Science Quiz / Lin Day 1

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Can you name the Lin Day 1?

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These proteins are endogenous anticoagulants
Low molecular weight heparin inhibits this factor
Factor VII
these blood disorders are treated by anticoagulants
A vit K dependent serine protease that is activated by thrombin to APC
ATIII inactivates these 3 clotting factors (answer in numerical order)
Factor IV
these vitamin facilitate clotting
Vitamin K dependent glycoprotein, has two forms, free and c4b bound
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
This racemic mixture has a long halflife and has 100% bioavailability
enoxaparin, dalteparin, and tinzaparin are types of this drug
synthetic form of heparin
DTI used for HIT, beware of liver, increases INRs
heparin should not be given to pregnant or breast feeding because of this solution
Factor II
HIT
this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
Factor VIII
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor
Factor X
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
irudin and gatro are suffixes for this class
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis
Factor I
recombinant form of hirudin used for HIT, beware of renal insufficiency
Direct Thrombin Inhibitor, an oral prodrug
abciximab and eptifibatide and tirofiban act on this receptor
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Serine protease inhibitor that inactivates clotting factors
heparin can clear lipemia by increasing the level of this enzyme
These factors facilitate clotting
the oral standard long term therapy
this antagonist is used to reverse heparin
WISN
heparin's half life in hours
the famous indirect thrombin inhibitor, can induce thrombocytopenia
These three bivalent DTIs also bind to the substrate site
Serine protease inhibitor that inhibits plasmin
This parenterally administered drug should not be used intramuscularly
if the pt has HIT, switch to this drug
Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
isolated from leech saliva, bivalent irreversible thrombin inhibitor
allergy, alopecia, and osteoporosis are secondary side effects of this drug
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus
use the aPTT to measure the drug use
This vitamin K antagonist inhibits epoxide reductase
a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
The effects of WISN are caused by a decrease in activity of this protein
This proteins free form acts as a cofactor to protein C
Long half life, low side effects, less frequent dosing are traits of this heparin modification
UFH
Factor IX
This LMWH is administered in mg, as opposed to anti factor Xa units
clopidogrel and ticlopidine act on this receptor
This occurs if heparin is given intramuscularly
this enzyme degrades many blood plasma proteins, most notably, the clot

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