Science Quiz / USMLE First Aid Rapid Review - Classic Labs / Findings

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Can you name the USMLE First Aid Rapid Review - Classic Labs / Findings?

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Clinical presentationDiagnosis / diseasecharacteristic features
“Tennis-racket” shaped cytoplasmic organelles (EM) in Langerhans cells
“Soap bubble” in femur or tibia on x-ray
Monoclonal antibody spike (AL)
Anti-glomerular basement membrane antibodies
Stippled vaginal epithelial cells
“Brown” tumor of bone
RBC casts in urine
“wire-loop” glomerular appearance on LM
Triglyceride accumulation in liver cell vacuoles
Monoclonal antibody spike (M proteins = IgM)
Mammary gland (blue-domed) cyst
Narrowing of bowel lumen on barium radiograph
Increased uric acid levels (arthritis)
Circular grouping of dark tumor cells surrounding pale neurofibrils
Monoclonal antibody spike (normal consequences of aging)
Anti-IgG antibodies
Hexagonal, double-pointed, needle-like crystals in bronchial secretions
Cardiomegaly with apical atrophy
Lumpy-bumpy appearance of glomeruli on immunofluorescence
Hypersegmented neutrophils
Nodular hyaline deposits in glomeruli
Branching gram-positive rods with sulfur granules
Degeneration of dorsal column nerves
Renal epithelial casts in urine
Basophilci nuclear remnants in RBCs
Enlarged cells with intranuclear inclusion bodies
Anti-mitochondrial antibodies
Stacks of red blood cells
Increased uric acid levels (hypertension)
Monoclonal globulin protein in blood / urine (κ or λ Ig chains)
Hilar lymphadenopathy, peripheral granulomatous lesion in middle or lower lung lobes (can calcify)
Colonies of mucoid Pseudomonas in lungs
Hypochromic, microcytic anemia (abnormal hemoglobin)
Silver-staining spherical aggregation of tau proteins in neurons
Clinical presentationDiagnosis / diseasecharacteristic features
Periosteum raised from bone, creating triangular area
Pseudopalisading tumor cells on brain biopsy
Monoclonal antibody spike (M protein = usually IgG or IgA)
High level of D-dimers
“Chocolate cyst” of ovary
Heterophile antibodies
Antihistone antibodies
Podocyte fusion on EM
“Thumb sign” on lateral x-ray
Depigmentation of neurons in substantia nigra
Rectangular, crystal-like, cytoplasmic inclusions in Leydig cells
Glomerulus-like structure surrounding vessel in germ cells
“Nutmeg” appearance of liver
Hypochromic, microcytic anemia (stippling)
Anti-neutrophil cytoplasmic antibodies
Thrombi made of white / red layers
Iron-containing nodules in alveolar septum
Eosinophilic inclusion bodies in cytoplasm of hippocampal nerve cells
Basophilic stipping of RBCs
Rhomboid crystals, positive birefringent
Increased α-fetoprotein in amniotic fluid / maternal serum
Anti-transglutimnase / antigliadin / anti-endomysial antibodies
Disarrayed granulosa cells in eosinophilic fluid
“Tram-track” appearance on LM
Low serum ceruloplasmin
Extracellular amyloid deposition in gray matter of brain
Antiplatelet antibodies
Eosinophilic cytoplasmic inclusion in liver cell
Bloody tap on LP
Monoclonal globulin protein in blood / urine (IgM)
Azurophilic granular needles in leukemic blasts
Mucin-filled cell with peripheral nucleus
“spikes” on basement membrane, “dome-like” endothelial deposits
Heart nodules (inflammatory)
Clinical presentationDiagnosis / diseasecharacteristic features
Anticentromere antibodies
Desquamated epithelium casts in sputum
Antidesmoglein (epithelial) antibodies
Eosinophilic globule in liver
Cellular crescents in Bowman’s capsule
Elevated hCG
Intranuclear eosinophilic droplet-like bodies
Bronchogenic apical lung tumor
Rib notching
“boot shaped heart on X-ray
“Onion-skin” periosteal reaction
Giant B cells with bilobed nuclei with prominent inclusions (“owl’s eyes”)
Dysplastic squamous cervical cells with enlargement and hyperchromasia
Thyroid-like appearance of kidney
Lytic (hole-punched) bone lesions on x-ray
Antinuclear antibodies (ANAs: anti-Smith and anti-dsDNA)
Yellow CSF
Sheets of medium-sized lymphoid cells (“starry sky” appearance on histology)
Hypochromic, microcytic anemia (bleeding)
Protein aggregates in neurons from hyperphosphorylation of protein tau
Needle-shaped, negatively birefringent crystals
Anti-topoisomerase antibodies
Eosinophilic cytoplasmic inclusion in nerve cell
WBCs that look “smudged”
Enlarged thyroid cells with ground-glass nuclei
Polished, “ivory-like appearance of bone at cartilage erosion
Honeycomb lung on x-ray
Increased uric acid levels (lymphomas)
“Hair-on-end” (crew cut) appearance on x-ray
Bamboo spine on X-ray
Large lysosomal vesicles in phagocytes, immunodeficiency
Increased uric acid levels (HGPRT deficiency)

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