Science Quiz / Biology Exam 3-7

Random Science or Biology Quiz

Can you name the Biology Exam 3-7?

Quiz not verified by Sporcle

Forced Order
Also try: Think Fast Math II
Score 0/133 Timer 20:00
Receptor Protein Kinases phosphorlate _____ residue on target proteins
There are about ___ different membrane bound RTK
There are also soulbe RTK in the ___
RTK can be binded by epidermal and ____derived growth factors
RTK must form ___ to be activated
To form dimers, if the ligand has similar of identical binding domains, it can ___ between two subunits of the receptor
Or, two ligands can bind to ___ subinits and change their confomraitons to form the ___
The two subunits of the dimer ____ each other
Dimer RTK - regulate __ activites, act as ______ sites for other molecules
When RTK are actived the phosphorlyated ___ become ___ sites for other proteins
____ sites are domains on the signaling proteins (bind to cytoplamsic tails of RTKS) that recofnise the __site on the receptor
Two binding domains are ___ and __.
Both are about ___ amino acids long and have a binding pocket for ____tyorsine residue
In humane genome, about ___ SH2 domains
Specific tyorsone resides are emdiated by the ____ sequences surround the _____ tyosine on the recepotr
The SH2 domain of the ___protein tyrosine kinase recognizes pTyr-__-__-__
The SH2 domain for ___ kinase recognizes pTyr-__-___-__
The PTB domin can someitmes dock without haveing a phosphorylated ___ to recognize
For RTK, adaptor proteins are linkers that bind oe or more proteins as a ___complex. They have an ___ and 1< interaction domains
The adaptor proetien ___ has one SH2 domian and 2 __ domians, binds to receptor, which binds to other proteins
The adaptor proteins are floating around in the __- with proteins
When receptor is activated by _____, the adaptor protein binds to the ____ and the attached proteins can be acted upon by other nearby enzymes like ___proteins
Docking proteins bind to the Phosphroylated recrot and have ____ or ___ domains which are then ___ by the activated receptor
Some things on docking proteins are transcription factors like _______
STATs have ___ domains with tyrosine phosphorylation sites
The cytoplasmic domains of the receptors phosphorylate the ___ when they bind and then the STATs form ___ and become ______
Signaling enzymes have __ dominas and associte with RTK
To end the response, activated receptors bind a _______ that induces the receptor to be ____ and degraded
RTK - low glucose levels cause the pancreas to secrete____
Glucagon stimulates ___ to start a cascadeleading to the acitivation of _____ phosphorylase that breaks down glycogen to glucose
Glycogen turns into glucose __ phosphate to glcuose __ phosphate to glucose
Eat, our glucose levels increase the __ cells in the pancrease secrete ___-
The insulin recptor is a ___ made of two __ and two ___, encoded by the same gene, but undergo ___ processing to make them different
Insulin receptors bind insulin and cells take up glucose from blood or make ___ and shut down ____
The alpha and beat are bound to each other by ____ bonds
Insulin causes the two beta chains to _____anactivate the RTK
The activated phosphorylated receptor __ chains have docking proteins called ____ which bind to the phosphorylated tails of the ___ by a PTB domain.
Activated __ then provide binding sites for ___ domains on signaling proteins
Receptor binds insulin, the ___ subunit autophosphorylates ____resiudes on beta cahins as well as ___
The RTK also phosphorylates tyrosine __ that creates a ___ domain, the domain bnds the IRS to the receptor through its __ domain
The IRS provide docking sites for the ___ containg signaling prteins
The IRS have ___ on their N-terminus that binds to the phosphatidylinositides on the palsma membrane
Sites on the IRS are _____
Other signaling proteins bind to the IRSs, ___ , the adaptor protein ___ and protein-tyroisne phosphatase___
PI3K and ___ are actiavted, PI3 has two ___ domains which attach it to the ___ and catalytic site
PI3K covert memrane lipids to PIP2 and ___ - which becoe bidning sites for __ domain-containg proteins like kinases PKB and ___ which are activated
____ phosphorylates and activates PKB which wil detach and move to nculeus
Activated PKB is incolved in ___ transport and ___ synthesis
PKB causes ____ to fuse with the plasma membrane
All of these Receptors when activated by their respective ligans can express ____ binding sites for the ___ domain of the adapotr protein, ___ whichbinds to Sos
All of these recepors can activates ___, leading to formation of PLC --> DAG and ___
The receptors can _____ to accomplish same things
___, GPCR, RTK can all act as docking sites for ___
About 30% of human cancers contain mutant versions of oncogenses nown as ___ genes
Ras oncogenes produce prtoeins known as ___ proteins
Ras protiens are a large family of ___ small g-proteins
Ras is a small, single polpypeptide that has ___ activty.
Ras is similar to the heterotrimeric G-proteins, when ___ bound to it, it is off
Ras is bound to the inner leaflet of the ____ membrane by a lipid tail
Ras-GTP are improtant in stumulating ___ division
If GTP on the ___is not hydrolyzed, the pathway divides in a uncontrolled manner
Ras proteins is aided by ___ proteins that regulate its acitvity
GTPase activating proteins (GAP) accelerate ___ hydorylsis and shorten the G-protien''s activity
Guanine nucleotide-exchange factors (GEF) bind to inactive ____ and stiumlate diassociation of ___
Guanine nucelotide-dosassocaiton inhibitors (GDI) inhbit disasscaiton of ___ and the protein remains ___
Ras-MAP kinase has a ligand bound to ___
RTK is autophosphorylated, and cytoplamsic domains are activated, ____residues are phosphorylated
Signaling proteins called adaptor proteins have ___ domains which bind to the phosphorylated RTK
Grb2 will have GEF on it that will acitvate __-
RTK binds a ligand and is ____
Grb2 binds to RTK and binds ___
Sos is a ___ and interacts with Ras-GDP and incduces release of ___ which is replaced by ___
Ras-GTP activates ___(kinase) which binds to plasma membrane
Raf activated MEK (____ ERK kinase)
MEK activates ERK (____)
ERK moves into unucleus and activates a ____ which turns on genes
Gene MKP-1 dephosphorlyates ___ and cascade stops
MAP is very important for cellular ____ and ____ pathways
Mitogens bind to surface of clel and induce the cells to undergo ____ and cell divison
MAP stands for ___
Mitogens are referred to as ____ acitvators
Map Kinases very involved in ____ and DNA synthesis
The RasMap occurs in ____ respond to mating hormones
Fruit flies -_____ of receptors in eye
Flowering plants - ____ mechanisms against pathogens
All events involve a cascade of ____, MAPKK, ___ with varitons in substrate of different kinases
Under extreme stress, the Ras-MAP kinase pathwaywas can be ___ down, so damaged cells can repair themselves
Some MAP kinases are bound to ____ proteins in specifc areas of cell and in a spatial oritentaiton that allows them to interact with nearby kinases and usbtrates
Cross over of receptors: Beta-andrenergic receptor stimulates by _, adneyly cyclase is acitvated, ___ is acitvaed which inhibits _ blocking the MAP kinase pathway and PKA activates
Steroid are transproted in blood by _ and serum albumin
SHBG receptors are outside of cell, receptors for ____are inside cell
Nitric oxide, smallest molecule, dilation of blood vessles, ____, nerve __ transmission,smooth muscle relaxation, ___reception, immune response
NO is an __ gas, works as both extracellular and ____ second messanger
NO is formed by breakdown of terminal amino group of ____, and requires ____, NADPH and ___-
nNosS is found in____ tissues and participates in cell comm
eNOS is found in ___ cells and funcitons in vasodilation
iNOS is _____ and important in immunity
Vasodilation occurs by _____ binds to receptor on endothelial cells
Causes an icrease in intracellular __ which binds to ___
The Ca-calmodulin can then bind to activate nitric oxide synthase which produces ___
___ diffuses quickly from the endothelial cell into nearby smooth muscles of blood vessel to relax
NO acticates guanyly cyclase that coverts ___ into ___
cGMP activates a ___-dependent protein kinase which phosphorylates additional siganling molecules that induces relaxation of the vessel
Angina -insufficent blood suply to heart, ___ helps with cornary arties to relax
Viagra acts to inhibit ___which breaks down cGMP to inactive GMP, so prolonged dilation of blood vessels
Cells kill thesleves because they are ____
Cells recieve a signal that turns on ____
Proeznymes are activated by function enzymes by having a peice of ___ cleaved off or an inhibitor removed
In apoptisis pathways these proenzyemes are called
The pathay involved with apoptosis is called the ____ cascade
Caspase stands for ___,___,___ that is a cysteine protease that cleaves after an ___ residue
____cleave and destrory and inactivate other critical prtoeins
Targeted - Focal adhesion kinases (lose contact with cells), PKB, PKC and ___ are also tragets
Lamins are protein that line the nuclear envelope and when target, the nucleus ___
Strucutral elements of the cytoplasm are cleaved, changing the ___ of cell
Endonuclease (___ activated DNase) is activated and moves inot the ____ and breaks down DNA
The events leading to apoptosis are __ (damaged DNA) or by ____(extracellualr signlas)
The extrinsic pathway can also activate the ____ pathway
____ is a extracellualr signal
TNF binds to its membrane spanninf receptor (TNG) which has ___ intracellualr domains of ___ aminos acids called ___ domains
Binding of TNF to its receptor induces a conformational change in the ___ domains and causes protei-protein inetactions
Two adaptor proteins bind to activated death domains ___ and ___
FADD stands for ___
TRADD stands for ___
Two ____-8 molecules bind to the ___ domains and form a complex called ____domains
When the two procaspase__moleucles are assmebled into the complex, they cleave each to become activated and forma a singe ___-8 molecule containing ___ polypeptides
Caspase __ ititates down-stream activation of exectuioner ___
Any severe physiologic pertubration insde the cell could cause the ____ pathway
Intrinsic is mediated by ____
Some Bcl-2 induce apotosis (Bad and __), ohter act to prevent apoptosis
The expresion of some Bcl-2 memrbanes cause inhbition of ___
Bax translocates to the ___ outer memebrane, binds and incudes a peremability chainge in the memb cause realse of ___ proteins, expecially ____
Cytochome c binds to cytoplasmic proteins and ____ forming a large multi-proten complex known as the ____ which activates the executioner procaspases

You're not logged in!

Compare scores with friends on all Sporcle quizzes.
Sign Up with Email
Log In

You Might Also Like...

Show Comments


Top Quizzes Today

Score Distribution

Your Account Isn't Verified!

In order to create a playlist on Sporcle, you need to verify the email address you used during registration. Go to your Sporcle Settings to finish the process.