Science Quiz / Pharmacology of Infection and Immunity

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Can you name the drugs in Pharmacology of Infection and Immunity?

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ClassDrugClue
Anti Parasiticalters Ca2+ memb. perm. - Flukes, Tapeworms
Musc. AntagonistNo selective
GlucocorticoidName one
Glycopeptidebind D-Ala-D-Ala
Anti Parasiticblock neurotransmitter, administered with Sennosides - Roundworms, Pinworms
Anti Parasiticblock microtubule assembly and Glu uptake - Tapeworms and Intest. Nematodes
Beta-lactamase inhibitorBromine
MucolyticName one
New HAART classMeraviroc
Anti-inflammatoryUsed in Meningitis
ImmunotherapyAnti TNF recombinant receptor
HAART classZidovudine, Didanosine, Zalcitabine, Stavudine, Lamivudine, Abacavir
2nd Line TBName 1
Administer with beta lactamsdecrease kidney secretion
Beta-lactam (Penicillin)First Penicillin
Cell Wall SynthBactoprenol Inhibitor
MacrolideBind 50s blocking pep bond form. Legionella
MMP blockTrialled in RA
TB drugIncrease Cell wall perm
Beta-lactamase inhibitorCoamoxyclav
Anti ParasiticBlock neurone ion channel - Filarial Nematodes
ImmunotherapyAnti ICAM
Cephalosporin 1st GenerationOral Gram Positive
EchinocandinsInh. 1,3b D-glucan synthase
RifamycinTB binds RNA polymerase
Abminister with beta lactamsinhibits dehydropeptidase in renal tubule
Beta-lactam (Monobactam)i.m. or i.v. for septicaemia or complicated UTI
NSAIDPainkiller & Gastric Side Effects
HAART classNevirapine, Delavirdine, Efavirenz
New HAART classFuzeon
HAART classSaquinavir, Ritonavir,Indinavir, Nelfinavir
ATSClass of anti ATS, inh. PPARa and inc. Lipoprot. Lipase
Anti fungalPokes holes in membrane
ATSVitamin inh. Liver TG prod. and VLDL secr. also in in tobacco
ClassDrugClue
Anti viral drugType of Cytokine used to decrease prolif and increase immune resp.
NSAIDAnti inflammatory
Cephalosporin 2nd Generationi.m. G +ve & G -ve
DMARDSounds like a malaria drug
Beta-lactam (Imipenem)Broad spectrum of anaerobes and aerobes
Anti fungalInterferes with tubulin. Old
ATSGrab secreted bile acids - name one
TetracyclineInhibit tRNA binding on 30s and peptide release
Beta-lactam (Penicillin)Definition of resistance in MRSA
DMARDOld drug. May affect macrophages
Type4 PDEIAnti inflammatory
Anti fungalblocks ^14 reduction & ^7-8 isomerisation
QuinoloneInhibit Topoisomerase 2 - racemic
ArthopodName one
Beta-lactam (Penicillin)First Oral Penicillin
ImmunotherapyANti IL1R
Neuraminidase InhName one
Beta adrenoceptor agonistLong duration diffuses laterally in memb to interact with R
5-LO inh.Block LT formation
Cell Wall SynthPrevents D-Ala-D-Ala assembly
Lincosamide50s prevent aa forming pep bond
Adamantanes (M2 inh)Name one
ImmunotherapyAnti TNF ab Humanised
Cephalosporin 3rd Generationi.v. Meningitis & G -ve
QuinoloneInhibit DNA gyrase
NitroimidazoleAnaerobes and Parasites. Affects NA synth.
DecongestantName one
Beta adrenoceptor agonistLong duration forms depot in membrane and leaks to R
Cephalosporin 3rd Generationi.v. Meningitis & G -ve
Beta adrenoceptor agonistShort Duration
CromonesMast Cell stabilisers
Nucleic Acid InhibitorsDihydropterate Synthetase
Streptogramins50s inh. elongation
Beta-lactam (Penicillin)Broad Spec, Oral Common Penicillin
ClassDrugClue
Beta-lactamase inhibitorSulphur
ImmunotherapyAnti TNF antibody
PDEINon selective
QuinoloneLast resort quinolone
Anti Parasiticuncouples Oxidative Phosphorylation - Tapeworms
ImmunotherapyAnti IL-6 (begins with T)
AllylamineSqualene epoxidase inh.
Fungal efflux InhibitorBegins Mil
AminoglycosideSee above begins with Ge
Azole/TriazoleInh. Lanosterol 14a demethylase
Musc. AntagonistM3 selective
ATSDrug class inhibit HMG CoA reductase - name one
LipopeptideDepolarise membrane
OxazolidinoneWorks on VRE and MRSA
DMARDInhibit dihydrofolate reductase
Glycopeptidebind D-Ala-D-Ala
TB drugFAS1 inh.
DMARDAdministrered as a salt. Old drug.
DMARDPeni...
 bind Elongation Factor G
TB drugMycolic Acid Inhibitor
 Broad Spec. binds 50s blocking pep bond form
Anti fungalRNA & DNA biosynthesis
Affects Eicosanoid StructureIn diet, Fish
AminoglycosideAnti TB Ototoxic
ImmunosuppressantNo grapefruit
PainkillerCommon
LT inh. Blocks specific LTs
Nucleic Acid InhibitorsDihydrofolate Reducatase
ImmunotherapyAnti IgE (Mast Cell sensitiser Igs)
Cell Membrane DisruptionMycoplasma & Chlamydia
Chain terminatormost common antiviral, type of NNRRI

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