Science Quiz / Lin Day 1

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Can you name the Lin Day 1?

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Factor II
Factor VII
Low molecular weight heparin inhibits this factor
heparin can clear lipemia by increasing the level of this enzyme
UFH
These three bivalent DTIs also bind to the substrate site
if the pt has HIT, switch to this drug
abciximab and eptifibatide and tirofiban act on this receptor
synthetic form of heparin
heparin should not be given to pregnant or breast feeding because of this solution
This proteins free form acts as a cofactor to protein C
allergy, alopecia, and osteoporosis are secondary side effects of this drug
DTI used for HIT, beware of liver, increases INRs
A vit K dependent serine protease that is activated by thrombin to APC
This vitamin K antagonist inhibits epoxide reductase
Factor X
recombinant form of hirudin used for HIT, beware of renal insufficiency
This LMWH is administered in mg, as opposed to anti factor Xa units
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor
use the aPTT to measure the drug use
Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis
this enzyme degrades many blood plasma proteins, most notably, the clot
these blood disorders are treated by anticoagulants
the famous indirect thrombin inhibitor, can induce thrombocytopenia
Factor I
This parenterally administered drug should not be used intramuscularly
clopidogrel and ticlopidine act on this receptor
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WISN
Long half life, low side effects, less frequent dosing are traits of this heparin modification
this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
ATIII inactivates these 3 clotting factors (answer in numerical order)
enoxaparin, dalteparin, and tinzaparin are types of this drug
Factor IV
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus
Direct Thrombin Inhibitor, an oral prodrug
these vitamin facilitate clotting
Vitamin K dependent glycoprotein, has two forms, free and c4b bound
Factor IX
Serine protease inhibitor that inhibits plasmin
a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
isolated from leech saliva, bivalent irreversible thrombin inhibitor
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
Serine protease inhibitor that inactivates clotting factors
this antagonist is used to reverse heparin
HIT
These factors facilitate clotting
the oral standard long term therapy
This occurs if heparin is given intramuscularly
Factor VIII
irudin and gatro are suffixes for this class
This racemic mixture has a long halflife and has 100% bioavailability
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
These proteins are endogenous anticoagulants
heparin's half life in hours
The effects of WISN are caused by a decrease in activity of this protein

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