Science Quiz / Pharmacology of Infection and Immunity

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Can you name the drugs in Pharmacology of Infection and Immunity?

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ATSGrab secreted bile acids - name one
Beta-lactamase inhibitorSulphur
Anti-inflammatoryUsed in Meningitis
 Broad Spec. binds 50s blocking pep bond form
TB drugFAS1 inh.
Beta-lactam (Penicillin)First Oral Penicillin
Azole/TriazoleInh. Lanosterol 14a demethylase
Anti ParasiticBlock neurone ion channel - Filarial Nematodes
Beta-lactamase inhibitorCoamoxyclav
PDEINon selective
Type4 PDEIAnti inflammatory
ImmunotherapyAnti IgE (Mast Cell sensitiser Igs)
Cephalosporin 3rd Generationi.v. Meningitis & G -ve
DMARDOld drug. May affect macrophages
GlucocorticoidName one
ATSDrug class inhibit HMG CoA reductase - name one
Abminister with beta lactamsinhibits dehydropeptidase in renal tubule
Lincosamide50s prevent aa forming pep bond
 bind Elongation Factor G
CromonesMast Cell stabilisers
Anti fungalInterferes with tubulin. Old
DecongestantName one
NSAIDPainkiller & Gastric Side Effects
ArthopodName one
RifamycinTB binds RNA polymerase
ImmunotherapyAnti TNF ab Humanised
DMARDSounds like a malaria drug
EchinocandinsInh. 1,3b D-glucan synthase
ImmunotherapyAnti TNF recombinant receptor
ImmunosuppressantNo grapefruit
Cell Wall SynthPrevents D-Ala-D-Ala assembly
ImmunotherapyAnti IL-6 (begins with T)
MucolyticName one
Musc. AntagonistM3 selective
TB drugIncrease Cell wall perm
ATSVitamin inh. Liver TG prod. and VLDL secr. also in in tobacco
ImmunotherapyAnti TNF antibody
ImmunotherapyAnti ICAM
Musc. AntagonistNo selective
Anti Parasiticuncouples Oxidative Phosphorylation - Tapeworms
Anti Parasiticblock neurotransmitter, administered with Sennosides - Roundworms, Pinworms
Cell Membrane DisruptionMycoplasma & Chlamydia
Cephalosporin 1st GenerationOral Gram Positive
New HAART classFuzeon
Fungal efflux InhibitorBegins Mil
Beta-lactam (Penicillin)First Penicillin
Nucleic Acid InhibitorsDihydropterate Synthetase
MacrolideBind 50s blocking pep bond form. Legionella
LT inh. Blocks specific LTs
TB drugMycolic Acid Inhibitor
NSAIDAnti inflammatory
Chain terminatormost common antiviral, type of NNRRI
Anti fungalRNA & DNA biosynthesis
Anti fungalPokes holes in membrane
Streptogramins50s inh. elongation
Cephalosporin 2nd Generationi.m. G +ve & G -ve
New HAART classMeraviroc
HAART classNevirapine, Delavirdine, Efavirenz
Cephalosporin 3rd Generationi.v. Meningitis & G -ve
Nucleic Acid InhibitorsDihydrofolate Reducatase
Adamantanes (M2 inh)Name one
Beta-lactam (Penicillin)Definition of resistance in MRSA
Glycopeptidebind D-Ala-D-Ala
Beta-lactam (Monobactam)i.m. or i.v. for septicaemia or complicated UTI
Beta adrenoceptor agonistLong duration forms depot in membrane and leaks to R
HAART classSaquinavir, Ritonavir,Indinavir, Nelfinavir
Affects Eicosanoid StructureIn diet, Fish
Beta-lactam (Imipenem)Broad spectrum of anaerobes and aerobes
Beta-lactam (Penicillin)Broad Spec, Oral Common Penicillin
Anti viral drugType of Cytokine used to decrease prolif and increase immune resp.
NitroimidazoleAnaerobes and Parasites. Affects NA synth.
Beta adrenoceptor agonistLong duration diffuses laterally in memb to interact with R
Beta adrenoceptor agonistShort Duration
QuinoloneInhibit Topoisomerase 2 - racemic
QuinoloneLast resort quinolone
Anti Parasiticalters Ca2+ memb. perm. - Flukes, Tapeworms
Anti Parasiticblock microtubule assembly and Glu uptake - Tapeworms and Intest. Nematodes
2nd Line TBName 1
Glycopeptidebind D-Ala-D-Ala
ImmunotherapyANti IL1R
AllylamineSqualene epoxidase inh.
OxazolidinoneWorks on VRE and MRSA
ATSClass of anti ATS, inh. PPARa and inc. Lipoprot. Lipase
AminoglycosideAnti TB Ototoxic
AminoglycosideSee above begins with Ge
LipopeptideDepolarise membrane
5-LO inh.Block LT formation
DMARDAdministrered as a salt. Old drug.
Neuraminidase InhName one
Anti fungalblocks ^14 reduction & ^7-8 isomerisation
QuinoloneInhibit DNA gyrase
Beta-lactamase inhibitorBromine
TetracyclineInhibit tRNA binding on 30s and peptide release
Cell Wall SynthBactoprenol Inhibitor
HAART classZidovudine, Didanosine, Zalcitabine, Stavudine, Lamivudine, Abacavir
Administer with beta lactamsdecrease kidney secretion
DMARDInhibit dihydrofolate reductase
MMP blockTrialled in RA

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