Amitriptyline, Imipramine, Nortriptyline, Desipramine, & Clomipramine are what type of drug for depression?
What is the MOA of Tricyclic Antidepressants? (Half-life= 24 hours)
What are the Side Effects of Tricyclic Antidepressants? (Prescribe 1 week supply at a time)
How do you treat OD of Tricyclic Antidepressants?
Phenelzineu, Tranylcypromine, Isocarboxazid, & Selgelline Patch are what type of drug for depression?
Monamine Oxidase Inhibitors inhibit both MAO-A & MAO-B except for _________ which is specific for MAO-B & used in Parkinson's and depression
Why must people on Monamine Oxidase Inhibitors be cautious of entering 'Hypertensive Crisis' when eating certain foods? (high levels of this in blood causes HTN)
TCA's & MOAI's are used less frequently for 1st line treatment than the new agents (SSRI's). TRUE or FALSE?
Fluoxetine, Paroxetine, Sertraline, Citalopram, & Escitalopram are what type of drug for depression?
Which SSRI has the longest half-life approved for only children & adolescents (less withdrawal)?
Which SSRI has the shortest half-life (more withdrawal)?
What 2 SSRIs are significant inhibitors of P450 2D6? (drug-drug interactions) (more decreased libido than other SSRI's)
What adverse side effects are possible with SSRIs?
Why can occur if an SSRI is used in combination with an MAOI? (Medical Emergency, stop medications)
How can you avoid 'SSRI withdrawal'
Which SSRI can cause 'QT Prolongation'?
Venlafaxine, Desvenlafaxine, Duloxetine are what type of drug for depression?
Venlafaxine (SNRI) adverse side effect is?
Desvenlafaxine (SNRI) is an active metabolite of ___________ FDA approved for depression.
Duloxetine (for pain secondary to 'diabetic peripheral neuropathy') side effect is (SNRI)
Nefazodone & Trazodone are what type of drug for depression?
Serotonin Receptor Antagonist that is a CYP 450 3A4 inhibitor that can cause 'hepatic failure' which dramatically decreased its clinical use.
Serotonin Receptor Antagonist used mainly as a sleep aid and has a side effect of priapism
Bupropion is what type of drug?
Bupropion (DNRI) approved for 'smoking cessation' and not good for anxiety has these characteristics:
Alpha 2 Antagonist with side effects of 'increased appetite and significant weight gain, no GI effects'
SSRI & 5HT1a partial agonist with 'almost no sexual side effects & minimal weight gain'
What treatment for depression is most effective & quicker acting with a 80% response rate?
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