Science Quiz / Lin Day 1

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Can you name the Lin Day 1?

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use the aPTT to measure the drug use
Factor II
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis
enoxaparin, dalteparin, and tinzaparin are types of this drug
this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
These factors facilitate clotting
heparin should not be given to pregnant or breast feeding because of this solution
irudin and gatro are suffixes for this class
These three bivalent DTIs also bind to the substrate site
a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
This racemic mixture has a long halflife and has 100% bioavailability
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
abciximab and eptifibatide and tirofiban act on this receptor
the famous indirect thrombin inhibitor, can induce thrombocytopenia
Factor IV
heparin's half life in hours
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus
HIT
synthetic form of heparin
The effects of WISN are caused by a decrease in activity of this protein
Low molecular weight heparin inhibits this factor
A vit K dependent serine protease that is activated by thrombin to APC
these blood disorders are treated by anticoagulants
clopidogrel and ticlopidine act on this receptor
UFH
Factor VIII
Serine protease inhibitor that inhibits plasmin
This proteins free form acts as a cofactor to protein C
xxx
Factor VII
this enzyme degrades many blood plasma proteins, most notably, the clot
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
this antagonist is used to reverse heparin
the oral standard long term therapy
Vitamin K dependent glycoprotein, has two forms, free and c4b bound
ATIII inactivates these 3 clotting factors (answer in numerical order)
Serine protease inhibitor that inactivates clotting factors
allergy, alopecia, and osteoporosis are secondary side effects of this drug
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor
This vitamin K antagonist inhibits epoxide reductase
Long half life, low side effects, less frequent dosing are traits of this heparin modification
Direct Thrombin Inhibitor, an oral prodrug
WISN
Factor X
isolated from leech saliva, bivalent irreversible thrombin inhibitor
if the pt has HIT, switch to this drug
This parenterally administered drug should not be used intramuscularly
heparin can clear lipemia by increasing the level of this enzyme
This occurs if heparin is given intramuscularly
Factor IX
These proteins are endogenous anticoagulants
DTI used for HIT, beware of liver, increases INRs
Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
This LMWH is administered in mg, as opposed to anti factor Xa units
these vitamin facilitate clotting
recombinant form of hirudin used for HIT, beware of renal insufficiency
Factor I

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Created Nov 24, 2010ReportNominate
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