Science Quiz / Diseases in Infection and Immunity

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Can you name the Diseases in Infection and Immunity?

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AreaDiseaseClue
Parasite (Helminth)Egg dropped in faeces and mature in soil. they are ingested and hatch in intestine. they penetrate the gut wall and migrate to liver then heart then lung. they grow and are then coughed up and swallowed.10-30cm adult can escape from any orifice though larval migration causes most morbidity.
Immune DeficiencyRecurrent bacterial infections, no pus, Leukocytes don't adhere to endothelium
ArthopodsScalp itching
Parasite (Protozoa)Short stage in blood then muscle (esp. heart).
Immune DeficiencyNeutrophilia, no pus, defective fucose metabolism (affects selectins), decreased rolling
InflammationNeutrophil driven, often causes cyanosis, hypoxia and right heart failure. Mucous is a problem!
BacteriaSusceptible to Linezolid but not vancomycin
FungusCaused by trichophyton (mould) often
FungusMore common where earth is being moved. In lungs.
Skin DiseaseTetracycline often applied topically to cure
Parasite (Helminth)S. mansoni, S. haematobium, S. japonicus. Use water snail as intermediate host (can also have secondary host)
VirusHemaglutinnin, Neuraminidase, ...
InfectionIsoniazid/Ethambutol/Pyrazinamide/Rifampicin prescribed
FungusCan be oral or vaginal. Often treated with oral miconazole.
BacteriaOften cause gut infection after oral broad spectrum antibiotic
Mendelian DisorderLDLR doesn't recognise ApoA or ApoE
Parasite (Protozoa)Multiplies in blood and CSF disturbing circadian rythms. avoids immune system by using cyclical antigen coats.
Systemic InflammationRF present but not Rheumatoid Arthritis. Often features in 'House'
VirusCauses SARS
VirusMost common cold causer
Risk FactorIncreases risk of ATS
AreaDiseaseClue
InflammationTh2 (IL-4,5 & 13) and Eosinophil driven. Hyperresponsiveness
Side EffectPenicillin can cause this in about 5% of people
InflammationHomocysteine implicated
VirusT cells increase but there are less T cells
Virus/InflammationRibavirin used, can be caused by alcohol
Mendelian disorderABCA1 doesn't work so ApoA1 can't pick up cholesterol
Risk Factor - BacteriaCo-morbidity with ATS
Parasite (Protozoa)They multiply in Liver then RBCs. Can cause severe anaemia, haemolysis, pulmonary oedema, metabolic acidosis and hypoglycaemia. Most serious in P. falciparum
Infection/InflammationCefotaxime/Ceftriaxone often prescribed. Caused by N. meningitidis, H. influenzae, S. pneumoniae, L. monocytogenes, possible C. albicans...
Parasite (Helminth)Live in subcutaneous tissue and lymphatic tissue. Adults discharge tiny babies which can be ingested by insects. Can cause Elephantiasis and River Blindness.
BacteriaOften susceptible to vancomycin and linezolid but resistant to Methicillin
FungusCaused by Yeast
Parasite (Helminth)If humans are primary host, no morbidity. Worm just stays in gut. Intermediate host causes morbidity as organism in tissues
Side EffectDeath after Chloramphenicol
ArthopodsMite burrows into epidermis. Papular eruption.
InflammationChronic Inflammation, Synovium (Hyaluronan, PGE2), MMPs (TIMP & Serpin inactivation), TNFa, IL-1b, Pannus formation
ArthopodsItching in Pubic Area
Side EffectCan be caused by Clindamycin. Killing all susceptible bacteria in gut using a broad spectrum antibiotic can cause...
BacteriaSusceptible to few drugs, often causes septicaemia. Susceptible to Ceftazidime, Cefoperazone, Cefepime, Cefpirome, Imipenem, Polymixins, Ciprofloxacin
Side EffectTetracyclin forms ROS causing damage
Side EffectAminoglycoside SE

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