Science Quiz / Hermel Day 3

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Can you name the Hermel Day 3?

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Abatacept is fusion protein that interferes with this receptor
Acronym: CSF
Recently fda approved, trafficking inhibitor, moa not fully understood, blocks lymphocytes from exiting lymph nodes
thrombocytopenia puts pts at increased risk of __________
first ORAL drug for Multiple Sclerosis
This treatment down-modulates auto antibody productionused to treat lupus, xla, cvid
First FDA approved immunoconjugate
Reversible B lymphoproliferative disorders are a toxicity of this type of drug
neumega, leukine, and filgrastim are fda approved _____________ therapies
only fda mab used as an antibiotic
etanercept and abatacept are examples of this type of protein
T cells proliferate due to this interleukin
these drugs decrease the production of adhesion molecules
This protein phosphatase activates NFATc which upregulates IL2
Toxicity highly associated with cyclosporine
Acronym mTOR
Def: these are biologics containing a toxin or prodrug
Mylotarg/gemtuzumab ozogamicin targets cells bearing this receptor
Tacrolimus: major side effect
A critical enzyme for the production of guanosine nucleotides required for DNA synthesis
denileukin only binds to cells that contain a ____ receptor
Etanercept binds to this factor
These agents have fewer side effects than any other immunosuppressive drugs
This treatment is effective in reducing the mortality of sepsis
this drug targets active t cells only
This fusion protein is used for RA, Crohn's disease, ulcerative colitis, psoriasis
mycophenolate mofetil and azathioprine belong to this category of drugs
These types of drugs are used for treatment of nearly all inflammatory conditions, especially on a short term basis
denileukin delivers this toxin
sirolimus aka rapamycin and rapamune, and everolimus are inhibitors of:
drug: treat cancer AND immunosuppresant
these drugs inhibit transcription of inflammatory mediator genes
calcineurin and mTOR inhibitors inhibit this immune cell activation
Methotrexate/rheumatrex is an antagonist of:
This drug inhibits T and B cell proliferation by blocking IMP-DH
cyclosporin, tacrolimus, and pimecrolimus are inhibitors of:
gemtuzumab delivers this toxin
drug: soluble IL1 receptor antagonist
This drug is used in the treatment of atopic dermatitis
Pancreatitis is a contraindication of this antiRA drug
To reduce the emigration of leukocytes from vessels, you could decrease the number of _________ molecules
the gold standard for treatment of rheumatoid arthritis
These drugs are antiinflammatory, but they are not immunosuppressive
Avoidance of patient immune response is a key requirement for the use of this type of drug
Mylotarg/gemtuzumab ozogamicin results in this type of DNA damage
A homogenous antibody population that recognizes only one epitope
This TNF antagonist is indicated in Crohn's disease, ulcerative colitis, and rheumatoid arthritis
daclizumab targets the receptor of this interleukin
This receptor is the target of rituximab
these chemical signals are used for restoration of hematopoiesis

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Created Nov 13, 2010ReportNominate

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