Science Quiz / Antiepileptic Drugs

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Can you name the Antiepileptic Drugs?

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HintDrug
'New' AED that inhibits glutamate function
Blocks T-current, prolongs the inactivated state of Na+ channels, and increases GABA levels; inhibits platelet aggregation, leading to gingival bleeding
Unknown mechanism of action; CNS side effects; no known drug interactions
Metabolized by CYP2C9/10
Induces CYP2C
Induces CYP3A
'New' AED that enhances GABA function
'Old' AED that enhances GABA function
Analog designed to eliminate the epoxide metabolite of carbamazepine; a weaker CYP3A inducer
HintDrug
Metabolized by CYP3A4
Prolongs the inactivated state of Na+ channels; first non-sedative AED
Blocks T-current, inhibiting 3-Hz activity; useful for absence seizures
Prolongs the inactivated state of Na+ channels, is a GABA receptor agonist, and is an AMPA/kainite receptor antagonist; side effects include nephrolithiasis and glaucoma
Prolongs the inactivated state of Na+ channels; exacerbates absence and myoclonic seizures
Metabolized by UGT
'New' AED that acts at both Na+ and Ca2+ channels
Induces UGT
Prolongs the inactivated state of Na+ channels and inhibits glutamate release; side effects include Stevens-Johnson syndrome

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