Science Quiz / USMLE First Aid Rapid Review - Classic Presentations

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Can you name the Classic Presentations of diseases?

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Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Cold intolerance
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis, c-ANCA positive
Painful blue fingers toes, hemolytic anemia
Chest pain, pericardial effusion / friction rub, persistent fever following MI
Hamartamous GI polyps, hyperpigmentation of mouth / feet / hands
Pink complexion, dyspnea, hyperventilation
Chorea, dementia, caudate degeneration
Resting tremor, rigidity, akinesia, postural instability
Infant with hypoglycemia, failure to thrive, and hepatomegaly
Painful, pale, cold fingers / toes
Indurated, painful ulcerated genital lesion with exudates
Short stature, ↑ incidence of tumors / leukemia, aplastic anemia
Thyroid and parathyroid tumors, pheochromocytoma
“Strawberry tongue” (Staph. aureus)
“Waxy” casts with very low urine flow
“Strawberry tongue” (Vasculitis)
Child uses arms to stand up from squat
Sudden swollen / painful big toe joint, tophi
Rapidly progressive leg weakness that ascends (following GI/upper respiratory infection)
Splinter hemorrhages in fingernails
Recurrent colds unusual eczema, high serum IgE
Vascular birthmark (port-wine stain)
Abdominal pain, ascites, hepatomegaly
Dark purple skin / mouth nodules
Café-au-lait spots, Lisch nodules (iris hamartoma), pheochromocytoma, optic gliomas
Urethritis, conjunctivitis, arthritis in a male
Red urine in the morning, fragile RBCs
Oscillating slow/fast breathing
Polyuria, acidosis, growth failure, electrolyte imbalances
Adrenal hemorrhage, hypotension, DIC
Fever, chills, headache, myalgia following antibiotic treatment for syphilis
Conjugate lateral gaze palsy, horizontal diplopia
Vasculitis from exposure to endotoxin causing glomerular thrombosis
“Cherry-red spot” on macula (vascular)
Infant with failure to thrive, hepatosplenomegaly, neurodegeneration
WBC casts in urine
Facial muscle spasm upon tapping
Cutaneous / dermal edema due to connective tissue deposition
Hepatosplenomegaly, osteoporosis, neurologic symptoms
Infant with microcephaly, rocker-bottom feet, clenched hands, and structural heart defect
Toe extension / fanning upon plantar scrape
Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Rash on palms and soles
Severe RLQ pain with rebound tenderness
Blue sclera
“Worst headache of my life”
Slow, progressive muscle weakness in boys
“Cherry-red spot” on macula (sphingomyelinase)
Rash on palms and soles
Lucid interval after traumatic brain injury
Athlete with polycythemia
Painful, raised red lesions on palms and soles
“Cherry-red spot” on macula (hexosaminidase
Red “currant jelly” sputum in alcoholic or diabetic patients
Single palm crease
Café-au-lait spots, polyostotic fibrous dysplasia, precocious puberty
Calf pseudohypertrophy
Hypercoagulability leading to migrating DVTs and vascultitis
Painless jaundice
Hypoxemia, polycythemia, hypercapnia
Deep labored breathing / hyperventilation
Bounding pulses, diastolic heart murmur, head bobbing
Hypertension, hypokalemia, metabolic acidosis
Continuous “machinery” heart murmur
Dermatitis, dementia, diarrhea
Pupil accommodates but doesn’t react
Green-yellow rings around peripheral cornea
Retinal hemorrhages with pale centers
Streak ovaries, congenital heart disease, horseshoe kidney
Hyperphagia, hypersexuality, hyperorality, hyperdocility
Hereditary nephritis, sensorineural hearing loss, cataracts
Chronic exercise intolerance with myalgia, fatigue, painful cramps
Jaundice, RUQ pain, fever
Large rash with bull’s-eye appearance
No lactation postpartum, absent menstruation, cold intolerance
Male child, recurrent infections, no mature B cells
Pancreatic, pituitary, parathyroid tumors
Multiple colon polyps, osteomas / soft tissue tumors, impacted / supernumerary teeth
Child with fever develops red rash on face that spread to body
Gout, mental retardation, self-mutilating behavior in boy
Painful erythematous lesions on palms and soles
Erytheroderma, lymphadenopathy, hepatosplenomegaly, atypical T cells
Indurated, non-painful ulcerated genital lesion
Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Arachnodactyly, lens discoloration, aortic dissection, hyperflexible joints
Dog or cat bite resulting in infection
Renal cell carcinoma, hemangioblastomas, angiomatosis, pheochromocytoma
“Strawberry tongue” (Strep. pyogenes)
Dysphagia (esophageal webs), glossitis, iron deficiency anemia
Dry eyes, dry mouth, arthritis
Muscoal bleeding and prolonged bleeding time
Weight loss, diarrhea, arthritis, fever, adenopathy
Bilateral hilar adenopathy, uveitis
Neonate with arm paralysis following difficult birth
Achilles tendon xanthoma
Nystagmus, intention tremor, scanning speech, bilateral intranuclear opthalmoplegia
Fever, cough, conjunctivitis, coryza, diffuse rash
Systolic ejection murmur (crescendo-decrescendo)
Severe jaundice in neonate
Elastic skin, hypermobility of joints
Café-au-lait spots, Lisch nodules (iris hamartoma), pheochromocytoma, optic gliomas, bilateral acoustic neuromas
Restrictive cardiomyopathy (juvenile form: cardiomegaly), exercise intolerance
Swollen gums, mucous leeding, poor wound healing, spots on skin
Fever, night sweats, weight loss
Smooth, flat, moist white lesions on genitals
Swollen, hard, painful finger joints
Bluish line on gingiva
Keratin pearls in a skin biopsy
Dilated cardiomyopathy, edema, polyneuropathy
Skin hyperpigmentation
Red, itchy, swollen rash of nipple areola
Small, irregular red spots on buccal / inguinal mucosa with blue-white centers
Situs inversus, chronic sinusitis, bronchiectasis
Bone pain, bone enlargement, arthritis
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis, anti-basement membrane antibodies
Palpable purpura, joint pain, abdominal pain (child)
Unilateral facial dropping invoving forhead
Ptosis, miosis, anhydrosis
Positive anterior “drawer sign”
Fat, female, forty, and fertile
Enlarged, hard left supraclavicular node
Vomiting blood following esophagogastric lacerations
Back pain, fever, night sweats, weight loss
Fibrous plaques in soft tissue of penis

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