Science Quiz / Cephalosporins in the BNF 2012 by generation

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Can you name the Cephalosporins in the BNF by generation?

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GenerationDrugExtra Info
First GenOrally active. useful for urinary-tract infections which do not respond to other drugs or which occur in pregnancy, respiratory-tract infections, otitis media, sinusitis, and skin and soft-tissue infections
First GenOrally active.useful for urinary-tract infections which do not respond to other drugs or which occur in pregnancy, respiratory-tract infections, otitis media, sinusitis, and skin and soft-tissue infections
First GenOrally active, long duration of action, poor effectiveness vs. H. influenzae
Second GenGood activity vs. H. influenzae but associated with skin infections
Second GenLess susceptible to beta lacatamase than first gen
Third GenLonger duration of action than other p.o. cephalosporins
Third GenMore active than other cephalosporins vs. respiratory pathogens, licensed for upper and lower RTIs
Third GenGood activity vs. Pseudomonas and other Gram negatives.
Third GenExtra activity against Gm negatives, but diminished activity against Staph aureus. Ppt may sequester in gallbladder and cause symptoms. o.d. administration
Third GenExtra activity against Gm negatives, but diminished activity against Staph aureus. Good for infections of the CNS.

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