Science Quiz / Hermel Day 3

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Can you name the Hermel Day 3?

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ddd
This fusion protein is used for RA, Crohn's disease, ulcerative colitis, psoriasis
These agents have fewer side effects than any other immunosuppressive drugs
calcineurin and mTOR inhibitors inhibit this immune cell activation
thrombocytopenia puts pts at increased risk of __________
A homogenous antibody population that recognizes only one epitope
the gold standard for treatment of rheumatoid arthritis
gemtuzumab delivers this toxin
Etanercept binds to this factor
Tacrolimus: major side effect
sirolimus aka rapamycin and rapamune, and everolimus are inhibitors of:
These types of drugs are used for treatment of nearly all inflammatory conditions, especially on a short term basis
Pancreatitis is a contraindication of this antiRA drug
Def: these are biologics containing a toxin or prodrug
first ORAL drug for Multiple Sclerosis
A critical enzyme for the production of guanosine nucleotides required for DNA synthesis
Methotrexate/rheumatrex is an antagonist of:
Acronym mTOR
mycophenolate mofetil and azathioprine belong to this category of drugs
Abatacept is fusion protein that interferes with this receptor
these chemical signals are used for restoration of hematopoiesis
This protein phosphatase activates NFATc which upregulates IL2
To reduce the emigration of leukocytes from vessels, you could decrease the number of _________ molecules
First FDA approved immunoconjugate
denileukin delivers this toxin
Recently fda approved, trafficking inhibitor, moa not fully understood, blocks lymphocytes from exiting lymph nodes
ddd
These drugs are antiinflammatory, but they are not immunosuppressive
This receptor is the target of rituximab
Mylotarg/gemtuzumab ozogamicin targets cells bearing this receptor
Reversible B lymphoproliferative disorders are a toxicity of this type of drug
these drugs decrease the production of adhesion molecules
drug: treat cancer AND immunosuppresant
This TNF antagonist is indicated in Crohn's disease, ulcerative colitis, and rheumatoid arthritis
This treatment down-modulates auto antibody productionused to treat lupus, xla, cvid
Toxicity highly associated with cyclosporine
etanercept and abatacept are examples of this type of protein
neumega, leukine, and filgrastim are fda approved _____________ therapies
drug: soluble IL1 receptor antagonist
Mylotarg/gemtuzumab ozogamicin results in this type of DNA damage
This treatment is effective in reducing the mortality of sepsis
this drug targets active t cells only
This drug inhibits T and B cell proliferation by blocking IMP-DH
only fda mab used as an antibiotic
daclizumab targets the receptor of this interleukin
cyclosporin, tacrolimus, and pimecrolimus are inhibitors of:
Avoidance of patient immune response is a key requirement for the use of this type of drug
denileukin only binds to cells that contain a ____ receptor
Acronym: CSF
T cells proliferate due to this interleukin
This drug is used in the treatment of atopic dermatitis
these drugs inhibit transcription of inflammatory mediator genes

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