibodies
Anti-IgG antibodies
Thrombi made of white / red layers
Eosinophilic cytoplasmic inclusion in liver cell
Branching gram-positive rods with sulfur granules
Disarrayed granulosa cells in eosinophilic fluid
“Nutmeg” appearance of liver
Antinuclear antibodies (ANAs: anti-Smith and anti-dsDNA)
Desquamated epithelium casts in sputum
“Soap bubble” in femur or tibia on x-ray
“Tram-track” appearance on LM
Colonies of mucoid Pseudomonas in lungs
Heart nodules (inflammatory)
Thyroid-like appearance of kidney
RBC casts in urine
“Hair-on-end” (crew cut) appearance on x-ray
Eosinophilic globule in liver
Degeneration of dorsal column nerves
Needle-shaped, negatively birefringent crystals
WBCs that look “smudged”
“Chocolate cyst” of ovary
Anti-neutrophil cytoplasmic antibodies
Clinical presentationDiagnosis / diseasecharacteristic features
Heterophile antibodies
Lytic (hole-punched) bone lesions on x-ray
Hypochromic, microcytic anemia (abnormal hemoglobin)
Hilar lymphadenopathy, peripheral granulomatous lesion in middle or lower lung lobes (can calcify)
Anticentromere antibodies
“wire-loop” glomerular appearance on LM
Increased uric acid levels (hypertension)
Monoclonal antibody spike (M protein = usually IgG or IgA)
Monoclonal antibody spike (AL)
Anti-topoisomerase antibodies
Increased uric acid levels (HGPRT deficiency)
Rhomboid crystals, positive birefringent
Protein aggregates in neurons from hyperphosphorylation of protein tau
Sheets of medium-sized lymphoid cells (“starry sky” appearance on histology)
Anti-mitochondrial antibodies
Basophilci nuclear remnants in RBCs
Bronchogenic apical lung tumor
Mammary gland (blue-domed) cyst
Eosinophilic inclusion bodies in cytoplasm of hippocampal nerve cells
Podocyte fusion on EM
Depigmentation of neurons in substantia nigra
Anti-glomerular basement membrane antibodies
Stacks of red blood cells
Enlarged cells with intranuclear inclusion bodies
Cellular crescents in Bowman’s capsule
Glomerulus-like structure surrounding vessel in germ cells
Stippled vaginal epithelial cells
Bamboo spine on X-ray
“spikes” on basement membrane, “dome-like” endothelial deposits
Cardiomegaly with apical atrophy
High level of D-dimers
Hypochromic, microcytic anemia (stippling)
Circular grouping of dark tumor cells surrounding pale neurofibrils
Monoclonal antibody spike (M proteins = IgM)
Clinical presentationDiagnosis / diseasecharacteristic features
Rib notching
Extracellular amyloid deposition in gray matter of brain
“Onion-skin” periosteal reaction
Lumpy-bumpy appearance of glomeruli on immunofluorescence
Iron-containing nodules in alveolar septum
Intranuclear eosinophilic droplet-like bodies
“Thumb sign” on lateral x-ray
Giant B cells with bilobed nuclei with prominent inclusions (“owl’s eyes”)
Increased α-fetoprotein in amniotic fluid / maternal serum
Yellow CSF
Monoclonal globulin protein in blood / urine (κ or λ Ig chains)
Elevated hCG
Hypersegmented neutrophils
Eosinophilic cytoplasmic inclusion in nerve cell
Anti-transglutimnase / antigliadin / anti-endomysial antibodies
Increased uric acid levels (arthritis)
Low serum ceruloplasmin
Renal epithelial casts in urine
Large lysosomal vesicles in phagocytes, immunodeficiency
Increased uric acid levels (lymphomas)
Enlarged thyroid cells with ground-glass nuclei
Basophilic stipping of RBCs
Azurophilic granular needles in leukemic blasts
Pseudopalisading tumor cells on brain biopsy
Hypochromic, microcytic anemia (bleeding)
Narrowing of bowel lumen on barium radiograph
“Tennis-racket” shaped cytoplasmic organelles (EM) in Langerhans cells
Monoclonal globulin protein in blood / urine (IgM)
Silver-staining spherical aggregation of tau proteins in neurons
Rectangular, crystal-like, cytoplasmic inclusions in Leydig cells
Triglyceride accumulation in liver cell vacuoles
Antidesmoglein (epithelial) antibodies

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