Science Quiz / Lin Day 1

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Can you name the Lin Day 1?

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Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
Factor VIII
DTI used for HIT, beware of liver, increases INRs
Low molecular weight heparin inhibits this factor
Factor X
if the pt has HIT, switch to this drug
Long half life, low side effects, less frequent dosing are traits of this heparin modification
heparin should not be given to pregnant or breast feeding because of this solution
these vitamin facilitate clotting
This vitamin K antagonist inhibits epoxide reductase
ATIII inactivates these 3 clotting factors (answer in numerical order)
use the aPTT to measure the drug use
Factor I
Serine protease inhibitor that inhibits plasmin
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
these blood disorders are treated by anticoagulants
These three bivalent DTIs also bind to the substrate site
Factor VII
heparin can clear lipemia by increasing the level of this enzyme
Direct Thrombin Inhibitor, an oral prodrug
This racemic mixture has a long halflife and has 100% bioavailability
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor
This LMWH is administered in mg, as opposed to anti factor Xa units
This occurs if heparin is given intramuscularly
irudin and gatro are suffixes for this class
abciximab and eptifibatide and tirofiban act on this receptor
allergy, alopecia, and osteoporosis are secondary side effects of this drug
This parenterally administered drug should not be used intramuscularly
isolated from leech saliva, bivalent irreversible thrombin inhibitor
Factor IX
this antagonist is used to reverse heparin
These factors facilitate clotting
These proteins are endogenous anticoagulants
A vit K dependent serine protease that is activated by thrombin to APC
Factor II
recombinant form of hirudin used for HIT, beware of renal insufficiency
the oral standard long term therapy
The effects of WISN are caused by a decrease in activity of this protein
this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
Vitamin K dependent glycoprotein, has two forms, free and c4b bound
heparin's half life in hours
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
synthetic form of heparin
this enzyme degrades many blood plasma proteins, most notably, the clot
a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
clopidogrel and ticlopidine act on this receptor
Factor IV
the famous indirect thrombin inhibitor, can induce thrombocytopenia
This proteins free form acts as a cofactor to protein C
enoxaparin, dalteparin, and tinzaparin are types of this drug
Serine protease inhibitor that inactivates clotting factors
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus

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