Science Quiz / Hermel Day 3

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Can you name the Hermel Day 3?

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First FDA approved immunoconjugate
Avoidance of patient immune response is a key requirement for the use of this type of drug
This receptor is the target of rituximab
A homogenous antibody population that recognizes only one epitope
the gold standard for treatment of rheumatoid arthritis
Recently fda approved, trafficking inhibitor, moa not fully understood, blocks lymphocytes from exiting lymph nodes
Methotrexate/rheumatrex is an antagonist of:
denileukin only binds to cells that contain a ____ receptor
first ORAL drug for Multiple Sclerosis
This treatment is effective in reducing the mortality of sepsis
daclizumab targets the receptor of this interleukin
This drug is used in the treatment of atopic dermatitis
A critical enzyme for the production of guanosine nucleotides required for DNA synthesis
To reduce the emigration of leukocytes from vessels, you could decrease the number of _________ molecules
drug: soluble IL1 receptor antagonist
These drugs are antiinflammatory, but they are not immunosuppressive
denileukin delivers this toxin
gemtuzumab delivers this toxin
cyclosporin, tacrolimus, and pimecrolimus are inhibitors of:
This fusion protein is used for RA, Crohn's disease, ulcerative colitis, psoriasis
This drug inhibits T and B cell proliferation by blocking IMP-DH
only fda mab used as an antibiotic
These types of drugs are used for treatment of nearly all inflammatory conditions, especially on a short term basis
drug: treat cancer AND immunosuppresant
These agents have fewer side effects than any other immunosuppressive drugs
Acronym mTOR
this drug targets active t cells only
Acronym: CSF
Toxicity highly associated with cyclosporine
Tacrolimus: major side effect
Etanercept binds to this factor
This TNF antagonist is indicated in Crohn's disease, ulcerative colitis, and rheumatoid arthritis
Mylotarg/gemtuzumab ozogamicin results in this type of DNA damage
etanercept and abatacept are examples of this type of protein
sirolimus aka rapamycin and rapamune, and everolimus are inhibitors of:
these chemical signals are used for restoration of hematopoiesis
neumega, leukine, and filgrastim are fda approved _____________ therapies
This protein phosphatase activates NFATc which upregulates IL2
This treatment down-modulates auto antibody productionused to treat lupus, xla, cvid
thrombocytopenia puts pts at increased risk of __________
Mylotarg/gemtuzumab ozogamicin targets cells bearing this receptor
these drugs inhibit transcription of inflammatory mediator genes
T cells proliferate due to this interleukin
mycophenolate mofetil and azathioprine belong to this category of drugs
Def: these are biologics containing a toxin or prodrug
Pancreatitis is a contraindication of this antiRA drug
these drugs decrease the production of adhesion molecules
Abatacept is fusion protein that interferes with this receptor
calcineurin and mTOR inhibitors inhibit this immune cell activation
Reversible B lymphoproliferative disorders are a toxicity of this type of drug

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