Science Quiz / USMLE First Aid Rapid Review - Classic Labs / Findings

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QUIZ: Can you name the USMLE First Aid Rapid Review - Classic Labs / Findings?

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Clinical presentationDiagnosis / diseasecharacteristic features
Monoclonal antibody spike (M proteins = IgM)
Protein aggregates in neurons from hyperphosphorylation of protein tau
Lumpy-bumpy appearance of glomeruli on immunofluorescence
“Nutmeg” appearance of liver
Increased uric acid levels (hypertension)
Thyroid-like appearance of kidney
Eosinophilic globule in liver
“Tennis-racket” shaped cytoplasmic organelles (EM) in Langerhans cells
Triglyceride accumulation in liver cell vacuoles
Rib notching
Anti-mitochondrial antibodies
Monoclonal globulin protein in blood / urine (κ or λ Ig chains)
“wire-loop” glomerular appearance on LM
“Hair-on-end” (crew cut) appearance on x-ray
Anticentromere antibodies
Pseudopalisading tumor cells on brain biopsy
“Brown” tumor of bone
Monoclonal antibody spike (M protein = usually IgG or IgA)
Monoclonal antibody spike (AL)
Bloody tap on LP
Desquamated epithelium casts in sputum
Circular grouping of dark tumor cells surrounding pale neurofibrils
Increased uric acid levels (lymphomas)
Depigmentation of neurons in substantia nigra
Degeneration of dorsal column nerves
Eosinophilic inclusion bodies in cytoplasm of hippocampal nerve cells
Anti-topoisomerase antibodies
Rhomboid crystals, positive birefringent
Needle-shaped, negatively birefringent crystals
Nodular hyaline deposits in glomeruli
Anti-transglutimnase / antigliadin / anti-endomysial antibodies
Elevated hCG
Podocyte fusion on EM
Cellular crescents in Bowman’s capsule
Clinical presentationDiagnosis / diseasecharacteristic features
Bamboo spine on X-ray
Hilar lymphadenopathy, peripheral granulomatous lesion in middle or lower lung lobes (can calcify)
Stippled vaginal epithelial cells
Intranuclear eosinophilic droplet-like bodies
Cardiomegaly with apical atrophy
Enlarged cells with intranuclear inclusion bodies
“Onion-skin” periosteal reaction
Hypochromic, microcytic anemia (abnormal hemoglobin)
Disarrayed granulosa cells in eosinophilic fluid
Enlarged thyroid cells with ground-glass nuclei
Giant B cells with bilobed nuclei with prominent inclusions (“owl’s eyes”)
Extracellular amyloid deposition in gray matter of brain
“Tram-track” appearance on LM
Increased α-fetoprotein in amniotic fluid / maternal serum
Eosinophilic cytoplasmic inclusion in nerve cell
Large lysosomal vesicles in phagocytes, immunodeficiency
Eosinophilic cytoplasmic inclusion in liver cell
RBC casts in urine
Renal epithelial casts in urine
Heterophile antibodies
Yellow CSF
Mammary gland (blue-domed) cyst
Hypersegmented neutrophils
Honeycomb lung on x-ray
Anti-glomerular basement membrane antibodies
Branching gram-positive rods with sulfur granules
Bronchogenic apical lung tumor
“spikes” on basement membrane, “dome-like” endothelial deposits
Increased uric acid levels (arthritis)
Sheets of medium-sized lymphoid cells (“starry sky” appearance on histology)
Hypochromic, microcytic anemia (stippling)
Basophilci nuclear remnants in RBCs
Colonies of mucoid Pseudomonas in lungs
Antinuclear antibodies (ANAs: anti-Smith and anti-dsDNA)
Clinical presentationDiagnosis / diseasecharacteristic features
“boot shaped heart on X-ray
Periosteum raised from bone, creating triangular area
Anti-neutrophil cytoplasmic antibodies
Basophilic stipping of RBCs
Monoclonal globulin protein in blood / urine (IgM)
Monoclonal antibody spike (normal consequences of aging)
Iron-containing nodules in alveolar septum
Increased uric acid levels (HGPRT deficiency)
Antiplatelet antibodies
Narrowing of bowel lumen on barium radiograph
Glomerulus-like structure surrounding vessel in germ cells
Hexagonal, double-pointed, needle-like crystals in bronchial secretions
Silver-staining spherical aggregation of tau proteins in neurons
Mucin-filled cell with peripheral nucleus
Anti-IgG antibodies
Azurophilic granular needles in leukemic blasts
Rectangular, crystal-like, cytoplasmic inclusions in Leydig cells
“Chocolate cyst” of ovary
Polished, “ivory-like appearance of bone at cartilage erosion
Hypochromic, microcytic anemia (bleeding)
High level of D-dimers
Dysplastic squamous cervical cells with enlargement and hyperchromasia
Heart nodules (inflammatory)
“Soap bubble” in femur or tibia on x-ray
Stacks of red blood cells
WBCs that look “smudged”
Thrombi made of white / red layers
Lytic (hole-punched) bone lesions on x-ray
“Thumb sign” on lateral x-ray
Low serum ceruloplasmin
Antidesmoglein (epithelial) antibodies
Antihistone antibodies

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