Science Quiz / Hermel Day 3

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Can you name the Hermel Day 3?

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gemtuzumab delivers this toxin
these drugs inhibit transcription of inflammatory mediator genes
A homogenous antibody population that recognizes only one epitope
This fusion protein is used for RA, Crohn's disease, ulcerative colitis, psoriasis
neumega, leukine, and filgrastim are fda approved _____________ therapies
Def: these are biologics containing a toxin or prodrug
Avoidance of patient immune response is a key requirement for the use of this type of drug
This receptor is the target of rituximab
only fda mab used as an antibiotic
daclizumab targets the receptor of this interleukin
Toxicity highly associated with cyclosporine
T cells proliferate due to this interleukin
First FDA approved immunoconjugate
A critical enzyme for the production of guanosine nucleotides required for DNA synthesis
etanercept and abatacept are examples of this type of protein
first ORAL drug for Multiple Sclerosis
Acronym: CSF
drug: treat cancer AND immunosuppresant
These drugs are antiinflammatory, but they are not immunosuppressive
sirolimus aka rapamycin and rapamune, and everolimus are inhibitors of:
this drug targets active t cells only
This protein phosphatase activates NFATc which upregulates IL2
these drugs decrease the production of adhesion molecules
Mylotarg/gemtuzumab ozogamicin results in this type of DNA damage
Mylotarg/gemtuzumab ozogamicin targets cells bearing this receptor
This TNF antagonist is indicated in Crohn's disease, ulcerative colitis, and rheumatoid arthritis
cyclosporin, tacrolimus, and pimecrolimus are inhibitors of:
the gold standard for treatment of rheumatoid arthritis
Methotrexate/rheumatrex is an antagonist of:
denileukin delivers this toxin
These agents have fewer side effects than any other immunosuppressive drugs
Tacrolimus: major side effect
These types of drugs are used for treatment of nearly all inflammatory conditions, especially on a short term basis
Etanercept binds to this factor
Recently fda approved, trafficking inhibitor, moa not fully understood, blocks lymphocytes from exiting lymph nodes
This treatment down-modulates auto antibody productionused to treat lupus, xla, cvid
Pancreatitis is a contraindication of this antiRA drug
these chemical signals are used for restoration of hematopoiesis
Abatacept is fusion protein that interferes with this receptor
calcineurin and mTOR inhibitors inhibit this immune cell activation
thrombocytopenia puts pts at increased risk of __________
This drug inhibits T and B cell proliferation by blocking IMP-DH
mycophenolate mofetil and azathioprine belong to this category of drugs
This treatment is effective in reducing the mortality of sepsis
Reversible B lymphoproliferative disorders are a toxicity of this type of drug
Acronym mTOR
This drug is used in the treatment of atopic dermatitis
drug: soluble IL1 receptor antagonist
To reduce the emigration of leukocytes from vessels, you could decrease the number of _________ molecules
denileukin only binds to cells that contain a ____ receptor

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