Science Quiz / Hermel Day 3

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Can you name the Hermel Day 3?

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ddd
This treatment is effective in reducing the mortality of sepsis
This TNF antagonist is indicated in Crohn's disease, ulcerative colitis, and rheumatoid arthritis
This treatment down-modulates auto antibody productionused to treat lupus, xla, cvid
daclizumab targets the receptor of this interleukin
drug: treat cancer AND immunosuppresant
To reduce the emigration of leukocytes from vessels, you could decrease the number of _________ molecules
these drugs decrease the production of adhesion molecules
only fda mab used as an antibiotic
calcineurin and mTOR inhibitors inhibit this immune cell activation
Acronym mTOR
Etanercept binds to this factor
Avoidance of patient immune response is a key requirement for the use of this type of drug
A critical enzyme for the production of guanosine nucleotides required for DNA synthesis
Pancreatitis is a contraindication of this antiRA drug
Toxicity highly associated with cyclosporine
Recently fda approved, trafficking inhibitor, moa not fully understood, blocks lymphocytes from exiting lymph nodes
A homogenous antibody population that recognizes only one epitope
Abatacept is fusion protein that interferes with this receptor
This fusion protein is used for RA, Crohn's disease, ulcerative colitis, psoriasis
these chemical signals are used for restoration of hematopoiesis
T cells proliferate due to this interleukin
Tacrolimus: major side effect
mycophenolate mofetil and azathioprine belong to this category of drugs
Mylotarg/gemtuzumab ozogamicin results in this type of DNA damage
This protein phosphatase activates NFATc which upregulates IL2
ddd
etanercept and abatacept are examples of this type of protein
This receptor is the target of rituximab
the gold standard for treatment of rheumatoid arthritis
these drugs inhibit transcription of inflammatory mediator genes
denileukin only binds to cells that contain a ____ receptor
Def: these are biologics containing a toxin or prodrug
denileukin delivers this toxin
thrombocytopenia puts pts at increased risk of __________
These drugs are antiinflammatory, but they are not immunosuppressive
Acronym: CSF
Methotrexate/rheumatrex is an antagonist of:
First FDA approved immunoconjugate
cyclosporin, tacrolimus, and pimecrolimus are inhibitors of:
sirolimus aka rapamycin and rapamune, and everolimus are inhibitors of:
These agents have fewer side effects than any other immunosuppressive drugs
Reversible B lymphoproliferative disorders are a toxicity of this type of drug
neumega, leukine, and filgrastim are fda approved _____________ therapies
These types of drugs are used for treatment of nearly all inflammatory conditions, especially on a short term basis
drug: soluble IL1 receptor antagonist
This drug is used in the treatment of atopic dermatitis
this drug targets active t cells only
Mylotarg/gemtuzumab ozogamicin targets cells bearing this receptor
This drug inhibits T and B cell proliferation by blocking IMP-DH
gemtuzumab delivers this toxin
first ORAL drug for Multiple Sclerosis

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