Science Quiz / USMLE First Aid Rapid Review - Classic Presentations

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Can you name the Classic Presentations of diseases?

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Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Cutaneous / dermal edema due to connective tissue deposition
Chest pain, pericardial effusion / friction rub, persistent fever following MI
Elastic skin, hypermobility of joints
Skin hyperpigmentation
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis, c-ANCA positive
Thyroid and parathyroid tumors, pheochromocytoma
Palpable purpura, joint pain, abdominal pain (child)
Ptosis, miosis, anhydrosis
Small, irregular red spots on buccal / inguinal mucosa with blue-white centers
Chorea, dementia, caudate degeneration
Fever, cough, conjunctivitis, coryza, diffuse rash
Indurated, non-painful ulcerated genital lesion
Calf pseudohypertrophy
Vomiting blood following esophagogastric lacerations
Muscoal bleeding and prolonged bleeding time
“Cherry-red spot” on macula (hexosaminidase
Dark purple skin / mouth nodules
“Strawberry tongue” (Staph. aureus)
Weight loss, diarrhea, arthritis, fever, adenopathy
Erytheroderma, lymphadenopathy, hepatosplenomegaly, atypical T cells
Green-yellow rings around peripheral cornea
Jaundice, RUQ pain, fever
“Strawberry tongue” (Vasculitis)
Streak ovaries, congenital heart disease, horseshoe kidney
Nystagmus, intention tremor, scanning speech, bilateral intranuclear opthalmoplegia
Pink complexion, dyspnea, hyperventilation
Lucid interval after traumatic brain injury
Single palm crease
Vascular birthmark (port-wine stain)
Rash on palms and soles
Fever, night sweats, weight loss
Dry eyes, dry mouth, arthritis
Sudden swollen / painful big toe joint, tophi
“Cherry-red spot” on macula (sphingomyelinase)
Hypoxemia, polycythemia, hypercapnia
No lactation postpartum, absent menstruation, cold intolerance
Bounding pulses, diastolic heart murmur, head bobbing
Hypercoagulability leading to migrating DVTs and vascultitis
Situs inversus, chronic sinusitis, bronchiectasis
Deep labored breathing / hyperventilation
Dysphagia (esophageal webs), glossitis, iron deficiency anemia
Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Infant with hypoglycemia, failure to thrive, and hepatomegaly
Smooth, flat, moist white lesions on genitals
Oscillating slow/fast breathing
Child uses arms to stand up from squat
Painful, pale, cold fingers / toes
Dog or cat bite resulting in infection
Toe extension / fanning upon plantar scrape
Rapidly progressive leg weakness that ascends (following GI/upper respiratory infection)
Back pain, fever, night sweats, weight loss
Positive anterior “drawer sign”
Severe jaundice in neonate
Hereditary nephritis, sensorineural hearing loss, cataracts
Rash on palms and soles
Indurated, painful ulcerated genital lesion with exudates
Continuous “machinery” heart murmur
Arachnodactyly, lens discoloration, aortic dissection, hyperflexible joints
Athlete with polycythemia
Neonate with arm paralysis following difficult birth
Infant with microcephaly, rocker-bottom feet, clenched hands, and structural heart defect
Short stature, ↑ incidence of tumors / leukemia, aplastic anemia
Child with fever develops red rash on face that spread to body
Hypertension, hypokalemia, metabolic acidosis
Adrenal hemorrhage, hypotension, DIC
Café-au-lait spots, Lisch nodules (iris hamartoma), pheochromocytoma, optic gliomas, bilateral acoustic neuromas
Chronic exercise intolerance with myalgia, fatigue, painful cramps
Slow, progressive muscle weakness in boys
“Strawberry tongue” (Strep. pyogenes)
Pupil accommodates but doesn’t react
Polyuria, acidosis, growth failure, electrolyte imbalances
Enlarged, hard left supraclavicular node
Café-au-lait spots, Lisch nodules (iris hamartoma), pheochromocytoma, optic gliomas
Resting tremor, rigidity, akinesia, postural instability
Painful, raised red lesions on palms and soles
Painless jaundice
Renal cell carcinoma, hemangioblastomas, angiomatosis, pheochromocytoma
Fever, chills, headache, myalgia following antibiotic treatment for syphilis
Gout, mental retardation, self-mutilating behavior in boy
Dermatitis, dementia, diarrhea
Painful erythematous lesions on palms and soles
Splinter hemorrhages in fingernails
Blue sclera
Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Painful blue fingers toes, hemolytic anemia
Red “currant jelly” sputum in alcoholic or diabetic patients
Restrictive cardiomyopathy (juvenile form: cardiomegaly), exercise intolerance
Pancreatic, pituitary, parathyroid tumors
Facial muscle spasm upon tapping
Bone pain, bone enlargement, arthritis
Systolic ejection murmur (crescendo-decrescendo)
Male child, recurrent infections, no mature B cells
Vasculitis from exposure to endotoxin causing glomerular thrombosis
Red, itchy, swollen rash of nipple areola
Café-au-lait spots, polyostotic fibrous dysplasia, precocious puberty
Fibrous plaques in soft tissue of penis
“Waxy” casts with very low urine flow
Large rash with bull’s-eye appearance
Cold intolerance
Keratin pearls in a skin biopsy
Bilateral hilar adenopathy, uveitis
Severe RLQ pain with rebound tenderness
Conjugate lateral gaze palsy, horizontal diplopia
Infant with failure to thrive, hepatosplenomegaly, neurodegeneration
WBC casts in urine
Swollen gums, mucous leeding, poor wound healing, spots on skin
Hyperphagia, hypersexuality, hyperorality, hyperdocility
Hamartamous GI polyps, hyperpigmentation of mouth / feet / hands
Hepatosplenomegaly, osteoporosis, neurologic symptoms
Multiple colon polyps, osteomas / soft tissue tumors, impacted / supernumerary teeth
Fat, female, forty, and fertile
Dilated cardiomyopathy, edema, polyneuropathy
Bluish line on gingiva
“Worst headache of my life”
Unilateral facial dropping invoving forhead
Swollen, hard, painful finger joints
Achilles tendon xanthoma
Abdominal pain, ascites, hepatomegaly
Retinal hemorrhages with pale centers
Red urine in the morning, fragile RBCs
Urethritis, conjunctivitis, arthritis in a male
“Cherry-red spot” on macula (vascular)
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis, anti-basement membrane antibodies
Recurrent colds unusual eczema, high serum IgE

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