Science Quiz / Pharmacology of Infection and Immunity

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Can you name the drugs in Pharmacology of Infection and Immunity?

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Glycopeptidebind D-Ala-D-Ala
QuinoloneInhibit Topoisomerase 2 - racemic
ATSDrug class inhibit HMG CoA reductase - name one
HAART classZidovudine, Didanosine, Zalcitabine, Stavudine, Lamivudine, Abacavir
Cell Membrane DisruptionMycoplasma & Chlamydia
DMARDAdministrered as a salt. Old drug.
ImmunotherapyAnti TNF ab Humanised
Beta-lactam (Penicillin)First Oral Penicillin
LT inh. Blocks specific LTs
Anti Parasiticalters Ca2+ memb. perm. - Flukes, Tapeworms
Musc. AntagonistNo selective
ATSVitamin inh. Liver TG prod. and VLDL secr. also in in tobacco
DecongestantName one
5-LO inh.Block LT formation
ImmunotherapyAnti ICAM
Beta-lactam (Monobactam)i.m. or i.v. for septicaemia or complicated UTI
HAART classSaquinavir, Ritonavir,Indinavir, Nelfinavir
Anti-inflammatoryUsed in Meningitis
Abminister with beta lactamsinhibits dehydropeptidase in renal tubule
Cell Wall SynthBactoprenol Inhibitor
LipopeptideDepolarise membrane
Anti Parasiticblock microtubule assembly and Glu uptake - Tapeworms and Intest. Nematodes
ArthopodName one
NSAIDAnti inflammatory
NSAIDPainkiller & Gastric Side Effects
ATSClass of anti ATS, inh. PPARa and inc. Lipoprot. Lipase
Affects Eicosanoid StructureIn diet, Fish
Beta-lactamase inhibitorBromine
ImmunotherapyAnti IgE (Mast Cell sensitiser Igs)
Type4 PDEIAnti inflammatory
QuinoloneLast resort quinolone
ATSGrab secreted bile acids - name one
Anti fungalRNA & DNA biosynthesis
ImmunotherapyAnti TNF antibody
MMP blockTrialled in RA
Anti viral drugType of Cytokine used to decrease prolif and increase immune resp.
AllylamineSqualene epoxidase inh.
TB drugIncrease Cell wall perm
Glycopeptidebind D-Ala-D-Ala
2nd Line TBName 1
Lincosamide50s prevent aa forming pep bond
OxazolidinoneWorks on VRE and MRSA
TetracyclineInhibit tRNA binding on 30s and peptide release
GlucocorticoidName one
Nucleic Acid InhibitorsDihydrofolate Reducatase
HAART classNevirapine, Delavirdine, Efavirenz
TB drugFAS1 inh.
Anti fungalInterferes with tubulin. Old
Adamantanes (M2 inh)Name one
Azole/TriazoleInh. Lanosterol 14a demethylase
Beta-lactam (Penicillin)Definition of resistance in MRSA
Beta-lactamase inhibitorCoamoxyclav
Anti Parasiticblock neurotransmitter, administered with Sennosides - Roundworms, Pinworms
Beta adrenoceptor agonistShort Duration
MucolyticName one
Anti fungalblocks ^14 reduction & ^7-8 isomerisation
Cephalosporin 1st GenerationOral Gram Positive
DMARDInhibit dihydrofolate reductase
Beta-lactam (Penicillin)Broad Spec, Oral Common Penicillin
ImmunosuppressantNo grapefruit
 bind Elongation Factor G
Fungal efflux InhibitorBegins Mil
 Broad Spec. binds 50s blocking pep bond form
Cephalosporin 3rd Generationi.v. Meningitis & G -ve
Beta-lactam (Imipenem)Broad spectrum of anaerobes and aerobes
AminoglycosideAnti TB Ototoxic
Anti fungalPokes holes in membrane
Neuraminidase InhName one
Chain terminatormost common antiviral, type of NNRRI
Musc. AntagonistM3 selective
New HAART classMeraviroc
New HAART classFuzeon
Nucleic Acid InhibitorsDihydropterate Synthetase
Beta adrenoceptor agonistLong duration diffuses laterally in memb to interact with R
Administer with beta lactamsdecrease kidney secretion
Beta-lactamase inhibitorSulphur
Beta adrenoceptor agonistLong duration forms depot in membrane and leaks to R
AminoglycosideSee above begins with Ge
ImmunotherapyANti IL1R
MacrolideBind 50s blocking pep bond form. Legionella
Streptogramins50s inh. elongation
TB drugMycolic Acid Inhibitor
ImmunotherapyAnti IL-6 (begins with T)
Anti Parasiticuncouples Oxidative Phosphorylation - Tapeworms
CromonesMast Cell stabilisers
Cephalosporin 3rd Generationi.v. Meningitis & G -ve
QuinoloneInhibit DNA gyrase
Cell Wall SynthPrevents D-Ala-D-Ala assembly
NitroimidazoleAnaerobes and Parasites. Affects NA synth.
DMARDOld drug. May affect macrophages
DMARDSounds like a malaria drug
ImmunotherapyAnti TNF recombinant receptor
Cephalosporin 2nd Generationi.m. G +ve & G -ve
RifamycinTB binds RNA polymerase
Beta-lactam (Penicillin)First Penicillin
EchinocandinsInh. 1,3b D-glucan synthase
Anti ParasiticBlock neurone ion channel - Filarial Nematodes
PDEINon selective

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