Science Quiz / Immunologists

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Immunized mice with a small dose of protein toxin, and discovered that mothers pass on immunityEarly 1900’s
Showed that induced antibodies are positively charged gamma globulins1939
Showed that Ab’s are proteins, and thus come from genes1940
Showed that 2 Ab’s of different specificity had similar AAc composition1950
Showed that a B cell clone always makes the same antibodies1958
Determined structure of Ab’s by different proteolytic enzymes
T cells still develop in chickens without Bursa fabricia1965
Bone marrow cells could restore graft rejection1966
Developed anitbodies to L3T4 and Lyt-2 anitgen to permit isolation of T cells1975
Identified and cloned T cell growth factor gene (IL-2) to permit growth of T cells for use1980
Used subtractive hybridization to clone mouse and human TCR genes1986
Showed that T cells recognize self and foreign antigens1976
Showed that T cells can recognize peptides derived from other cells presented on MHC I proteins1976
Genetically mapped H-antigens and showed that these were responsible for tissue rejection1946
Identified proteins, including, GILT, and invariant chain, that were important for MHC II loading2010’s
Crystalized MHC1984
Crystalized TCR1998
Fragmentation of peptides resulted in TCR recognition1984
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Created Oct 2, 2019ReportNominate
Tags:Discovery Quiz

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