Science Quiz / Lin Day 1

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Can you name the Lin Day 1?

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Factor II
abciximab and eptifibatide and tirofiban act on this receptor
This parenterally administered drug should not be used intramuscularly
Factor IV
the famous indirect thrombin inhibitor, can induce thrombocytopenia
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus
enoxaparin, dalteparin, and tinzaparin are types of this drug
clopidogrel and ticlopidine act on this receptor
Serine protease inhibitor that inhibits plasmin
These proteins are endogenous anticoagulants
This occurs if heparin is given intramuscularly
ATIII inactivates these 3 clotting factors (answer in numerical order)
a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
HIT
heparin's half life in hours
this enzyme degrades many blood plasma proteins, most notably, the clot
allergy, alopecia, and osteoporosis are secondary side effects of this drug
These factors facilitate clotting
these blood disorders are treated by anticoagulants
synthetic form of heparin
Factor I
Factor IX
Factor VIII
DTI used for HIT, beware of liver, increases INRs
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heparin should not be given to pregnant or breast feeding because of this solution
heparin can clear lipemia by increasing the level of this enzyme
Factor X
the oral standard long term therapy
recombinant form of hirudin used for HIT, beware of renal insufficiency
Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
use the aPTT to measure the drug use
Vitamin K dependent glycoprotein, has two forms, free and c4b bound
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis
if the pt has HIT, switch to this drug
UFH
Factor VII
This vitamin K antagonist inhibits epoxide reductase
Low molecular weight heparin inhibits this factor
irudin and gatro are suffixes for this class
This proteins free form acts as a cofactor to protein C
The effects of WISN are caused by a decrease in activity of this protein
Long half life, low side effects, less frequent dosing are traits of this heparin modification
this antagonist is used to reverse heparin
Serine protease inhibitor that inactivates clotting factors
Direct Thrombin Inhibitor, an oral prodrug
WISN
This LMWH is administered in mg, as opposed to anti factor Xa units
A vit K dependent serine protease that is activated by thrombin to APC
This racemic mixture has a long halflife and has 100% bioavailability
these vitamin facilitate clotting
These three bivalent DTIs also bind to the substrate site
isolated from leech saliva, bivalent irreversible thrombin inhibitor

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Created Nov 24, 2010ReportNominate
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