damage DNA; Normal cells arrest cell cycle & repair damage; Cancer cells: cell death after exposure from unrepaired DNA
repair pathway of ss DNA breaks by recombination
repairs ss DNA breaks
Inhibit Synthesis/ Function of DNA via Antimetabolite function
Topoisomerase Inhibitors to Inhibit Synthesis/ Function of DNA
Intercalating Agents that induce DNA damage form complexes between guanine nucleotidesïƒ mutation, DNA cross-linking, base excision & double strand breaks
Alkylation induces DNA damage via Abnormal base-pairing with thymine mutation; excision of alkylated guanine residues (depurination); strand breakage
Inhibit enzymes of nucleoside triphosphate synthesis
Substitute for purines or pyrimidines
Bind topoisomerases & block ability to re-seal DNA breaks: cell death
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