| Hint | Answer |
|---|
| Receptor Protein Kinases phosphorlate _____ residue on target proteins | |
| There are about ___ different membrane bound RTK | |
| There are also soulbe RTK in the ___ | |
| RTK can be binded by epidermal and ____derived growth factors | |
| RTK must form ___ to be activated | |
| To form dimers, if the ligand has similar of identical binding domains, it can ___ between two subunits of the receptor | |
| Or, two ligands can bind to ___ subinits and change their confomraitons to form the ___ | |
| The two subunits of the dimer ____ each other | |
| Dimer RTK - regulate __ activites, act as ______ sites for other molecules | |
| When RTK are actived the phosphorlyated ___ become ___ sites for other proteins | |
| ____ sites are domains on the signaling proteins (bind to cytoplamsic tails of RTKS) that recofnise the __site on the receptor | |
| Two binding domains are ___ and __. | |
| Both are about ___ amino acids long and have a binding pocket for ____tyorsine residue | |
| In humane genome, about ___ SH2 domains | |
| Specific tyorsone resides are emdiated by the ____ sequences surround the _____ tyosine on the recepotr | |
| The SH2 domain of the ___protein tyrosine kinase recognizes pTyr-__-__-__ | |
| The SH2 domain for ___ kinase recognizes pTyr-__-___-__ | |
| The PTB domin can someitmes dock without haveing a phosphorylated ___ to recognize | |
| For RTK, adaptor proteins are linkers that bind oe or more proteins as a ___complex. They have an ___ and 1< interaction domains | |
| The adaptor proetien ___ has one SH2 domian and 2 __ domians, binds to receptor, which binds to other proteins | |
| The adaptor proteins are floating around in the __- with proteins | |
| When receptor is activated by _____, the adaptor protein binds to the ____ and the attached proteins can be acted upon by other nearby enzymes like ___proteins | |
| Docking proteins bind to the Phosphroylated recrot and have ____ or ___ domains which are then ___ by the activated receptor | |
| Some things on docking proteins are transcription factors like _______ | |
| STATs have ___ domains with tyrosine phosphorylation sites | |
| The cytoplasmic domains of the receptors phosphorylate the ___ when they bind and then the STATs form ___ and become ______ | |
| Signaling enzymes have __ dominas and associte with RTK | |
| To end the response, activated receptors bind a _______ that induces the receptor to be ____ and degraded | |
| RTK - low glucose levels cause the pancreas to secrete____ | |
| Glucagon stimulates ___ to start a cascadeleading to the acitivation of _____ phosphorylase that breaks down glycogen to glucose | |
| Glycogen turns into glucose __ phosphate to glcuose __ phosphate to glucose | |
| Eat, our glucose levels increase the __ cells in the pancrease secrete ___- | |
| The insulin recptor is a ___ made of two __ and two ___, encoded by the same gene, but undergo ___ processing to make them different | |
| Insulin receptors bind insulin and cells take up glucose from blood or make ___ and shut down ____ | |
| The alpha and beat are bound to each other by ____ bonds | |
| Insulin causes the two beta chains to _____anactivate the RTK | |
| The activated phosphorylated receptor __ chains have docking proteins called ____ which bind to the phosphorylated tails of the ___ by a PTB domain. | |
| Activated __ then provide binding sites for ___ domains on signaling proteins | |
| Receptor binds insulin, the ___ subunit autophosphorylates ____resiudes on beta cahins as well as ___ | |
| The RTK also phosphorylates tyrosine __ that creates a ___ domain, the domain bnds the IRS to the receptor through its __ domain | |
| The IRS provide docking sites for the ___ containg signaling prteins | |
| The IRS have ___ on their N-terminus that binds to the phosphatidylinositides on the palsma membrane | |
| Sites on the IRS are _____ | |
| Other signaling proteins bind to the IRSs, ___ , the adaptor protein ___ and protein-tyroisne phosphatase___ | |
| PI3K and ___ are actiavted, PI3 has two ___ domains which attach it to the ___ and catalytic site | |
