Science Quiz / Lin Day 1

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xxx
recombinant form of hirudin used for HIT, beware of renal insufficiency
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
this antagonist is used to reverse heparin
These proteins are endogenous anticoagulants
abciximab and eptifibatide and tirofiban act on this receptor
heparin should not be given to pregnant or breast feeding because of this solution
these blood disorders are treated by anticoagulants
These factors facilitate clotting
A vit K dependent serine protease that is activated by thrombin to APC
These three bivalent DTIs also bind to the substrate site
Factor VII
Long half life, low side effects, less frequent dosing are traits of this heparin modification
WISN
This occurs if heparin is given intramuscularly
heparin can clear lipemia by increasing the level of this enzyme
The effects of WISN are caused by a decrease in activity of this protein
Direct Thrombin Inhibitor, an oral prodrug
Low molecular weight heparin inhibits this factor
This parenterally administered drug should not be used intramuscularly
Vitamin K dependent glycoprotein, has two forms, free and c4b bound
a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
ATIII inactivates these 3 clotting factors (answer in numerical order)
the famous indirect thrombin inhibitor, can induce thrombocytopenia
isolated from leech saliva, bivalent irreversible thrombin inhibitor
the oral standard long term therapy
this enzyme degrades many blood plasma proteins, most notably, the clot
Factor I
This proteins free form acts as a cofactor to protein C
xxx
allergy, alopecia, and osteoporosis are secondary side effects of this drug
Serine protease inhibitor that inactivates clotting factors
this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
Serine protease inhibitor that inhibits plasmin
enoxaparin, dalteparin, and tinzaparin are types of this drug
UFH
irudin and gatro are suffixes for this class
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor
This racemic mixture has a long halflife and has 100% bioavailability
heparin's half life in hours
Factor VIII
synthetic form of heparin
these vitamin facilitate clotting
Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
This vitamin K antagonist inhibits epoxide reductase
Factor II
if the pt has HIT, switch to this drug
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis
DTI used for HIT, beware of liver, increases INRs
Factor X
This LMWH is administered in mg, as opposed to anti factor Xa units
Factor IV
clopidogrel and ticlopidine act on this receptor
use the aPTT to measure the drug use
Factor IX
HIT
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
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Created Nov 24, 2010ReportNominate
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