Science Quiz / USMLE First Aid Rapid Review - Classic Presentations

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Can you name the Classic Presentations of diseases?

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Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Back pain, fever, night sweats, weight loss
Adrenal hemorrhage, hypotension, DIC
Erytheroderma, lymphadenopathy, hepatosplenomegaly, atypical T cells
Infant with failure to thrive, hepatosplenomegaly, neurodegeneration
Calf pseudohypertrophy
Pink complexion, dyspnea, hyperventilation
Red “currant jelly” sputum in alcoholic or diabetic patients
Fever, cough, conjunctivitis, coryza, diffuse rash
Toe extension / fanning upon plantar scrape
Chronic exercise intolerance with myalgia, fatigue, painful cramps
Systolic ejection murmur (crescendo-decrescendo)
Thyroid and parathyroid tumors, pheochromocytoma
Enlarged, hard left supraclavicular node
Hyperphagia, hypersexuality, hyperorality, hyperdocility
Bounding pulses, diastolic heart murmur, head bobbing
“Strawberry tongue” (Staph. aureus)
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis, c-ANCA positive
Vomiting blood following esophagogastric lacerations
Bone pain, bone enlargement, arthritis
Fever, chills, headache, myalgia following antibiotic treatment for syphilis
“Worst headache of my life”
Keratin pearls in a skin biopsy
Fibrous plaques in soft tissue of penis
“Strawberry tongue” (Vasculitis)
Cold intolerance
Chorea, dementia, caudate degeneration
Cutaneous / dermal edema due to connective tissue deposition
No lactation postpartum, absent menstruation, cold intolerance
Indurated, painful ulcerated genital lesion with exudates
Renal cell carcinoma, hemangioblastomas, angiomatosis, pheochromocytoma
Red, itchy, swollen rash of nipple areola
Painful erythematous lesions on palms and soles
Café-au-lait spots, polyostotic fibrous dysplasia, precocious puberty
Abdominal pain, ascites, hepatomegaly
Rash on palms and soles
Painful, raised red lesions on palms and soles
Vasculitis from exposure to endotoxin causing glomerular thrombosis
Severe RLQ pain with rebound tenderness
WBC casts in urine
Rapidly progressive leg weakness that ascends (following GI/upper respiratory infection)
Multiple colon polyps, osteomas / soft tissue tumors, impacted / supernumerary teeth
Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Restrictive cardiomyopathy (juvenile form: cardiomegaly), exercise intolerance
Unilateral facial dropping invoving forhead
Swollen gums, mucous leeding, poor wound healing, spots on skin
Conjugate lateral gaze palsy, horizontal diplopia
Positive anterior “drawer sign”
Infant with microcephaly, rocker-bottom feet, clenched hands, and structural heart defect
Palpable purpura, joint pain, abdominal pain (child)
Hypertension, hypokalemia, metabolic acidosis
Dry eyes, dry mouth, arthritis
Facial muscle spasm upon tapping
Child with fever develops red rash on face that spread to body
Situs inversus, chronic sinusitis, bronchiectasis
Painful, pale, cold fingers / toes
Single palm crease
Recurrent colds unusual eczema, high serum IgE
Hypercoagulability leading to migrating DVTs and vascultitis
Athlete with polycythemia
Elastic skin, hypermobility of joints
Vascular birthmark (port-wine stain)
Dermatitis, dementia, diarrhea
Smooth, flat, moist white lesions on genitals
Gout, mental retardation, self-mutilating behavior in boy
Ptosis, miosis, anhydrosis
Blue sclera
Jaundice, RUQ pain, fever
Dilated cardiomyopathy, edema, polyneuropathy
Muscoal bleeding and prolonged bleeding time
Neonate with arm paralysis following difficult birth
Swollen, hard, painful finger joints
Short stature, ↑ incidence of tumors / leukemia, aplastic anemia
Lucid interval after traumatic brain injury
Male child, recurrent infections, no mature B cells
Resting tremor, rigidity, akinesia, postural instability
“Waxy” casts with very low urine flow
“Cherry-red spot” on macula (sphingomyelinase)
Skin hyperpigmentation
Café-au-lait spots, Lisch nodules (iris hamartoma), pheochromocytoma, optic gliomas, bilateral acoustic neuromas
Hereditary nephritis, sensorineural hearing loss, cataracts
Deep labored breathing / hyperventilation
Rash on palms and soles
Retinal hemorrhages with pale centers
Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Fat, female, forty, and fertile
Painful blue fingers toes, hemolytic anemia
Large rash with bull’s-eye appearance
Painless jaundice
Urethritis, conjunctivitis, arthritis in a male
Bluish line on gingiva
Hypoxemia, polycythemia, hypercapnia
Dark purple skin / mouth nodules
Bilateral hilar adenopathy, uveitis
Sudden swollen / painful big toe joint, tophi
“Cherry-red spot” on macula (hexosaminidase
Pancreatic, pituitary, parathyroid tumors
Green-yellow rings around peripheral cornea
Chest pain, pericardial effusion / friction rub, persistent fever following MI
Red urine in the morning, fragile RBCs
Polyuria, acidosis, growth failure, electrolyte imbalances
“Strawberry tongue” (Strep. pyogenes)
Café-au-lait spots, Lisch nodules (iris hamartoma), pheochromocytoma, optic gliomas
Splinter hemorrhages in fingernails
Weight loss, diarrhea, arthritis, fever, adenopathy
Pupil accommodates but doesn’t react
Streak ovaries, congenital heart disease, horseshoe kidney
Continuous “machinery” heart murmur
Severe jaundice in neonate
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis, anti-basement membrane antibodies
Indurated, non-painful ulcerated genital lesion
Hepatosplenomegaly, osteoporosis, neurologic symptoms
Hamartamous GI polyps, hyperpigmentation of mouth / feet / hands
Slow, progressive muscle weakness in boys
Small, irregular red spots on buccal / inguinal mucosa with blue-white centers
Infant with hypoglycemia, failure to thrive, and hepatomegaly
Nystagmus, intention tremor, scanning speech, bilateral intranuclear opthalmoplegia
Fever, night sweats, weight loss
Oscillating slow/fast breathing
Dysphagia (esophageal webs), glossitis, iron deficiency anemia
Child uses arms to stand up from squat
Arachnodactyly, lens discoloration, aortic dissection, hyperflexible joints
Achilles tendon xanthoma
“Cherry-red spot” on macula (vascular)
Dog or cat bite resulting in infection

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